메뉴 건너뛰기




Volumn 127, Issue 1, 2017, Pages 103-105

The interferon paradox: Can inhibiting an antiviral mechanism advance an HIV cure?

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; INTERFERON; ANTIRETROVIRUS AGENT;

EID: 85008384523     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI91916     Document Type: Review
Times cited : (31)

References (24)
  • 1
    • 84978120368 scopus 로고    scopus 로고
    • International AIDS Society global scientific strategy: Towards an HIV cure 2016
    • Deeks SG, et al. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016;22(8):839-850.
    • (2016) Nat Med. , vol.22 , Issue.8 , pp. 839-850
    • Deeks, S.G.1
  • 2
    • 84901933676 scopus 로고    scopus 로고
    • Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression
    • Sandler NG, et al. Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature. 2014;511(7511):601-605.
    • (2014) Nature , vol.511 , Issue.7511 , pp. 601-605
    • Sandler, N.G.1
  • 3
    • 84874280676 scopus 로고    scopus 로고
    • Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
    • Hardy GA, et al. Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers. PLoS One. 2013;8(2):e56527.
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e56527
    • Hardy, G.A.1
  • 4
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D, et al. Tryptophan catabolism by indoleamine 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med. 2010;2(32):32-36.
    • (2010) Sci Transl Med. , vol.2 , Issue.32 , pp. 32-36
    • Favre, D.1
  • 5
    • 84897420506 scopus 로고    scopus 로고
    • Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis
    • Le Saout C, et al. Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS Pathog. 2014;10(3):e1003976.
    • (2014) PLoS Pathog. , vol.10 , Issue.3 , pp. e1003976
    • Le Saout, C.1
  • 6
    • 81055124967 scopus 로고    scopus 로고
    • CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon- stimulated genes in CD4+ T cells
    • Fernandez S, et al. CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon- stimulated genes in CD4+ T cells. J Infect Dis. 2011;204(12):1927-1935.
    • (2011) J Infect Dis. , vol.204 , Issue.12 , pp. 1927-1935
    • Fernandez, S.1
  • 7
    • 84893745203 scopus 로고    scopus 로고
    • Discordance between peripheral and colonic markers of inflammation during suppressive ART
    • Dunham RM, et al. Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr. 2014;65(2):133-141.
    • (2014) J Acquir Immune Defic Syndr. , vol.65 , Issue.2 , pp. 133-141
    • Dunham, R.M.1
  • 8
    • 84910010874 scopus 로고    scopus 로고
    • Soluble markers of inflammation and coagulation, but not T-cell activation, are predictors of non-AIDS-defining morbid events during suppressive antiretroviral treatment
    • Tenorio AR, et al. Soluble markers of inflammation and coagulation, but not T-cell activation, are predictors of non-AIDS-defining morbid events during suppressive antiretroviral treatment. J Infect Dis. 2014;210(8):1248-1259.
    • (2014) J Infect Dis. , vol.210 , Issue.8 , pp. 1248-1259
    • Tenorio, A.R.1
  • 9
    • 84902281875 scopus 로고    scopus 로고
    • Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection
    • Hunt PW, et al. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis. 2014;210(8):1228-1238.
    • (2014) J Infect Dis. , vol.210 , Issue.8 , pp. 1228-1238
    • Hunt, P.W.1
  • 10
    • 80052882129 scopus 로고    scopus 로고
    • Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    • Lederman MM, et al. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis. 2011;204(8):1217-1226.
    • (2011) J Infect Dis. , vol.204 , Issue.8 , pp. 1217-1226
    • Lederman, M.M.1
  • 11
    • 79951825000 scopus 로고    scopus 로고
    • CD4 and CD8 T cell immune activation during chronic HIV infection: Roles of homeostasis, HIV, type I IFN, and IL-7
    • Catalfamo M, et al. CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7. J Immunol. 2011;186(4):2106-2116.
    • (2011) J Immunol. , vol.186 , Issue.4 , pp. 2106-2116
    • Catalfamo, M.1
  • 12
    • 84879429159 scopus 로고    scopus 로고
    • Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes
    • Mudd JC, et al. Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes. Blood. 2013;121(15):2914-2922.
    • (2013) Blood , vol.121 , Issue.15 , pp. 2914-2922
    • Mudd, J.C.1
  • 13
