메뉴 건너뛰기




Volumn 127, Issue 5, 1999, Pages 1195-1205

Differential inhibitory mechanism of cyclic AMP on TNF-α and IL-12 synthesis by macrophages exposed to microbial stimuli

Author keywords

Cyclic AMP; Glycosylphosphatidylinositol mucins; IL 10; IL 12; Lipopolysaccharide; Macrophage; Microbial stimuli; Prostaglandins; TNF ; Trypanosoma cruzi

Indexed keywords

8 BROMO CYCLIC AMP; 9 (TETRAHYDRO 2 FURYL)ADENINE; BUCLADESINE; CHOLERA TOXIN; CYCLIC AMP; INTERLEUKIN 10; INTERLEUKIN 12; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

EID: 0345879223     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702624     Document Type: Article
Times cited : (53)

References (47)
  • 2
    • 0030010929 scopus 로고    scopus 로고
    • IL-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
    • ALIBERTI, J.C.S., CARDOSO, M.A.G., MARTINS, G.A., GAZZINELLI, R.T., VIEIRA, L.Q. & SILVA, J.S. (1996). IL-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect. Immun., 64, 1961-1967.
    • (1996) Infect. Immun. , vol.64 , pp. 1961-1967
    • Aliberti, J.C.S.1    Cardoso, M.A.G.2    Martins, G.A.3    Gazzinelli, R.T.4    Vieira, L.Q.5    Silva, J.S.6
  • 3
    • 0028670563 scopus 로고
    • Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel o-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi
    • ALMEIDA, I.C., FERGUSON, M.A.J., SCHENKMAN, S. & TRAVASSOS, L.R. (1994a). Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi. Biochem. J., 304, 793-802.
    • (1994) Biochem. J. , vol.304 , pp. 793-802
    • Almeida, I.C.1    Ferguson, M.A.J.2    Schenkman, S.3    Travassos, L.R.4
  • 4
    • 0028090417 scopus 로고
    • Chemiluminescent immunoassays: Discrimination between the reactivities of natural and human patient antibodies with antigens from eukaryotic pathogens, Trypanoama cruzi and Paracoccidioides brasiliensis
    • ALMEIDA, I.C., RODRIGUES, E.G. & TRAVASSOS, L.R. (1994b). Chemiluminescent immunoassays: discrimination between the reactivities of natural and human patient antibodies with antigens from eukaryotic pathogens, Trypanoama cruzi and Paracoccidioides brasiliensis. J. Clin. Lab. Analysis, 8, 424-431.
    • (1994) J. Clin. Lab. Analysis , vol.8 , pp. 424-431
    • Almeida, I.C.1    Rodrigues, E.G.2    Travassos, L.R.3
  • 5
    • 0030848073 scopus 로고    scopus 로고
    • Differential regulation of IFN-γ, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway
    • BENBERNOU, N., ESNAULT, S., SHIN, H.C.K., FEKKAR, H. & GUENOUNOU, M. (1997). Differential regulation of IFN-γ, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Immunology, 91, 361-368.
    • (1997) Immunology , vol.91 , pp. 361-368
    • Benbernou, N.1    Esnault, S.2    Shin, H.C.K.3    Fekkar, H.4    Guenounou, M.5
  • 6
    • 0029099391 scopus 로고
    • Effects of IL-12 on immune responses to microbial infections: A key mediator in regulating disease outcome
    • BIRON, C.A. & GAZZINELLI, R.T. (1995). Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol., 7, 485-496.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 485-496
    • Biron, C.A.1    Gazzinelli, R.T.2
  • 7
    • 0030870893 scopus 로고    scopus 로고
    • Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease
    • BRENER, Z. & GAZZINELLI, R.T. (1997). Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int. Arch. Allergy Immunol., 114, 103-110.
    • (1997) Int. Arch. Allergy Immunol. , vol.114 , pp. 103-110
    • Brener, Z.1    Gazzinelli, R.T.2
  • 8
    • 0031570514 scopus 로고    scopus 로고
    • Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages
    • CAMARGO, M.M., ALMEIDA, I.C., PEREIRA, M.E., FERGUSON, M.A., TRAVASSOS, L.R. & GAZZINELLI, R.T. (1997a). Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages. J. Immunol., 158, 5890-5901.
