메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

(19)  Li, Xiujuan a   Padhan, Narendra a   Sjöström, Elisabet O a   Roche, Francis P a   Testini, Chiara a   Honkura, Naoki a   Sáinz Jaspeado, Miguel a   Gordon, Emma a   Bentley, Katie a,b   Philippides, Andrew c   Tolmachev, Vladimir a   Dejana, Elisabetta a,d   Stan, Radu V e   Vestweber, Dietmar f   Ballmer Hofer, Kurt g   Betsholtz, Christer a,h   Pietras, Kristian i   Jansson, Leif j   Claesson Welsh, Lena a  


Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TEMOZOLOMIDE; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN RECEPTOR; CADHERIN; LEUKOCYTE ANTIGEN; MICROSPHERE; PROTEIN KINASE P60; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; VEGFR2 PROTEIN, MOUSE;

EID: 84962295137     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11017     Document Type: Article
Times cited : (115)

References (48)
  • 1
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • Baluk, P., Hashizume, H. & McDonald, D. M. Cellular abnormalities of blood vessels as targets in cancer. Curr. Opin. Genet. Dev. 15, 102-111 (2005).
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 102-111
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 2
    • 34547124062 scopus 로고    scopus 로고
    • Hypoxia: A key regulator of angiogenesis in cancer
    • Liao, D. & Johnson, R. S. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 26, 281-290 (2007).
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 281-290
    • Liao, D.1    Johnson, R.S.2
  • 3
    • 48049094159 scopus 로고    scopus 로고
    • The role of adherens junctions and VE-cadherin in the control of vascular permeability
    • Dejana, E., Orsenigo, F. & Lampugnani, M. G. The role of adherens junctions and VE-cadherin in the control of vascular permeability. J. Cell Sci. 121, 2115-2122 (2008).
    • (2008) J. Cell Sci. , vol.121 , pp. 2115-2122
    • Dejana, E.1    Orsenigo, F.2    Lampugnani, M.G.3
  • 4
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • Goel, S. et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol. Rev. 91, 1071-1121 (2011).
    • (2011) Physiol. Rev. , vol.91 , pp. 1071-1121
    • Goel, S.1
  • 5
    • 69349097400 scopus 로고    scopus 로고
    • Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy
    • Ebos, J. M., Lee, C. R. & Kerbel, R. S. Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy. Clin. Cancer Res. 15, 5020-5025 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5020-5025
    • Ebos, J.M.1    Lee, C.R.2    Kerbel, R.S.3
  • 6
    • 79957902010 scopus 로고    scopus 로고
    • Signal transduction by vascular endothelial growth factor receptors
    • Koch, S., Tugues, S., Li, X., Gualandi, L. & Claesson-Welsh, L. Signal transduction by vascular endothelial growth factor receptors. Biochem. J. 437, 169-183 (2011).
    • (2011) Biochem. J. , vol.437 , pp. 169-183
    • Koch, S.1    Tugues, S.2    Li, X.3    Gualandi, L.4    Claesson-Welsh, L.5
  • 7
    • 22744447871 scopus 로고    scopus 로고
    • VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
    • Matsumoto, T. et al. VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J. 24, 2342-2353 (2005).
    • (2005) EMBO J. , vol.24 , pp. 2342-2353
    • Matsumoto, T.1
  • 8
    • 84864292241 scopus 로고    scopus 로고
    • VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd
    • Sun, Z. et al. VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd. J. Exp. Med. 209, 1363-1377 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1363-1377
    • Sun, Z.1
  • 9
    • 0035355472 scopus 로고    scopus 로고
    • A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
    • Takahashi, T., Yamaguchi, S., Chida, K. & Shibuya, M. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20, 2768-2778 (2001).
    • (2001) EMBO J. , vol.20 , pp. 2768-2778
    • Takahashi, T.1    Yamaguchi, S.2    Chida, K.3    Shibuya, M.4
  • 10
    • 12844264070 scopus 로고    scopus 로고
    • Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
    • Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N. & Shibuya, M. Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl Acad. Sci. USA 102, 1076-1081 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1076-1081
    • Sakurai, Y.1    Ohgimoto, K.2    Kataoka, Y.3    Yoshida, N.4    Shibuya, M.5
  • 11
    • 0038023191 scopus 로고    scopus 로고
    • High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
    • Valenzuela, D. M. et al. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat. Biotechnol. 21, 652-659 (2003).
