Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration

Cell Metabolism

Volumn 17, Issue 4, 2013, Pages 549-561

  Sene, Abdoulaye ^a   Khan, Aslam A ^a   Cox, Douglas ^a   Nakamura, Rei E I ^a   Santeford, Andrea ^a   Kim, Bryan M ^a   Sidhu, Rohini ^a   Onken, Michael D ^a   Harbour, J William ^a   Hagbi Levi, Shira ^b   Chowers, Itay ^b   Edwards, Peter A ^c   Baldan, Angel ^d   Parks, John S ^e   Ory, Daniel S ^a   Apte, Rajendra S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; CHOLESTEROL; LIVER X RECEPTOR AGONIST; MICRORNA; MICRORNA 33; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL POLARITY; CELL PROLIFERATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MACROPHAGE; MACROPHAGE FUNCTION; MICROVASCULAR ENDOTHELIAL CELL; MONOCYTE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CHOLESTEROL; DIET, HIGH-FAT; ENDOTHELIUM, VASCULAR; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPOPROTEINS; MACROPHAGES; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; PHENOTYPE;

MUS;

EID: 84875884191     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.03.009     Document Type: Article

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