Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

BMC Biology

Volumn 16, Issue 1, 2018, Pages

  Mead, Benjamin E ^a,b,c,d,e   Ordovas Montanes, Jose ^c,e,f,g   Braun, Alexandra P ^a,c,d,e   Levy, Lauren E ^a,c,d   Bhargava, Prerna ^e,f   Szucs, Matthew J ^e   Ammendolia, Dustin A ^a,d   MacMullan, Melanie A ^e   Yin, Xiaolei ^a,b,c,d   Hughes, Travis K ^b,c,e,f   Wadsworth, Marc H ^c,e,f   Ahmad, Rushdy ^e   Rakoff Nahoum, Seth ^g   Carr, Steven A ^e   Langer, Robert ^b,c,f   Collins, James J ^b,c,e,f,h   Shalek, Alex K ^b,c,e,f   Karp, Jeffrey M ^a,b,d,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f USA   (United States)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h HARVARD UNIVERSITY   (United States)

Author keywords

Chemical biology; Differentiation; Intestinal organoid; Intestinal stem cell; Paneth cell; Single cell RNA seq; Stem cell derived models; Systems biology

Indexed keywords

BIOLOGICAL MODEL; CYTOLOGY; GENOMICS; HUMAN; ORGANOID; PANETH CELL; PROCEDURES; PROTEOMICS; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; STEM CELL NICHE;

GENOMICS; HUMANS; MODELS, BIOLOGICAL; ORGANOIDS; PANETH CELLS; PROTEOMICS; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; STEM CELL NICHE;

EID: 85048081043     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/s12915-018-0527-2     Document Type: Article

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