    • (2003) Nat. Biotechnol. , vol.21 , pp. 652-659
    • Valenzuela, D.M.1
  • 12
    • 11144357189 scopus 로고    scopus 로고
    • Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction
    • Weis, S. et al. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. J. Clin. Invest. 113, 885-894 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 885-894
    • Weis, S.1
  • 13
    • 84875241774 scopus 로고    scopus 로고
    • The role of VE-cadherin in vascular morphogenesis and permeability control
    • Dejana, E. & Vestweber, D. The role of VE-cadherin in vascular morphogenesis and permeability control. Prog. Mol. Biol. Transl. Sci. 116, 119-144 (2013).
    • (2013) Prog. Mol. Biol. Transl. Sci. , vol.116 , pp. 119-144
    • Dejana, E.1    Vestweber, D.2
  • 14
    • 0037815292 scopus 로고    scopus 로고
    • VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    • Gerhardt, H. et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161, 1163-1177 (2003).
    • (2003) J. Cell Biol. , vol.161 , pp. 1163-1177
    • Gerhardt, H.1
  • 15
    • 84897536435 scopus 로고    scopus 로고
    • The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis
    • Bentley, K. et al. The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat. Cell. Biol. 16, 309-321 (2014).
    • (2014) Nat. Cell. Biol. , vol.16 , pp. 309-321
    • Bentley, K.1
  • 16
    • 84870798143 scopus 로고    scopus 로고
    • The diaphragms of fenestrated endothelia: Gatekeepers of vascular permeability and blood composition
    • Stan, R. V. et al. The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition. Dev. Cell 23, 1203-1218 (2012).
    • (2012) Dev. Cell , vol.23 , pp. 1203-1218
    • Stan, R.V.1
  • 17
    • 79751525900 scopus 로고    scopus 로고
    • The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?
    • Paolinelli, R., Corada, M., Orsenigo, F. & Dejana, E. The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery? Pharmacol. Res. 63, 165-171 (2011).
    • (2011) Pharmacol. Res. , vol.63 , pp. 165-171
    • Paolinelli, R.1    Corada, M.2    Orsenigo, F.3    Dejana, E.4
  • 18
    • 79151475507 scopus 로고    scopus 로고
    • Experimental immunotherapy for malignant glioma: Lessons from two decades of research in the GL261 model
    • Maes, W. & Van Gool, S. W. Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model. Cancer Immunol. Immunother. 60, 153-160 (2011).
    • (2011) Cancer Immunol. Immunother. , vol.60 , pp. 153-160
    • Maes, W.1    Van Gool, S.W.2
  • 19
    • 78649467527 scopus 로고    scopus 로고
    • Pericytes regulate the blood-brain barrier
    • Armulik, A. et al. Pericytes regulate the blood-brain barrier. Nature 468, 557-561 (2010).
    • (2010) Nature , vol.468 , pp. 557-561
    • Armulik, A.1
  • 20
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
    • Hanahan, D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315, 115-122 (1985).
    • (1985) Nature , vol.315 , pp. 115-122
    • Hanahan, D.1
  • 21
    • 84877629719 scopus 로고    scopus 로고
    • Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
    • Anderberg, C. et al. Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination. J. Exp. Med. 210, 563-579 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 563-579
    • Anderberg, C.1
  • 22
    • 77952275181 scopus 로고    scopus 로고
    • B16 as a mouse model for human melanoma
    • Chapter 20, Unit 20.1
    • Overwijk, W. W. & Restifo, N. P. B16 as a mouse model for human melanoma. Curr. Protoc. Immunol. Chapter 20, Unit 20.1 (2001).
    • (2001) Curr. Protoc. Immunol
    • Overwijk, W.W.1    Restifo, N.P.2
  • 23
    • 0026348557 scopus 로고
    • A simple, dual tracer method for the measurement of transvascular flux of albumin into the lung
    • Graham, M. M. & Evans, M. L. A simple, dual tracer method for the measurement of transvascular flux of albumin into the lung. Microvasc. Res. 42, 266-279 (1991).
