메뉴 건너뛰기




Volumn 16, Issue 10, 2010, Pages 1107-1111

Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; PEGAPTANIB; RANIBIZUMAB; VASCULOTROPIN; VERTEPORFIN; MONOCLONAL ANTIBODY; VASCULOTROPIN A;

EID: 77957764473     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1010-1107     Document Type: Note
Times cited : (180)

References (56)
  • 1
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara, N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev. Cancer 2, 795-803 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 2
    • 0000912662 scopus 로고
    • Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • Ide, A.G., Baker, N.H. & Warren, S.L. Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. AJR Am. J. Roentgenol. 42, 891-899 (1939).
    • (1939) AJR Am. J. Roentgenol. , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 3
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire, G.H., Chalkley, H.W., Legallais, F.Y. & Park, H.D. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J. Natl. Cancer Inst. 6, 73-85 (1945).
    • (1945) J. Natl. Cancer Inst. , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2    Legallais, F.Y.3    Park, H.D.4
  • 4
    • 0000230096 scopus 로고
    • The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders
    • Michaelson, I.C. The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders. Trans. Ophthalmol. Soc. U. K. 68, 137-180 (1948).
    • (1948) Trans. Ophthalmol. Soc. U. K. , vol.68 , pp. 137-180
    • Michaelson, I.C.1
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971).
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 7
  • 8
    • 0022457546 scopus 로고
    • Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor
    • Abraham, J.A. et al. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science 233, 545-548 (1986).
    • (1986) Science , vol.233 , pp. 545-548
    • Abraham, J.A.1
  • 9
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara, N. & Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161, 851-858 (1989).
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 10
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V. & Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306-1309 (1989).
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 11
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck, P.J. et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246, 1309-1312 (1989).
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1
  • 12
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger, D.R. et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983-985 (1983).
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1
  • 13
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck, K.A., Leung, D.W., Rowland, A.M., Winer, J. & Ferrara, N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 267, 26031-26037 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 14
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor isoforms (VEGF): Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park, J.E., Keller, G.-A. & Ferrara, N. The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4, 1317-1326 (1993).
    • (1993) Mol. Biol. Cell , vol.4 , pp. 1317-1326
    • Park, J.E.1    Keller, G.-A.2    Ferrara, N.3
  • 15
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family
    • Shibuya, M. et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family. Oncogene 5, 519-527 (1990).
    • (1990) Oncogene , vol.5 , pp. 519-527
    • Shibuya, M.1
  • 16
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • de Vries, C. et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255, 989-991 (1992).
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1
  • 17
    • 0026702970 scopus 로고
    • Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
    • Terman, B.I. et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187, 1579-1586 (1992).
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 1579-1586
    • Terman, B.I.1
  • 18
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: Insights from physiological angiogenesis
    • Chung, A.S., Lee, J. & Ferrara, N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat. Rev. Cancer 10, 505-514 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 19
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim, K.J. et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362, 841-844 (1993).
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1
  • 20
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta, L.G. et al. Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57, 4593-4599 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 4593-4599
    • Presta, L.G.1
  • 21
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N., Hillan, K.J., Gerber, H.P. & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3, 391-400 (2004).
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 22
    • 0029790466 scopus 로고    scopus 로고
    • The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade
    • Davis-Smyth, T., Chen, H., Park, J., Presta, L.G. & Ferrara, N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15, 4919-4927 (1996).
    • (1996) EMBO J. , vol.15 , pp. 4919-4927
    • Davis-Smyth, T.1    Chen, H.2    Park, J.3    Presta, L.G.4    Ferrara, N.5
  • 23
    • 0032931234 scopus 로고    scopus 로고
    • VEGF is required for growth and survival in neonatal mice
    • Gerber, H.P. et al. VEGF is required for growth and survival in neonatal mice. Development 126, 1149-1159 (1999).
    • (1999) Development , vol.126 , pp. 1149-1159
    • Gerber, H.P.1
  • 24
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber, H.P. et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5, 623-628 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 623-628
    • Gerber, H.P.1
  • 25
    • 0031940839 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is essential for corpus luteum angiogenesis
    • Ferrara, N. et al. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat. Med. 4, 336-340 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 336-340
    • Ferrara, N.1
  • 26
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996).
