Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells

Journal of Experimental Medicine

Volumn 192, Issue 6, 2000, Pages 823-833

  Hochrein, Hubertus ^a   O'Keeffe, Meredith ^a   Luft, Thomas ^b   Vandenabeele, Stéphane ^a   Grumont, Raelene J ^a   Maraskovsky, Eugene ^b   Shortman, Ken ^a,c  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Granulocyte macrophage colony stimulating factor; Homodimeric interleukin 12; Interferon ; T helper type 1; T helper type 2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM; SPLEEN CELL; TH1 CELL; TH2 CELL; THYMOCYTE;

ANIMALS; CELLS, CULTURED; DENDRITIC CELLS; GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTORS, RECOMBINANT; HUMANS; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-12; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MONOCYTES; RECOMBINANT PROTEINS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0033802387     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.6.823     Document Type: Article

References (52)

1. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
2. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
3. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
4. Interleukin-12: A cytokine at the interface of inflammation and immunity
5. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
6. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
7. In vivo production and function of IL-12 p40 homodimers
8. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
9. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
10. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
11. Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2
12. Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock
13. Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo
14. Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection
15. Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice
16. Reduced T helper 1 responses in IL-12 p40 transgenic mice
17. Increased IL-12 P40 homodimer secretion by spleen cells during in vivo growth of the BW-19 T cell hybridoma accompanies suppression of natural immunity
18. + T cells
19. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells
20. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
21. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
22. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: Evidence for a soluble CD14-dependent pathway
23. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
24. Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
25. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
26. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor alpha production
27. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10
28. Priming with IL-4 and IL-13 during HIV-1 infection restores in vitro IL-12 production by mononuclear cells of HIV-infected patients
29. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
30. Interleukin-4 regulation of human monocyte and macrophage interleukin-10 and interleukin-12 production. Role of a functional interleukin-2 receptor gamma-chain
31. Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
32. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4
33. Bacterial DNA causes septic shock
34. The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells
35. Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes
36. Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes
37. Post-transcriptional regulation of glyceraldehyde 3-phosphate-dehydrogenase gene expression in rat tissues
38. Dramatic increase in the numbers of functionally mature dendritic cells in mice treated with Flt3 ligand: Multiple dendritic cell subpopulations identified
39. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen
40. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
41. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
42. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo
43. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells
44. Recombinant IL-4 aggravates experimental autoimmune uveoretinitis in rats
45. + T helper type 1 cell responses to Candida albicans
46. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
47. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: Implications for the initiation of anti-Leishmania immunity
48. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
49. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
50. Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production
51. Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response
52. CpG oligodeoxy-nucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis