Antagonism of PDGF-BB suppresses subretinal neovascularization and enhances the effects of blocking VEGF-A

Angiogenesis

Volumn 17, Issue 3, 2014, Pages 553-562

  Dong, Aling ^a   Seidel, Christopher ^a   Snell, Daniel ^b   Ekawardhani, Savira ^b   Ahlskog, Julia K J ^b   Baumann, Michael ^b   Shen, Jikui ^a   Iwase, Takeshi ^a   Tian, Jing ^a   Stevens, Rebecca ^a   Hackett, Sean F ^a   Stumpp, Michael T ^b   Campochiaro, Peter A ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOLECULAR PARTNERS AG   (Switzerland)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Age related macular degeneration; DARPin; Diabetic retinopathy; HIF 1

Indexed keywords

ANKYRIN; ANTIBODY; HYPOXIA INDUCIBLE FACTOR 1; OPSIN; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BB DESIGNED ANKYRIN REPEAT PROTEIN ANTIBODY; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH FACTOR A DESIGNED ANKYRIN REPEAT PROTEIN ANTIBODY; VASCULOTROPIN; VASCULOTROPIN A; HYBRID PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR BB; PROTEIN BINDING; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRUCH MEMBRANE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; GENE PRODUCT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RETINA DETACHMENT; RETINA ISCHEMIA; RETROLENTAL FIBROPLASIA; SUBRETINAL NEOVASCULARIZATION; 3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHOROIDAL NEOVASCULARIZATION; COMPLICATION; DEFICIENCY; DRUG EFFECTS; INTRAOCULAR DRUG ADMINISTRATION; ISCHEMIA; METABOLISM; PATHOLOGY; RAT; RETINAL DETACHMENT; RETINAL NEOVASCULARIZATION; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; CHOROIDAL NEOVASCULARIZATION; INJECTIONS, INTRAOCULAR; ISCHEMIA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NIH 3T3 CELLS; OPSINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RECEPTORS, LDL; RECOMBINANT FUSION PROTEINS; RETINAL DETACHMENT; RETINAL NEOVASCULARIZATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84903884921     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-013-9402-5     Document Type: Article

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