Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Cell

Volumn 178, Issue 3, 2019, Pages 714-730.e22

  Smillie, Christopher S ^a   Biton, Moshe ^a,b   Ordovas Montanes, Jose ^a,c,d,e   Sullivan, Keri M ^b   Burgin, Grace ^a   Graham, Daniel B ^a,b,d,f   Herbst, Rebecca H ^a,f   Rogel, Noga ^a   Slyper, Michal ^a   Waldman, Julia ^a   Sud, Malika ^a   Andrews, Elizabeth ^b   Velonias, Gabriella ^b   Haber, Adam L ^a   Jagadeesh, Karthik ^a   Vickovic, Sanja ^a   Yao, Junmei ^b   Stevens, Christine ^a   Dionne, Danielle ^a   Nguyen, Lan T ^a   Villani, Alexandra Chloé ^a,b   Hofree, Matan ^a   Creasey, Elizabeth A ^b   Huang, Hailiang ^a,b   Rozenblatt Rosen, Orit ^a   Garber, John J ^b   Khalili, Hamed ^b   Desch, A Nicole ^a,b   Daly, Mark J ^a,b,g   Ananthakrishnan, Ashwin N ^b   Shalek, Alex K ^a,c,d   Xavier, Ramnik J ^a,b,d,f   Regev, Aviv ^a,d   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Massachusetts Institute of Technology   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF HELSINKI   (Finland)

Author keywords

anti TNF resistance; cell cell interactions; colon; genome wide association studies; inflammation; inflammatory bowel disease; large intestine; single cell genomics; single cell RNA seq; ulcerative colitis

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 11; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 17; TUMOR NECROSIS FACTOR; BEST4 PROTEIN, HUMAN; BESTROPHIN; MONOCLONAL ANTIBODY; RSPO3 PROTEIN, HUMAN; THROMBOSPONDIN;

ADULT; AGED; ARTICLE; BEST4 GENE; CD8 GENE; CELL COMPOSITION; CELL DIFFERENTIATION; CELL INFILTRATION; CELL INTERACTION; CELL PROLIFERATION; CELL REPROGRAMMING TECHNIQUE; CELL SPECIFICITY; CLINICAL ARTICLE; COHORT ANALYSIS; COLON BIOPSY; COLON MUCOSA; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE LOCUS; GENETIC RISK; GENETIC VARIABILITY; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IL 17 GENE; IL11GENE; IL13RA2 GENE; INTESTINE EPITHELIUM CELL; MALE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; RNA SEQUENCE; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; STROMA CELL; T LYMPHOCYTE; TNF GENE; ULCERATIVE COLITIS; CASE CONTROL STUDY; COLON; CYTOLOGY; IMMUNOLOGY; INTESTINE CELL; METABOLISM; MIDDLE AGED; PATHOLOGY; RISK FACTOR; YOUNG ADULT;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BESTROPHINS; CASE-CONTROL STUDIES; CD8 ANTIGENS; COLITIS, ULCERATIVE; COLON; ENTEROCYTES; FEMALE; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INTERLEUKIN-17; MALE; MIDDLE AGED; RISK FACTORS; T-LYMPHOCYTES; THROMBOSPONDINS; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 85069176109     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2019.06.029     Document Type: Article

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