Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions

Cancer Research

Volumn 60, Issue 19, 2000, Pages 5565-5570

  Lee, C G ^a   Heijn, M ^a   Di Tomaso, E ^a   Griffon Etienne, G ^a   Ancukiewicz, M ^a   Koike, C ^a   Park, K R ^a   Ferrara, N ^a   Jain, R K ^a   Suit, H D ^a   Boucher, Y ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER RADIOTHERAPY; COLON ADENOCARCINOMA; CONTROLLED STUDY; GLIOBLASTOMA; HYPOXIA; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIZATION; SOLID TUMOR; TUMOR GROWTH; VASCULAR RESISTANCE;

ADENOCARCINOMA; ANIMAL; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL DIVISION; CELL HYPOXIA; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; ENDOTHELIAL GROWTH FACTORS; EXTRACELLULAR SPACE; GLIOBLASTOMA; HUMAN; LYMPHOKINES; MALE; MICE; MICE, NUDE; OXYGEN; PARTIAL PRESSURE; SUPPORT, U.S. GOV'T, P.H.S.; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0034306974     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Anti-angiogenic agents can increase tumor oxygenation and response to radiation therapy
2. Combined effects of angiostatin and ionizing radiation in antitumor therapy
3. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposure to angiostatin
4. Blockade of vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
5. Angiostatin induces and sustains dormancy of human primary tumors in mice
6. Angiostatin suppresses malignant tumor growth in vivo
7. Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma
8. Antitumor effect on human gastric cancer and induction of apoptosis by vascular endothelial growth factor neutralizing antibody
9. Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma
10. The biology of vascular endothelial growth factor
11. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
12. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
13. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
14. Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice
15. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor
16. Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor
17. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor
18. Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
19. Interstitial hypertension in superficial metastatic melanomas in humans
20. Bootstrap methods: Another look at the jackknife
21. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
22. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
23. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
24. Metabolic characteristics of cells cultured from human umbilical vessels: Comparison with 3T3 fibroblasts
25. Microvascular and tissue nxygen gradients in the rat mesentery
26. The next frontier of molecular medicine: Delivery of therapeutics
27. Interstitial fluid balance in experimental animals and man
28. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: Implications for vascular collapse
29. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: Clinical implications
30. Tumor induction of VEGF promoter activity in stromal cells
31. Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
32. Dormancy of micrometastasis: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
33. Vascular changes in a human malignant melanoma xenograft after single-dose irradiation