메뉴 건너뛰기




Volumn 97, Issue 1, 2019, Pages 15-23

A meta-analysis of patients with treatment-resistant macular oedema secondary to retinal vein occlusions following switching to aflibercept

Author keywords

aflibercept; anti VEGF; retinal vein occlusion; treatment resistance

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; RANIBIZUMAB; ANGIOGENESIS INHIBITOR; FUSION PROTEIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

EID: 85053726149     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/aos.13802     Document Type: Review
Times cited : (11)

References (52)
  • 1
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG et al. (1994): Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331: 1480–1487.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 2
    • 84968542370 scopus 로고    scopus 로고
    • Diabetic macular oedema: pathophysiology, management challenges and treatment resistance
    • &
    • Bahrami B, Zhu M, Hong T & Chang A (2016): Diabetic macular oedema: pathophysiology, management challenges and treatment resistance. Diabetologia 59: 1594–1608.
    • (2016) Diabetologia , vol.59 , pp. 1594-1608
    • Bahrami, B.1    Zhu, M.2    Hong, T.3    Chang, A.4
  • 3
    • 85017172178 scopus 로고    scopus 로고
    • Switching therapy from bevacizumab to aflibercept for the management of persistent diabetic macular edema
    • &
    • Bahrami B, Hong T, Zhu M, Schlub TE & Chang A (2017): Switching therapy from bevacizumab to aflibercept for the management of persistent diabetic macular edema. Graefes Arch Clin Exp Ophthalmol 255: 1451–1452.
    • (2017) Graefes Arch Clin Exp Ophthalmol , vol.255 , pp. 1451-1452
    • Bahrami, B.1    Hong, T.2    Zhu, M.3    Schlub, T.E.4    Chang, A.5
  • 4
    • 84455180610 scopus 로고    scopus 로고
    • Loss of reactivity in intravitreal anti-VEGF therapy: tachyphylaxis or tolerance?
    • Binder S. (2012): Loss of reactivity in intravitreal anti-VEGF therapy: tachyphylaxis or tolerance? Br J Ophthalmol 96: 1–2.
    • (2012) Br J Ophthalmol , vol.96 , pp. 1-2
    • Binder, S.1
  • 5
    • 85027938688 scopus 로고    scopus 로고
    • Treating the untreatable patient: current options for the management of treatment-resistant neovascular age-related macular degeneration
    • &
    • Broadhead GK, Hong T & Chang AA (2014): Treating the untreatable patient: current options for the management of treatment-resistant neovascular age-related macular degeneration. Acta Ophthalmol 92: 713–723.
    • (2014) Acta Ophthalmol , vol.92 , pp. 713-723
    • Broadhead, G.K.1    Hong, T.2    Chang, A.A.3
  • 6
    • 77952889477 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study
    • e1121
    • Brown DM, Campochiaro PA, Singh RP et al. (2010): Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 117: 1124–1133. e1121
    • (2010) Ophthalmology , vol.117 , pp. 1124-1133
    • Brown, D.M.1    Campochiaro, P.A.2    Singh, R.P.3
  • 7
    • 84873738185 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the phase 3 COPERNICUS study
    • e427
    • Brown DM, Heier JS, Clark WL et al. (2013): Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the phase 3 COPERNICUS study. Am J Ophthalmol 155: 429–437. e427
    • (2013) Am J Ophthalmol , vol.155 , pp. 429-437
    • Brown, D.M.1    Heier, J.S.2    Clark, W.L.3
  • 8
    • 84891631064 scopus 로고    scopus 로고
    • Long-term outcomes in patients with retinal vein occlusion treated with ranibizumab: the RETAIN study
    • Campochiaro PA, Sophie R, Pearlman J et al. (2014): Long-term outcomes in patients with retinal vein occlusion treated with ranibizumab: the RETAIN study. Ophthalmology 121: 209–219.
    • (2014) Ophthalmology , vol.121 , pp. 209-219
    • Campochiaro, P.A.1    Sophie, R.2    Pearlman, J.3
  • 9
    • 84992597388 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor agents in the treatment of retinal disease: from bench to bedside
    • &
    • Campochiaro PA, Aiello LP & Rosenfeld PJ (2016): Anti-vascular endothelial growth factor agents in the treatment of retinal disease: from bench to bedside. Ophthalmology 123: S78–S88.
    • (2016) Ophthalmology , vol.123 , pp. S78-S88
    • Campochiaro, P.A.1    Aiello, L.P.2    Rosenfeld, P.J.3
  • 10
    • 84954373397 scopus 로고    scopus 로고
    • Intravitreal aflibercept for treatment-resistant neovascular age-related macular degeneration: 12-month safety and efficacy outcomes
    • Chang AA, Broadhead GK, Hong T et al. (2015): Intravitreal aflibercept for treatment-resistant neovascular age-related macular degeneration: 12-month safety and efficacy outcomes. Ophthalmic Res 55: 84–90.
    • (2015) Ophthalmic Res , vol.55 , pp. 84-90
    • Chang, A.A.1    Broadhead, G.K.2    Hong, T.3
  • 11
    • 85018291669 scopus 로고    scopus 로고
    • Long-term anatomical and functional outcomes in patients with ischemic central retinal vein occlusion treated with anti-vascular endothelial growth factor agents
    • &
    • Chatziralli I, Theodossiadis G, Parikakis E, Mitropoulos PG & Theodossiadis P. (2017): Long-term anatomical and functional outcomes in patients with ischemic central retinal vein occlusion treated with anti-vascular endothelial growth factor agents. Ophthalmic Res 58: 203–208.
    • (2017) Ophthalmic Res , vol.58 , pp. 203-208
    • Chatziralli, I.1    Theodossiadis, G.2    Parikakis, E.3    Mitropoulos, P.G.4    Theodossiadis, P.5
  • 12
    • 84961942659 scopus 로고    scopus 로고
    • Intravitreal aflibercept for macular edema following branch retinal vein occlusion: 52-week results of the VIBRANT study
    • Clark WL, Boyer DS, Heier JS et al. (2016): Intravitreal aflibercept for macular edema following branch retinal vein occlusion: 52-week results of the VIBRANT study. Ophthalmology 123: 330–336.
    • (2016) Ophthalmology , vol.123 , pp. 330-336
    • Clark, W.L.1    Boyer, D.S.2    Heier, J.S.3
  • 13
    • 84994504601 scopus 로고    scopus 로고
    • Effect of aflibercept on refractory macular edema associated with central retinal vein occlusion
    • &
    • Cohen MN, Houston SK, Juhn A, Ho AC, Regillo CD, Vander J & Chiang A. (2016): Effect of aflibercept on refractory macular edema associated with central retinal vein occlusion. Can J Ophthalmol 51: 342–347.
    • (2016) Can J Ophthalmol , vol.51 , pp. 342-347
    • Cohen, M.N.1    Houston, S.K.2    Juhn, A.3    Ho, A.C.4    Regillo, C.D.5    Vander, J.6    Chiang, A.7
  • 14
    • 79956068310 scopus 로고    scopus 로고
    • Management of retinal vein occlusion–consensus document
    • Coscas G, Loewenstein A, Augustin A et al. (2011): Management of retinal vein occlusion–consensus document. Ophthalmologica 226: 4–28.
    • (2011) Ophthalmologica , vol.226 , pp. 4-28
    • Coscas, G.1    Loewenstein, A.2    Augustin, A.3
  • 15
    • 0031754739 scopus 로고    scopus 로고
    • The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions
    • &
    • Downs SH & Black N (1998): The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 52: 377–384.
    • (1998) J Epidemiol Community Health , vol.52 , pp. 377-384
    • Downs, S.H.1    Black, N.2
  • 16
    • 84916596593 scopus 로고    scopus 로고
    • Response to aflibercept as secondary therapy in patients with persistent retinal edema due to central retinal vein occlusion initially treated with bevacizumab or ranibizumab
    • &
    • Eadie JA, Ip MS & Kulkarni AD (2014): Response to aflibercept as secondary therapy in patients with persistent retinal edema due to central retinal vein occlusion initially treated with bevacizumab or ranibizumab. Retina 34: 2439–2443.
    • (2014) Retina , vol.34 , pp. 2439-2443
    • Eadie, J.A.1    Ip, M.S.2    Kulkarni, A.D.3
  • 17
    • 0029066175 scopus 로고
    • Misleading meta-analysis
    • &
    • Egger M & Smith GD (1995): Misleading meta-analysis. BMJ 311: 753–754.
    • (1995) BMJ , vol.311 , pp. 753-754
    • Egger, M.1    Smith, G.D.2
  • 18
    • 67749106387 scopus 로고    scopus 로고
    • Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration
    • &
    • Forooghian F, Cukras C, Meyerle CB, Chew EY & Wong WT (2009): Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration. Retina 29: 723–731.
    • (2009) Retina , vol.29 , pp. 723-731
    • Forooghian, F.1    Cukras, C.2    Meyerle, C.B.3    Chew, E.Y.4    Wong, W.T.5
  • 19
    • 84903819352 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for macular edema due to central retinal vein occlusion: two-year results from the COPERNICUS study
    • e1411.
    • Heier JS, Clark WL, Boyer DS et al. (2014): Intravitreal aflibercept injection for macular edema due to central retinal vein occlusion: two-year results from the COPERNICUS study. Ophthalmology 121: 1414–1420.e1411.
    • (2014) Ophthalmology , vol.121 , pp. 1414-1420
    • Heier, J.S.1    Clark, W.L.2    Boyer, D.S.3
  • 20
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • &
    • Higgins JP & Thompson SG (2002): Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539–1558.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 22
    • 84876955894 scopus 로고    scopus 로고
    • Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature
    • &
    • Jaulim A, Ahmed B, Khanam T & Chatziralli IP (2013): Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. Retina 33: 901–910.
    • (2013) Retina , vol.33 , pp. 901-910
    • Jaulim, A.1    Ahmed, B.2    Khanam, T.3    Chatziralli, I.P.4
  • 23
    • 85020768229 scopus 로고    scopus 로고
    • Comparison of Ranibizumab and Bevacizumab for Macular Edema Secondary to Retinal Vein Occlusions in Routine Clinical Practice
    • Khan M, Wai KM, Silva FQ et al. (2017): Comparison of Ranibizumab and Bevacizumab for Macular Edema Secondary to Retinal Vein Occlusions in Routine Clinical Practice. Ophthalmic Surg Lasers Imaging Retina 48: 465–472.
    • (2017) Ophthalmic Surg Lasers Imaging Retina , vol.48 , pp. 465-472
    • Khan, M.1    Wai, K.M.2    Silva, F.Q.3
  • 24
    • 0034527456 scopus 로고    scopus 로고
    • The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study
    • &, discussion 141-133.
    • Klein R, Klein BE, Moss SE & Meuer SM (2000): The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc 98: 133–141. discussion 141-133.
    • (2000) Trans Am Ophthalmol Soc , vol.98 , pp. 133-141
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Meuer, S.M.4
  • 25
    • 85017441212 scopus 로고    scopus 로고
    • Outcomes of switching treatment to aflibercept in patients with macular oedema secondary to central retinal vein occlusion refractory to ranibizumab
    • &
    • Konidaris V, Al-Hubeshy Z, Tsaousis KT, Gorgoli K, Banerjee S & Empeslidis T (2017): Outcomes of switching treatment to aflibercept in patients with macular oedema secondary to central retinal vein occlusion refractory to ranibizumab. Int Ophthalmol 38: 207–213.
    • (2017) Int Ophthalmol , vol.38 , pp. 207-213
    • Konidaris, V.1    Al-Hubeshy, Z.2    Tsaousis, K.T.3    Gorgoli, K.4    Banerjee, S.5    Empeslidis, T.6
  • 26
    • 84891626905 scopus 로고    scopus 로고
    • Intravitreal Aflibercept injection for macular edema resulting from central retinal vein occlusion: one-year results of the phase 3 GALILEO study
    • Korobelnik JF, Holz FG, Roider J et al. (2014): Intravitreal Aflibercept injection for macular edema resulting from central retinal vein occlusion: one-year results of the phase 3 GALILEO study. Ophthalmology 121: 202–208.
    • (2014) Ophthalmology , vol.121 , pp. 202-208
    • Korobelnik, J.F.1    Holz, F.G.2    Roider, J.3
  • 27
    • 84943351924 scopus 로고    scopus 로고
    • Aflibercept administration in neovascular age-related macular degeneration refractory to previous anti-vascular endothelial growth factor drugs: a critical review and new possible approaches to move forward
    • &
    • Lazzeri S, Ripandelli G & Sartini MS. (2015): Aflibercept administration in neovascular age-related macular degeneration refractory to previous anti-vascular endothelial growth factor drugs: a critical review and new possible approaches to move forward. Angiogenesis 18: 397–432.
