메뉴 건너뛰기




Volumn 141, Issue 1, 2010, Pages 166-177

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

Author keywords

Cellcycle; Humdisease

Indexed keywords

ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PLACENTA GROWTH FACTOR ANTIBODY; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR 1;

EID: 77950953984     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2010.01.033     Document Type: Article
Times cited : (142)

References (50)
  • 1
    • 0141721621 scopus 로고    scopus 로고
    • Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
    • Autiero M., Luttun A., Tjwa M., Carmeliet P. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J. Thromb. Haemost. 2003, 1:1356-1370.
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 1356-1370
    • Autiero, M.1    Luttun, A.2    Tjwa, M.3    Carmeliet, P.4
  • 2
    • 11144356721 scopus 로고    scopus 로고
    • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    • Avecilla S.T., Hattori K., Heissig B., Tejada R., Liao F., Shido K., Jin D.K., Dias S., Zhang F., Hartman T.E., et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat. Med. 2004, 10:64-71.
    • (2004) Nat. Med. , vol.10 , pp. 64-71
    • Avecilla, S.T.1    Hattori, K.2    Heissig, B.3    Tejada, R.4    Liao, F.5    Shido, K.6    Jin, D.K.7    Dias, S.8    Zhang, F.9    Hartman, T.E.10
  • 3
    • 13344259980 scopus 로고    scopus 로고
    • Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR
    • Cao Y., Chen H., Zhou L., Chiang M.K., Anand-Apte B., Weatherbee J.A., Wang Y., Fang F., Flanagan J.G., Tsang M.L. Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J. Biol. Chem. 1996, 271:3154-3162.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3154-3162
    • Cao, Y.1    Chen, H.2    Zhou, L.3    Chiang, M.K.4    Anand-Apte, B.5    Weatherbee, J.A.6    Wang, Y.7    Fang, F.8    Flanagan, J.G.9    Tsang, M.L.10
  • 5
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P., Moons L., Luttun A., Vincenti V., Compernolle V., De Mol M., Wu Y., Bono F., Devy L., Beck H., et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 2001, 7:575-583.
    • (2001) Nat. Med. , vol.7 , pp. 575-583
    • Carmeliet, P.1    Moons, L.2    Luttun, A.3    Vincenti, V.4    Compernolle, V.5    De Mol, M.6    Wu, Y.7    Bono, F.8    Devy, L.9    Beck, H.10
  • 6
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O., Hicklin D.J., Bergers G., Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8:299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 8
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • Clynes R.A., Towers T.L., Presta L.G., Ravetch J.V. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat. Med. 2000, 6:443-446.
    • (2000) Nat. Med. , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 9
    • 0029790466 scopus 로고    scopus 로고
    • The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade
    • Davis-Smyth T., Chen H., Park J., Presta L.G., Ferrara N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 1996, 15:4919-4927.
    • (1996) EMBO J. , vol.15 , pp. 4919-4927
    • Davis-Smyth, T.1    Chen, H.2    Park, J.3    Presta, L.G.4    Ferrara, N.5
  • 10
    • 70349280375 scopus 로고    scopus 로고
    • VEGFR1-activity-independent metastasis formation
    • Dawson M.R., Duda D.G., Fukurama D., Jain R.K. VEGFR1-activity-independent metastasis formation. Nature 2009, 461:E4-E5.
    • (2009) Nature , vol.461
    • Dawson, M.R.1    Duda, D.G.2    Fukurama, D.3    Jain, R.K.4
  • 11
    • 70349464463 scopus 로고    scopus 로고
    • VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation
    • Dawson M.R., Duda D.G., Chae S.S., Fukumura D., Jain R.K. VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation. PLoS ONE 2009, 4:e6525.
    • (2009) PLoS ONE , vol.4
    • Dawson, M.R.1    Duda, D.G.2    Chae, S.S.3    Fukumura, D.4    Jain, R.K.5
  • 12
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 2008, 8:579-591.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 13
    • 17044441694 scopus 로고    scopus 로고
    • Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
    • Eriksson A., Cao R., Pawliuk R., Berg S.M., Tsang M., Zhou D., Fleet C., Tritsaris K., Dissing S., Leboulch P., et al. Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers. Cancer Cell 2002, 1:99-108.
    • (2002) Cancer Cell , vol.1 , pp. 99-108
    • Eriksson, A.1    Cao, R.2    Pawliuk, R.3    Berg, S.M.4    Tsang, M.5    Zhou, D.6    Fleet, C.7    Tritsaris, K.8    Dissing, S.9    Leboulch, P.10
  • 14
    • 77549088772 scopus 로고    scopus 로고
    • Pathways mediating VEGF-independent tumor angiogenesis
    • Ferrara N. Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev. 2010, 21:21-26.
    • (2010) Cytokine Growth Factor Rev. , vol.21 , pp. 21-26
    • Ferrara, N.1
  • 17
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat. Med. 2003, 9:669-676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 18
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N., Hillan K.J., Gerber H.P., Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 2004, 3:391-400.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 20
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
    • Fischer C., Mazzone M., Jonckx B., Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?. Nat. Rev. Cancer 2008, 8:942-956.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jonckx, B.3    Carmeliet, P.4
  • 21
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G.H., Rossant J., Gertsenstein M., Breitman M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995, 376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 22
    • 0033708398 scopus 로고    scopus 로고
    • Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor
    • Gerber H.P., Kowalski J., Sherman D., Eberhard D.A., Ferrara N. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res. 2000, 60:6253-6258.
    • (2000) Cancer Res. , vol.60 , pp. 6253-6258
    • Gerber, H.P.1    Kowalski, J.2    Sherman, D.3    Eberhard, D.A.4    Ferrara, N.5
  • 23
    • 0034703022 scopus 로고    scopus 로고
    • Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165
    • Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165. J. Biol. Chem. 2000, 275:29922.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29922
    • Gluzman-Poltorak, Z.1    Cohen, T.2    Herzog, Y.3    Neufeld, G.4
  • 24
    • 0036344496 scopus 로고    scopus 로고
    • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    • Hattori K., Heissig B., Wu Y., Dias S., Tejada R., Ferris B., Hicklin D.J., Zhu Z., Bohlen P., Witte L., et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat. Med. 2002, 8:841-849.
    • (2002) Nat. Med. , vol.8 , pp. 841-849
    • Hattori, K.1    Heissig, B.2    Wu, Y.3    Dias, S.4    Tejada, R.5    Ferris, B.6    Hicklin, D.J.7    Zhu, Z.8    Bohlen, P.9    Witte, L.10
  • 25
    • 0035114105 scopus 로고    scopus 로고
    • Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    • Hiratsuka S., Maru Y., Okada A., Seiki M., Noda T., Shibuya M. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res. 2001, 61:1207-1213.
    • (2001) Cancer Res. , vol.61 , pp. 1207-1213
    • Hiratsuka, S.1    Maru, Y.2    Okada, A.3    Seiki, M.4    Noda, T.5    Shibuya, M.6
  • 26
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka S., Minowa O., Kuno J., Noda T., Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 1998, 95:9349-9354.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 31
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel R.S. Tumor angiogenesis. N. Engl. J. Med. 2008, 358:2039-2049.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 33
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim K.J., Li B., Winer J., Armanini M., Gillett N., Phillips H.S., Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993, 362:841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 34
    • 33644863498 scopus 로고    scopus 로고
    • Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
    • Liang W.C., Wu X., Peale F.V., Lee C.V., Meng Y.G., Gutierrez J., Fu L., Malik A.K., Gerber H.P., Ferrara N., et al. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J. Biol. Chem. 2006, 281:951-961.
