An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 44, 2009, Pages 18751-18756

  Saint Geniez, Magali ^a,b   Kurihara, Tomoki ^a   Sekiyama, Eiichi ^a,b   Maldonado, Angel E ^a   D'Amore, Patricia A ^a,b  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Age related macular degeneration; Bruch's membrane; Geographic atrophy; Retinal pigmented epithelium

Indexed keywords

UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 188;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATROPHY; BRUCH MEMBRANE; CELL DEGENERATION; CELL FUNCTION; CELL LOSS; CELL MATURATION; CELL SURVIVAL; CHOROID CAPILLARY LAYER; CONTROLLED STUDY; ELECTRORETINOGRAM; MOUSE; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA; VASCULARIZATION; VISION; VISUAL ACUITY;

AGING; ANIMALS; APOPTOSIS; ATROPHY; BLOOD-AQUEOUS BARRIER; CHOROID; ELECTRORETINOGRAPHY; MACULAR DEGENERATION; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL PIGMENT EPITHELIUM; SOLUBILITY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VISION, OCULAR;

MUS;

EID: 73249132759     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905010106     Document Type: Article

References (38)

1. Holmes DI, Zachary I (2005) The vascular endothelial growth factor (VEGF) family: Angiogenic factors in health and disease. Genome Biol 6:209.
2. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L (2006) VEGF receptor signalling-in control of vascular function. Nat Rev Mol Cell Biol 7:359-371.
3. Soker S, Miao HQ, Nomi M,Takashima S, Klagsbrun M (2002) VEGF165mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding. J Cell Biochem 85:357-368.
4. Maharaj AS, Saint-Geniez M, Maldonado AE, D'Amore PA (2006) Vascular endothelial growth factor localization in the adult. Am J Pathol 168:639-648.
5. Eremina V, Quaggin SE (2004) The role of VEGF-A in glomerular development and function. Curr Opin Nephrol Hypertens 13:9-15.
6. Maynard SE, et al. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649-658.
7. Eremina V, et al. (2008) VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358:1129-1136.
8. Kamba T, et al. (2006) VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 290:H560-H576.
9. Lammert E, et al. (2003) Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 13:1070-1074.
10. Maharaj AS, et al. (2008) VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med 205:491-501.
11. Peters S, et al. (2007) Ultrastructural findings in the primate eye after intravitreal injection of bevacizumab. Am J Ophthalmol 143:995-1002.
12. D'Amore PA (2007) Vascular endothelial cell growth factor-a: Not just for endothelial cells anymore. Am J Pathol 171:14-18.
13. Zachary I (2005) Neuroprotective role of vascular endothelial growth factor: Signalling mechanisms, biological function, and therapeutic potential. Neurosignals 14:207-221.
14. Saint-Geniez M, et al. (2008) Endogenous VEGF is required for visual function: Evidence for a survival role on muller cells and photoreceptors. PLoS One 3:e3554.
15. Shima DT, et al. (1996) The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit and characterization of transcriptional and post-transcriptional regulatory sequences. J Biol Chem 271:3877-3883.
16. Carmeliet P, et al. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med 5:495-502.
17. Ng Y-S, Rohan R, Sunday M, deMello DE, D'Amore PA (2001) Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 220:112-121.
18. deMello DE, Reid LM (2000) Embryonic and early fetal development of human lung vasculature and its functional implications. Pediatr Dev Pathol 3:439-449.
19. Saint-Geniez M, Maldonado AE, D'Amore PA (2006) VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci 47:3135-3142.
20. Blaauwgeers HG, et al. (1999) Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. Am J Pathol 155:421-428.
21. Kannan R, et al. (2006) Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol Vis 12:1649-1659.
22. Ikeda Y, et al. (2006) The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium. Exp Eye Res 83:1031-1040.
23. Delori FC, Fleckner MR, Goger DG, Weiter JJ, Dorey CK (2000) Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci 41:496-504.
24. Dunaief JL, Dentchev T, Ying GS, Milam AH (2002) The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 120:1435-1442.
25. Li J, Tso MO, Lam TT (2001) Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration. Br J Ophthalmol 85:287-290.
26. Rizzolo LJ (2007) Development and role of tight junctions in the retinal pigment epithe-lium. Int Rev Cytol 258:195-234.
27. Konari K, et al. (1995) Development of the blood-retinal barrier in vitro: Formation of tight junctions as revealed by occludin and ZO-1 correlates with the barrier function of chick retinal pigment epithelial cells. Exp Eye Res 61:99-108.
28. Ambati J, Ambati B, Yoo S, Ianchulev S, Adamis A (2003) Age-related macular degen-eration: Etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 48:257-293.
29. Marneros AG, et al. (2005) Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function.AmJ Pathol 167:1451-1459.
30. Ramrattan RS, et al. (1994) Morphometric analysis of Bruch's membrane, the choriocap-illaris, and the choroid in aging. Invest Ophthalmol Vis Sci 35:2857-2864.
31. Moore DJ, Hussain AA, Marshall J (1995) Age-related variation in the hydraulic conductivity of Bruch's membrane. Invest Ophthalmol Vis Sci 36:1290-1297.
32. Bird AC (1992) Bruch's membrane change with age. Br J Ophthalmol 76:166-168.
33. Zarbin MA (2004) Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol 122:598-614.
34. Houssier M, et al. (2008) CD36 deficiency leads to choroidal involution via COX2 down-regulation in rodents. PLoS Med 5:e39.
35. Inai T, et al. (2004) Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 165:35-52.
36. Guerrin M, et al. (1995) Vasculotropin/vascular endothelial growth factor is an autocrine growth factor for human retinal pigment epithelial cells cultured in vitro. J Cell Physiol 64:385-394.
37. Herve MA, Buteau-Lozano H, Mourah S, Calvo F, Perrot-Applanat M (2005) VEGF189 stimulates endothelial cells proliferation and migration in vitro and up-regulates the expression of Flk-1/KDR mRNA. Exp Cell Res 309:24-31.
38. Carmeliet P, et al. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439.