메뉴 건너뛰기




Volumn 25, Issue 7, 2019, Pages 1153-1163

A cellular census of human lungs identifies novel cell states in health and in asthma

(35)  Vieira Braga, Felipe A a,b   Kar, Gozde a,b   Berg, Marijn c   Carpaij, Orestes A c   Polanski, Krzysztof a   Simon, Lukas M d   Brouwer, Sharon c   Gomes, Tomás a   Hesse, Laura c   Jiang, Jian c   Fasouli, Eirini S a,b   Efremova, Mirjana a   Vento Tormo, Roser a   Talavera López, Carlos a   Jonker, Marnix R c   Affleck, Karen e   Palit, Subarna d,f,g   Strzelecka, Paulina M a,h,i   Firth, Helen V a   Mahbubani, Krishnaa T h   more..


Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TRANSCRIPTOME;

EID: 85067892275     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/s41591-019-0468-5     Document Type: Article
Times cited : (563)

References (51)
  • 1
    • 85015279062 scopus 로고    scopus 로고
    • Plasticity in the lung: making and breaking cell identity
    • COI: 1:CAS:528:DC%2BC2sXhtF2hu77L
    • Tata, P. R. & Rajagopal, J. Plasticity in the lung: making and breaking cell identity. Development 144, 755–766 (2017).
    • (2017) Development , vol.144 , pp. 755-766
    • Tata, P.R.1    Rajagopal, J.2
  • 2
    • 84929684999 scopus 로고    scopus 로고
    • Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
    • COI: 1:CAS:528:DC%2BC2MXpt1Sgt7o%3D
    • Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202–1214 (2015).
    • (2015) Cell , vol.161 , pp. 1202-1214
    • Macosko, E.Z.1
  • 3
    • 85051624261 scopus 로고    scopus 로고
    • A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
    • COI: 1:CAS:528:DC%2BC1cXhsVensrjJ
    • Montoro, D. T. et al. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature 560, 319–324 (2018).
    • (2018) Nature , vol.560 , pp. 319-324
    • Montoro, D.T.1
  • 4
    • 85051647983 scopus 로고    scopus 로고
    • A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte
    • COI: 1:CAS:528:DC%2BC1cXhsVensrnM
    • Plasschaert, L. W. et al. A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Nature 560, 377–381 (2018).
    • (2018) Nature , vol.560 , pp. 377-381
    • Plasschaert, L.W.1
  • 5
    • 13244283293 scopus 로고    scopus 로고
    • Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective
    • COI: 1:CAS:528:DC%2BD2MXntFyjtg%3D%3D
    • Bisset, L. R. & Schmid-Grendelmeier, P. Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective. Curr. Opin. Pulm. Med. 11, 35–42 (2005).
    • (2005) Curr. Opin. Pulm. Med. , vol.11 , pp. 35-42
    • Bisset, L.R.1    Schmid-Grendelmeier, P.2
  • 6
    • 77952575435 scopus 로고    scopus 로고
    • Synaptotagmin-mediated vesicle fusion regulates cell migration
    • COI: 1:CAS:528:DC%2BC3cXmtFaltbY%3D
    • Colvin, R. A. et al. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat. Immunol. 11, 495–502 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 495-502
    • Colvin, R.A.1
  • 7
    • 84983294324 scopus 로고    scopus 로고
    • Protein S is protective in pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BC28Xhtlyls7nJ
    • Urawa, M. et al. Protein S is protective in pulmonary fibrosis. J. Thromb. Haemost. 14, 1588–1599 (2016).
    • (2016) J. Thromb. Haemost. , vol.14 , pp. 1588-1599
    • Urawa, M.1
  • 8
    • 84943327627 scopus 로고    scopus 로고
    • +-ATPase activity in lung alveolar epithelial cells
    • COI: 1:CAS:528:DC%2BC2MXhs1WjsL3F
    • +-ATPase activity in lung alveolar epithelial cells. Respir. Physiol. Neurobiol. 220, 54–61 (2016).