    • (1991) Microvasc. Res. , vol.42 , pp. 266-279
    • Graham, M.M.1    Evans, M.L.2
  • 24
    • 84877788239 scopus 로고    scopus 로고
    • VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation
    • Hayashi, M. et al. VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat. Commun. 4, 1672 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 1672
    • Hayashi, M.1
  • 25
    • 0033393771 scopus 로고    scopus 로고
    • Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
    • Eliceiri, B. P. et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell 4, 915-924 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 915-924
    • Eliceiri, B.P.1
  • 26
  • 27
    • 84870688010 scopus 로고    scopus 로고
    • Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo
    • Orsenigo, F. et al. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat. Commun. 3, 1208 (2012).
    • (2012) Nat. Commun. , vol.3 , pp. 1208
    • Orsenigo, F.1
  • 28
    • 84897421093 scopus 로고    scopus 로고
    • NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation
    • Koch, S. et al. NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Dev. Cell 28, 633-646 (2014).
    • (2014) Dev. Cell , vol.28 , pp. 633-646
    • Koch, S.1
  • 29
    • 0026459937 scopus 로고
    • Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels
    • Kohn, S., Nagy, J. A., Dvorak, H. F. & Dvorak, A. M. Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels. Lab. Invest. 67, 596-607 (1992).
    • (1992) Lab. Invest. , vol.67 , pp. 596-607
    • Kohn, S.1    Nagy, J.A.2    Dvorak, H.F.3    Dvorak, A.M.4
  • 30
    • 49949152181 scopus 로고    scopus 로고
    • Vascular permeability, vascular hyperpermeability and angiogenesis
    • Nagy, J. A., Benjamin, L., Zeng, H., Dvorak, A. M. & Dvorak, H. F. Vascular permeability, vascular hyperpermeability and angiogenesis. Angiogenesis 11, 109-119 (2008).
    • (2008) Angiogenesis , vol.11 , pp. 109-119
    • Nagy, J.A.1    Benjamin, L.2    Zeng, H.3    Dvorak, A.M.4    Dvorak, H.F.5
  • 31
    • 0033093483 scopus 로고    scopus 로고
    • Endothelial gaps as sites for plasma leakage in inflammation
    • McDonald, D. M., Thurston, G. & Baluk, P. Endothelial gaps as sites for plasma leakage in inflammation. Microcirculation 6, 7-22 (1999).
    • (1999) Microcirculation , vol.6 , pp. 7-22
    • McDonald, D.M.1    Thurston, G.2    Baluk, P.3
  • 32
    • 0027104066 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors
    • Berse, B., Brown, L. F., Van de Water, L., Dvorak, H. F. & Senger, D. R. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell 3, 211-220 (1992).
    • (1992) Mol. Biol. Cell , vol.3 , pp. 211-220
    • Berse, B.1    Brown, L.F.2    Van De Water, L.3    Dvorak, H.F.4    Senger, D.R.5
  • 33
    • 84862907457 scopus 로고    scopus 로고
    • VEGF-induced vascular permeability is mediated by FAK
    • Chen, X. L. et al. VEGF-induced vascular permeability is mediated by FAK. Dev. Cell 22, 146-157 (2012).
    • (2012) Dev. Cell , vol.22 , pp. 146-157
    • Chen, X.L.1
  • 34
    • 84892894930 scopus 로고    scopus 로고
    • Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function
    • Jean, C. et al. Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J. Cell Biol. 204, 247-263 (2014).
    • (2014) J. Cell Biol. , vol.204 , pp. 247-263
    • Jean, C.1
  • 35
    • 70350433522 scopus 로고    scopus 로고
    • The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo
    • Schleicher, M. et al. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci. Signal. 2, ra41 (2009).
    • (2009) Sci. Signal. , vol.2 , pp. ra41
    • Schleicher, M.1
  • 36
    • 84859487532 scopus 로고    scopus 로고
    • Nitric oxide synthases: Regulation and function
    • 837a-837d
    • Forstermann, U. & Sessa, W. C. Nitric oxide synthases: regulation and function. Eur. Heart J. 33, 829-837 837a-837d (2012).
    • (2012) Eur. Heart J. , vol.33 , pp. 829-837
    • Forstermann, U.1    Sessa, W.C.2
  • 37
    • 10744231084 scopus 로고    scopus 로고
    • Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice
    • Gratton, J. P. et al. Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell 4, 31-39 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 31-39
    • Gratton, J.P.1
  • 38
    • 84912044850 scopus 로고    scopus 로고
    • Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation
    • Manni, S., Kisko, K., Schleier, T., Missimer, J. & Ballmer-Hofer, K. Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation. FASEB J. 28, 4914-4923 (2014).