    • (2015) Angiogenesis , vol.18 , pp. 397-432
    • Lazzeri, S.1    Ripandelli, G.2    Sartini, M.S.3
  • 28
    • 84928491964 scopus 로고    scopus 로고
    • The effect of switching ranibizumab to aflibercept in refractory cases of macular edema secondary to ischemic central vein occlusion
    • &
    • Lehmann-Clarke L, Dirani A, Mantel I & Ambresin A (2015): The effect of switching ranibizumab to aflibercept in refractory cases of macular edema secondary to ischemic central vein occlusion. Klin Monbl Augenheilkd 232: 552–555.
    • (2015) Klin Monbl Augenheilkd , vol.232 , pp. 552-555
    • Lehmann-Clarke, L.1    Dirani, A.2    Mantel, I.3    Ambresin, A.4
  • 29
    • 80053371459 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
    • &
    • Meyer CH, Krohne TU & Holz FG (2011): Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans. Retina 31: 1877–1884.
    • (2011) Retina , vol.31 , pp. 1877-1884
    • Meyer, C.H.1    Krohne, T.U.2    Holz, F.G.3
  • 30
    • 85017353979 scopus 로고    scopus 로고
    • Ranibizumab for macular edema after branch retinal vein occlusion: one Initial injection versus three monthly injections
    • Miwa Y, Muraoka Y, Osaka R et al. (2017): Ranibizumab for macular edema after branch retinal vein occlusion: one Initial injection versus three monthly injections. Retina 37: 702–709.
    • (2017) Retina , vol.37 , pp. 702-709
    • Miwa, Y.1    Muraoka, Y.2    Osaka, R.3
  • 31
    • 84859046696 scopus 로고    scopus 로고
    • Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy
    • Mowat FM, Gonzalez F, Luhmann UF et al. (2012): Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. Am J Pathol 180: 1726–1739.
    • (2012) Am J Pathol , vol.180 , pp. 1726-1739
    • Mowat, F.M.1    Gonzalez, F.2    Luhmann, U.F.3
  • 32
    • 57949103669 scopus 로고    scopus 로고
    • Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion
    • &
    • Noma H, Funatsu H, Mimura T, Harino S & Hori S (2009): Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. Ophthalmology 116: 87–93.
    • (2009) Ophthalmology , vol.116 , pp. 87-93
    • Noma, H.1    Funatsu, H.2    Mimura, T.3    Harino, S.4    Hori, S.5
  • 33
    • 84902676785 scopus 로고    scopus 로고
    • Role of soluble vascular endothelial growth factor receptors-1 and -2, their ligands, and other factors in branch retinal vein occlusion with macular edema
    • &
    • Noma H, Mimura T, Yasuda K & Shimura M (2014): Role of soluble vascular endothelial growth factor receptors-1 and -2, their ligands, and other factors in branch retinal vein occlusion with macular edema. Invest Ophthalmol Vis Sci 55: 3878–3885.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 3878-3885
    • Noma, H.1    Mimura, T.2    Yasuda, K.3    Shimura, M.4
  • 34
    • 84908658307 scopus 로고    scopus 로고
    • Intravitreal aflibercept for macular edema secondary to central retinal vein occlusion: 18-month results of the phase 3 GALILEO study
    • Ogura Y, Roider J, Korobelnik JF et al. (2014): Intravitreal aflibercept for macular edema secondary to central retinal vein occlusion: 18-month results of the phase 3 GALILEO study. Am J Ophthalmol 158: 1032–1038.
    • (2014) Am J Ophthalmol , vol.158 , pp. 1032-1038
    • Ogura, Y.1    Roider, J.2    Korobelnik, J.F.3
  • 35
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • Papadopoulos N, Martin J, Ruan Q et al. (2012): Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis 15: 171–185.
    • (2012) Angiogenesis , vol.15 , pp. 171-185
    • Papadopoulos, N.1    Martin, J.2    Ruan, Q.3
  • 36
    • 84954285677 scopus 로고    scopus 로고
    • Intravitreal aflibercept for macular oedema secondary to central retinal vein occlusion in patients with prior treatment with bevacizumab or ranibizumab
    • Papakostas TD, Lim L, van Zyl T et al. (2016): Intravitreal aflibercept for macular oedema secondary to central retinal vein occlusion in patients with prior treatment with bevacizumab or ranibizumab. Eye (Lond) 30: 79–84.
