Milk and Dairy Product Consumption and Cardiovascular Diseases: An Overview of Systematic Reviews and Meta-Analyses

Advances in Nutrition

Volumn 10, Issue , 2019, Pages S164-S189

  Fontecha, Javier ^a   Calvo, Maria Visitación ^a   Juarez, Manuela ^a   Gil, Angel ^b,c,d   Martínez Vizcaino, Vicente ^e,f  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^f UNIVERSIDAD AUTÓNOMA DE CHILE   (Chile)

Author keywords

cardiovascular diseases; coronary heart disease; dairy products; milk consumption; stroke

Indexed keywords

CHOLESTEROL;

ADMINISTRATION AND DOSAGE; ADVERSE EVENT; ANIMAL; BLOOD; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; DAIRY PRODUCT; DIET; DRUG EFFECT; FAT INTAKE; FEEDING BEHAVIOR; HUMAN; MILK;

ANIMALS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CHOLESTEROL; DAIRY PRODUCTS; DIET; DIETARY FATS; FEEDING BEHAVIOR; HUMANS; MILK;

EID: 85066833487     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.1093/advances/nmy099     Document Type: Review

References (80)

1. GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017;390:1345-422.
2. WHO. Noncommunicable Diseases ProgressMonitor, 2017. [Internet]. Geneva, World Health Organization; 2017. Available from: Http://www. who.int/nmh/publications/ncd-progress-monitor-2017/en/.
3. Fontecha J, Juarez M. Recent advances in dairy ingredients and cardiovascular diseases with special interest inmilk fat components. In: Watson RR, Collier RJ, Preedy VR, editors.Milk in Human Health and Disease Across the Lifespan. London: Academic Press; 2017. pp. 251-61.
4. Mensink R, Zock PL, Kester AD, KatanMB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146-55.
5. Mensink RP. Effects of Saturated Fatty Acids on Serum Lipids and Lipoproteins: A Systematic Review and Regression Analysis. Geneva: World Health Organization; 2016.
6. US Department of Health and Human Services and USDA. 2015-2020 Dietary Guidelines for Americans. 8th ed. December 2015. [Internet]. Available from: Https://health.gov/dietaryguidelines/2015/guidelines/.
7. Dehghan M, Mente A, Rangarajan S, Sheridan P, Mohan V, Iqbal R, Gupta R, Lear S, Wentzel-Viljoen E, Avezum A, et al.; Prospective Urban Rural Epidemiology (PURE) study investigators. Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): A prospective cohort study. Lancet 2018;392(10161):2288-2297 doi: 10.1016/S0140-6736(18)31812-9, Epub 2018 Sep 11.
8. Astrup A. Yogurt and dairy product consumption to prevent cardiometabolic diseases: Epidemiologic and experimental studies. Am J Clin Nutr 2014;99(5 Suppl):1235S-42S.
9. Bernic D, Brassard D, Tessier-Grenier M, Rajendiran E, She Y, Ramprasath V, Gigleux I, Levy E, Tremblay A, Jones P, et al. Comparing the impact of saturated fatty acids from different dairy sources on LDL particle size phenotype. FASEB J 2017;31(1 Suppl):966.5.
10. Lordan R, Tsoupras A, Mitra B, Zabetakis I. Dairy fats and cardiovascular disease: Do we really need to be concerned Foods 2018;7(3):29.
11. Park YW. Bioactive components in cow's milk. In: Belzen N, editor. Achieving Sustainable Production of Milk. Volume 1 Part 1: Milk Composition, Genetics and Breeding. London: Burleigh Dodds Science Publishing; 2018. 339pp. ISBN: 9781786760449.
12. Qin LQ, Xu JY, Han SF, Zhang ZL, Zhao YY, Szeto IMY. Dairy consumption and risk of cardiovascular disease: An updated metaanalysis of prospective cohort studies. Asia Pac J Clin Nutr 2015;24:90-100.
