Angiogenesis-independent endothelial protection of liver: Role of VEGFR-1

Science

Volumn 299, Issue 5608, 2003, Pages 890-893

  LeCouter, Jennifer ^a   Moritz, Dirk R ^a,b   Li, Bing ^a   Phillips, Gail Lewis ^a   Liang, Xiao Huan ^a   Gerber, Hans Peter ^a   Hillan, Kenneth J ^a   Ferraral, Napoleone ^a  

^a GENENTECH INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; TISSUE;

HOMEOSTASIS;

ANGIOGRAPHY;

BASIC FIBROBLAST GROWTH FACTOR; CARBON TETRACHLORIDE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; SCATTER FACTOR; TOXIN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 1 AGONIST;

BIOLOGY;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CHO CELL; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER; LIVER CELL; LIVER DISEASE; LIVER INJURY; LIVER PROTECTION; LIVER SINUSOID; LIVER TUMOR; MOUSE; NONHUMAN; NUDE MOUSE; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VASCULAR ENDOTHELIUM;

ANIMALS; CARBON TETRACHLORIDE; CELL DIVISION; CELLS, CULTURED; CHO CELLS; COCULTURE TECHNIQUES; CRICETINAE; DNA REPLICATION; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; LIVER DISEASES; LIVER REGENERATION; LYMPHOKINES; MICE; MICE, NUDE; MITOSIS; MUTATION; NECROSIS; NEOVASCULARIZATION, PHYSIOLOGIC; PARACRINE COMMUNICATION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; MUS MUSCULUS;

EID: 0037423321     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079562     Document Type: Article

References (33)

1. N. Simionescu, M. Simionescu, Endothelial Cell Dysfunctions (Plenum, New York, 1992).
2. K. Matsumoto, H. Yoshitomi, J. Rossant, K. S. Zaret, Science 294, 559 (2001).
3. E. Lammert, O. Cleaver, D. Melton, Science 294, S64 (2001).
4. D. W. Leung, G. Cachianes, W. J. Kuang, D. V. Goeddel, N. Ferrara, Science 246, 1306 (1989).
5. C. de Vries et al., Science 255, 989 (1992).
6. B. I. Terman et al., Biochem. Biophys. Res. Commun. 187, 1579 (1992).
7. T. P. Quinn, K. G., Peters, C. De Vries, N. Ferrara, L. T. Williams, Proc. Natl. Acad. Sci. U.S.A. 90, 7533 (1993).
8. N. Ferrara, T. Davis-Smyth, Endocr. Rev. 18, 4 (1997).
9. J. E. Park, H. H. Chen, J. Winer, K. A. Houck, N. Ferrara, J. Biol. Chem. 269 25646 (1994).
10. H. Zeng, H. F. Dvorak, D. Mukhopadhyay, J. Biol. Chem. 276, 26969 (2001).
11. H. Gille et al., EMBO J. 19, 4064 (2000).
12. B. Barleon et al., Blood 87, 3336 (1996).
13. D. Lyden et al., Nature Med. 7, 1194 (2001).
14. H.-P. Gerber et al., Nature 417, 954 (2002).
15. A. Luttun et al., Nature Med. 8, 831 (2002).
16. See supporting data on Science Online.
17. J. LeCouter et al., data not shown.
18. N. Ferrara, K. Alitato, Nature Med. 5, 1359 (1999).
19. H. Gille et al., J. Biol. Chem. 276, 3222 (2001).
20. S. Ogawa et al., J. Biol. Chem. 273, 31273 (1998).
21. L. B. Jakeman, J. Winer, G. L. Bennett, C. A. Altar, N. Ferrara, J. Clin. Invest. 89, 244 (1992).
22. A. Yamane et al., Oncogene 9, 2683 (1994).
23. J. J. Maher, J. Clin. Invest. 91, 2244 (1993).
24. G. K. Michalopoulos, M. C. DeFrances, Science 276, 60 (1997).
25. Y. Baruch, G. Shoshany, G. Neufeld, R. Enat, J. Hepatol. 23, 328 (1995).
26. C. Jhappan et al., Cell 61, 1137 (1990).
27. D. E. Cressman et al., Science 274, 1379 (1996).
28. K. Suzuma et al., J. Biol. Chem. 275, 40725 (2000).
29. N. Ito et al., Biochem. Biophys. Res. Commun. 198, 25 (1994).
30. S. Kliche, J. Waltenberger, IUBMB Life 52, 61 (2001).
31. J. LeCouter et al., unpublished data.
32. J. LeCouter et al., Nature 412, 877 (2001).
33. We thank C. Crowley for transfected CHO cells; B. Moffat for purification of VEGF mutants; J. Harris. J. Kowalski, L. DeGuzman, Y. Li, and M. van Hoy for animal studies; B. Wright for immunohistochemistry; G. Meng for enzyme-linked immunosorbent assay; R. Schwall for HGF antibodies; the Genentech Clinical Pathology lab for serum analysis; E. Stoelting for artwork; and G. Frantz and F. Peale for early in situ hybridization and morphological studies.