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Volumn 176, Issue 6, 2019, Pages 1248-1264

VEGF in Signaling and Disease: Beyond Discovery and Development

Author keywords

[No Author keywords available]

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR; AFLIBERCEPT; AKB 9778; ANAPLASTIC LYMPHOMA KINASE; ATEZOLIZUMAB; BEVACIZUMAB; CARBOPLATIN; CEDIRANIB; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR; LOMUSTINE; NEUROPILIN 1; PACLITAXEL; PEGAPTANIB; PLACEBO; PLACENTAL GROWTH FACTOR; PLACENTAL GROWTH FACTOR ANTIBODY; PLATELET DERIVED GROWTH FACTOR; PROTEIN ANTIBODY; RANIBIZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 85060334156     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2019.01.021     Document Type: Review
Times cited : (1765)

References (206)
  • 1
    • 14944361800 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor in ocular health and disease
    • Adamis, A.P., Shima, D.T., The role of vascular endothelial growth factor in ocular health and disease. Retina 25 (2005), 111–118.
    • (2005) Retina , vol.25 , pp. 111-118
    • Adamis, A.P.1    Shima, D.T.2
  • 2
    • 84959830787 scopus 로고
    • Vasculae reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire, G.H., Chalkley, H.W., Legallais, F.Y., Park, H.D., Vasculae reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J. Natl. Cancer Inst. 6 (1945), 73–85.
    • (1945) J. Natl. Cancer Inst. , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2    Legallais, F.Y.3    Park, H.D.4
  • 3
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • Alitalo, K., Tammela, T., Petrova, T.V., Lymphangiogenesis in development and human disease. Nature 438 (2005), 946–953.
    • (2005) Nature , vol.438 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 5
    • 84962381533 scopus 로고    scopus 로고
    • What Is Chronic or Persistent Diabetic Macular Edema and How Should It Be Treated?
    • Apte, R.S., What Is Chronic or Persistent Diabetic Macular Edema and How Should It Be Treated?. JAMA Ophthalmol. 134 (2016), 285–286.
    • (2016) JAMA Ophthalmol. , vol.134 , pp. 285-286
    • Apte, R.S.1
  • 6
    • 85044132232 scopus 로고    scopus 로고
    • Gene Therapy for Retinal Degeneration
    • Apte, R.S., Gene Therapy for Retinal Degeneration. Cell, 173, 2018, 5.
    • (2018) Cell , vol.173 , pp. 5
    • Apte, R.S.1
  • 7
    • 33748353004 scopus 로고    scopus 로고
    • Macrophages inhibit neovascularization in a murine model of age-related macular degeneration
    • Apte, R.S., Richter, J., Herndon, J., Ferguson, T.A., Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med., 3, 2006, e310.
    • (2006) PLoS Med. , vol.3 , pp. e310
    • Apte, R.S.1    Richter, J.2    Herndon, J.3    Ferguson, T.A.4
  • 8
    • 84890306325 scopus 로고    scopus 로고
    • Bevacizumab-induced vessel normalization hampers tumor uptake of antibodies–response
    • Arjaans, M., Oosting, S.F., Schröder, C.P., de Vries, E.G., Bevacizumab-induced vessel normalization hampers tumor uptake of antibodies–response. Cancer Res. 73 (2013), 7147–7148.
    • (2013) Cancer Res. , vol.73 , pp. 7147-7148
    • Arjaans, M.1    Oosting, S.F.2    Schröder, C.P.3    de Vries, E.G.4
  • 9
    • 0000283010 scopus 로고
    • Observations on the choroidal circulation
    • Ashton, N., Observations on the choroidal circulation. Br. J. Ophthalmol. 36 (1952), 465–481.
    • (1952) Br. J. Ophthalmol. , vol.36 , pp. 465-481
    • Ashton, N.1
  • 10
    • 0013942868 scopus 로고
    • Oxygen and the growth and development of retinal vessels. In vivo and in vitro studies. The XX Francis I. Proctor Lecture
    • Ashton, N., Oxygen and the growth and development of retinal vessels. In vivo and in vitro studies. The XX Francis I. Proctor Lecture. Am. J. Ophthalmol. 62 (1966), 412–435.
    • (1966) Am. J. Ophthalmol. , vol.62 , pp. 412-435
    • Ashton, N.1
  • 11
    • 85029665479 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors in advanced renal cell carcinoma: experience to date and future directions
    • Atkins, M.B., Clark, J.I., Quinn, D.I., Immune checkpoint inhibitors in advanced renal cell carcinoma: experience to date and future directions. Ann. Oncol. 28 (2017), 1484–1494.
    • (2017) Ann. Oncol. , vol.28 , pp. 1484-1494
    • Atkins, M.B.1    Clark, J.I.2    Quinn, D.I.3
  • 12
    • 85042621605 scopus 로고    scopus 로고
    • Axitinib in combination with pembrolizumab in patients with advanced renal cell cancer: a non-randomised, open-label, dose-finding, and dose-expansion phase 1b trial
    • Atkins, M.B., Plimack, E.R., Puzanov, I., Fishman, M.N., McDermott, D.F., Cho, D.C., Vaishampayan, U., George, S., Olencki, T.E., Tarazi, J.C., et al. Axitinib in combination with pembrolizumab in patients with advanced renal cell cancer: a non-randomised, open-label, dose-finding, and dose-expansion phase 1b trial. Lancet Oncol. 19 (2018), 405–415.
    • (2018) Lancet Oncol. , vol.19 , pp. 405-415
    • Atkins, M.B.1    Plimack, E.R.2    Puzanov, I.3    Fishman, M.N.4    McDermott, D.F.5    Cho, D.C.6    Vaishampayan, U.7    George, S.8    Olencki, T.E.9    Tarazi, J.C.10
  • 13
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin, H.G., Koh, G.Y., Thurston, G., Alitalo, K., Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat. Rev. Mol. Cell Biol. 10 (2009), 165–177.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 15
    • 84879235232 scopus 로고    scopus 로고
    • Aflibercept therapy for exudative age-related macular degeneration resistant to bevacizumab and ranibizumab
    • Bakall, B., Folk, J.C., Boldt, H.C., Sohn, E.H., Stone, E.M., Russell, S.R., Mahajan, V.B., Aflibercept therapy for exudative age-related macular degeneration resistant to bevacizumab and ranibizumab. Am. J. Ophthalmol. 156 (2013), 15–22.
    • (2013) Am. J. Ophthalmol. , vol.156 , pp. 15-22
    • Bakall, B.1    Folk, J.C.2    Boldt, H.C.3    Sohn, E.H.4    Stone, E.M.5    Russell, S.R.6    Mahajan, V.B.7
  • 17
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon, B., Sozzani, S., Zhou, D., Weich, H.A., Mantovani, A., Marmé, D., Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 (1996), 3336–3343.
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Weich, H.A.4    Mantovani, A.5    Marmé, D.6
  • 20
    • 84887116872 scopus 로고    scopus 로고
    • Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
    • Batchelor, T.T., Mulholland, P., Neyns, B., Nabors, L.B., Campone, M., Wick, A., Mason, W., Mikkelsen, T., Phuphanich, S., Ashby, L.S., et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J. Clin. Oncol. 31 (2013), 3212–3218.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3212-3218
    • Batchelor, T.T.1    Mulholland, P.2    Neyns, B.3    Nabors, L.B.4    Campone, M.5    Wick, A.6    Mason, W.7    Mikkelsen, T.8    Phuphanich, S.9    Ashby, L.S.10
  • 21
    • 0037098860 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma
    • Bates, D.O., Cui, T.G., Doughty, J.M., Winkler, M., Sugiono, M., Shields, J.D., Peat, D., Gillatt, D., Harper, S.J., VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res. 62 (2002), 4123–4131.
    • (2002) Cancer Res. , vol.62 , pp. 4123-4131
    • Bates, D.O.1    Cui, T.G.2    Doughty, J.M.3    Winkler, M.4    Sugiono, M.5    Shields, J.D.6    Peat, D.7    Gillatt, D.8    Harper, S.J.9
  • 23
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers, G., Hanahan, D., Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer 8 (2008), 592–603.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 24
    • 84871959114 scopus 로고    scopus 로고
    • A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer
    • Berlin, J., Bendell, J.C., Hart, L.L., Firdaus, I., Gore, I., Hermann, R.C., Mulcahy, M.F., Zalupski, M.M., Mackey, H.M., Yauch, R.L., et al. A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer. Clin. Cancer Res. 19 (2013), 258–267.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 258-267
    • Berlin, J.1    Bendell, J.C.2    Hart, L.L.3    Firdaus, I.4    Gore, I.5    Hermann, R.C.6    Mulcahy, M.F.7    Zalupski, M.M.8    Mackey, H.M.9    Yauch, R.L.10
  • 25
    • 30344447284 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration
    • Bhutto, I.A., McLeod, D.S., Hasegawa, T., Kim, S.Y., Merges, C., Tong, P., Lutty, G.A., Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Exp. Eye Res. 82 (2006), 99–110.
    • (2006) Exp. Eye Res. , vol.82 , pp. 99-110
    • Bhutto, I.A.1    McLeod, D.S.2    Hasegawa, T.3    Kim, S.Y.4    Merges, C.5    Tong, P.6    Lutty, G.A.7
  • 26
    • 84927607560 scopus 로고    scopus 로고
    • A double-edged sword: the role of VEGF in wound repair and chemoattraction of opportunist pathogens
    • Birkenhauer, E., Neethirajan, S., A double-edged sword: the role of VEGF in wound repair and chemoattraction of opportunist pathogens. Int. J. Mol. Sci. 16 (2015), 7159–7172.
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 7159-7172
    • Birkenhauer, E.1    Neethirajan, S.2
  • 27
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy
    • Borgström, P., Hillan, K.J., Sriramarao, P., Ferrara, N., Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. 56 (1996), 4032–4039.
    • (1996) Cancer Res. , vol.56 , pp. 4032-4039
    • Borgström, P.1    Hillan, K.J.2    Sriramarao, P.3    Ferrara, N.4
  • 29
    • 84885022258 scopus 로고    scopus 로고
    • Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE
    • Brown, D.M., Nguyen, Q.D., Marcus, D.M., Boyer, D.S., Patel, S., Feiner, L., Schlottmann, P.G., Rundle, A.C., Zhang, J., Rubio, R.G., et al., RIDE and RISE Research Group. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE. Ophthalmology 120 (2013), 2013–2022.
    • (2013) Ophthalmology , vol.120 , pp. 2013-2022
    • Brown, D.M.1    Nguyen, Q.D.2    Marcus, D.M.3    Boyer, D.S.4    Patel, S.5    Feiner, L.6    Schlottmann, P.G.7    Rundle, A.C.8    Zhang, J.9    Rubio, R.G.10
  • 32
    • 84930366128 scopus 로고    scopus 로고
    • Dexamethasone intravitreal implant as adjunct therapy for patients with wet age-related macular degeneration with incomplete response to ranibizumab
    • Calvo, P., Ferreras, A., Al Adel, F., Wang, Y., Brent, M.H., Dexamethasone intravitreal implant as adjunct therapy for patients with wet age-related macular degeneration with incomplete response to ranibizumab. Br. J. Ophthalmol. 99 (2015), 723–726.
    • (2015) Br. J. Ophthalmol. , vol.99 , pp. 723-726
    • Calvo, P.1    Ferreras, A.2    Al Adel, F.3    Wang, Y.4    Brent, M.H.5
  • 33
    • 84992327346 scopus 로고    scopus 로고
    • Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema
    • Campochiaro, P.A., Peters, K.G., Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema. Curr. Diab. Rep., 16, 2016, 126.
    • (2016) Curr. Diab. Rep. , vol.16 , pp. 126
    • Campochiaro, P.A.1    Peters, K.G.2
  • 35
    • 84857127780 scopus 로고    scopus 로고
    • From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease
    • Caprara, C., Grimm, C., From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease. Prog. Retin. Eye Res. 31 (2012), 89–119.
    • (2012) Prog. Retin. Eye Res. , vol.31 , pp. 89-119
    • Caprara, C.1    Grimm, C.2
  • 37
    • 85012145261 scopus 로고
    • Artificial Activation of the Growth in Vitro of Connective Tissue
    • Carrel, A., Artificial Activation of the Growth in Vitro of Connective Tissue. J. Exp. Med. 17 (1913), 14–19.
    • (1913) J. Exp. Med. , vol.17 , pp. 14-19
    • Carrel, A.1
  • 38
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas, O., Hicklin, D.J., Bergers, G., Hanahan, D., Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8 (2005), 299–309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 41
    • 85056621398 scopus 로고    scopus 로고
    • Combinations of Bevacizumab With Cancer Immunotherapy
    • Chen, D.S., Hurwitz, H., Combinations of Bevacizumab With Cancer Immunotherapy. Cancer J. 24 (2018), 193–204.
    • (2018) Cancer J. , vol.24 , pp. 193-204
    • Chen, D.S.1    Hurwitz, H.2
  • 42
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: the cancer-immunity cycle
    • Chen, D.S., Mellman, I., Oncology meets immunology: the cancer-immunity cycle. Immunity 39 (2013), 1–10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 43
    • 85016548232 scopus 로고    scopus 로고
    • Elements of cancer immunity and the cancer-immune set point
    • Chen, D.S., Mellman, I., Elements of cancer immunity and the cancer-immune set point. Nature 541 (2017), 321–330.
    • (2017) Nature , vol.541 , pp. 321-330
    • Chen, D.S.1    Mellman, I.2
  • 44
    • 80054012347 scopus 로고    scopus 로고
    • Developmental and pathological angiogenesis
    • Chung, A.S., Ferrara, N., Developmental and pathological angiogenesis. Annu. Rev. Cell Dev. Biol. 27 (2011), 563–584.