    • (2006) J. Biol. Chem. , vol.281 , pp. 951-961
    • Liang, W.C.1    Wu, X.2    Peale, F.V.3    Lee, C.V.4    Meng, Y.G.5    Gutierrez, J.6    Fu, L.7    Malik, A.K.8    Gerber, H.P.9    Ferrara, N.10
  • 35
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    • Luttun A., Tjwa M., Moons L., Wu Y., Angelillo-Scherrer A., Liao F., Nagy J.A., Hooper A., Priller J., De Klerck B., et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 2002, 8:831-840.
    • (2002) Nat. Med. , vol.8 , pp. 831-840
    • Luttun, A.1    Tjwa, M.2    Moons, L.3    Wu, Y.4    Angelillo-Scherrer, A.5    Liao, F.6    Nagy, J.A.7    Hooper, A.8    Priller, J.9    De Klerck, B.10
  • 36
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • Lyden D., Hattori K., Dias S., Costa C., Blaikie P., Butros L., Chadburn A., Heissig B., Marks W., Witte L., et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 2001, 7:1194-1201.
    • (2001) Nat. Med. , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3    Costa, C.4    Blaikie, P.5    Butros, L.6    Chadburn, A.7    Heissig, B.8    Marks, W.9    Witte, L.10
  • 37
  • 38
    • 0037025311 scopus 로고    scopus 로고
    • Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain
    • Mamluk R., Gechtman Z., Kutcher M.E., Gasiunas N., Gallagher J., Klagsbrun M. Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain. J. Biol. Chem. 2002, 277:24818-24825.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24818-24825
    • Mamluk, R.1    Gechtman, Z.2    Kutcher, M.E.3    Gasiunas, N.4    Gallagher, J.5    Klagsbrun, M.6
  • 40
    • 33748703844 scopus 로고    scopus 로고
    • Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages
    • Murakami M., Iwai S., Hiratsuka S., Yamauchi M., Nakamura K., Iwakura Y., Shibuya M. Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages. Blood 2006, 108:1849-1856.
    • (2006) Blood , vol.108 , pp. 1849-1856
    • Murakami, M.1    Iwai, S.2    Hiratsuka, S.3    Yamauchi, M.4    Nakamura, K.5    Iwakura, Y.6    Shibuya, M.7
  • 43
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park J.E., Chen H.H., Winer J., Houck K.A., Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 1994, 269:25646-25654.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 44
    • 0035910392 scopus 로고    scopus 로고
    • Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor
    • Samuelsson A., Towers T.L., Ravetch J.V. Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science 2001, 291:484-486.
    • (2001) Science , vol.291 , pp. 484-486
    • Samuelsson, A.1    Towers, T.L.2    Ravetch, J.V.3
  • 45
    • 36349030423 scopus 로고    scopus 로고
    • Placental growth factor-1 attenuates vascular endothelial growth factor-A-dependent tumor angiogenesis during beta cell carcinogenesis
    • Schomber T., Kopfstein L., Djonov V., Albrecht I., Baeriswyl V., Strittmatter K., Christofori G. Placental growth factor-1 attenuates vascular endothelial growth factor-A-dependent tumor angiogenesis during beta cell carcinogenesis. Cancer Res. 2007, 67:10840-10848.
    • (2007) Cancer Res. , vol.67 , pp. 10840-10848
    • Schomber, T.1    Kopfstein, L.2    Djonov, V.3    Albrecht, I.4    Baeriswyl, V.5    Strittmatter, K.6    Christofori, G.7
  • 46
    • 0035003384 scopus 로고    scopus 로고
    • Structure and function of VEGF/VEGF-receptor system involved in angiogenesis
    • Shibuya M. Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct. Funct. 2001, 26:25-35.
    • (2001) Cell Struct. Funct. , vol.26 , pp. 25-35
    • Shibuya, M.1
  • 48
    • 33747498714 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma
    • Wu Y., Hooper A.T., Zhong Z., Witte L., Bohlen P., Rafii S., Hicklin D.J. The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma. Int. J. Cancer 2006, 119:1519-1529.
    • (2006) Int. J. Cancer , vol.119 , pp. 1519-1529
    • Wu, Y.1    Hooper, A.T.2    Zhong, Z.3    Witte, L.4    Bohlen, P.5    Rafii, S.6    Hicklin, D.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.