    • (1997) J. Immunol. , vol.158 , pp. 5890-5901
    • Camargo, M.M.1    Almeida, I.C.2    Pereira, M.E.3    Ferguson, M.A.4    Travassos, L.R.5    Gazzinelli, R.T.6
  • 9
    • 0031573627 scopus 로고    scopus 로고
    • Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania sp. parasite membranes trigger nitric oxide synthesis as well as microbicidal activity by IFN-γ-primed macrophages
    • CAMARGO, M.M., ANDRADE, A.C., ALMEIDA, I.C., TRAVASSOS, L.R. & GAZZINELLI, R.T. (1997b). Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania sp. parasite membranes trigger nitric oxide synthesis as well as microbicidal activity by IFN-γ-primed macrophages. J. Immunol., 159, 6131-6139.
    • (1997) J. Immunol. , vol.159 , pp. 6131-6139
    • Camargo, M.M.1    Andrade, A.C.2    Almeida, I.C.3    Travassos, L.R.4    Gazzinelli, R.T.5
  • 10
    • 0027240219 scopus 로고
    • Interleukin-10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'ANDREA, A., ASTE-AMEZAGA, M., VALIANTE, N., MA, X., KUBIN, M. & TRINCHIERI, G. (1993). Interleukin-10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med., 178, 1041-1048.
    • (1993) J. Exp. Med. , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 11
    • 0028911482 scopus 로고
    • Stimulatory and inhibitory effects of IL-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and TNF-α production
    • D'ANDREA, A., MA, X., ASTE-AMEZAGA, M., PAGANIN, C. * TRINCHIERI, G. (1995). Stimulatory and inhibitory effects of IL-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and TNF-α production. J. Exp. Med., 181, 537-546.
    • (1995) J. Exp. Med. , vol.181 , pp. 537-546
    • D'Andrea, A.1    Ma, X.2    Aste-Amezaga, M.3    Paganin, C.4    Trinchieri, G.5
  • 12
    • 0031942752 scopus 로고    scopus 로고
    • Anti-inflammatory activities of cyclic AMP-elevating agents: Enhancement of IL-10 synthesis and concurrent suppression of TNF-α production
    • EIGLER, A., SIEGMUND, B., EMMERICH, U., BAUMMANN, K.H., HARTMANN, G. & ENDRES, S. (1998). Anti-inflammatory activities of cyclic AMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF-α production. J. Leuk. Biol., 63, 101-107.
    • (1998) J. Leuk. Biol. , vol.63 , pp. 101-107
    • Eigler, A.1    Siegmund, B.2    Emmerich, U.3    Baummann, K.H.4    Hartmann, G.5    Endres, S.6
  • 14
    • 0028943066 scopus 로고
    • Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon-γ and tumor necrosis factor-α
    • FLESCH, I.E.A., HESS, J.H., HUANG, S., AGUET, M., ROTHE, J., BLUETHMANN, H. & KAUFMANN, S.H.E. (1995). Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon-γ and tumor necrosis factor-α. J. Exp. Med., 181, 1615-1621.
    • (1995) J. Exp. Med. , vol.181 , pp. 1615-1621
    • Flesch, I.E.A.1    Hess, J.H.2    Huang, S.3    Aguet, M.4    Rothe, J.5    Bluethmann, H.6    Kaufmann, S.H.E.7
  • 15
    • 0027264849 scopus 로고
    • 1L-12 is required for the T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-deficient hosts
    • GAZZINELLI, R.T., HIENY, S., WYNN, T., WOLF, S. & SHER, A. (1993). 1L-12 is required for the T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-deficient hosts. Proc. Natl. Acad. Sci. U.S.A., 90, 6115-6119.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6115-6119
    • Gazzinelli, R.T.1    Hieny, S.2    Wynn, T.3    Wolf, S.4    Sher, A.5
  • 16
    • 0027939611 scopus 로고
    • Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
    • GAZZINELLI, R.T., WYSOCKA, M., HAYASHI, S., DENKERS, E.Y., HEINY, S., CASPAR, P., TRINCHIERI, G. & SHER, A. (1994). Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol., 153, 2533-2543.
    • (1994) J. Immunol. , vol.153 , pp. 2533-2543
    • Gazzinelli, R.T.1    Wysocka, M.2    Hayashi, S.3    Denkers, E.Y.4    Heiny, S.5    Caspar, P.6    Trinchieri, G.7    Sher, A.8
  • 17
    • 0029959459 scopus 로고    scopus 로고
    • In absence of endogenous IL-10 mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ, TNF-α
    • GAZZINELLI, R.T., WYSOCKA, M., HIENY, S., SCHARTON-KERSTEN, T., CHEEVER, A., KÜHN, R., MÜLLER, W., TRINCHIERI, G. & SHER, A. (1996). In absence of endogenous IL-10 mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ, TNF-α. J. Immunol., 157, 798-805.