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 563-584
    • Chung, A.S.1    Ferrara, N.2
  • 45
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: insights from physiological angiogenesis
    • Chung, A.S., Lee, J., Ferrara, N., Targeting the tumour vasculature: insights from physiological angiogenesis. Nat. Rev. Cancer 10 (2010), 505–514.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 49
    • 84887456534 scopus 로고    scopus 로고
    • Role of endothelial cell metabolism in vessel sprouting
    • De Bock, K., Georgiadou, M., Carmeliet, P., Role of endothelial cell metabolism in vessel sprouting. Cell Metab. 18 (2013), 634–647.
    • (2013) Cell Metab. , vol.18 , pp. 634-647
    • De Bock, K.1    Georgiadou, M.2    Carmeliet, P.3
  • 50
    • 85029290103 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumour angiogenesis
    • De Palma, M., Biziato, D., Petrova, T.V., Microenvironmental regulation of tumour angiogenesis. Nat. Rev. Cancer 17 (2017), 457–474.
    • (2017) Nat. Rev. Cancer , vol.17 , pp. 457-474
    • De Palma, M.1    Biziato, D.2    Petrova, T.V.3
  • 51
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • de Vries, C., Escobedo, J.A., Ueno, H., Houck, K., Ferrara, N., Williams, L.T., The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255 (1992), 989–991.
    • (1992) Science , vol.255 , pp. 989-991
    • de Vries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 53
    • 85019574224 scopus 로고    scopus 로고
    • Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial
    • Dugel, P.U., Jaffe, G.J., Sallstig, P., Warburton, J., Weichselberger, A., Wieland, M., Singerman, L., Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial. Ophthalmology 124 (2017), 1296–1304.
    • (2017) Ophthalmology , vol.124 , pp. 1296-1304
    • Dugel, P.U.1    Jaffe, G.J.2    Sallstig, P.3    Warburton, J.4    Weichselberger, A.5    Wieland, M.6    Singerman, L.7
  • 54
    • 0032853603 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox
    • Duh, E., Aiello, L.P., Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes 48 (1999), 1899–1906.
    • (1999) Diabetes , vol.48 , pp. 1899-1906
    • Duh, E.1    Aiello, L.P.2
  • 55
    • 85052014336 scopus 로고    scopus 로고
    • Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
    • Duh, E.J., Sun, J.K., Stitt, A.W., Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. JCI Insight, 2, 2017.
    • (2017) JCI Insight , vol.2
    • Duh, E.J.1    Sun, J.K.2    Stitt, A.W.3
  • 56
    • 85014880770 scopus 로고    scopus 로고
    • An Overview of the Fovista and Rinucumab Trials and the Fate of Anti-PDGF Medications
    • Dunn, E.N., Hariprasad, S.M., Sheth, V.S., An Overview of the Fovista and Rinucumab Trials and the Fate of Anti-PDGF Medications. Ophthalmic Surg. Lasers Imaging Retina 48 (2017), 100–104.
    • (2017) Ophthalmic Surg. Lasers Imaging Retina , vol.48 , pp. 100-104
    • Dunn, E.N.1    Hariprasad, S.M.2    Sheth, V.S.3
  • 57
    • 77957241701 scopus 로고    scopus 로고
    • Dynamics of endothelial cell behavior in sprouting angiogenesis
    • Eilken, H.M., Adams, R.H., Dynamics of endothelial cell behavior in sprouting angiogenesis. Curr. Opin. Cell Biol. 22 (2010), 617–625.
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 617-625
    • Eilken, H.M.1    Adams, R.H.2
  • 58
    • 79953299899 scopus 로고    scopus 로고
    • Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    • Elman, M.J., Bressler, N.M., Qin, H., Beck, R.W., Ferris, F.L. 3rd, Friedman, S.M., Glassman, A.R., Scott, I.U., Stockdale, C.R., Sun, J.K., Diabetic Retinopathy Clinical Research Network. Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 118 (2011), 609–614.
    • (2011) Ophthalmology , vol.118 , pp. 609-614
    • Elman, M.J.1    Bressler, N.M.2    Qin, H.3    Beck, R.W.4    Ferris, F.L.5    Friedman, S.M.6    Glassman, A.R.7    Scott, I.U.8    Stockdale, C.R.9    Sun, J.K.10
  • 59
    • 84868208071 scopus 로고    scopus 로고
    • Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results
    • Elman, M.J., Qin, H., Aiello, L.P., Beck, R.W., Bressler, N.M., Ferris, F.L. 3rd, Glassman, A.R., Maturi, R.K., Melia, M., Diabetic Retinopathy Clinical Research Network. Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results. Ophthalmology 119 (2012), 2312–2318.
    • (2012) Ophthalmology , vol.119 , pp. 2312-2318
    • Elman, M.J.1    Qin, H.2    Aiello, L.P.3    Beck, R.W.4    Bressler, N.M.5    Ferris, F.L.6    Glassman, A.R.7    Maturi, R.K.8    Melia, M.9
  • 61
    • 77957764473 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy
    • Ferrara, N., Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat. Med. 16 (2010), 1107–1111.
    • (2010) Nat. Med. , vol.16 , pp. 1107-1111
    • Ferrara, N.1
  • 62
    • 77649096200 scopus 로고    scopus 로고
    • Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action
    • Ferrara, N., Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action. Mol. Biol. Cell 21 (2010), 687–690.
    • (2010) Mol. Biol. Cell , vol.21 , pp. 687-690
    • Ferrara, N.1
  • 63
    • 84985943250 scopus 로고    scopus 로고
    • VEGF and Intraocular Neovascularization: From Discovery to Therapy
    • Ferrara, N., VEGF and Intraocular Neovascularization: From Discovery to Therapy. Transl. Vis. Sci. Technol., 5, 2016, 10.
    • (2016) Transl. Vis. Sci. Technol. , vol.5 , pp. 10
    • Ferrara, N.1
  • 64
    • 84954569855 scopus 로고    scopus 로고
    • Ten years of anti-vascular endothelial growth factor therapy
    • Ferrara, N., Adamis, A.P., Ten years of anti-vascular endothelial growth factor therapy. Nat. Rev. Drug Discov. 15 (2016), 385–403.
    • (2016) Nat. Rev. Drug Discov. , vol.15 , pp. 385-403
    • Ferrara, N.1    Adamis, A.P.2
  • 65
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara, N., Henzel, W.J., Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161 (1989), 851–858.
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 67
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N., Hillan, K.J., Gerber, H.P., Novotny, W., Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3 (2004), 391–400.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 69
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman, J., Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285 (1971), 1182–1186.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 70
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman, J., Klagsbrun, M., Angiogenic factors. Science 235 (1987), 442–447.
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 71
    • 0032833358 scopus 로고    scopus 로고
    • Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy
    • Fortune, B., Schneck, M.E., Adams, A.J., Multifocal electroretinogram delays reveal local retinal dysfunction in early diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 40 (1999), 2638–2651.
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 2638-2651
    • Fortune, B.1    Schneck, M.E.2    Adams, A.J.3
  • 72
    • 85044610191 scopus 로고    scopus 로고
    • Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges
    • Fukumura, D., Kloepper, J., Amoozgar, Z., Duda, D.G., Jain, R.K., Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat. Rev. Clin. Oncol. 15 (2018), 325–340.
    • (2018) Nat. Rev. Clin. Oncol. , vol.15 , pp. 325-340
    • Fukumura, D.1    Kloepper, J.2    Amoozgar, Z.3    Duda, D.G.4    Jain, R.K.5
  • 73
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • Gabrilovich, D., Ishida, T., Oyama, T., Ran, S., Kravtsov, V., Nadaf, S., Carbone, D.P., Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92 (1998), 4150–4166.
    • (1998) Blood , vol.92 , pp. 4150-4166
    • Gabrilovich, D.1    Ishida, T.2    Oyama, T.3    Ran, S.4    Kravtsov, V.5    Nadaf, S.6    Carbone, D.P.7
  • 74
    • 85017530406 scopus 로고    scopus 로고
    • Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer
    • García-Carbonero, R., van Cutsem, E., Rivera, F., Jassem, J., Gore, I. Jr., Tebbutt, N., Braiteh, F., Argiles, G., Wainberg, Z.A., Funke, R., et al. Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer. Oncologist, 22, 2017, 1281.
    • (2017) Oncologist , vol.22 , pp. 1281
    • García-Carbonero, R.1    van Cutsem, E.2    Rivera, F.3    Jassem, J.4    Gore, I.5    Tebbutt, N.6    Braiteh, F.7    Argiles, G.8    Wainberg, Z.A.9    Funke, R.10
  • 76
    • 84911953067 scopus 로고    scopus 로고
    • Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial
    • Geloneck, M.M., Chuang, A.Z., Clark, W.L., Hunt, M.G., Norman, A.A., Packwood, E.A., Tawansy, K.A., Mintz-Hittner, H.A., BEAT-ROP Cooperative Group. Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial. JAMA Ophthalmol. 132 (2014), 1327–1333.
    • (2014) JAMA Ophthalmol. , vol.132 , pp. 1327-1333
    • Geloneck, M.M.1    Chuang, A.Z.2    Clark, W.L.3    Hunt, M.G.4    Norman, A.A.5    Packwood, E.A.6    Tawansy, K.A.7    Mintz-Hittner, H.A.8
  • 77
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber, H.P., Ferrara, N., Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res. 65 (2005), 671–680.
    • (2005) Cancer Res. , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 79
    • 57349200481 scopus 로고    scopus 로고
    • VEGF and endothelial guidance in angiogenic sprouting
    • Gerhardt, H., VEGF and endothelial guidance in angiogenic sprouting. Organogenesis 4 (2008), 241–246.
    • (2008) Organogenesis , vol.4 , pp. 241-246
    • Gerhardt, H.1
  • 81
    • 84948165075 scopus 로고    scopus 로고
    • Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial
    • Gross, J.G., Glassman, A.R., Jampol, L.M., Inusah, S., Aiello, L.P., Antoszyk, A.N., Baker, C.W., Berger, B.B., Bressler, N.M., Browning, D., et al., Writing Committee for the Diabetic Retinopathy Clinical Research Network. Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. JAMA 314 (2015), 2137–2146.
    • (2015) JAMA , vol.314 , pp. 2137-2146
    • Gross, J.G.1    Glassman, A.R.2    Jampol, L.M.3    Inusah, S.4    Aiello, L.P.5    Antoszyk, A.N.6    Baker, C.W.7    Berger, B.B.8    Bressler, N.M.9    Browning, D.10
  • 84
    • 85041611023 scopus 로고    scopus 로고
    • Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics
    • Hegde, P.S., Wallin, J.J., Mancao, C., Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics. Semin. Cancer Biol. 52 (2018), 117–124.
    • (2018) Semin. Cancer Biol. , vol.52 , pp. 117-124
    • Hegde, P.S.1    Wallin, J.J.2    Mancao, C.3
  • 85
    • 85020105309 scopus 로고    scopus 로고
    • Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial
    • Heier, J.S., Kherani, S., Desai, S., Dugel, P., Kaushal, S., Cheng, S.H., Delacono, C., Purvis, A., Richards, S., Le-Halpere, A., et al. Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial. Lancet 390 (2017), 50–61.
    • (2017) Lancet , vol.390 , pp. 50-61
    • Heier, J.S.1    Kherani, S.2    Desai, S.3    Dugel, P.4    Kaushal, S.5    Cheng, S.H.6    Delacono, C.7    Purvis, A.8    Richards, S.9    Le-Halpere, A.10
  • 86
    • 58249091885 scopus 로고    scopus 로고
    • VEGF and Notch signaling: the yin and yang of angiogenic sprouting
    • Hellström, M., Phng, L.K., Gerhardt, H., VEGF and Notch signaling: the yin and yang of angiogenic sprouting. Cell Adhes. Migr. 1 (2007), 133–136.
    • (2007) Cell Adhes. Migr. , vol.1 , pp. 133-136
    • Hellström, M.1    Phng, L.K.2    Gerhardt, H.3
  • 87
    • 84908465944 scopus 로고    scopus 로고
    • Twenty-four-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration
    • Ho, A.C., Busbee, B.G., Regillo, C.D., Wieland, M.R., Van Everen, S.A., Li, Z., Rubio, R.G., Lai, P., HARBOR Study Group. Twenty-four-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration. Ophthalmology 121 (2014), 2181–2192.
    • (2014) Ophthalmology , vol.121 , pp. 2181-2192
    • Ho, A.C.1    Busbee, B.G.2    Regillo, C.D.3    Wieland, M.R.4    Van Everen, S.A.5    Li, Z.6    Rubio, R.G.7    Lai, P.8
  • 90
    • 85048747589 scopus 로고    scopus 로고
    • Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials
    • Holz, F.G., Sadda, S.R., Busbee, B., Chew, E.Y., Mitchell, P., Tufail, A., Brittain, C., Ferrara, D., Gray, S., Honigberg, L., et al., Chroma and Spectri Study Investigators. Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials. JAMA Ophthalmol. 136 (2018), 666–677.
    • (2018) JAMA Ophthalmol. , vol.136 , pp. 666-677
    • Holz, F.G.1    Sadda, S.R.2    Busbee, B.3    Chew, E.Y.4    Mitchell, P.5    Tufail, A.6    Brittain, C.7    Ferrara, D.8    Gray, S.9    Honigberg, L.10
  • 91
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck, K.A., Leung, D.W., Rowland, A.M., Winer, J., Ferrara, N., Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 267 (1992), 26031–26037.
    • (1992) J. Biol. Chem. , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 93
    • 84890282284 scopus 로고    scopus 로고
    • Benefits of vascular normalization are dose and time dependent–letter
    • Huang, Y., Stylianopoulos, T., Duda, D.G., Fukumura, D., Jain, R.K., Benefits of vascular normalization are dose and time dependent–letter. Cancer Res. 73 (2013), 7144–7146.
    • (2013) Cancer Res. , vol.73 , pp. 7144-7146
    • Huang, Y.1    Stylianopoulos, T.2    Duda, D.G.3    Fukumura, D.4    Jain, R.K.5
  • 94
    • 0000912662 scopus 로고
    • Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • Ide, A.G., Baker, N.H., Warren, S.L., Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am. J. Roentgenol. 42 (1939), 891–899.