13. AlexanderDD, Bylsma LC, VargasAJ, Cohen SS, Doucette A, Mohamed M, Irvin SR, Miller PE, Watson H, Fryzek JP. Dairy consumption and CVD: A systematic review and meta-analysis. Br J Nutr 2016;115:737-50.
14. Guo J, AstrupA, Lovegrove JA, Gijsbers L, GivensDI, Soedamah-Muthu SS. Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: Dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 2017;32:269-87.
15. Gholami F, Khoramdad M, Esmailnasab N, Moradi G, Nouri B, Safiri S, Alimohamadi Y. The effect of dairy consumption on the prevention of cardiovascular diseases: A meta-analysis of prospective studies. J Cardiovasc Thorac Res 2017;9:1-11.
16. Chen GC, Wang Y, Tong X, Szeto IMY, Smit G, Li ZN, Qin LQ. Cheese consumption and risk of cardiovascular disease: A meta-analysis of prospective studies. Eur J Nutr 2017;56:2565-75.
17. Drouin-Chartier JP, Brassard D, Tessier-Grenier M, Cote JA, Labonte ME, Desroches S, Couture P, Lamarche B. Systematic review of the association between dairy product consumption and risk of cardiovascular-related clinical outcomes. Adv Nutr 2016;7:1026-40.
18. Huth PJ, ParkMP. Influence of dairy product andmilk fat consumption on cardiovascular disease risk: A review of the evidence. Adv Nutr 2012;3:266-85.
19. Anderson TJ, Gregoire J, Hegele RA, Couture P, Mancini GB, McPherson R, Francis GA, Poirier P, Lau DC, Grover S, et al. 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol 2013;29: 151-67.
20. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009;338:b1665.
21. Kaptoge S, Seshasai SR, Gao P, Freitag DF, Butterworth AS, Borglykke A, Di Angelantonio E, Gudnason V, Rumley A, Lowe GD, et al. Inflammatory cytokines and risk of coronary heart disease: New prospective study and updated meta-analysis. Eur Heart J 2014;35:578-89.
22. Danesh J, Lewington S, Thompson SG, Lowe GD, Collins R, Kostis JB, Wilson AC, Folsom AR, Wu K, Benderly M, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: An individual participant meta-analysis. JAMA 2005;294:1799-809.
23. Ulven SM, Holven KB, Gil A, Rangel-Huerta OD. Milk and dairy product consumption and inflammatory biomarkers: An updated systematic review of randomized clinical trials. Adv Nutr 2018;(Suppl 1). doi: 10.1093/advances/nmy072.
24. Agerholm-Larsen L, Bell ML, Grunwald GK, Astrup A. The effect of a probiotic milk product on plasma cholesterol: A metaanalysis of short-term intervention studies. Eur J Clin Nutr 2000;54: 856-60.
25. Sun J, Buys N. Effects of probiotics consumption on lowering lipids and CVD risk factors: A systematic review and meta-analysis of randomized controlled trials. Ann Med 2015;47(6):430-40.
26. Benatar JR, Sidhu K, Stewart RAH. Effects of high and low fat dairy food on cardio-metabolic risk factors: Ameta-analysis of randomized studies. PLoS One 2013;8(10):e76480.
27. de Goede J, Geleijnse JM, Ding EL, Soedamah-Muthu SS. Effect of cheese consumption on blood lipids: A systematic review and meta-analysis of randomized controlled trials. Nutr Rev 2015;73(5): 259-75.
28. Shimizu M, Hashiguchi M, Shiga T, Tamura H-o, Mochizuki M. Meta-analysis: Effects of probiotic supplementation on lipid profiles in normal to mildly hypercholesterolemic individuals. PLoS One 2015;10(10):e0139795.
29. Ding M, TaoH, Bergholdt HKM, Nordestgaard BG, Ellervik C, Qi L, on behalf of the CHARGE Consortium. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ 2017;356:j1000.