    • 84856183595 scopus 로고    scopus 로고
    • Interferon-alpha administration enhances CD8+ T cell activation in HIV infection
    • Manion M, et al. Interferon-alpha administration enhances CD8+ T cell activation in HIV infection. PLoS One. 2012;7(1):e30306.
    • (2012) PLoS One , vol.7 , Issue.1 , pp. e30306
    • Manion, M.1
  • 14
    • 77649244528 scopus 로고    scopus 로고
    • IFN- α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo
    • Stoddart CA, Keir ME, McCune JM. IFN- α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathog. 2010;6(2):e1000766.
    • (2010) PLoS Pathog , vol.6 , Issue.2 , pp. e1000766
    • Stoddart, C.A.1    Keir, M.E.2    McCune, J.M.3
  • 15
    • 84876332379 scopus 로고    scopus 로고
    • Immunology
    • Odorizzi PM, Wherry EJ. Immunology. Science. 2013;340(6129):155-156.
    • (2013) Science , vol.340 , Issue.6129 , pp. 155-156
    • Odorizzi, P.M.1    Wherry, E.J.2
  • 16
    • 84876299371 scopus 로고    scopus 로고
    • Blockade of chronic type I interferon signaling to control persistent LCMV infection
    • Wilson EB, et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science. 2013;340(6129):202-207.
    • (2013) Science , vol.340 , Issue.6129 , pp. 202-207
    • Wilson, E.B.1
  • 17
    • 84876311772 scopus 로고    scopus 로고
    • Persistent LCMV infection is controlled by blockade of type I interferon signaling
    • Teijaro JR, et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science. 2013;340(6129):207-211.
    • (2013) Science , vol.340 , Issue.6129 , pp. 207-211
    • Teijaro, J.R.1
  • 18
    • 85008331088 scopus 로고    scopus 로고
    • Targeting type I interferon- mediated activation restores immune function in chronic HIV infection
    • Zhen A, et al. Targeting type I interferon- mediated activation restores immune function in chronic HIV infection. J Clin Invest. 2017;127(1):260-268.
    • (2017) J Clin Invest. , vol.127 , Issue.1 , pp. 260-268
    • Zhen, A.1
  • 19
    • 85008395064 scopus 로고    scopus 로고
    • Blocking type I interferon signaling enhances T cell recovery reduces HIV-1 reservoirs
    • Cheng L, et al. Blocking type I interferon signaling enhances T cell recovery reduces HIV-1 reservoirs. J Clin Invest. 2017;127(1):269-279.
    • (2017) J Clin Invest. , vol.127 , Issue.1 , pp. 269-279
    • Cheng, L.1
  • 20
    • 84879318140 scopus 로고    scopus 로고
    • Immune activation and HIV persistence: Implications for curative approaches to HIV infection
    • Klatt NR, Chomont N, Douek DC, Deeks SG. Immune activation and HIV persistence: implications for curative approaches to HIV infection. Immunol Rev. 2013;254(1):326-342.
    • (2013) Immunol Rev. , vol.254 , Issue.1 , pp. 326-342
    • Klatt, N.R.1    Chomont, N.2    Douek, D.C.3    Deeks, S.G.4
  • 21
    • 84878981012 scopus 로고    scopus 로고
    • Barriers to a cure for HIV: Newways to target and eradicate HIV-1 reservoirs
    • Katlama C, et al. Barriers to a cure for HIV: newways to target and eradicate HIV-1 reservoirs. Lancet. 2013;381(9883):2109-2117.
    • (2013) Lancet , vol.381 , Issue.9883 , pp. 2109-2117
    • Katlama, C.1
  • 22
    • 85048742182 scopus 로고    scopus 로고
    • Targeted therapeutics in SLE: Emerging strategies to modulate the interferon pathway
    • Oon S, Wilson NJ, Wicks I. Targeted therapeutics in SLE: emerging strategies to modulate the interferon pathway. Clin Transl Immunology. 2016;5(5):e79.
    • (2016) Clin Transl Immunology , vol.5 , Issue.5 , pp. e79
    • Oon, S.1    Wilson, N.J.2    Wicks, I.3
  • 23
    • 84954384327 scopus 로고    scopus 로고
    • A phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)
    • Kalunian KC, et al. A phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE). Ann Rheum Dis. 2016;75(1):196-202.
    • (2016) Ann Rheum Dis. , vol.75 , Issue.1 , pp. 196-202
    • Kalunian, K.C.1
  • 24
    • 84962815312 scopus 로고    scopus 로고
    • Sifalimumab, an anti-interferon- α monoclonal antibody, in moderate to severe systemic lupus erythematosus: A randomised, double-blind, placebo-controlled study
    • Khamashta M, et al. Sifalimumab, an anti-interferon- α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study. Ann Rheum Dis. 2016;75(11):1909-1916.
    • (2016) Ann Rheum Dis. , vol.75 , Issue.11 , pp. 1909-1916
    • Khamashta, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.