    • (2016) Respir. Physiol. Neurobiol. , vol.220 , pp. 54-61
    • Wujak, A.1
  • 9
    • 85026874971 scopus 로고    scopus 로고
    • Alpha-1 antitrypsin-deficient macrophages have increased matriptase-mediated proteolytic activity
    • COI: 1:CAS:528:DC%2BC2sXitVSktbzK
    • Krotova, K. et al. Alpha-1 antitrypsin-deficient macrophages have increased matriptase-mediated proteolytic activity. Am. J. Respir. Cell Mol. Biol. 57, 238–247 (2017).
    • (2017) Am. J. Respir. Cell Mol. Biol. , vol.57 , pp. 238-247
    • Krotova, K.1
  • 10
    • 0040886358 scopus 로고    scopus 로고
    • S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14
    • COI: 1:CAS:528:DyaK1MXmtVWitLk%3D
    • Vogl, T. et al. S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. J. Biol. Chem. 274, 25291–25296 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 25291-25296
    • Vogl, T.1
  • 11
    • 59749106642 scopus 로고    scopus 로고
    • LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-α, IL-10 and IFN-γ
    • COI: 1:CAS:528:DC%2BD1MXosVCk
    • Mitchell, A. et al. LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-α, IL-10 and IFN-γ. Eur. J. Immunol. 38, 3459–3473 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3459-3473
    • Mitchell, A.1
  • 12
    • 80055068577 scopus 로고    scopus 로고
    • Lung dendritic cells at the innate-adaptive immune interface
    • COI: 1:CAS:528:DC%2BC3MXhsFSjsr7E
    • Condon, T. V., Sawyer, R. T., Fenton, M. J. & Riches, D. W. H. Lung dendritic cells at the innate-adaptive immune interface. J. Leukoc. Biol. 90, 883–895 (2011).
    • (2011) J. Leukoc. Biol. , vol.90 , pp. 883-895
    • Condon, T.V.1    Sawyer, R.T.2    Fenton, M.J.3    Riches, D.W.H.4
  • 13
    • 85054929479 scopus 로고    scopus 로고
    • The lung in primary immunodeficiencies: new concepts in infection and inflammation
    • Baumann, U., Routes, J. M., Soler-Palacín, P. & Jolles, S. The lung in primary immunodeficiencies: new concepts in infection and inflammation. Front. Immunol. 9, 1837 (2018).
    • (2018) Front. Immunol. , vol.9 , pp. 1837
    • Baumann, U.1    Routes, J.M.2    Soler-Palacín, P.3    Jolles, S.4
  • 15
    • 84859128562 scopus 로고    scopus 로고
    • Airway epithelial cells from asthmatic children differentially express proremodeling factors
    • COI: 1:CAS:528:DC%2BC38XkvFSqsbw%3D
    • Lopez-Guisa, J. M. et al. Airway epithelial cells from asthmatic children differentially express proremodeling factors. J. Allergy Clin. Immunol. 129, 990–997.e6 (2012).
    • (2012) J. Allergy Clin. Immunol. , vol.129 , pp. 990-997.e6
    • Lopez-Guisa, J.M.1
  • 16
    • 84906859849 scopus 로고    scopus 로고
    • Mitotic asynchrony induces transforming growth factor-β1 secretion from airway epithelium
    • COI: 1:CAS:528:DC%2BC2cXhs1yqt7bJ
    • Alcala, S. E. et al. Mitotic asynchrony induces transforming growth factor-β1 secretion from airway epithelium. Am. J. Respir. Cell Mol. Biol. 51, 363–369 (2014).
    • (2014) Am. J. Respir. Cell Mol. Biol. , vol.51 , pp. 363-369
    • Alcala, S.E.1
  • 17
    • 84923277893 scopus 로고    scopus 로고
    • Asthma is not only an airway disease, but also a vascular disease
    • COI: 1:CAS:528:DC%2BC2cXitVWhurfN
    • Harkness, L. M., Ashton, A. W. & Burgess, J. K. Asthma is not only an airway disease, but also a vascular disease. Pharmacol. Ther. 148, 17–33 (2015).