    • (2016) Eye (Lond) , vol.30 , pp. 79-84
    • Papakostas, T.D.1    Lim, L.2    van, Z.T.3
  • 38
    • 84942683494 scopus 로고    scopus 로고
    • Clinical outcome after switching therapy from ranibizumab and/or bevacizumab to aflibercept in central retinal vein occlusion
    • &
    • Pfau M, Fassnacht-Riederle H, Becker MD, Graf N & Michels S (2015): Clinical outcome after switching therapy from ranibizumab and/or bevacizumab to aflibercept in central retinal vein occlusion. Ophthalmic Res 54: 150–156.
    • (2015) Ophthalmic Res , vol.54 , pp. 150-156
    • Pfau, M.1    Fassnacht-Riederle, H.2    Becker, M.D.3    Graf, N.4    Michels, S.5
  • 39
    • 75149172639 scopus 로고    scopus 로고
    • The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia
    • e311.
    • Rogers S., McIntosh R. L., Cheung N. et al. (2010): The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 117: 313–319. e311.
    • (2010) Ophthalmology , vol.117 , pp. 313-319
    • Rogers, S.1    McIntosh, R.L.2    Cheung, N.3
  • 40
    • 85019585340 scopus 로고    scopus 로고
    • Effect of Bevacizumab vs Aflibercept on visual acuity among patients with macular edema due to central retinal vein occlusion: the SCORE2 randomized clinical trial
    • Scott IU, VanVeldhuisen PC, Ip MS et al. (2017): Effect of Bevacizumab vs Aflibercept on visual acuity among patients with macular edema due to central retinal vein occlusion: the SCORE2 randomized clinical trial. JAMA 317: 2072.
    • (2017) JAMA , vol.317 , pp. 2072
    • Scott, I.U.1    VanVeldhuisen, P.C.2    Ip, M.S.3
  • 41
    • 79951560006 scopus 로고    scopus 로고
    • Long-term effect of early intervention with single intravitreal injection of bevacizumab followed by panretinal and macular grid photocoagulation in central retinal vein occlusion (CRVO) with macular edema: a pilot study
    • &
    • Shah NJ & Shah UN (2011): Long-term effect of early intervention with single intravitreal injection of bevacizumab followed by panretinal and macular grid photocoagulation in central retinal vein occlusion (CRVO) with macular edema: a pilot study. Eye (Lond) 25: 239–244.
    • (2011) Eye (Lond) , vol.25 , pp. 239-244
    • Shah, N.J.1    Shah, U.N.2
  • 42
    • 84884553088 scopus 로고    scopus 로고
    • Long-term outcomes in ranibizumab-treated patients with retinal vein occlusion; the role of progression of retinal nonperfusion
    • Sophie R, Hafiz G, Scott AW et al. (2013): Long-term outcomes in ranibizumab-treated patients with retinal vein occlusion; the role of progression of retinal nonperfusion. Am J Ophthalmol 156: 693–705.
    • (2013) Am J Ophthalmol , vol.156 , pp. 693-705
    • Sophie, R.1    Hafiz, G.2    Scott, A.W.3
  • 43
    • 85010886931 scopus 로고    scopus 로고
    • Switching to aflibercept among patients with treatment-resistant neovascular age-related macular degeneration: a systematic review with meta-analysis
    • &
    • Spooner K, Hong T, Wijeyakumar W & Chang AA (2017): Switching to aflibercept among patients with treatment-resistant neovascular age-related macular degeneration: a systematic review with meta-analysis. Clin Ophthalmol 11: 161–177.
    • (2017) Clin Ophthalmol , vol.11 , pp. 161-177
    • Spooner, K.1    Hong, T.2    Wijeyakumar, W.3    Chang, A.A.4
  • 44
    • 0033667445 scopus 로고    scopus 로고
    • Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature
    • &
    • Sterne JA, Gavaghan D & Egger M (2000): Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 53: 1119–1129.
    • (2000) J Clin Epidemiol , vol.53 , pp. 1119-1129
    • Sterne, J.A.1    Gavaghan, D.2    Egger, M.3
  • 45
    • 85027955048 scopus 로고    scopus 로고
    • Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye)
    • &
    • Stewart MW, Rosenfeld PJ & Penha FM (2012): Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye). Retina 3: 2.