    • (1939) Am. J. Roentgenol. , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 96
    • 85045939115 scopus 로고    scopus 로고
    • Resistance to Anti-Angiogenic Therapy in Cancer-Alterations to Anti-VEGF Pathway
    • Itatani, Y., Kawada, K., Yamamoto, T., Sakai, Y., Resistance to Anti-Angiogenic Therapy in Cancer-Alterations to Anti-VEGF Pathway. Int. J. Mol. Sci., 19, 2018.
    • (2018) Int. J. Mol. Sci. , vol.19
    • Itatani, Y.1    Kawada, K.2    Yamamoto, T.3    Sakai, Y.4
  • 99
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain, R.K., Molecular regulation of vessel maturation. Nat. Med. 9 (2003), 685–693.
    • (2003) Nat. Med. , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 100
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain, R.K., Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 (2005), 58–62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 101
    • 84912096468 scopus 로고    scopus 로고
    • Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
    • Jain, R.K., Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 26 (2014), 605–622.
    • (2014) Cancer Cell , vol.26 , pp. 605-622
    • Jain, R.K.1
  • 102
    • 84989159343 scopus 로고    scopus 로고
    • Antiangiogenic therapy in oncology: current status and future directions
    • Jayson, G.C., Kerbel, R., Ellis, L.M., Harris, A.L., Antiangiogenic therapy in oncology: current status and future directions. Lancet 388 (2016), 518–529.
    • (2016) Lancet , vol.388 , pp. 518-529
    • Jayson, G.C.1    Kerbel, R.2    Ellis, L.M.3    Harris, A.L.4
  • 103
    • 85027936469 scopus 로고    scopus 로고
    • Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A
    • Joyal, J.S., Omri, S., Sitaras, N., Rivera, J.C., Sapieha, P., Chemtob, S., Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A. Acta Paediatr. 101 (2012), 819–826.
    • (2012) Acta Paediatr. , vol.101 , pp. 819-826
    • Joyal, J.S.1    Omri, S.2    Sitaras, N.3    Rivera, J.C.4    Sapieha, P.5    Chemtob, S.6
  • 105
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila, M.R., de Sauvage, F.J., Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501 (2013), 346–354.
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    de Sauvage, F.J.2
  • 106
    • 66349121063 scopus 로고    scopus 로고
    • Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice
    • Kamoun, W.S., Ley, C.D., Farrar, C.T., Duyverman, A.M., Lahdenranta, J., Lacorre, D.A., Batchelor, T.T., di Tomaso, E., Duda, D.G., Munn, L.L., et al. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J. Clin. Oncol. 27 (2009), 2542–2552.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2542-2552
    • Kamoun, W.S.1    Ley, C.D.2    Farrar, C.T.3    Duyverman, A.M.4    Lahdenranta, J.5    Lacorre, D.A.6    Batchelor, T.T.7    di Tomaso, E.8    Duda, D.G.9    Munn, L.L.10
  • 107
  • 108
    • 85046048189 scopus 로고    scopus 로고
    • The Cancer Immunotherapy Revolution
    • Kelly, P.N., The Cancer Immunotherapy Revolution. Science 359 (2018), 1344–1345.
    • (2018) Science , vol.359 , pp. 1344-1345
    • Kelly, P.N.1
  • 109
    • 36048953291 scopus 로고    scopus 로고
    • Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice
    • Kelly, J., Ali Khan, A., Yin, J., Ferguson, T.A., Apte, R.S., Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J. Clin. Invest. 117 (2007), 3421–3426.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3421-3426
    • Kelly, J.1    Ali Khan, A.2    Yin, J.3    Ferguson, T.A.4    Apte, R.S.5
  • 110
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel, R.S., Tumor angiogenesis. N. Engl. J. Med. 358 (2008), 2039–2049.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 111
    • 85045575210 scopus 로고    scopus 로고
    • Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa
    • Khan, K.A., Kerbel, R.S., Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa. Nat. Rev. Clin. Oncol. 15 (2018), 310–324.
    • (2018) Nat. Rev. Clin. Oncol. , vol.15 , pp. 310-324
    • Khan, K.A.1    Kerbel, R.S.2
  • 112
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies
    • Kim, K.J., Li, B., Houck, K., Winer, J., Ferrara, N., The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 7 (1992), 53–64.
    • (1992) Growth Factors , vol.7 , pp. 53-64
    • Kim, K.J.1    Li, B.2    Houck, K.3    Winer, J.4    Ferrara, N.5
  • 113
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim, K.J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H.S., Ferrara, N., Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362 (1993), 841–844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 115
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement, G., Baruchel, S., Rak, J., Man, S., Clark, K., Hicklin, D.J., Bohlen, P., Kerbel, R.S., Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105 (2000), R15–R24.
    • (2000) J. Clin. Invest. , vol.105 , pp. R15-R24
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 117
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • Kopetz, S., Hoff, P.M., Morris, J.S., Wolff, R.A., Eng, C., Glover, K.Y., Adinin, R., Overman, M.J., Valero, V., Wen, S., et al. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J. Clin. Oncol. 28 (2010), 453–459.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3    Wolff, R.A.4    Eng, C.5    Glover, K.Y.6    Adinin, R.7    Overman, M.J.8    Valero, V.9    Wen, S.10
  • 118
    • 84936797491 scopus 로고    scopus 로고
    • Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma
    • Lassen, U., Chinot, O.L., McBain, C., Mau-Sørensen, M., Larsen, V.A., Barrie, M., Roth, P., Krieter, O., Wang, K., Habben, K., et al. Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma. Neuro-oncol. 17 (2015), 1007–1015.
    • (2015) Neuro-oncol. , vol.17 , pp. 1007-1015
    • Lassen, U.1    Chinot, O.L.2    McBain, C.3    Mau-Sørensen, M.4    Larsen, V.A.5    Barrie, M.6    Roth, P.7    Krieter, O.8    Wang, K.9    Habben, K.10
  • 121
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V., Ferrara, N., Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989), 1306–1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 125
    • 84943339800 scopus 로고    scopus 로고
    • Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease
    • Ma, W., Wong, W.T., Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease. Adv. Exp. Med. Biol. 854 (2016), 73–78.
    • (2016) Adv. Exp. Med. Biol. , vol.854 , pp. 73-78
    • Ma, W.1    Wong, W.T.2
  • 128
    • 84964865566 scopus 로고    scopus 로고
    • Five-Year Outcomes with Anti-Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials
    • Maguire, M.G., Martin, D.F., Ying, G.S., Jaffe, G.J., Daniel, E., Grunwald, J.E., Toth, C.A., Ferris, F.L. 3rd, Fine, S.L., Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group. Five-Year Outcomes with Anti-Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology 123 (2016), 1751–1761.
