Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration

Science Translational Medicine

Volumn 9, Issue 395, 2017, Pages

  Yaspan, Brian L ^a   Williams, David F ^b   Holz, Frank G ^c   Regillo, Carl D ^d   Li, Zhengrong ^a   Dressen, Amy ^a   Van Lookeren Campagne, Menno ^a   Le, Kha N ^a   Graham, Robert R ^a   Beres, Tatiana ^a   Bhangale, Tushar R ^a   Honigberg, Lee A ^a   Smith, Ashley ^a   Henry, Erin C ^a   Ho, Carole ^a   Strauss, Erich C ^a  

^a GENENTECH INC   (United States)

^b VitreoRetinal Surgery   (United States)

^c UNIVERSITY OF BONN   (Germany)

^d WILLS EYE HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT FACTOR D; COMPLEMENT FACTOR I; COMPLEMENT FACTOR D, HUMAN; IMMUNOGLOBULIN F(AB) FRAGMENT; LAMPALIZUMAB;

AGE RELATED MACULAR DEGENERATION; AGED; ALLELE; ARTICLE; COMPLEMENT ALTERNATIVE PATHWAY; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GEOGRAPHIC ATROPHY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; DISEASE EXACERBATION; MACULAR DEGENERATION; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL;

AGED; COMPLEMENT FACTOR D; COMPLEMENT PATHWAY, ALTERNATIVE; DISEASE PROGRESSION; FEMALE; GEOGRAPHIC ATROPHY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MACULAR DEGENERATION; MALE; MIDDLE AGED;

EID: 85021165876     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaf1443     Document Type: Article

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