SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Cell

Volumn 181, Issue 5, 2020, Pages 1016-1035.e19

  Ziegler, Carly G K ^a,b,c,d,e   Allon, Samuel J ^b,c,d   Nyquist, Sarah K ^b,c,d,f   Mbano, Ian M ^g,h   Miao, Vincent N ^a,b,c,d   Tzouanas, Constantine N ^a,b,c,d   Cao, Yuming ⁱ   Yousif, Ashraf S ^c   Bals, Julia ^c   Hauser, Blake M ^a,c   Feldman, Jared ^a,c   Muus, Christoph ^d,j   Wadsworth, Marc H ^b,c,d   Kazer, Samuel W ^b,c,d   Hughes, Travis K ^a,c,d   Doran, Benjamin ^b,c,d,k   Gatter, G James ^b,c,d   Vukovic, Marko ^b,c,d   Taliaferro, Faith ^d,k   Mead, Benjamin E ^b,c,d   Guo, Zhiru ⁱ   Wang, Jennifer P ⁱ   Gras, Delphine ^l   Plaisant, Magali ^m   Ansari, Meshal ^n,o   Angelidis, Ilias ^n,o   Adler, Heiko ^n,o   Sucre, Jennifer M S ^p   Taylor, Chase J ^p   Lin, Brian ^q   Waghray, Avinash ^q   Mitsialis, Vanessa ^k,r   Dwyer, Daniel F ^r   Buchheit, Kathleen M ^r   Boyce, Joshua A ^r   Barrett, Nora A ^r   Laidlaw, Tanya M ^r   Carroll, Shaina L ^s   Colonna, Lucrezia ^t   Tkachev, Victor ^a,k,u   Peterson, Christopher W ^v,w   Yu, Alison ^k,x   Zheng, Hengqi Betty ^t,x   Gideon, Hannah P ^y   Winchell, Caylin G ^y   Lin, Philana Ling ^y,z   Bingle, Colin D ^aa   Snapper, Scott B ^k,r   Kropski, Jonathan A ^p,ab,ac,ag   Theis, Fabian J ^n,ag   Schiller, Herbert B ^n,o   Zaragosi, Laure Emmanuelle ^m,ag   Barbry, Pascal ^m,ag   Leslie, Alasdair ^g,h,ad   Kiem, Hans Peter ^v,w   Flynn, JoAnne L ^y   Fortune, Sarah M ^c,d,ae   Berger, Bonnie ^c,f   Finberg, Robert W ⁱ   Kean, Leslie S ^a,k,u   Garber, Manuel ⁱ   Schmidt, Aaron G ^a,c   Lingwood, Daniel ^c   Shalek, Alex K ^{a,b,c,d,e,af,ag}   Ordovas Montanes, Jose ^a,d,k,af,ag   Banovich, Nicholas ^ag   Brazma, Alvis ^ag   Desai, Tushar ^ag   Duong, Thu Elizabeth ^ag   Eickelberg, Oliver ^ag   Falk, Christine ^ag   Farzan, Michael ^ag   Glass, Ian ^ag   Haniffa, Muzlifah ^ag   Horvath, Peter ^ag   Hung, Deborah ^ag   Kaminski, Naftali ^ag   Krasnow, Mark ^ag   Kuhnemund, Malte ^ag   Lafyatis, Robert ^ag   Lee, Haeock ^ag   Leroy, Sylvie ^ag   Linnarson, Sten ^ag   Lundeberg, Joakim ^ag   Meyer, Kerstin ^ag   Misharin, Alexander ^ag   Nawijn, Martijn ^ag   Nikolic, Marko Z ^ag   Pe'er, Dana ^ag   Powell, Joseph ^ag   Quake, Stephen ^ag   Rajagopal, Jay ^ag   Tata, Purushothama Rao ^ag   Rawlins, Emma L ^ag   Regev, Aviv ^ag   Reyfman, Paul A ^ag   Rojas, Mauricio ^ag   Rosen, Orit ^ag   Saeb Parsy, Kourosh ^ag   Samakovlis, Christos ^ag   Schiller, Herbert ^ag   Schultze, Joachim L ^ag   Seibold, Max A ^ag   Shepherd, Douglas ^ag   Spence, Jason ^ag   Spira, Avrum ^ag   Sun, Xin ^ag   Teichmann, Sarah ^ag   Tsankov, Alexander ^ag   van den Berge, Maarten ^ag   von Papen, Michael ^ag   Whitsett, Jeffrey ^ag   Xavier, Ramnik ^ag   Xu, Yan ^ag   Zhang, Kun ^ag   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b Massachusetts Institute of Technology   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HARVARD UNIVERSITY   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g AFRICA HEALTH RESEARCH INSTITUTE   (South Africa)