    • (2016) Ophthalmology , vol.123 , pp. 1751-1761
    • Maguire, M.G.1    Martin, D.F.2    Ying, G.S.3    Jaffe, G.J.4    Daniel, E.5    Grunwald, J.E.6    Toth, C.A.7    Ferris, F.L.8    Fine, S.L.9
  • 130
    • 85048001150 scopus 로고    scopus 로고
    • Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma
    • McDermott, D.F., Huseni, M.A., Atkins, M.B., Motzer, R.J., Rini, B.I., Escudier, B., Fong, L., Joseph, R.W., Pal, S.K., Reeves, J.A., et al. Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma. Nat. Med. 24 (2018), 749–757.
    • (2018) Nat. Med. , vol.24 , pp. 749-757
    • McDermott, D.F.1    Huseni, M.A.2    Atkins, M.B.3    Motzer, R.J.4    Rini, B.I.5    Escudier, B.6    Fong, L.7    Joseph, R.W.8    Pal, S.K.9    Reeves, J.A.10
  • 131
    • 0000230096 scopus 로고
    • The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders
    • Michaelson, I.C., The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders. Trans. Ophthalmol. Soc. UK 68 (1948), 137–180.
    • (1948) Trans. Ophthalmol. Soc. UK , vol.68 , pp. 137-180
    • Michaelson, I.C.1
  • 132
    • 0030875072 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and ocular neovascularization
    • Miller, J.W., Vascular endothelial growth factor and ocular neovascularization. Am. J. Pathol. 151 (1997), 13–23.
    • (1997) Am. J. Pathol. , vol.151 , pp. 13-23
    • Miller, J.W.1
  • 133
    • 84872021668 scopus 로고    scopus 로고
    • Vascular endothelial growth factor a in intraocular vascular disease
    • Miller, J.W., Le Couter, J., Strauss, E.C., Ferrara, N., Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology 120 (2013), 106–114.
    • (2013) Ophthalmology , vol.120 , pp. 106-114
    • Miller, J.W.1    Le Couter, J.2    Strauss, E.C.3    Ferrara, N.4
  • 134
    • 79951821800 scopus 로고    scopus 로고
    • Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity
    • Mintz-Hittner, H.A., Kennedy, K.A., Chuang, A.Z., BEAT-ROP Cooperative Group. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N. Engl. J. Med. 364 (2011), 603–615.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 603-615
    • Mintz-Hittner, H.A.1    Kennedy, K.A.2    Chuang, A.Z.3
  • 137
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune suppression
    • Motz, G.T., Coukos, G., Deciphering and reversing tumor immune suppression. Immunity 39 (2013), 61–73.
    • (2013) Immunity , vol.39 , pp. 61-73
    • Motz, G.T.1    Coukos, G.2
  • 138
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • Nagy, J.A., Chang, S.H., Dvorak, A.M., Dvorak, H.F., Why are tumour blood vessels abnormal and why is it important to know?. Br. J. Cancer 100 (2009), 865–869.
    • (2009) Br. J. Cancer , vol.100 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3    Dvorak, H.F.4
  • 139
    • 84939137853 scopus 로고    scopus 로고
    • IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis
    • Nakamura, R., Sene, A., Santeford, A., Gdoura, A., Kubota, S., Zapata, N., Apte, R.S., IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat. Commun., 6, 2015, 7847.
    • (2015) Nat. Commun. , vol.6 , pp. 7847
    • Nakamura, R.1    Sene, A.2    Santeford, A.3    Gdoura, A.4    Kubota, S.5    Zapata, N.6    Apte, R.S.7
  • 140
    • 85044828809 scopus 로고    scopus 로고
    • The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis
    • Negri, L., Ferrara, N., The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis. Physiol. Rev. 98 (2018), 1055–1082.
    • (2018) Physiol. Rev. , vol.98 , pp. 1055-1082
    • Negri, L.1    Ferrara, N.2
  • 142
    • 0034984740 scopus 로고    scopus 로고
    • VEGF as a mediator of tumor-associated immunodeficiency
    • Ohm, J.E., Carbone, D.P., VEGF as a mediator of tumor-associated immunodeficiency. Immunol. Res. 23 (2001), 263–272.
    • (2001) Immunol. Res. , vol.23 , pp. 263-272
    • Ohm, J.E.1    Carbone, D.P.2
  • 146
    • 84944716738 scopus 로고    scopus 로고
    • Inhibition of Immune Checkpoints and Vascular Endothelial Growth Factor as Combination Therapy for Metastatic Melanoma: An Overview of Rationale, Preclinical Evidence, and Initial Clinical Data
    • Ott, P.A., Hodi, F.S., Buchbinder, E.I., Inhibition of Immune Checkpoints and Vascular Endothelial Growth Factor as Combination Therapy for Metastatic Melanoma: An Overview of Rationale, Preclinical Evidence, and Initial Clinical Data. Front. Oncol., 5, 2015, 202.
    • (2015) Front. Oncol. , vol.5 , pp. 202
    • Ott, P.A.1    Hodi, F.S.2    Buchbinder, E.I.3
  • 147
    • 0026699255 scopus 로고
    • FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
    • Pajusola, K., Aprelikova, O., Korhonen, J., Kaipainen, A., Pertovaara, L., Alitalo, R., Alitalo, K., FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 52 (1992), 5738–5743.
    • (1992) Cancer Res. , vol.52 , pp. 5738-5743
    • Pajusola, K.1    Aprelikova, O.2    Korhonen, J.3    Kaipainen, A.4    Pertovaara, L.5    Alitalo, R.6    Alitalo, K.7
  • 148
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park, J.E., Chen, H.H., Winer, J., Houck, K.A., Ferrara, N., Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 269 (1994), 25646–25654.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 150
    • 0027946382 scopus 로고
    • Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization
    • Penn, J.S., Tolman, B.L., Henry, M.M., Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization. Invest. Ophthalmol. Vis. Sci. 35 (1994), 3429–3435.
    • (1994) Invest. Ophthalmol. Vis. Sci. , vol.35 , pp. 3429-3435
    • Penn, J.S.1    Tolman, B.L.2    Henry, M.M.3
  • 152
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente, M., Gerhardt, H., Carmeliet, P., Basic and therapeutic aspects of angiogenesis. Cell 146 (2011), 873–887.
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 153
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta, L.G., Chen, H., O'Connor, S.J., Chisholm, V., Meng, Y.G., Krummen, L., Winkler, M., Ferrara, N., Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57 (1997), 4593–4599.
    • (1997) Cancer Res. , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 154
    • 84962159246 scopus 로고    scopus 로고
    • Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet-Induced Diabetic Retinopathy
    • Rajagopal, R., Bligard, G.W., Zhang, S., Yin, L., Lukasiewicz, P., Semenkovich, C.F., Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet-Induced Diabetic Retinopathy. Diabetes 65 (2016), 1072–1084.
    • (2016) Diabetes , vol.65 , pp. 1072-1084
    • Rajagopal, R.1    Bligard, G.W.2    Zhang, S.3    Yin, L.4    Lukasiewicz, P.5    Semenkovich, C.F.6
  • 157
    • 0037108152 scopus 로고    scopus 로고
    • Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    • Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C., Shima, D.T., Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16 (2002), 2684–2698.
