TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

Journal of Virology

Volumn 93, Issue 6, 2019, Pages

  Iwata Yoshikawa, Naoko ^a   Okamura, Tadashi ^b   Shimizu, Yukiko ^b   Hasegawa, Hideki ^a   Takeda, Makoto ^a   Nagata, Noriyo ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Animal model; Immunopathology; MERS CoV; SARS CoV; TMPRSS2

Indexed keywords

CHEMOKINE; CYTOKINE; DPP4 PROTEIN; POLYINOSINIC POLYCYTIDYLIC ACID; SERINE PROTEINASE; TMPRSS2 PROTEIN; UNCLASSIFIED DRUG; VIRUS RECEPTOR; CORONAVIRUS SPIKE GLYCOPROTEIN; TMPRSS2 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT LOSS; CONTROLLED STUDY; FEMALE; GENE KNOCKOUT; IMMUNOPATHOLOGY; INFLAMMATION; MALE; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CELL LINE; CHLOROCEBUS AETHIOPS; CORONAVIRUS INFECTION; DISEASE MODEL; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; METABOLISM; TRANSGENIC MOUSE; VERO CELL LINE; VIROLOGY;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CORONAVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; POLY I-C; SARS VIRUS; SERINE ENDOPEPTIDASES; SEVERE ACUTE RESPIRATORY SYNDROME; SPIKE GLYCOPROTEIN, CORONAVIRUS; TOLL-LIKE RECEPTOR 3; VERO CELLS;

EID: 85062601344     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01815-18     Document Type: Article

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