Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: Implications for pathogenesis virus transmission pathways

Journal of Pathology

Volumn 203, Issue 2, 2004, Pages 622-630

  Ding, Yanqing ^a   He, Li ^a   Zhang, Qingling ^a   Huang, Zhongxi ^a   Che, Xiaoyan ^a   Hou, Jinlin ^b   Wang, Huijun ^a   Shen, Hong ^a   Qiu, Liwen ^b   Li, Zhuguo ^a   Geng, Jian ^a   Cai, Junjie ^a   Han, Huixia ^a   Li, Xin ^a   Kang, Wei ^a   Weng, Desheng ^a   Liang, Ping ^a   Jiang, Shibo ^c  

^a FIRST MILITARY MEDICAL UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c NEW YORK BLOOD CENTER   (United States)

Author keywords

Detection; Distribution; Pathogenesis; SARS; SARS CoV; Transmission

Indexed keywords

MONOCLONAL ANTIBODY; RNA POLYMERASE; VIRUS NUCLEOPROTEIN;

ADRENAL GLAND; ADULT; ANTIBODY SPECIFICITY; AORTA; ARTICLE; BONE MARROW; BRAIN; BRONCHUS; CASE REPORT; CAUSE OF DEATH; CEREBELLUM; CONTROLLED STUDY; CYTOPATHOLOGY; ESOPHAGUS; FECES; FEMALE; GASTROINTESTINAL TRACT; HEART; HUMAN; HUMAN TISSUE; HYPOPHYSIS; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY DISTAL TUBULE; LIVER; LUNG; LYMPH NODE; MALE; MUSCLE; ORGAN DISTRIBUTION; OVARY; PANCREAS; PARATHYROID GLAND; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY FAILURE; RESPIRATORY SYSTEM; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SMALL INTESTINE; SPLEEN; STOMACH; SWEAT; SWEAT GLAND; TESTIS; THYROID GLAND; TRACHEA; URINARY EXCRETION; UTERUS; VIRUS DETECTION; VIRUS REPLICATION; VIRUS TRANSMISSION;

ADULT; DNA-DIRECTED RNA POLYMERASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG; MALE; MIDDLE AGED; NUCLEOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL PROTEINS;

EID: 2642544842     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1560     Document Type: Article

References (31)

1. WHO. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. www.who.int [2003].
2. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953-1966.
3. Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1967-1976.
4. Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361: 1319-1325.
5. Marra MA, Jones SJM, Astell CR, et al. The genome sequence of the SARS-associated coronavirus. Science 2003; 300: 1399-1404.
6. Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003; 300: 1394-1399.
7. Guan Y, Zheng BJ, He YQ, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China. Science 2003; 302: 276-278.
8. Li WH, Moore MJ, Vasilieva NY, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003; 426: 450-454.
9. Wong SK, Li W, Moore MJ, et al. A 193-amino-acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem 2003; 279: 3197-3201.
10. Xiao X, Chakraborti S, Dimitrov AS, et al. The SARS-CoV S glycoprotein: expression and functional characterization. Biochem Biophys Res Commun 2003; 312: 1159-1164.
11. Dimitrov DS. The secret life of ACE2 as a receptor for the SARS virus. Cell 2003; 115: 652-653.
12. Liu S, Xiao G, Chen Y, et al. Interaction between the heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implication for virus fusogenic mechanism and identification of fusion inhibitors. Lancet 2004; 363: 938-947.
13. Kuiken T, Fouchier RAM, Schutten M, et al. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 2003; 362: 263-270.
14. Lin Y, Shen X, Yang RF, et al. Identification of an epitope of SARS-coronavirus nucleocapsid protein. Cell Res 2003; 13: 141-145.
15. WHO. Consensus document on the epidemiology of severe acute respiratory syndrome (SARS). www.who.int 2003.
16. Macfie, N. China confirms SARS case in Southern Guangzhou. Reuters Health Information. www.medscape.com/viewarticle/466710 2004.
17. Ding Y, Wang H, Shen H, et al. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol 2003; 200: 282-289.
18. Wang H, Ding Y, Li X, et al. Fatal aspergillosis in a patient with SARS who was treated with corticosteroids. N Engl J Med 2003; 349: 507-508.
19. Che XY, Qiu LW, Pan YX, et al. Rapid and efficient preparation of monoclonal antibodies against SARS-associated coronavirus nucleocapsid protein by immunizing mice. Di Yi Jun Yi Da Xue Xue Bao 2003; 23: 640-642.
20. Lounsbury KM, Stern M, Taatjes D, et al. Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos. Am J Pathol 2002; 160: 1991-2000.
21. Yang J, Wang ZH, Chen JJ, et al. Clinical detection of polymerase gene of SARS-associated coronavirus. Di Yi Jun Yi Da Xue Xue Bao 2003; 23: 424-427.
22. Che XY, Hao W, Qiu LW, et al. Antibody response of patients with severe acute respiratory syndrome (SARS) to nucleocapsid antigen of SARS-associated coronavirus. Di Yi Jun Yi Da Xue Xue Bao 2003; 23: 637-639.
23. Enserink M. SARS in China. The big question now: will it be back? Science 2003; 301: 299.
24. Enserink M. Infectious diseases: Singapore lab faulted in SARS case. Science 2003; 301: 1824.
25. Ding Y, Wang HJ, Shen H, et al. Study on etiology and pathology of severe acute respiratory syndrome. Zhonghua Bing Li Xue Za Zhi 2003; 32: 195-200.
26. Yeager CL, Ashmun RA, Williams RK, et al. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature 1992; 357: 420-422.
27. Delmas B, Gelfi J, L'Haridon R, et al. Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV. Nature 1992; 357: 417-420.
28. Kontoyiannis DP, Pasqualini R, Arap W. Aminopeptidase N inhibitors and SARS. Lancet 2003; 361: 1558.
29. Harmer D, Gilbert M, Borman R, et al. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett 2002; 532: 107-110.
30. Leung WK, To KF, Chan PK, et al. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology 2003; 125: 1011-1017.
31. Rados C. SARS: protecting against a deadly disease. FDA Consum 2003; 37: 14-17.