30. Hidayat K, DuHZ, Yang J, Chen GC, Zhang Z, Li ZN, Qin LQ. Effects of milk proteins on blood pressure: A meta-analysis of randomized control trials. Hypertens Res 2017;40(3):264-70.
31. Cicero AF, Aubin F, Azais-Braesco V, Borghi C. Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects A meta-analysis of randomized controlled trials. Am J Hypertens 2013;26(3):442-9.
32. Dong JY, Szeto IMY, Makinen K, Gao Q, Wang J, Qin L-Q, Zhao Y. Effect of probiotic fermentedmilk on blood pressure: A meta-analysis of randomised controlled trials. Br J Nutr 2013;110(7):1188-94.
33. Turpeinen AM, Jarvenpaa S, Kautiainen H, Korpela R, Vapaatalo H. Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis. Ann Med 2013;45(1):51-6.
34. Usinger L, Reimer C, Ibsen H. Fermented milk for hypertension. Cochrane Database Syst Rev 2012;(4):CD008118.
35. Xu JY, Qin LQ, Wang PY, Li W, Chang C. Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials. Nutrition 2008;24(10):933-40.
36. Drouin-Chartier JP, Cote JA, Labonte ME, Brassard D, Tessier-Grenier M, Desroches S, Couture P, Lamarche B. Comprehensive review of the impact of dairy foods and dairy fat on cardiometabolic risk. Adv Nutr 2016;7(6):1041-51.
37. Stroup DF. Meta-analysis of observational studies in epidemiology: A proposal for reporting. JAMA 2000;283(15):2008-12.
38. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group. Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. Syst Rev 2015;4(1):1.
39. Alvarez-Bueno C, Cavero-Redondo I, Martinez-Andres M, Arias-Palencia N, Ramos-Blanes R, Salcedo-Aguilar F. Effectiveness of multifactorial interventions in primary health care settings for primary prevention of cardiovascular disease: A systematic review of systematic reviews. Prev Med 2015;76:S68-75.
40. Alvarez-Bueno C, Rodriguez-Martin B, Garcia-Ortiz L, Gomez-Marcos MA, Martinez-Vizcaino V. Effectiveness of brief interventions in primary health care settings to decrease alcohol consumption by adult non-dependent drinkers: A systematic review of systematic reviews. Prev Med 2015;76:S33-8.
41. Higgins JPT, Green S, (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0[updated March 2011]. The Cochrane Collaboration; 2011.Available from www.cochranehandbook. org.
42. Bechthold A, Boeing H, SchwedhelmC, HoffmannG, Knuppel S, Iqbal K, De Henauw S, Michels N, Devleesschauwer B, Schlesinger S, et al. Food groups and risk of coronary heart disease, stroke and heart failure: A systematic review and dose-response meta-analysis of prospective studies. Crit Rev Food Sci Nutr 2017;17:1-20.
43. Elwood PC, Pickering JE, Givens DI, Gallacher JE. The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: An overview of the evidence. Lipids 2010;45:925-39.
44. Elwood PC, Pickering JE, Hughes J, FehilyAM, Ness AR.Milk drinking, ischaemic heart disease and ischaemic stroke II. Evidence from cohort studies. Eur J Clin Nutr 2004;58:718-24.
45. Elwood PC, GivensDI, Beswick AD, Fehily AM, Pickering JE, Gallacher J. The survival advantage ofmilk and dairy consumption: An overviewof evidence from cohort studies of vascular diseases, diabetes and cancer. J Am Coll Nutr 2008;27(6):723S-34S.
46. Gholami F, Khoramdad M, Shakiba E, Alimohamadi Y, Shafiei J, Firouzi A. Subgroup dairy products consumption on the risk of stroke and CHD: A systematic review and meta-analysis.Med J Islam Repub Iran 2017;31:25.