    • (1996) J. Immunol. , vol.157 , pp. 798-805
    • Gazzinelli, R.T.1    Wysocka, M.2    Hieny, S.3    Scharton-Kersten, T.4    Cheever, A.5    Kühn, R.6    Müller, W.7    Trinchieri, G.8    Sher, A.9
  • 19
    • 0028085437 scopus 로고
    • Interleukin-12 is produced in vivo during endotoxemia and stimulates synthesis of interferon-γ
    • HEINZEL, F.P., RERKO, R.M., LING, P., HAKIMI, J. & SCHOENHAUT, D.S. (1994). Interleukin-12 is produced in vivo during endotoxemia and stimulates synthesis of interferon-γ. Infect. Immun., 62, 4244-4249.
    • (1994) Infect. Immun. , vol.62 , pp. 4244-4249
    • Heinzel, F.P.1    Rerko, R.M.2    Ling, P.3    Hakimi, J.4    Schoenhaut, D.S.5
  • 20
    • 0027336689 scopus 로고
    • Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • HSIEH, C.S., MACATONIA, S.E., TRIPP, C.S., WOLF, S., O'GARRA, A. & MURPHY, K.M. (1993). Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science, 260, 547-549.
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.S.1    Macatonia, S.E.2    Tripp, C.S.3    Wolf, S.4    O'Garra, A.5    Murphy, K.M.6
  • 22
    • 0029967256 scopus 로고    scopus 로고
    • Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor-α and interferon-γ
    • HUNTER, C.A., SLIFER, T. & ARAUJO, F. (1996). Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor-α and interferon-γ. Infect. Immun., 64, 2381-2386.
    • (1996) Infect. Immun. , vol.64 , pp. 2381-2386
    • Hunter, C.A.1    Slifer, T.2    Araujo, F.3
  • 23
    • 0031225598 scopus 로고    scopus 로고
    • Adsortion to aluminum hidroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp 120
    • JANKOVIC, D., CASPAR, P., ZWEIG, M., GARCIA-MOLL, M., SHOWALTER, S.D., VOGEL, F.R. & SHER, A. (1997). Adsortion to aluminum hidroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp 120. J. Immunol., 159, 2409-2417.
    • (1997) J. Immunol. , vol.159 , pp. 2409-2417
    • Jankovic, D.1    Caspar, P.2    Zweig, M.3    Garcia-Moll, M.4    Showalter, S.D.5    Vogel, F.R.6    Sher, A.7
  • 25
    • 0028843980 scopus 로고
    • Cyclic nucleotide phosphodiesterase Type IV participates in the regulation of IL-10 and in subsequent inhibition of TNF-α and IL-6 release by endotoxinstimulaled macrophages
    • KAMBAYASHI. T., JACOB, C.O., ZHOU, D., MAZUREK, N., FONG, M. & STRASSMANN, G. (1995b). Cyclic nucleotide phosphodiesterase Type IV participates in the regulation of IL-10 and in subsequent inhibition of TNF-α and IL-6 release by endotoxinstimulaled macrophages. J. Immunol., 155, 4909-4916.
    • (1995) J. Immunol. , vol.155 , pp. 4909-4916
    • Kambayashi, T.1    Jacob, C.O.2    Zhou, D.3    Mazurek, N.4    Fong, M.5    Strassmann, G.6
  • 26
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • KOBAYASHI, M., FITZ, L., RYAN, M., HEWIK, R.M., CLARK, S.C., CHAN, S., LOUDON, R., SHERMAN, F., PERUSSIA, B & TRINCHIERI, G. (1989). Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med., 170, 827-845.
    • (1989) J. Exp. Med. , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3    Hewik, R.M.4    Clark, S.C.5    Chan, S.6    Loudon, R.7    Sherman, F.8    Perussia, B.9    Trinchieri, G.10
  • 27
    • 0028316546 scopus 로고
    • Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β, production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
    • KUBIN, M., CHOW, M.J. & TRINCHIERI, G. (1994). Differential regulation of interleukin-12 (IL-12), tumor necrosis factor-α, and IL-1β, production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood, 83, 1847-1855.