    • (2015) Pharmacol. Ther. , vol.148 , pp. 17-33
    • Harkness, L.M.1    Ashton, A.W.2    Burgess, J.K.3
  • 18
    • 79551511756 scopus 로고    scopus 로고
    • Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program
    • Balzar, S. et al. Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. Am. J. Respir. Crit. Care Med. 183, 299–309 (2011).
    • (2011) Am. J. Respir. Crit. Care Med. , vol.183 , pp. 299-309
    • Balzar, S.1
  • 19
    • 33645059692 scopus 로고    scopus 로고
    • Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients
    • COI: 1:STN:280:DC%2BD287jtFWnsQ%3D%3D
    • Truyen, E. et al. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax 61, 202–208 (2006).
    • (2006) Thorax , vol.61 , pp. 202-208
    • Truyen, E.1
  • 20
    • 84900873950 scopus 로고    scopus 로고
    • The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
    • COI: 1:CAS:528:DC%2BC2cXks12ku7c%3D
    • Trapnell, C. et al. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat. Biotechnol. 32, 381–386 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 381-386
    • Trapnell, C.1
  • 21
    • 84902352161 scopus 로고    scopus 로고
    • The cell biology of asthma
    • COI: 1:CAS:528:DC%2BC2cXhtVSktrbO
    • Erle, D. J. & Sheppard, D. The cell biology of asthma. J. Cell Biol. 205, 621–631 (2014).
    • (2014) J. Cell Biol. , vol.205 , pp. 621-631
    • Erle, D.J.1    Sheppard, D.2
  • 22
    • 84920874540 scopus 로고    scopus 로고
    • Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung
    • COI: 1:CAS:528:DC%2BC2MXmvFansw%3D%3D
    • Danahay, H. et al. Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Rep. 10, 239–252 (2015).
    • (2015) Cell Rep. , vol.10 , pp. 239-252
    • Danahay, H.1
  • 23
    • 84923675686 scopus 로고    scopus 로고
    • Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway
    • Gomi, K., Arbelaez, V., Crystal, R. G. & Walters, M. S. Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS ONE 10, e0116507 (2015).
    • (2015) PLoS ONE , vol.10
    • Gomi, K.1    Arbelaez, V.2    Crystal, R.G.3    Walters, M.S.4
  • 24
    • 85052698825 scopus 로고    scopus 로고
    • Allergic inflammatory memory in human respiratory epithelial progenitor cells
    • COI: 1:CAS:528:DC%2BC1cXhsFOgsL3P
    • Ordovas-Montanes, J. et al. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature 560, 649–654 (2018).
    • (2018) Nature , vol.560 , pp. 649-654
    • Ordovas-Montanes, J.1
  • 25
    • 84963838559 scopus 로고    scopus 로고
    • Airway epithelial expression quantitative trait loci reveal genes underlying asthma and other airway diseases
    • COI: 1:CAS:528:DC%2BC28XhtVKlurbO
    • Luo, W. et al. Airway epithelial expression quantitative trait loci reveal genes underlying asthma and other airway diseases. Am. J. Respir. Cell Mol. Biol. 54, 177–187 (2016).
    • (2016) Am. J. Respir. Cell Mol. Biol. , vol.54 , pp. 177-187
    • Luo, W.1
  • 26
    • 77954144226 scopus 로고    scopus 로고
    • Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways
    • COI: 1:CAS:528:DC%2BC3cXosVGgsL8%3D
    • Wu, C. A. et al. Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways. Cell. Immunol. 264, 32–41 (2010).
    • (2010) Cell. Immunol. , vol.264 , pp. 32-41
    • Wu, C.A.1
  • 27
    • 0027535474 scopus 로고
    • Airway mucosal inflammation even in patients with newly diagnosed asthma
    • COI: 1:STN:280:DyaK3s7ot1yksw%3D%3D
    • Laitinen, L. A., Laitinen, A. & Haahtela, T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am. Rev. Respir. Dis. 147, 697–704 (1993).