    • (2002) Genes Dev. , vol.16 , pp. 2684-2698
    • Ruhrberg, C.1    Gerhardt, H.2    Golding, M.3    Watson, R.4    Ioannidou, S.5    Fujisawa, H.6    Betsholtz, C.7    Shima, D.T.8
  • 158
    • 85028701474 scopus 로고    scopus 로고
    • Therapeutic targeting of the angiopoietin-TIE pathway
    • Saharinen, P., Eklund, L., Alitalo, K., Therapeutic targeting of the angiopoietin-TIE pathway. Nat. Rev. Drug Discov. 16 (2017), 635–661.
    • (2017) Nat. Rev. Drug Discov. , vol.16 , pp. 635-661
    • Saharinen, P.1    Eklund, L.2    Alitalo, K.3
  • 160
    • 12844264070 scopus 로고    scopus 로고
    • Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
    • Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N., Shibuya, M., Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl. Acad. Sci. USA 102 (2005), 1076–1081.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1076-1081
    • Sakurai, Y.1    Ohgimoto, K.2    Kataoka, Y.3    Yoshida, N.4    Shibuya, M.5
  • 162
    • 85019585340 scopus 로고    scopus 로고
    • Effect of Bevacizumab vs Aflibercept on Visual Acuity Among Patients With Macular Edema Due to Central Retinal Vein Occlusion: The SCORE2 Randomized Clinical Trial
    • Scott, I.U., VanVeldhuisen, P.C., Ip, M.S., Blodi, B.A., Oden, N.L., Awh, C.C., Kunimoto, D.Y., Marcus, D.M., Wroblewski, J.J., King, J., SCORE2 Investigator Group. Effect of Bevacizumab vs Aflibercept on Visual Acuity Among Patients With Macular Edema Due to Central Retinal Vein Occlusion: The SCORE2 Randomized Clinical Trial. JAMA 317 (2017), 2072–2087.
    • (2017) JAMA , vol.317 , pp. 2072-2087
    • Scott, I.U.1    VanVeldhuisen, P.C.2    Ip, M.S.3    Blodi, B.A.4    Oden, N.L.5    Awh, C.C.6    Kunimoto, D.Y.7    Marcus, D.M.8    Wroblewski, J.J.9    King, J.10
  • 164
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: mediator of physiological and pathophysiological responses to hypoxia
    • Semenza, G.L., HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88 (2000), 1474–1480.
    • (2000) J. Appl. Physiol. , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 165
    • 0034531766 scopus 로고    scopus 로고
    • HIF-1: using two hands to flip the angiogenic switch
    • Semenza, G.L., HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev. 19 (2000), 59–65.
    • (2000) Cancer Metastasis Rev. , vol.19 , pp. 59-65
    • Semenza, G.L.1
  • 166
    • 84894339894 scopus 로고    scopus 로고
    • Eyeballing cholesterol efflux and macrophage function in disease pathogenesis
    • Sene, A., Apte, R.S., Eyeballing cholesterol efflux and macrophage function in disease pathogenesis. Trends Endocrinol. Metab. 25 (2014), 107–114.
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 107-114
    • Sene, A.1    Apte, R.S.2
  • 168
    • 84927640278 scopus 로고    scopus 로고
    • Seeing through VEGF: innate and adaptive immunity in pathological angiogenesis in the eye
    • Sene, A., Chin-Yee, D., Apte, R.S., Seeing through VEGF: innate and adaptive immunity in pathological angiogenesis in the eye. Trends Mol. Med. 21 (2015), 43–51.
    • (2015) Trends Mol. Med. , vol.21 , pp. 43-51
    • Sene, A.1    Chin-Yee, D.2    Apte, R.S.3
  • 169
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger, D.R., Galli, S.J., Dvorak, A.M., Perruzzi, C.A., Harvey, V.S., Dvorak, H.F., Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 (1983), 983–985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 170
    • 0025194878 scopus 로고
    • Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor
    • Senger, D.R., Connolly, D.T., Van de Water, L., Feder, J., Dvorak, H.F., Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 50 (1990), 1774–1778.
    • (1990) Cancer Res. , vol.50 , pp. 1774-1778
    • Senger, D.R.1    Connolly, D.T.2    Van de Water, L.3    Feder, J.4    Dvorak, H.F.5
  • 174
    • 66149092730 scopus 로고    scopus 로고
    • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    • Shojaei, F., Wu, X., Qu, X., Kowanetz, M., Yu, L., Tan, M., Meng, Y.G., Ferrara, N., G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc. Natl. Acad. Sci. USA 106 (2009), 6742–6747.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 6742-6747
    • Shojaei, F.1    Wu, X.2    Qu, X.3    Kowanetz, M.4    Yu, L.5    Tan, M.6    Meng, Y.G.7    Ferrara, N.8
  • 175
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali, R.K., Yu, Z., Theoret, M.R., Chinnasamy, D., Restifo, N.P., Rosenberg, S.A., Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 70 (2010), 6171–6180.
    • (2010) Cancer Res. , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 176
    • 0344441357 scopus 로고    scopus 로고
    • Pathogenesis of retinopathy of prematurity
    • Smith, L.E., Pathogenesis of retinopathy of prematurity. Semin. Neonatol. 8 (2003), 469–473.
    • (2003) Semin. Neonatol. , vol.8 , pp. 469-473
    • Smith, L.E.1
  • 180
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker, S., Takashima, S., Miao, H.Q., Neufeld, G., Klagsbrun, M., Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92 (1998), 735–745.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 181
    • 44349089596 scopus 로고    scopus 로고
    • Vitreous levels of stromal cell-derived factor 1 and vascular endothelial growth factor in patients with retinopathy of prematurity
    • Sonmez, K., Drenser, K.A., Capone, A. Jr., Trese, M.T., Vitreous levels of stromal cell-derived factor 1 and vascular endothelial growth factor in patients with retinopathy of prematurity. Ophthalmology 115 (2008), 1065–1070.
    • (2008) Ophthalmology , vol.115 , pp. 1065-1070
    • Sonmez, K.1    Drenser, K.A.2    Capone, A.3    Trese, M.T.4
  • 182
    • 85053726149 scopus 로고    scopus 로고
    • A meta-analysis of patients with treatment-resistant macular oedema secondary to retinal vein occlusions following switching to aflibercept
    • Spooner, K., Hong, T., Bahrami, B., Chang, A., A meta-analysis of patients with treatment-resistant macular oedema secondary to retinal vein occlusions following switching to aflibercept. Acta Ophthalmol., 2018.
    • (2018) Acta Ophthalmol.
    • Spooner, K.1    Hong, T.2    Bahrami, B.3    Chang, A.4
  • 183
    • 70349124649 scopus 로고    scopus 로고
    • Comparison of intravitreal bevacizumab followed by ranibizumab for the treatment of neovascular age-related macular degeneration
    • Stepien, K.E., Rosenfeld, P.J., Puliafito, C.A., Feuer, W., Shi, W., Al-Attar, L., Dubovy, S.R., Murray, T.G., Davis, J.L., Lee, W.H., et al. Comparison of intravitreal bevacizumab followed by ranibizumab for the treatment of neovascular age-related macular degeneration. Retina 29 (2009), 1067–1073.