    • (2014) FASEB J. , vol.28 , pp. 4914-4923
    • Manni, S.1    Kisko, K.2    Schleier, T.3    Missimer, J.4    Ballmer-Hofer, K.5
  • 39
    • 84899463890 scopus 로고    scopus 로고
    • Phosphatases and kinases as regulators of the endothelial barrier function
    • Kuppers, V., Vockel, M., Nottebaum, A. F. & Vestweber, D. Phosphatases and kinases as regulators of the endothelial barrier function. Cell Tissue Res. 355, 577-586 (2014).
    • (2014) Cell Tissue Res. , vol.355 , pp. 577-586
    • Kuppers, V.1    Vockel, M.2    Nottebaum, A.F.3    Vestweber, D.4
  • 40
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers, G. & Hanahan, D. Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer 8, 592-603 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 41
    • 0016824929 scopus 로고
    • Bulk transfer of fluid in the interstitial compartment of mammary tumors
    • Butler, T. P., Grantham, F. H. & Gullino, P. M. Bulk transfer of fluid in the interstitial compartment of mammary tumors. Cancer Res. 35, 3084-3088 (1975).
    • (1975) Cancer Res. , vol.35 , pp. 3084-3088
    • Butler, T.P.1    Grantham, F.H.2    Gullino, P.M.3
  • 42
    • 33749092517 scopus 로고
    • The vascular space of growing tumors
    • Gullino, P. M. & Grantham, F. H. The vascular space of growing tumors. Cancer Res. 24, 1727-1732 (1964).
    • (1964) Cancer Res. , vol.24 , pp. 1727-1732
    • Gullino, P.M.1    Grantham, F.H.2
  • 43
    • 80054935637 scopus 로고    scopus 로고
    • Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability
    • Schulte, D. et al. Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 30, 4157-4170 (2011).
    • (2011) EMBO J. , vol.30 , pp. 4157-4170
    • Schulte, D.1
  • 44
    • 80355142032 scopus 로고    scopus 로고
    • Experimental metastasis assay
    • Mohanty, S. & Xu, L. Experimental metastasis assay. J. Vis. Exp. 42, 1942-1944 (2010).
    • (2010) J. Vis. Exp. , vol.42 , pp. 1942-1944
    • Mohanty, S.1    Xu, L.2
  • 45
    • 84881116481 scopus 로고    scopus 로고
    • Angiopoietin-2 is critical for cytokine-induced vascular leakage
    • Benest, A. V. et al. Angiopoietin-2 is critical for cytokine-induced vascular leakage. PLoS ONE 8, e70459 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e70459
    • Benest, A.V.1
  • 46
    • 0030460592 scopus 로고    scopus 로고
    • Pancreatic islet blood flow in normal and obese-hyperglycemic (ob/ob) mice
    • Carlsson, P. O., Andersson, A. & Jansson, L. Pancreatic islet blood flow in normal and obese-hyperglycemic (ob/ob) mice. Am. J. Physiol. 271, E990-E995 (1996).
    • (1996) Am. J. Physiol. , vol.271 , pp. E990-E995
    • Carlsson, P.O.1    Andersson, A.2    Jansson, L.3
  • 47
    • 0019847044 scopus 로고
    • A rapid method of visualizing the pancreatic islets for studies of islet capillary blood flow using non-radioactive microspheres
    • Jansson, L. & Hellerstrom, C. A rapid method of visualizing the pancreatic islets for studies of islet capillary blood flow using non-radioactive microspheres. Acta Physiol. Scand. 113, 371-374 (1981).
    • (1981) Acta Physiol. Scand. , vol.113 , pp. 371-374
    • Jansson, L.1    Hellerstrom, C.2
  • 48
    • 34249689717 scopus 로고    scopus 로고
    • Implantation site-dependent dysfunction of transplanted pancreatic islets
    • Lau, J. et al. Implantation site-dependent dysfunction of transplanted pancreatic islets. Diabetes 56, 1544-1550 (2007).
    • (2007) Diabetes , vol.56 , pp. 1544-1550
    • Lau, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.