    • (2012) Retina , vol.3 , pp. 2
    • Stewart, M.W.1    Rosenfeld, P.J.2    Penha, F.M.3
  • 46
    • 85013742294 scopus 로고    scopus 로고
    • Prolongation of injection interval after switching therapy from ranibizumab to aflibercept in Japanese patients with macular edema secondary to branch retinal vein occlusion
    • &
    • Tagami M, Sai R, Fukuda M & Azumi A (2017): Prolongation of injection interval after switching therapy from ranibizumab to aflibercept in Japanese patients with macular edema secondary to branch retinal vein occlusion. Clin Ophthalmol 11: 403–408.
    • (2017) Clin Ophthalmol , vol.11 , pp. 403-408
    • Tagami, M.1    Sai, R.2    Fukuda, M.3    Azumi, A.4
  • 48
    • 84867100215 scopus 로고    scopus 로고
    • Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: results from the BRAVO and CRUISE trials
    • &
    • Varma R, Bressler NM, Suner I, Lee P, Dolan CM, Ward J, Colman S & Rubio RG (2012): Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: results from the BRAVO and CRUISE trials. Ophthalmology 119: 2108–2118.
    • (2012) Ophthalmology , vol.119 , pp. 2108-2118
    • Varma, R.1    Bressler, N.M.2    Suner, I.3    Lee, P.4    Dolan, C.M.5    Ward, J.6    Colman, S.7    Rubio, R.G.8
  • 49
    • 84889592452 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor drugs safety and efficacy in ophthalmic diseases
    • Ventrice P, Leporini C, Aloe JF et al. (2013): Anti-vascular endothelial growth factor drugs safety and efficacy in ophthalmic diseases. J Pharmacol Pharmacother 4(Suppl 1): S38–S42.
    • (2013) J Pharmacol Pharmacother , vol.4 , pp. S38-S42
    • Ventrice, P.1    Leporini, C.2    Aloe, J.F.3
  • 50
    • 85030617531 scopus 로고    scopus 로고
    • Five-year visual acuity outcomes and injection patterns in patients with pro-re-nata treatments for AMD, DME, RVO and myopic CNV
    • &
    • Wecker T, Ehlken C, Buhler A, Lange C, Agostini H, Bohringer D & Stahl A (2017): Five-year visual acuity outcomes and injection patterns in patients with pro-re-nata treatments for AMD, DME, RVO and myopic CNV. Br J Ophthalmol 101: 353–359.
    • (2017) Br J Ophthalmol , vol.101 , pp. 353-359
    • Wecker, T.1    Ehlken, C.2    Buhler, A.3    Lange, C.4    Agostini, H.5    Bohringer, D.6    Stahl, A.7
  • 51
    • 85013838715 scopus 로고    scopus 로고
    • Aflibercept in branch retinal vein occlusion as second line therapy: clinical outcome 12 months after changing treatment from bevacizumab/ranibizumab-a pilot study
    • &
    • Wirth MA, Becker MD, Graf N & Michels S (2016): Aflibercept in branch retinal vein occlusion as second line therapy: clinical outcome 12 months after changing treatment from bevacizumab/ranibizumab-a pilot study. Int J Retina Vitreous 2: 20.
    • (2016) Int J Retina Vitreous , vol.2 , pp. 20
    • Wirth, M.A.1    Becker, M.D.2    Graf, N.3    Michels, S.4
  • 52
    • 84958746076 scopus 로고    scopus 로고
    • Receiver operating characteristic curve to predict anti-VEGF resistance in retinal vein occlusions and efficacy of Ozurdex
    • &
    • Wolfe JD, Shah AR, Yonekawa Y, Al Faran A, Franklin MS, Abbey AM & Capone A Jr. (2016). Receiver operating characteristic curve to predict anti-VEGF resistance in retinal vein occlusions and efficacy of Ozurdex. Eur J Ophthalmol 26: 168–173.
    • (2016) Eur J Ophthalmol , vol.26 , pp. 168-173
    • Wolfe, J.D.1    Shah, A.R.2    Yonekawa, Y.3    Al, F.A.4    Franklin, M.S.5    Abbey, A.M.6    Capone, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.