47. deGoede J, Soedamah-MuthuSS, PanA, Gijsbers L, Geleijnse JM.Dairy consumption and risk of stroke: A systematic review and updated dose-response meta-analysis of prospective cohort studies. J Am Heart Assoc 2016;5(5):e002787.
48. Hu D, Huang J, Wang Y, Zhang D, Qu Y. Dairy foods and risk of stroke: A meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis 2014;24:460-9.
49. Larsson SC, Crippa A, Orsini N, Wolk A, Michaelsson K. Milk consumption and mortality fromall causes, cardiovascular disease, and cancer: A systematic review and meta-analysis. Nutrients 2015;7:7749-63.
50. Mullie P, Pizot C, Autier P. Daily milk consumption and all-cause mortality, coronary heart disease and stroke: A systematic review and meta-analysis of observational cohort studies. BMC Public Health 2016;16:1236.
51. PimpinL, WuJHY, HaskelbergH, DelGobboL, MozaffarianD. Is butter backAsystematic reviewandmeta-analysis of butter consumption and risk of cardiovascular disease, diabetes, and total mortality. PLoS One 2016;11:e0158118.
52. Soedamah-Muthu SS, Ding EL, Al-DelaimyWK, Hu FB, Engberink MF, Willett WC, Geleijnse JM. Milk and dairy consumption and incidence of cardiovascular diseases and all-causemortality: Dose-responsemetaanalysis of prospective cohort studies. Am J Clin Nutr 2011;93: 158-71.
53. Wu L, Sun D. Consumption of yogurt and the incident risk of cardiovascular disease: Ameta-analysis of nine cohort studies.Nutrients 2017;9(3):E315.
54. Shea BJ, Reeves BC, Wells G, ThukuM, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, et al.AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ 2017;358:j4008.
55. Higgins JPT, Altman DG, Sterne JAC. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011. Available from : Www.cochrane-handbook.org.
56. Drouin-Chartier JP, Gigleux I, Tremblay AJ, Poirier L, Lamarche B, Couture P. Impact of dairy consumption on essential hypertension: A clinical study. Nutr J 2014;13:83.
57. Drouin-Chartier JP, Gagnon J, Labonte ME, Desroches S, Charest A, Grenier G, Dodin S, Lemieux S, Couture P, Lamarche B. Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity. Nutr J 2015;14:12.
58. Fathi Y, Ghodrati N, Zibaeenezhad MJ, Faghih S. Kefir drink causes a significant yet similar improvement in serum lipid profile, compared with low-fat milk, in a dairy-rich diet in overweight or obese premenopausal women: A randomized controlled trial. J Clin Lipidol 2017;11(1):136-46.
59. Machin DR, Park W, Alkatan M, Mouton M, Tanaka H. Hypotensive effects of solitary addition of conventional nonfat dairy products to the routine diet: A randomized controlled trial. Am J Clin Nutr 2014;100(1):80-7.
60. Tanaka S, Uenishi K, Ishida H, Takami Y, Hosoi T, Kadowaki T, Orimo H, Ohashi Y. A randomized intervention trial of 24-wk dairy consumption on waist circumference, blood pressure, and fasting blood sugar and lipids in Japanese men with metabolic syndrome. J Nutr Sci Vitaminol (Tokyo) 2014;60(5):305-12.
61. Maki KC, Rains TM, Schild AL, Dicklin MR, Park KM, Lawless AL, Kelley KM. Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension. Vasc Health Risk Manag 2013;9:369-79.
62. Rideout TC, Marinangeli CPF, Martin H, Browne RW, Rempel CB. Consumption of low-fat dairy foods for 6 months improves insulin resistance without adversely affecting lipids or bodyweight in healthy adults: A randomized free-living cross-over study. Nutr J 2013;12: 56.
