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Volumn 176, Issue , 2020, Pages

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Author keywords

2019 nCoV; Antivirals; Furin; Maturation protease; SARS CoV; Spike protein

Indexed keywords

FURIN; VIRUS ENVELOPE PROTEIN; VIRUS FUSION PROTEIN; VIRUS GLYCOPROTEIN; VIRUS HEMAGGLUTININ; VITRONECTIN; CORONAVIRUS SPIKE GLYCOPROTEIN; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2;

EID: 85079394767     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2020.104742     Document Type: Article
Times cited : (1317)

References (36)
  • 1
    • 0027429771 scopus 로고
    • Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed α1-antitrypsin variant
    • Anderson, E.D., Thomas, L., Hayflick, J.S., Thomas, G., Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed α1-antitrypsin variant. J. Biol. Chem. 268 (1993), 24887–24891.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24887-24891
    • Anderson, E.D.1    Thomas, L.2    Hayflick, J.S.3    Thomas, G.4
  • 2
    • 84988649922 scopus 로고    scopus 로고
    • Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth
    • Bassi, D.E., Zhang, J., Renner, C., Klein-Szanto, A.J., Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth. Mol. Carcinog. 56 (2017), 1182–1188, 10.1002/mc.22550.
    • (2017) Mol. Carcinog. , vol.56 , pp. 1182-1188
    • Bassi, D.E.1    Zhang, J.2    Renner, C.3    Klein-Szanto, A.J.4
  • 3
    • 50149113012 scopus 로고    scopus 로고
    • Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide
    • Bosch, B.J., Bartelink, W., Rottier, P.J.M., Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide. J. Virol. 82 (2008), 8887–8890, 10.1128/jvi.00415-08.
    • (2008) J. Virol. , vol.82 , pp. 8887-8890
    • Bosch, B.J.1    Bartelink, W.2    Rottier, P.J.M.3
  • 4
    • 85079563205 scopus 로고    scopus 로고
    • Furin-mediated protein processing in infectious diseases and cancer
    • Braun, E., Sauter, D., Furin-mediated protein processing in infectious diseases and cancer. Clin. Transl. Immunol., 8, 2019, e1073, 10.1002/cti2.1073.
    • (2019) Clin. Transl. Immunol. , vol.8 , pp. e1073
    • Braun, E.1    Sauter, D.2
  • 5
    • 58749109053 scopus 로고    scopus 로고
    • Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection
    • Chan, C.M., Woo, P.C., Lau, S.K., Tse, H., Chen, H.L., Li, F., Zheng, B.J., Chen, L., Huang, J.D., Yuen, K.Y., Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection. Exp. Biol. Med. 233 (2008), 1527–1536, 10.3181/0806-RM-197.
    • (2008) Exp. Biol. Med. , vol.233 , pp. 1527-1536
    • Chan, C.M.1    Woo, P.C.2    Lau, S.K.3    Tse, H.4    Chen, H.L.5    Li, F.6    Zheng, B.J.7    Chen, L.8    Huang, J.D.9    Yuen, K.Y.10
  • 6
    • 85078500139 scopus 로고    scopus 로고
    • Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
    • Chan, J.F., Kok, K.H., Zhu, Z., Chu, H., To, K.K., Yuan, S., Yuen, K.Y., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg. Microb. Infect. 9 (2020), 221–236, 10.1080/22221751.2020.1719902.
    • (2020) Emerg. Microb. Infect. , vol.9 , pp. 221-236
    • Chan, J.F.1    Kok, K.H.2    Zhu, Z.3    Chu, H.4    To, K.K.5    Yuan, S.6    Yuen, K.Y.7
  • 7
    • 85074140882 scopus 로고    scopus 로고
    • The S2 subunit of QX-type infectious bronchitis coronavirus spike protein is an essential determinant of neurotropism
    • Cheng, J., Zhao, Y., Xu, G., Zhang, K., Jia, W., Sun, Y., Zhao, J., Xue, J., Hu, Y., Zhang, G., The S2 subunit of QX-type infectious bronchitis coronavirus spike protein is an essential determinant of neurotropism. Viruses 11, 2019, 10.3390/v11100972.
    • (2019) Viruses 11
    • Cheng, J.1    Zhao, Y.2    Xu, G.3    Zhang, K.4    Jia, W.5    Sun, Y.6    Zhao, J.7    Xue, J.8    Hu, Y.9    Zhang, G.10
  • 9
    • 85029650771 scopus 로고    scopus 로고
    • Structural studies revealed active site distortions of human furin by a small molecule inhibitor