    • (1994) Blood , vol.83 , pp. 1847-1855
    • Kubin, M.1    Chow, M.J.2    Trinchieri, G.3
  • 28
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against IL-12
    • LEONARD, J.P., WALDBURGER, K.E. & GOLDMAN, S.J. (1995). Prevention of experimental autoimmune encephalomyelitis by antibodies against IL-12. J. Exp. Med., 181, 381-386.
    • (1995) J. Exp. Med. , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 30
    • 0029980269 scopus 로고    scopus 로고
    • Differential regulation of monocytic tumor necrosis factor-α and interleukin-10 expression
    • MEISEL, C., VOGT, K., PLATZER, C., RANDOW, F., LIEBENTHAL, C. & VOLK, H.D. (1996). Differential regulation of monocytic tumor necrosis factor-α and interleukin-10 expression. Eur. J. Immunol., 26, 1580-1586.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1580-1586
    • Meisel, C.1    Vogt, K.2    Platzer, C.3    Randow, F.4    Liebenthal, C.5    Volk, H.D.6
  • 31
    • 0028862097 scopus 로고
    • Nonviable bacterial antigens administered with IL-12 generate antigen specific T cell responses and protective immunity against Listeria monocytogenis
    • MILLER, M.A., SKEEN, M.J. & ZIEGLER, H.K. (1995). Nonviable bacterial antigens administered with IL-12 generate antigen specific T cell responses and protective immunity against Listeria monocytogenis. J. Immunol., 155, 4817-4828.
    • (1995) J. Immunol. , vol.155 , pp. 4817-4828
    • Miller, M.A.1    Skeen, M.J.2    Ziegler, H.K.3
  • 32
    • 0343244100 scopus 로고
    • Quantification of functional T cells by limiting dilution
    • MILLER, R.A (1994). Quantification of functional T cells by limiting dilution. Curr. Protocols Immunol., 1, 3.15.5.
    • (1994) Curr. Protocols Immunol. , vol.1 , pp. 3155
    • Miller, R.A.1
  • 33
    • 0345671672 scopus 로고    scopus 로고
    • Isolation, structure and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentas acting at picomolar concentration
    • MÜHLRADT, P.F., KIEB, M., MEYER, H., SÜBMUTH, R. & JUNG, G. (1997). Isolation, structure and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentas acting at picomolar concentration. J. Exp. Med., 185, 1951-1958.
    • (1997) J. Exp. Med. , vol.185 , pp. 1951-1958
    • Mühlradt, P.F.1    Kieb, M.2    Meyer, H.3    Sübmuth, R.4    Jung, G.5
  • 34
    • 0029143632 scopus 로고
    • Regulation of interleukin 12 p40 expression through an NF-kB half-site
    • MURPHY, T., CLEVELAND, M., KULEZKA, P., MAGRAM, J. & MURPHY, K. (1995). Regulation of interleukin 12 p40 expression through an NF-kB half-site. Mol. Cell Biol., 15, 5258-5267.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 5258-5267
    • Murphy, T.1    Cleveland, M.2    Kulezka, P.3    Magram, J.4    Murphy, K.5
  • 35
    • 0027982098 scopus 로고
    • Interleukin-12, interferon-γ and tumour necrosis factor-α are key cytokines of the generalized Swartzman reaction
    • OZMEN, L., PERICIN, M., HAKIMI, J., CHIZZONITE, R.A., WYZOCKA, M., TRINCHIERI, G., GATELY, M. & GAROTTA, G. (1994). Interleukin-12, interferon-γ and tumour necrosis factor-α are key cytokines of the generalized Swartzman reaction. J. Exp. Med., 180, 907-915.
    • (1994) J. Exp. Med. , vol.180 , pp. 907-915
    • Ozmen, L.1    Pericin, M.2    Hakimi, J.3    Chizzonite, R.A.4    Wyzocka, M.5    Trinchieri, G.6    Gately, M.7    Garotta, G.8
  • 37
    • 0029021419 scopus 로고
    • IL-12 stimulates an anti-viral type 1 cytokine response but lacks adjuvant activity in IFN-γ receptor deficient mice
    • SCHIJNS, V.E.C.J., HAAGMANS, B.L. & HORZINEK, M.C. (1995). IL-12 stimulates an anti-viral type 1 cytokine response but lacks adjuvant activity in IFN-γ receptor deficient mice. J. Immunol., 155, 2525-2532.