    • (2009) Retina , vol.29 , pp. 1067-1073
    • Stepien, K.E.1    Rosenfeld, P.J.2    Puliafito, C.A.3    Feuer, W.4    Shi, W.5    Al-Attar, L.6    Dubovy, S.R.7    Murray, T.G.8    Davis, J.L.9    Lee, W.H.10
  • 184
    • 0035870297 scopus 로고    scopus 로고
    • The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors
    • Sweeney, C.J., Miller, K.D., Sissons, S.E., Nozaki, S., Heilman, D.K., Shen, J., Sledge, G.W. Jr., The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res. 61 (2001), 3369–3372.
    • (2001) Cancer Res. , vol.61 , pp. 3369-3372
    • Sweeney, C.J.1    Miller, K.D.2    Sissons, S.E.3    Nozaki, S.4    Heilman, D.K.5    Shen, J.6    Sledge, G.W.7
  • 186
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong, R.T., Boucher, Y., Kozin, S.V., Winkler, F., Hicklin, D.J., Jain, R.K., Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 64 (2004), 3731–3736.
    • (2004) Cancer Res. , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 188
    • 82555176570 scopus 로고    scopus 로고
    • Endothelial development taking shape
    • Wacker, A., Gerhardt, H., Endothelial development taking shape. Curr. Opin. Cell Biol. 23 (2011), 676–685.
    • (2011) Curr. Opin. Cell Biol. , vol.23 , pp. 676-685
    • Wacker, A.1    Gerhardt, H.2
  • 190
    • 85006741687 scopus 로고    scopus 로고
    • Efficacy and Safety of Onartuzumab in Combination With First-Line Bevacizumab- or Pemetrexed-Based Chemotherapy Regimens in Advanced Non-Squamous Non-Small-Cell Lung Cancer
    • Wakelee, H., Zvirbule, Z., De Braud, F., Kingsley, C.D., Mekhail, T., Lowe, T., Schütte, W., Lena, H., Lawler, W., Braiteh, F., et al. Efficacy and Safety of Onartuzumab in Combination With First-Line Bevacizumab- or Pemetrexed-Based Chemotherapy Regimens in Advanced Non-Squamous Non-Small-Cell Lung Cancer. Clin. Lung Cancer 18 (2017), 50–59.
    • (2017) Clin. Lung Cancer , vol.18 , pp. 50-59
    • Wakelee, H.1    Zvirbule, Z.2    De Braud, F.3    Kingsley, C.D.4    Mekhail, T.5    Lowe, T.6    Schütte, W.7    Lena, H.8    Lawler, W.9    Braiteh, F.10
  • 191
    • 84984870923 scopus 로고    scopus 로고
    • Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
    • Wallin, J.J., Bendell, J.C., Funke, R., Sznol, M., Korski, K., Jones, S., Hernandez, G., Mier, J., He, X., Hodi, F.S., et al. Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma. Nat. Commun., 7, 2016, 12624.
    • (2016) Nat. Commun. , vol.7 , pp. 12624
    • Wallin, J.J.1    Bendell, J.C.2    Funke, R.3    Sznol, M.4    Korski, K.5    Jones, S.6    Hernandez, G.7    Mier, J.8    He, X.9    Hodi, F.S.10
  • 192
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren, R.S., Yuan, H., Matli, M.R., Gillett, N.A., Ferrara, N., Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J. Clin. Invest. 95 (1995), 1789–1797.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 193
    • 0031193545 scopus 로고    scopus 로고
    • Retinal development: communication helps you see the light
    • Wechsler-Reya, R.J., Barres, B.A., Retinal development: communication helps you see the light. Curr. Biol. 7 (1997), R433–R436.
    • (1997) Curr. Biol. , vol.7 , pp. R433-R436
    • Wechsler-Reya, R.J.1    Barres, B.A.2
  • 198
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler, F., Kozin, S.V., Tong, R.T., Chae, S.S., Booth, M.F., Garkavtsev, I., Xu, L., Hicklin, D.J., Fukumura, D., di Tomaso, E., et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6 (2004), 553–563.
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3    Chae, S.S.4    Booth, M.F.5    Garkavtsev, I.6    Xu, L.7    Hicklin, D.J.8    Fukumura, D.9    di Tomaso, E.10
  • 199
    • 0000786901 scopus 로고
    • Retinal neovascularization
    • Wise, G.N., Retinal neovascularization. Trans. Am. Ophthalmol. Soc. 54 (1956), 729–826.
    • (1956) Trans. Am. Ophthalmol. Soc. , vol.54 , pp. 729-826
    • Wise, G.N.1
  • 200
    • 84988584464 scopus 로고    scopus 로고
    • Evidence for Pro-angiogenic Functions of VEGF-Ax
    • Xin, H., Zhong, C., Nudleman, E., Ferrara, N., Evidence for Pro-angiogenic Functions of VEGF-Ax. Cell 167 (2016), 275–284.
    • (2016) Cell , vol.167 , pp. 275-284
    • Xin, H.1    Zhong, C.2    Nudleman, E.3    Ferrara, N.4
  • 201
    • 0036845084 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors
    • Yang, S., Toy, K., Ingle, G., Zlot, C., Williams, P.M., Fuh, G., Li, B., de Vos, A., Gerritsen, M.E., Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors. Arterioscler. Thromb. Vasc. Biol. 22 (2002), 1797–1803.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1797-1803
    • Yang, S.1    Toy, K.2    Ingle, G.3    Zlot, C.4    Williams, P.M.5    Fuh, G.6    Li, B.7    de Vos, A.8    Gerritsen, M.E.9
  • 202
  • 205
    • 85044394391 scopus 로고    scopus 로고
    • Anti-Angiogenics: Current Situation and Future Perspectives
    • Zirlik, K., Duyster, J., Anti-Angiogenics: Current Situation and Future Perspectives. Oncol. Res. Treat. 41 (2018), 166–171.
    • (2018) Oncol. Res. Treat. , vol.41 , pp. 166-171
    • Zirlik, K.1    Duyster, J.2
  • 206
    • 79955025729 scopus 로고    scopus 로고
    • 18F-5-fluorouracil dynamic positron emission tomography/computed tomography shows decreased tracer activity after bevacizumab in colorectal metastases
    • Zissen, M.H., Kunz, P., Subbarayan, M., Chin, F.T., Conti, P.S., Fisher, G.A., Quon, A., 18F-5-fluorouracil dynamic positron emission tomography/computed tomography shows decreased tracer activity after bevacizumab in colorectal metastases. Nucl. Med. Commun. 32 (2011), 343–347.
    • (2011) Nucl. Med. Commun. , vol.32 , pp. 343-347
    • Zissen, M.H.1    Kunz, P.2    Subbarayan, M.3    Chin, F.T.4    Conti, P.S.5    Fisher, G.A.6    Quon, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.