^h UNIVERSITY OF KWAZULU NATAL   (South Africa)

ⁱ UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^j HARVARD UNIVERSITY   (United States)

^k BOSTON CHILDREN S HOSPITAL   (United States)

^l AIX MARSEILLE UNIVERSITY   (France)

^m INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

ⁿ INSTITUTE OF EPIDEMIOLOGY   (Germany)

^o German Center for Lung Research   (Germany)

^p VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^q MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^r BRIGHAM AND WOMEN S HOSPITAL   (United States)

^s UNIVERSITY OF CALIFORNIA   (United States)

^t UNIVERSITY OF WASHINGTON   (United States)

^u DANA FARBER CANCER INSTITUTE   (United States)

^v USA   (United States)

^w UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^x SEATTLE CHILDREN S HOSPITAL   (United States)

^y UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^z CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^aa UNIVERSITY OF SHEFFIELD   (United Kingdom)

^ab VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ac VETERANS AFFAIRS MEDICAL CENTER   (United States)

^ad UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ae HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^af HARVARD STEM CELL INSTITUTE   (United States)

^ag NONE

more..

Author keywords

ACE2; COVID 19; human; influenza; interferon; ISG; mouse; non human primate; SARS CoV 2; scRNA seq

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; DIPEPTIDYL CARBOXYPEPTIDASE; INTERFERON; SERINE PROTEINASE; TMPRSS2 PROTEIN, HUMAN; VIRUS RECEPTOR;

ACE2 GENE; ADULT; AIRWAY EPITHELIUM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SUBPOPULATION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORONAVIRUS DISEASE 2019; FEMALE; GENE; GOBLET CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CELL; LUNG ALVEOLUS CELL TYPE 2; LUNG INJURY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIMATE; PRIORITY JOURNAL; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SINGLE CELL RNA SEQ; TMPRSS2 GENE; UPREGULATION; ADOLESCENT; ANIMAL; BETACORONAVIRUS; CELL CULTURE; CELL LINE; CHILD; CORONAVIRUS INFECTION; CYTOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; INFLUENZA; LUNG; LUNG ALVEOLUS EPITHELIUM CELL; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; NOSE MUCOSA; PANDEMIC; PATHOLOGY; PHYSIOLOGY; RHESUS MONKEY; SINGLE CELL ANALYSIS; TUBERCULOSIS; VIROLOGY; VIRUS PNEUMONIA;

ADOLESCENT; ALVEOLAR EPITHELIAL CELLS; ANIMALS; BETACORONAVIRUS; CELL LINE; CELLS, CULTURED; CHILD; CORONAVIRUS INFECTIONS; ENTEROCYTES; GOBLET CELLS; HIV INFECTIONS; HUMANS; INFLUENZA, HUMAN; INTERFERON TYPE I; LUNG; MACACA MULATTA; MICE; MYCOBACTERIUM TUBERCULOSIS; NASAL MUCOSA; PANDEMICS; PEPTIDYL-DIPEPTIDASE A; PNEUMONIA, VIRAL; RECEPTORS, VIRUS; SERINE ENDOPEPTIDASES; SINGLE-CELL ANALYSIS; TUBERCULOSIS; UP-REGULATION;

EID: 85084425299     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2020.04.035     Document Type: Article

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