A double-edged sword: The role of VEGF in wound repair and chemoattraction of opportunist pathogens

International Journal of Molecular Sciences

Volumn 16, Issue 4, 2015, Pages 7159-7172

  Birkenhauer, Eric ^a   Neethirajan, Suresh ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Biofilms; Chemotaxis; Microfluidics; Pseudomonas aeruginosa; Vascular endothelial growth factor; Wound bacteria

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BIOFILM; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CELL MIGRATION; CELL MOTILITY; CHEMOATTRACTION; CHEMOTAXIS; DEVICES; DIFFUSION; FIBROBLAST; FLOW RATE; FLUORESCENCE; IMAGE ANALYSIS; INFLAMMATION; MICROFLUIDIC ANALYSIS; MICROFLUIDIC DEVICE; NONHUMAN; PSEUDOMONAS AERUGINOSA; SCANNING ELECTRON MICROSCOPY; TISSUE REPAIR; VISCOSITY; WOUND HEALING; WOUND INFECTION; HUMAN; METABOLISM; MICROFLUIDICS; PHYSIOLOGY; PROCEDURES; PSEUDOMONAS INFECTION;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

BIOFILMS; HUMANS; MICROFLUIDICS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84927607560     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16047159     Document Type: Article

References (22)

1. Edwards, R.; Harding, K.G. Bacteria and wound healing. Curr. Opin. Infect. Dis. 2004, 17, 91-96.
2. Olczyk, P.; Mencner, L.; Komosinska-Vassev, K. The role of extracellular matrix components in cutaneous wound healing. BioMed. Res. Int. 2014, doi:10.1155/2014/747584.
3. Stroncek, J.D.; Reichert, W.M. Overview of wound healing in different tissue types. In Indwelling Neural Implants: Strategies for Contending with the in Vivo Environment, 1st ed.; Reichert, W.M., Ed.; CRC Press: Boca Raton, FL, USA, 2008; Part I.
4. Asada, M.; Nakagami, G.; Minematsu, T.; Nagase, T.; Akase, T.; Huang, L.; Yoshimura, K.; Sanada, H. Novel models for bacterial colonization and infection of full-thickness wounds in rats. Wound Repair Regen. 2012, 20, 601-610.
5. Percival, S.L.; Emanuel, C.; Cutting, K.F.; Williams, D.W. Microbiology of the skin and the role of biofilms in infection. Int. Wound J. 2011, 9, 14-32.
6. Burrows, L.L. Pseudomonas aeruginosa twitching motility: Type IV pili in action. Ann. Rev. Microbiol. 2012, 66, 493-520.
7. O'Toole, G.A.; Kolter, R. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol. Microbiol. 1998, 30, 295-304.
8. Beaussart, A.; Baker, A.E.; Kuchma, S.L.; El-Kirat-Chantel, S.; O'Toole, G.A.; Dufrene, Y.F. Nanoscale adhesion forces of Pseudomonas aeruginosa type IV pili. ACS Nano 2014, 8, 10723-10733.
9. Harrison-Balestra, C.; Cazzaniga, A.L.; Davis, S.C.; Mertz, P.M. A wound-isolated pseudomonas aeruginosa grows a biofilm in vitro within 10 hours and is visualized by light microscopy. Dermatol. Surg. 2003, 26, 631-635.
10. Ciofu, O.; Mandsberg, L.F.; Wang, H.; Hoiby, N. Phenotypes selected during chronic lung infection in cystic fibrosis patients: Implications for the treatment of Pseudomonas aeruginosa biofilm infections. FEMS Immunol. Med. Microbiol. 2012, 65, 215-225.
11. Hoiby, N.; Johansen, H.; Moser, C.; Song, Z.; Ciofu, O.; Kharazmi, A. Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth. Microbes Infect. 2001, 3, 23-35.
12. Su, S.; Hassett, D.J. Anaerobic Pseudomonas aeruginosa and other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: An emerging paradigm or "old hat"? Expert Opin. Ther. Targets 2012, 16, 859-873.
13. Scales, B.S.; Huffnagle, G.B. The microbiome in wound repair and tissue fibrosis. J. Pathol. 2013, 229, 323-331.
14. Wright, E.; Neethirajan, S.; Warriner, K.; Retterer, S.; Srijanto, B. Single cell swimming dynamics of Listeria monocytogenes using a nanoporous microfluidic platform. Lab Chip 2014, 14, 938-946.
15. Mac Gabhann, F.; Ji, W.; Popel, A.S. Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy. PLoS Comput. Biol. 2006, e127, 1107-1120. 16. Hashambhoy, Y.L.; Chappell, J.C.; Peirce, S.M.; Bautch, V.L.; Mac Gabhann, F. Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients. Front. Physiol. 2011, 2, 1-12.
16. Lee, K.; Kim, C.; Ahn, B.; Panchapakesan, R.; Full, A.R.; Nordee, L.; Kang, J.Y.; Oh, K.W. Generalized serial dilution module for monotonic and arbitrary microfluidic gradient generators. Lab Chip 2009, 9, 709-717.
17. Infanger, M.; Schmidt, O.; Kossmehl, P.; Grad, S.; Ertel, W.; Grimm, D. Vascular endothelial growth factor serum level is strongly correlated with local and general tissue edema. Burns 2004, 30, 305-311.
18. Wu, F.P.K.; Hoekman, K.; Meijer, S.; Cuesta, M.A. VEGF and endostatin levels in wound fluid and plasma after breast surgery. Angiogenesis 2003, 6, 255-257.
19. Rivard, A.; Berthou-Soulie, L.; Principe, N.; Kearney, M.; Curry, C.; Branellec, D.; Semenza, G.L.; Isner, J.M. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J. Biol. Chem. 2000, 275, 29643-29647.
20. Mateo, I.; Llorca, J.; Infante, J.; Rodriguez-Rodriguez, E.; Fernandez-Viadero, C.; Pena, N.; Berciano, J.; Combarros, O. Low serum VEGF levels are associated with Alzheimer's disease. Acta Neurol. Scand. 2007, 116, 56-58.
21. Sampedro, I.; Parales, R.E.; Krell, T.; Hill, J.E. Pseudomonas chemotaxis. FEMS Microbiol. Rev. 2015, 39, 17-46.
22. Scher, F.M.; Kloepper, J.W.; Singleton, C.A. Chemotaxis of fluorescent Pseudomonas spp. to soybean seed exudates in vitro and in soil. Can. J. Microbiol. 1985, 31, 570-574.