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1
  • 27
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439 (1996).
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1
  • 28
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki, D., Itin, A., Soffer, D. & Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845 (1992).
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 29
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480-1487 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1480-1487
    • Aiello, L.P.1
  • 30
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with prolif-erative diabetic retinopathy
    • Adamis, A.P. et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with prolif-erative diabetic retinopathy. Am. J. Ophthalmol. 118, 445-450 (1994).
    • (1994) Am. J. Ophthalmol. , vol.118 , pp. 445-450
    • Adamis, A.P.1
  • 31
    • 0029879849 scopus 로고    scopus 로고
    • Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neo-vascular membranes
    • Lopez, P.F., Sippy, B.D., Lambert, H.M., Thach, A.B. & Hinton, D.R. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neo-vascular membranes. Invest. Ophthalmol. Vis. Sci. 37, 855-868 (1996).
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 855-868
    • Lopez, P.F.1    Sippy, B.D.2    Lambert, H.M.3    Thach, A.B.4    Hinton, D.R.5
  • 32
    • 0029831672 scopus 로고    scopus 로고
    • Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothe-lial growth factor
    • Kvanta, A., Algvere, P.V., Berglin, L. & Seregard, S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothe-lial growth factor. Invest. Ophthalmol. Vis. Sci. 37, 1929-1934 (1996).
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 1929-1934
    • Kvanta, A.1    Algvere, P.V.2    Berglin, L.3    Seregard, S.4
  • 34
    • 0028786651 scopus 로고
    • Suppression of retinal neovascular-ization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello, L.P. et al. Suppression of retinal neovascular-ization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA 92, 10457-10461 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1
  • 35
    • 0030067257 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate
    • Adamis, A.P. et al. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch. Ophthalmol. 114, 66-71 (1996).
    • (1996) Arch. Ophthalmol. , vol.114 , pp. 66-71
    • Adamis, A.P.1
  • 36
    • 0242456167 scopus 로고    scopus 로고
    • Ocular neovascu-larization: A valuable model system
    • Campochiaro, P.A. & Hackett, S.F. Ocular neovascu-larization: a valuable model system. Oncogene 22, 6537-6548 (2003).
    • (2003) Oncogene , vol.22 , pp. 6537-6548
    • Campochiaro, P.A.1    Hackett, S.F.2
  • 37
    • 0021752680 scopus 로고
    • Age-related macular degeneration and blindness due to neovascu-lar maculopathy
    • Ferris, F.L., III, Fine, S.L. & Hyman, L. Age-related macular degeneration and blindness due to neovascu-lar maculopathy. Arch. Ophthalmol. 102, 1640-1642 (1984).
    • (1984) Arch. Ophthalmol. , vol.102 , pp. 1640-1642
    • Ferris, F.L.1    Iii Fine, S.L.2    Hyman, L.3
  • 38
    • 33749632278 scopus 로고    scopus 로고
    • Developmemt of Ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Ferrara, N., Damico, L., Shams, N., Lowman, H. & Kim, R. Developmemt of Ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 26, 859-870 (2006).
    • (2006) Retina , vol.26 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3    Lowman, H.4    Kim, R.5
  • 39
    • 0029731813 scopus 로고    scopus 로고
    • Fc receptors and their interactions with immunoglobulins
    • Raghavan, M. & Bjorkman, P.J. Fc receptors and their interactions with immunoglobulins. Annu. Rev. Cell Dev. Biol. 12, 181-220 (1996).
    • (1996) Annu. Rev. Cell Dev. Biol. , vol.12 , pp. 181-220
    • Raghavan, M.1    Bjorkman, P.J.2
  • 40
    • 0033527584 scopus 로고    scopus 로고
    • Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen
    • Chen, Y. et al. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J. Mol. Biol. 293, 865-881 (1999).
