SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Cell

Volumn 181, Issue 2, 2020, Pages 271-280.e8

  Hoffmann, Markus ^a   Kleine Weber, Hannah ^a,b   Schroeder, Simon ^c,d   Krüger, Nadine ^e   Herrler, Tanja ^f   Erichsen, Sandra ^f,g   Schiergens, Tobias S ^h   Herrler, Georg ^e   Wu, Nai Huei ^e   Nitsche, Andreas ⁱ   Müller, Marcel A ^c,d,j   Drosten, Christian ^c,d   Pöhlmann, Stefan ^a,b  

^a GERMAN PRIMATE CENTER   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c BERLIN INSTITUTE OF HEALTH   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^f BG UNFALLKLINIK MURNAU   (Germany)

^g PARACELSUS MEDICAL UNIVERSITY   (Austria)

^h UNIVERSITY OF MUNICH   (Germany)

ⁱ ROBERT KOCH INSTITUTE   (Germany)

^j I M SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY   (Russian Federation)

more..

Author keywords

ACE2; coronavirus; COVID 19; entry; neutralization; priming; SARS CoV 2; spike; TMPRSS2

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; CAMOSTAT MESILATE; NEUTRALIZING ANTIBODY; SERINE PROTEASE TMPRSS2; SERINE PROTEINASE; UNCLASSIFIED DRUG; VIRUS SPIKE PROTEIN; (3-ETHOXYCARBONYLOXIRANE-2-CARBONYL)LEUCINE (3-METHYLBUTYL) AMIDE; AMMONIUM CHLORIDE; CAMOSTAT; CORONAVIRUS SPIKE GLYCOPROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE; GABEXATE; LEUCINE; PROTEINASE INHIBITOR; SPIKE GLYCOPROTEIN, SARS-COV; TMPRSS2 PROTEIN, HUMAN; VIRUS ANTIBODY; VIRUS RECEPTOR;

ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CORONAVIRUS DISEASE 2019; CORONAVIRUS INFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SARS CORONAVIRUS; SARS-RELATED CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VIRUS ENTRY; VIRUS NEUTRALIZATION; VIRUS SPIKE; ANIMAL; BETACORONAVIRUS; CELL LINE; CHEMISTRY; CORONAVIRINAE; DRUG DEVELOPMENT; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; PANDEMIC; PASSIVE IMMUNIZATION; PHYSIOLOGY; VESICULOVIRUS; VIRUS PNEUMONIA;

AMMONIUM CHLORIDE; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; BETACORONAVIRUS; CELL LINE; CORONAVIRUS; CORONAVIRUS INFECTIONS; DRUG DEVELOPMENT; GABEXATE; HUMANS; IMMUNIZATION, PASSIVE; LEUCINE; PANDEMICS; PEPTIDYL-DIPEPTIDASE A; PNEUMONIA, VIRAL; PROTEASE INHIBITORS; RECEPTORS, VIRUS; SARS VIRUS; SERINE ENDOPEPTIDASES; SPIKE GLYCOPROTEIN, CORONAVIRUS; VESICULOVIRUS; VIRUS INTERNALIZATION;

EID: 85082190084     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2020.02.052     Document Type: Article

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