    • (1993) Am. Rev. Respir. Dis. , vol.147 , pp. 697-704
    • Laitinen, L.A.1    Laitinen, A.2    Haahtela, T.3
  • 28
    • 79953288489 scopus 로고    scopus 로고
    • H2 inflammation in the pathogenesis of bronchial asthma
    • COI: 1:CAS:528:DC%2BC3MXnt1aktr0%3D
    • H2 inflammation in the pathogenesis of bronchial asthma. Korean J. Intern. Med. 26, 8–18 (2011).
    • (2011) Korean J. Intern. Med. , vol.26 , pp. 8-18
    • Arima, M.1    Fukuda, T.2
  • 29
    • 84897402119 scopus 로고    scopus 로고
    • H2 cells
    • COI: 1:CAS:528:DC%2BC2cXivVKnsA%3D%3D
    • H2 cells. J. Allergy Clin. Immunol. 133, 1184–1194 (2014).
    • (2014) J. Allergy Clin. Immunol. , vol.133 , pp. 1184-1194
    • Xue, L.1
  • 30
    • 77951672627 scopus 로고    scopus 로고
    • H2-high asthma
    • COI: 1:CAS:528:DC%2BC3cXlvVWmtbw%3D
    • H2-high asthma. J. Allergy Clin. Immunol. 125, 1046–1053.e8 (2010).
    • (2010) J. Allergy Clin. Immunol. , vol.125 , pp. 1046-1053.e8
    • Dougherty, R.H.1
  • 33
    • 85048028902 scopus 로고    scopus 로고
    • + T cells inhabit the human lungs
    • COI: 1:CAS:528:DC%2BC2sXhvVSmsLbK
    • + T cells inhabit the human lungs. Mucosal Immunol. 11, 654–667 (2018).
    • (2018) Mucosal Immunol. , vol.11 , pp. 654-667
    • Oja, A.E.1
  • 34
    • 84945548667 scopus 로고    scopus 로고
    • H2 cell subpopulation with enhanced function
    • COI: 1:CAS:528:DC%2BC2MXhsF2hu7nK
    • H2 cell subpopulation with enhanced function. J. Allergy Clin. Immunol. 137, 907–918.e9 (2016).
    • (2016) J. Allergy Clin. Immunol. , vol.137 , pp. 907-918.e9
    • Mitson-Salazar, A.1
  • 35
    • 85026646095 scopus 로고    scopus 로고
    • H2 cell subpopulation is associated with allergic disorders
    • H2 cell subpopulation is associated with allergic disorders. Sci. Transl. Med. 9, eaam9171 (2017).
    • (2017) Sci. Transl. Med. , vol.9 , pp. eaam9171
    • Wambre, E.1
  • 36
    • 84960886647 scopus 로고    scopus 로고
    • H17 signature in nasal mucosa
    • COI: 1:CAS:528:DC%2BC28XnslKhu70%3D
    • H17 signature in nasal mucosa. J. Allergy Clin. Immunol. 137, 1514–1524 (2016).
    • (2016) J. Allergy Clin. Immunol. , vol.137 , pp. 1514-1524
    • Lam, E.P.S.1
  • 37
    • 85056665737 scopus 로고    scopus 로고
    • Single-cell reconstruction of the early maternal–fetal interface in humans
    • COI: 1:CAS:528:DC%2BC1cXit1SnsbzI
    • Vento-Tormo, R. et al. Single-cell reconstruction of the early maternal–fetal interface in humans. Nature 563, 347–353 (2018).
    • (2018) Nature , vol.563 , pp. 347-353
    • Vento-Tormo, R.1
  • 38
    • 78851472074 scopus 로고    scopus 로고
    • Haplotypes covering the TNFSF10 gene are associated with bronchial asthma
    • Weckmann, M., Kopp, M. V., Heinzmann, A. & Mattes, J. Haplotypes covering the TNFSF10 gene are associated with bronchial asthma. Pediatr. Allergy Immunol. 22, 25–30 (2011).
    • (2011) Pediatr. Allergy Immunol. , vol.22 , pp. 25-30
    • Weckmann, M.1    Kopp, M.V.2    Heinzmann, A.3    Mattes, J.4
  • 39
    • 80051570509 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma
    • COI: 1:CAS:528:DC%2BC3MXot1Kjtrc%3D
    • Harada, M. et al. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am. J. Respir. Cell Mol. Biol. 44, 787–793 (2011).