    • (1999) J. Mol. Biol. , vol.293 , pp. 865-881
    • Chen, Y.1
  • 41
    • 0036129304 scopus 로고    scopus 로고
    • Prevention of experimental chor-oidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    • Krzystolik, M.G. et al. Prevention of experimental chor-oidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120, 338-346 (2002).
    • (2002) Arch. Ophthalmol. , vol.120 , pp. 338-346
    • Krzystolik, M.G.1
  • 42
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld, P.J. et al. Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1419-1431 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1
  • 43
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown, D.M. et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1432-1444 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1432-1444
    • Brown, D.M.1
  • 44
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin pho-todynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • Brown, D.M. et al. Ranibizumab versus verteporfin pho-todynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology 116, 57-65 (2009).
    • (2009) Ophthalmology , vol.116 , pp. 57-65
    • Brown, D.M.1
  • 45
    • 77952889477 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following central retinal vein occlusion: Six-month primary end point results of a phase III study
    • Brown, D.M. et al. Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 117, 1124-1133 (2010).
    • (2010) Ophthalmology , vol.117 , pp. 1124-1133
    • Brown, D.M.1
  • 46
    • 77952891051 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following branch retinal vein occlusion: Six-month primary end point results of a phase III study
    • Campochiaro, P.A. et al. Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 117, 1102-1112 (2010)
    • (2010) Ophthalmology , vol.117 , pp. 1102-1112
    • Campochiaro, P.A.1
  • 47
    • 0342632445 scopus 로고    scopus 로고
    • Photodynamic therapy of subfoveal choroidal neovas-cularization in age-related macular degeneration with verteporfin. one-year results of 2 randomized clinical trials\TAP Report 1
    • Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group
    • Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovas-cularization in age-related macular degeneration with verteporfin. one-year results of 2 randomized clinical trials\TAP Report 1. Arch. Ophthalmol. 117, 1329-1345 (1999).
    • (1999) Arch. Ophthalmol. , vol.117 , pp. 1329-1345
  • 49
    • 33746257413 scopus 로고    scopus 로고
    • Permeability properties of tumor surrogate blood vessels induced by VEGF-A
    • Nagy, J.A. et al. Permeability properties of tumor surrogate blood vessels induced by VEGF-A. Lab. Invest. 86, 767-780 (2006).
    • (2006) Lab. Invest. , vol.86 , pp. 767-780
    • Nagy, J.A.1
  • 51
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan, F. et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl. Acad. Sci. USA 93, 14765-14770 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14765-14770
    • Yuan, F.1
  • 52
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin, L.E., Golijanin, D., Itin, A., Pode, D. & Keshet, E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103, 159-165 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 53
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58-62 (2005).
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 54
    • 77957804396 scopus 로고    scopus 로고
    • Neovascular (exudative) age-related macular degeneration
    • (ed. Ryan, S.J.) Elsevier/Mosby Macular Photocoagulation Study Group
    • Bressler, N.M., Bressler, S.B. & Fine, S.L. Neovascular (exudative) age-related macular degeneration. in Retina vol. 2 (ed. Ryan, S.J.) 1075-1113 (Elsevier/Mosby, 2006), Macular Photocoagulation Study Group.
    • (2006) Retina , vol.2 , pp. 1075-1113
    • Bressler, N.M.1    Bressler, S.B.2    Fine, S.L.3
  • 55
    • 0025776268 scopus 로고
    • Subfoveal neo-vascular lesions in age-related macular degeneration
    • Macular Photocoagulation Study Group. Subfoveal neo-vascular lesions in age-related macular degeneration. Arch. Opthalmol. 109, 1242-1257 (1991).
    • (1991) Arch. Opthalmol. , vol.109 , pp. 1242-1257
  • 56
    • 77649096200 scopus 로고    scopus 로고
    • Binding to the extracellular matrix and pro-teolytic processing: Two key mechanisms regulating vascular endothelial growth factor action
    • Ferrara, N. Binding to the extracellular matrix and pro-teolytic processing: two key mechanisms regulating vascular endothelial growth factor action. Mol. Biol. Cell 21, 687-690 (2010).
    • (2010) Mol. Biol. Cell , vol.21 , pp. 687-690
    • Ferrara, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.