    • (1995) J. Immunol. , vol.155 , pp. 2525-2532
    • Schijns, V.E.C.J.1    Haagmans, B.L.2    Horzinek, M.C.3
  • 38
    • 0027177008 scopus 로고
    • IL-12; initiation cytokine for cell mediated immunity
    • SCOTT, P. (1993). IL-12; initiation cytokine for cell mediated immunity. Science, 260, 496-497.
    • (1993) Science , vol.260 , pp. 496-497
    • Scott, P.1
  • 39
    • 0027491655 scopus 로고
    • IL-12 acts directly on CD4+ T cells to enhance priming for IFN-γ production and dimminishes IL-4 inhibition of such priming
    • SEDER, R.A., GAZZINELLI, R.T., SHER, A. & PAUL, W.E. (1993). IL-12 acts directly on CD4+ T cells to enhance priming for IFN-γ production and dimminishes IL-4 inhibition of such priming. Proc. Natl. Acad. Sci. U.S.A., 90, 10188-10193.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10188-10193
    • Seder, R.A.1    Gazzinelli, R.T.2    Sher, A.3    Paul, W.E.4
  • 40
    • 0031616317 scopus 로고    scopus 로고
    • Interleukin-10 does not mediate inhibitory effect of PDE-4 inhibitors and other cyclic AMP-elevating drugs on lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes
    • SELDON, P.M., BARNES, P.J. & GIEMBYCZ, M.A. (1998). Interleukin-10 does not mediate inhibitory effect of PDE-4 inhibitors and other cyclic AMP-elevating drugs on lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes. Cell. Biochem. Biophys., 29, 179-201.
    • (1998) Cell. Biochem. Biophys. , vol.29 , pp. 179-201
    • Seldon, P.M.1    Barnes, P.J.2    Giembycz, M.A.3
  • 41
    • 0030051658 scopus 로고    scopus 로고
    • Regulation of murine IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
    • SKEEN, M.J., MILLER, M.A., SHINNICK, T.M. & ZIEGLER, H.K. (1996). Regulation of murine IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol., 156, 1196-1206.
    • (1996) J. Immunol. , vol.156 , pp. 1196-1206
    • Skeen, M.J.1    Miller, M.A.2    Shinnick, T.M.3    Ziegler, H.K.4
  • 42
    • 0028109394 scopus 로고
    • Evidence for the involvement of lnterleukin-10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2
    • STRASSMANN, G., PATIL-KOOTA, V., FINKELMAN, F., FONG, M. & KAMBAYASHI, T. (1994). Evidence for the involvement of lnterleukin-10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. Exp. Med., 180, 2365-2370.
    • (1994) J. Exp. Med. , vol.180 , pp. 2365-2370
    • Strassmann, G.1    Patil-Koota, V.2    Finkelman, F.3    Fong, M.4    Kambayashi, T.5
  • 43
    • 0028970060 scopus 로고
    • Interleukin-12: A pro-inflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptative immunity
    • TRINCHIERI, G. (1995). Interleukin-12: a pro-inflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptative immunity. Ann. Rev. Immunol., 13, 251-276.
    • (1995) Ann. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 44
    • 0009595788 scopus 로고
    • 62nd forum in immunology: Immunoregulation by interleukin-12
    • TRINCHIERI, G. & SCOTT, P. (1995). 62nd Forum in Immunology: immunoregulation by interleukin-12. Res. Immunol., 146, 419-422.
    • (1995) Res. Immunol. , vol.146 , pp. 419-422
    • Trinchieri, G.1    Scott, P.2
  • 46
    • 0029042649 scopus 로고
    • IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue cosinophilia
    • WYNN, T.A., JANKOVIC, D., HIENY, S., CHEEVER, A.W. & SHER, A. (1995). IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue cosinophilia. J. Immunol., 154, 4701-4709.
    • (1995) J. Immunol. , vol.154 , pp. 4701-4709
    • Wynn, T.A.1    Jankovic, D.2    Hieny, S.3    Cheever, A.W.4    Sher, A.5
  • 47
    • 0028987562 scopus 로고
    • Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice
    • WYSOKA, M., KUBIN, M., VIEIRA, L.Q., OZMEN, L., GAROTTA, G., SCOTT, P. & TRINCHIERI, G. ( 1995). Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol., 25, 672-676.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 672-676
    • Wysoka, M.1    Kubin, M.2    Vieira, L.Q.3    Ozmen, L.4    Garotta, G.5    Scott, P.6    Trinchieri, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.