Causing a commotion in the blood: Immunotherapy progresses from bacteria to bacterial DNA

Immunology Today

Volumn 21, Issue 10, 2000, Pages 521-526

  Krieg, Arthur M ^a,b,c   Wagner, Hermann ^d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c PFIZER INC   (United States)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BACTERIAL DNA; CPG DNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNE DISEASE; BACTERIUM; CANCER; CANCER IMMUNOTHERAPY; CPG ISLAND; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOPATHOGENESIS; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMAL; CPG ISLANDS; DNA, BACTERIAL; HUMAN; IMMUNITY, ACTIVE; IMMUNITY, CELLULAR; IMMUNITY, NATURAL; OLIGONUCLEOTIDES; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; VACCINES, DNA;

EID: 0033790347     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01719-9     Document Type: Review

References (66)

1. Coley's toxins, tumor necrosis factor and cancer research: A historical perspective
2. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
3. CpG motifs in bacterial DNA trigger direct B-cell activation
4. Macrophages ingest and are activated by bacterial DNA
5. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-α-mediated shock
6. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
7. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
8. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
9. Innate immunity: Impact on the adaptive immune response
10. CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL
11. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
12. Activation of human B cells by phosphorothioate oligodeoxynucleotides
13. Bacterial DNA and immunostimulatory CpG oligonucleotldes trigger maturation and activation of murine dendritic cells
14. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
15. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
16. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell indepedent cytotoxic T cell responses to soluble proteins
17. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses
18. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
19. Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
20. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesis in vitro
21. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
22. Oligodeoxynucleotides containing palindrome sequences with internal 5'-CpG-3' act directly on human NK and activated T cells to induce IFN-γ production in vitro
23. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
24. Type I interferon-mediated stimulation of T cells by CpG DNA
25. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
26. Poly-guanosine motifs costirnulate antigen reactive CD8 T cells while bacterial CpG-DNA affect T cell activation via APC derived cytokines
27. Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity
28. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
29. Lack of immune stimulation by immobilized CpG-oligodeoxynucleotide
30. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
31. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
32. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
33. + T cells into Th1 effectors
34. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
35. Immune cell activation by bacterial CpG-DNA through MyD88 and TRAF6
36. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
37. Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide
38. CpG DNA and LPS induce distinct patterns of activation in human monocytes
39. IFN-γ primes macrophage responses to bacterial DNA
40. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
41. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
42. Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice
43. Antisense c-myc and immunostimulatory oligonucleotide inhibition of tumorigenesis in a murine B-cell lymphoma transplant model
44. Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously
45. Dendritic cells and the control of immunity
46. CpG-DNA mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen driven responses
47. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
48. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface
49. Use of CpG DNA for enhancing specific immune responses
50. Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines
51. + T cell dependent
52. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
53. CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine m orangutans
54. Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys
55. Mechanism and function of a newly identified CpG DNA motif in human primary B cells
56. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
57. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
58. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
59. Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice
60. T cell-independent rescue of B lymphocytes from peripheral immune tolerance
61. Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis
62. Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA
63. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
64. Chlamydia infections and heart disease linked through antigenic mimicry
65. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis