Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

Cell

Volumn 181, Issue 4, 2020, Pages 905-913.e7

  Monteil, Vanessa ^a   Kwon, Hyesoo ^b   Prado, Patricia ^c   Hagelkrüys, Astrid ^d   Wimmer, Reiner A ^d   Stahl, Martin ^e   Leopoldi, Alexandra ^d   Garreta, Elena ^c   Hurtado del Pozo, Carmen ^c   Prosper, Felipe ^f   Romero, Juan Pablo ^f   Wirnsberger, Gerald ^g   Zhang, Haibo ^h   Slutsky, Arthur S ^h   Conder, Ryan ^e   Montserrat, Nuria ^c,i,j   Mirazimi, Ali ^a,b   Penninger, Josef M ^d,k  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NATIONAL VETERINARY INSTITUTE   (Sweden)

^c INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

^d INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

^e STEMCELL Technologies   (Canada)

^f UNIVERSITY OF NAVARRA   (Spain)

^g Apeiron Biologics Forschungs und Entwicklungsgesellschaft MbH   (Austria)

^h ST MICHAEL'S HOSPITAL   (Canada)

ⁱ INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^j BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^k UNIVERSITY OF BRITISH COLUMBIA   (Canada)

more..

Author keywords

angiotensin converting enzyme 2; blood vessels; COVID 19; human organoids; kidney; severe acute respiratory syndrome coronavirus; spike glycoproteins; treatment

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; RECOMBINANT ENZYME; RECOMBINANT SOLUBLE ANGIOTENSIN CONVERTING ENZYME 2; UNCLASSIFIED DRUG; CORONAVIRUS SPIKE GLYCOPROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE; RECOMBINANT PROTEIN; SPIKE PROTEIN, SARS-COV-2; VIRUS RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; CORONAVIRUS DISEASE 2019; DISEASE SEVERITY; DOSE RESPONSE; EMBRYO; GENETIC ENGINEERING; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; MOUSE; NONHUMAN; ORGANOID; PHYLOGENY; PRIORITY JOURNAL; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VERO CELL LINE; VIRUS INHIBITION; ANIMAL; BETACORONAVIRUS; CHLOROCEBUS AETHIOPS; CORONAVIRUS INFECTION; CYTOLOGY; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PANDEMIC; ULTRASTRUCTURE; VIROLOGY; VIRUS PNEUMONIA;

ANIMALS; BETACORONAVIRUS; BLOOD VESSELS; CHLOROCEBUS AETHIOPS; CORONAVIRUS INFECTIONS; HUMANS; KIDNEY; MICE; ORGANOIDS; PANDEMICS; PEPTIDYL-DIPEPTIDASE A; PNEUMONIA, VIRAL; RECEPTORS, VIRUS; RECOMBINANT PROTEINS; SPIKE GLYCOPROTEIN, CORONAVIRUS; VERO CELLS;

EID: 85083498362     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2020.04.004     Document Type: Article

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