    • Dahms, S.O., Jiao, G.-S., Than, M.E., Structural studies revealed active site distortions of human furin by a small molecule inhibitor. ACS Chem. Biol., 12, 2017, 2474, 10.1021/acschembio.7b00633.
    • (2017) ACS Chem. Biol. , vol.12 , pp. 2474
    • Dahms, S.O.1    Jiao, G.-S.2    Than, M.E.3
  • 12
    • 0028074306 scopus 로고
    • Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones
    • Garten, W., Hallenberger, S., Ortmann, D., Schäfer, W., Vey, M., Angliker, H., Shaw, E., Klenk, H.D., Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones. Biochimie 76 (1994), 217–225, 10.1016/0300-9084(94)90149-x.
    • (1994) Biochimie , vol.76 , pp. 217-225
    • Garten, W.1    Hallenberger, S.2    Ortmann, D.3    Schäfer, W.4    Vey, M.5    Angliker, H.6    Shaw, E.7    Klenk, H.D.8
  • 14
    • 85072014347 scopus 로고    scopus 로고
    • The proteolytic regulation of virus cell entry by furin and other proprotein convertases
    • Izaguirre, G., The proteolytic regulation of virus cell entry by furin and other proprotein convertases. Viruses 11, 2019, 10.3390/v11090837.
    • (2019) Viruses 11
    • Izaguirre, G.1
  • 17
    • 11144348687 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus
    • Kuhn, J.H., Li, W., Choe, H., Farzan, M., Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus. Cell. Mol. Life Sci. 61 (2004), 2738–2743, 10.1007/s00018-004-4242-5.
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 2738-2743
    • Kuhn, J.H.1    Li, W.2    Choe, H.3    Farzan, M.4
  • 18
    • 84948978625 scopus 로고    scopus 로고
    • Cleavage of a neuroinvasive human respiratory virus spike glycoprotein by proprotein convertases modulates neurovirulence and virus spread within the central nervous system
    • Le Coupanec, A., Desforges, M., Meessen-Pinard, M., Dubé, M., Day, R., Seidah, N.G., Talbot, P.J., Cleavage of a neuroinvasive human respiratory virus spike glycoprotein by proprotein convertases modulates neurovirulence and virus spread within the central nervous system. PLoS Pathog., 11, 2015, 10.1371/journal.ppat.1005261.
    • (2015) PLoS Pathog. , vol.11
    • Le Coupanec, A.1    Desforges, M.2    Meessen-Pinard, M.3    Dubé, M.4    Day, R.5    Seidah, N.G.6    Talbot, P.J.7
  • 19
    • 24944498409 scopus 로고    scopus 로고
    • Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
    • Li, F., Li, W., Farzan, M., Harrison, S.C., Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science 309 (2005), 1864–1868, 10.1126/science.1116480.
    • (2005) Science , vol.309 , pp. 1864-1868
    • Li, F.1    Li, W.2    Farzan, M.3    Harrison, S.C.4
  • 22
    • 84939255224 scopus 로고    scopus 로고
    • Bat-to-human: spike features determining “host jump” of coronaviruses SARS-CoV, MERS-CoV, and beyond
    • Lu, G., Wang, Q., Gao, G.F., Bat-to-human: spike features determining “host jump” of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends Microbiol., 2015, 10.1016/j.tim.2015.06.003.
    • (2015) Trends Microbiol.
    • Lu, G.1    Wang, Q.2    Gao, G.F.3
  • 23
    • 78649407547 scopus 로고    scopus 로고
    • Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2
    • Matsuyama, S., Nagata, N., Shirato, K., Kawase, M., Takeda, M., Taguchi, F., Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2. J. Virol. 84 (2010), 12658–12664, 10.1128/JVI.01542-10.
    • (2010) J. Virol. , vol.84 , pp. 12658-12664
    • Matsuyama, S.1    Nagata, N.2    Shirato, K.3    Kawase, M.4    Takeda, M.5    Taguchi, F.6
  • 24
    • 24644441711 scopus 로고    scopus 로고
    • Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection
    • Matsuyama, S., Ujike, M., Morikawa, S., Tashiro, M., Taguchi, F., Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection. Proc. Natl. Acad. Sci. U.S.A. 102 (2005), 12543–12547, 10.1073/pnas.0503203102.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 12543-12547
    • Matsuyama, S.1    Ujike, M.2    Morikawa, S.3    Tashiro, M.4    Taguchi, F.5
  • 25
    • 0030909584 scopus 로고    scopus 로고
    • Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours
    • Mbikay, M., Sirois, F., Yao, J., Seidah, N.G., Chrétien, M., Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours. Br. J. Canc. 75 (1997), 1509–1514, 10.1038/bjc.1997.258.
    • (1997) Br. J. Canc. , vol.75 , pp. 1509-1514
    • Mbikay, M.1    Sirois, F.2    Yao, J.3    Seidah, N.G.4    Chrétien, M.5
  • 26
    • 84908065761 scopus 로고    scopus 로고
    • Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
    • Mille, J.K., Whittaker, G.R., Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 15214–15219, 10.1073/pnas.1407087111.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 15214-15219
    • Mille, J.K.1    Whittaker, G.R.2
  • 27
    • 84930047858 scopus 로고    scopus 로고
    • Host cell proteases: critical determinants of coronavirus tropism and pathogenesis
    • Millet, J.K., Whittaker, G.R., Host cell proteases: critical determinants of coronavirus tropism and pathogenesis. Virus Res. 202 (2015), 120–134, 10.1016/j.virusres.2014.11.021.
    • (2015) Virus Res. , vol.202 , pp. 120-134
    • Millet, J.K.1    Whittaker, G.R.2
  • 28
    • 84908065761 scopus 로고    scopus 로고
    • Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
    • Millet, J.K., Whittaker, G.R., Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 15214–15219, 10.1073/pnas.1407087111.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 15214-15219
    • Millet, J.K.1    Whittaker, G.R.2
  • 29
    • 0034634728 scopus 로고    scopus 로고
    • Maturation of HIV envelope glycoprotein precursors by cellular endoproteases
    • Moulard, M., Decroly, E., Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. Biochim. Biophys. Acta Rev. Biomembr., 2000, 10.1016/S0304-4157(00)00014-9.
    • (2000) Biochim. Biophys. Acta Rev. Biomembr.
    • Moulard, M.1    Decroly, E.2
  • 30
    • 0014405092 scopus 로고
    • On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain
    • Schechter, I., Berger, A., On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain. Biochem. Biophys. Res. Commun. 32 (1968), 898–902, 10.1016/0006-291x(68)90326-4.
    • (1968) Biochem. Biophys. Res. Commun. , vol.32 , pp. 898-902
    • Schechter, I.1    Berger, A.2
  • 31
    • 0033452452 scopus 로고    scopus 로고
    • Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides
    • Seidah, N.G., Chretien, M., Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848 (1999), 45–62, 10.1016/S0006-8993(99)01909-5.
    • (1999) Brain Res. , vol.848 , pp. 45-62
    • Seidah, N.G.1    Chretien, M.2
  • 32
    • 84860383419 scopus 로고    scopus 로고
    • The biology and therapeutic targeting of the proprotein convertases
    • Seidah, N.G., Prat, A., The biology and therapeutic targeting of the proprotein convertases. Nat. Rev. Drug Discov., 2012, 10.1038/nrd3699.
    • (2012) Nat. Rev. Drug Discov.
    • Seidah, N.G.1    Prat, A.2
  • 33
    • 77956634502 scopus 로고    scopus 로고
    • Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus
    • Sun, X., Tse, L.V., Ferguson, A.D., Whittaker, G.R., Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus. J. Virol. 84 (2010), 8683–8690, 10.1128/JVI.00797-10.
    • (2010) J. Virol. , vol.84 , pp. 8683-8690
    • Sun, X.1    Tse, L.V.2    Ferguson, A.D.3    Whittaker, G.R.4
  • 34
    • 85079372059 scopus 로고    scopus 로고
    • Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS
    • Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS. J. Virol., 2020, 10.1128/JVI.00127-20.
    • (2020) J. Virol.
    • Wan, Y.1    Shang, J.2    Graham, R.3    Baric, R.S.4    Li, F.5
  • 36
    • 85079180879 scopus 로고    scopus 로고
    • Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak
    • Zhao, S., Ran, J., Musa, S.S., Yang, G., Wang, W., Lou, Y., Gao, D., Yang, L., He, D., Wang, M.H., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak. Int J Infect Dis, 2020, 30053–30059, 10.1016/j.ijid.2020.01.050.
    • (2020) Int J Infect Dis , pp. 30053-30059
    • Zhao, S.1    Ran, J.2    Musa, S.S.3    Yang, G.4    Wang, W.5    Lou, Y.6    Gao, D.7    Yang, L.8    He, D.9    Wang, M.H.10


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