63. Conway V, Couture P, Richard C, Gauthier SF, Pouliot Y, Lamarche B. Impact of buttermilk consumption on plasma lipids and surrogate markers of cholesterol homeostasis in men and women. Nutr Metab Cardiovasc Dis 2013;23(12):1255-62.
64. Conway V, Couture P, Gauthier S, Pouliot Y, Lamarche B. Effect of buttermilk consumption on blood pressure in moderately hypercholesterolemic men and women. Nutrition 2014;30:116-9.
65. Benatar JR, Jones E, White H, StewartRA.Arandomized trial evaluating the effects of change in dairy food consumption on cardio-metabolic risk factors. Eur J Prev Cardiol 2014;21(11):1376-86.
66. Soerensen KV, Thorning TK, Astrup A, Kristensen M, Lorenzen JK. Effect of dairy calcium from cheese and milk on fecal fat excretion, blood lipids, and appetite in young men. Am J Clin Nutr 2014;99(5):984-91.
67. Raziani F, Tholstrup T, Kristensen MD, SvanegaardML, Ritz C, Astrup A, Raben A. High intake of regular-fat cheese compared with reducedfat cheese does not affect LDL cholesterol or risk markers of the metabolic syndrome: A randomized controlled trial. Am J Clin Nutr 2016;104:973-81.
68. Borenstein M, Hedges L, Higgins J, Rothstein H. Introduction toMetaanalysis. Chichester: JohnWiley and Sons; 2009.
69. Carmena R. The dietary fat and cardiovascular risk. AlimentNutr Salud (ANS) 2016;23:1-3.
70. Thorning TK, Bertram HC, Bonjour JP, de Groot L, Dupont D, Feeney E, Ipsen R, Lecerf JM, Mackie A, McKinley MC, et al. Whole dairy matrix or single nutrients in assessment of health effects: Current evidence and knowledge gaps. Am J Clin Nutr 2017;105: 1033-45.
71. Samara A, Herbeth B, Ndiaye NC, Fumeron F, Billod S, Siest G, Visvikis-Siest S. Dairy product consumption, calcium intakes, and metabolic syndrome-related factors over 5 years in the STANISLAS study. Nutrition 2013;29:519-24.
72. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. Review article: The role of butyrate on colonic function. Aliment Pharmacol Ther 2008;27:104-19.
73. Parodi PW. Milk fat in human nutrition. Aust J Dairy Technol 2004;59:3-59.
74. Legrand P, Rioux V. Specific roles of saturated fatty acids: Beyond epidemiological data. Eur J Lipid Sci Technol 2015;117:1489-99.
75. Bohl M, Bjornshave A, Larsen MK, Gregersen S, Hermansen K. The effects of proteins and medium-chain fatty acids from milk on body composition, insulin sensitivity and blood pressure in abdominally obese adults. Eur J Clin Nutr 2017;71:76-82.
76. Kris-Etherton PM, Fleming JA. Emerging nutrition science on fatty acids and cardiovascular disease: Nutritionists' perspectives. Adv Nutr 2015;6:326S-37S.
77. Canfora EE, Jocken JW, Blaak EE. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol 2015;11:577-91.
78. Yakoob MY, Shi P, Willett WC, Rexrode KM, Campos H, Orav EJ, Hu FB, Mozaffarian D. Circulating biomarkers of dairy fat and risk of incident diabetes mellitus among US men and women in two large prospective cohorts. Circulation 2016;133(17): 1645-54.
79. Liang J, Zhou Q, Kwame Amakye W, Su Y, Zhang Z. Biomarkers of dairy fat intake and risk of cardiovascular disease: A systematic review andmeta-analysis of prospective studies. Crit Rev Food Sci Nutr 2018;58(7):1122-30.
80. Yan Y, Wang Z, Greenwald J, Kothapalli KS, Park HG, Liu R, Mendralla E, Lawrence P, Wang X, Brenna JT. BCFA suppresses LPS induced IL-8 mRNA expression in human intestinal epithelial cells. Prostaglandins Leukot Essent Fatty Acids 2017;16:27-31.