Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss

JCI insight

Volumn 3, Issue 17, 2018, Pages

  Ban, Norimitsu ^a   Lee, Tae Jun ^a   Sene, Abdoulaye ^a   Choudhary, Mayur ^b   Lekwuwa, Michael ^b   Dong, Zhenyu ^a   Santeford, Andrea ^a   Lin, Jonathan B ^a   Malek, Goldis ^b   Ory, Daniel S ^c   Apte, Rajendra S ^a,d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Diabetic Cardiovascular Disease Center

^d Department of Medicine ^*

Author keywords

Cholesterol; Innate immunity; Ophthalmology

Indexed keywords

ABC TRANSPORTER A1; ABCA1 PROTEIN, MOUSE; ABCG1 PROTEIN, MOUSE; ACTIN BINDING PROTEIN; ADGRE1 PROTEIN, MOUSE; AIF1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; CHOLESTEROL; CHOLESTEROL ESTER; G PROTEIN COUPLED RECEPTOR; OXYSTEROL;

ANIMAL; BLINDNESS; DISEASE EXACERBATION; GENE DELETION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; MACULAR DEGENERATION; METABOLISM; MONOCYTE; MOUSE; PATHOLOGY; RETINA; RETINAL PIGMENT EPITHELIUM; VERTEBRATE PHOTORECEPTOR CELL;

ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY G, MEMBER 1; BLINDNESS; CALCIUM-BINDING PROTEINS; CHOLESTEROL; CHOLESTEROL ESTERS; DISEASE PROGRESSION; GENE DELETION; HUMANS; IMMUNITY, INNATE; MACULAR DEGENERATION; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MONOCYTES; OXYSTEROLS; PHOTORECEPTOR CELLS, VERTEBRATE; RECEPTORS, G-PROTEIN-COUPLED; RETINA; RETINAL PIGMENT EPITHELIUM;

EID: 85060334675     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.120824     Document Type: Article

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