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.44 , pp. 787-793
    • Harada, M.1
  • 40
    • 84875231964 scopus 로고    scopus 로고
    • Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology
    • COI: 1:CAS:528:DC%2BC3sXitFKnsbc%3D
    • Grotenboer, N. S., Ketelaar, M. E., Koppelman, G. H. & Nawijn, M. C. Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology. J. Allergy Clin. Immunol. 131, 856–865 (2013).
    • (2013) J. Allergy Clin. Immunol. , vol.131 , pp. 856-865
    • Grotenboer, N.S.1    Ketelaar, M.E.2    Koppelman, G.H.3    Nawijn, M.C.4
  • 41
    • 14944365805 scopus 로고    scopus 로고
    • Epithelial-mesenchymal communication in the pathogenesis of chronic asthma
    • COI: 1:CAS:528:DC%2BD28XhsFGisL4%3D
    • Holgate, S. T. et al. Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc. Am. Thorac. Soc. 1, 93–98 (2004).
    • (2004) Proc. Am. Thorac. Soc. , vol.1 , pp. 93-98
    • Holgate, S.T.1
  • 42
    • 34250159407 scopus 로고    scopus 로고
    • Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity
    • COI: 1:CAS:528:DC%2BD2sXmtVKgurY%3D
    • Heijink, I. H. et al. Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity. J. Immunol. 178, 7678–7685 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 7678-7685
    • Heijink, I.H.1
  • 43
    • 85018547050 scopus 로고    scopus 로고
    • Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD
    • COI: 1:STN:280:DC%2BC1crhvFKiuw%3D%3D
    • Song, J. et al. Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD. Clin. Epigenetics 9, 42 (2017).
    • (2017) Clin. Epigenetics , vol.9
    • Song, J.1
  • 44
    • 84891677425 scopus 로고    scopus 로고
    • Full-length RNA-seq from single cells using Smart-seq2
    • COI: 1:CAS:528:DC%2BC2cXls1ejtrc%3D
    • Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171–181 (2014).
    • (2014) Nat. Protoc. , vol.9 , pp. 171-181
    • Picelli, S.1
  • 45
    • 77951820899 scopus 로고    scopus 로고
    • Fast and SNP-tolerant detection of complex variants and splicing in short reads
    • COI: 1:CAS:528:DC%2BC3cXjvFyktLs%3D
    • Wu, T. D. & Nacu, S. Fast and SNP-tolerant detection of complex variants and splicing in short reads. Bioinformatics 26, 873–881 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 873-881
    • Wu, T.D.1    Nacu, S.2
  • 46
    • 84871809302 scopus 로고    scopus 로고
    • STAR: ultrafast universal RNA-seq aligner
    • COI: 1:CAS:528:DC%2BC38XhvV2gsbnF
    • Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15–21 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 15-21
    • Dobin, A.1
  • 47
    • 85032485531 scopus 로고    scopus 로고
    • Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations
    • van den Brink, S. C. et al. Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations. Nat. Methods 14, 935–936 (2017).
    • (2017) Nat. Methods , vol.14 , pp. 935-936
    • van den Brink, S.C.1
  • 49
    • 85064408983 scopus 로고    scopus 로고
    • Scrublet: computational identification of cell doublets in single-cell transcriptomic data
    • Wolock, S. L., Lopez, R. & Klein, A. M. Scrublet: computational identification of cell doublets in single-cell transcriptomic data. Cell Syst. 8, P281–291.E9 (2019).
    • (2019) Cell Syst. , vol.8 , pp. P281-291.E9
    • Wolock, S.L.1    Lopez, R.2    Klein, A.M.3
  • 50
    • 85046298440 scopus 로고    scopus 로고
    • Integrating single-cell transcriptomic data across different conditions, technologies, and species
    • COI: 1:CAS:528:DC%2BC1cXmslKrtL0%3D
    • Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411–420 (2018).
    • (2018) Nat. Biotechnol. , vol.36 , pp. 411-420
    • Butler, A.1    Hoffman, P.2    Smibert, P.3    Papalexi, E.4    Satija, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.