Developmental and pathological angiogenesis

Annual Review of Cell and Developmental Biology

Volumn 27, Issue , 2011, Pages 563-584

  Chung, Alicia S ^a   Ferrara, Napoleone ^a  

^a GENENTECH INC   (United States)

Author keywords

Angiogenic factors; Myeloid cells; Stroma; VEGF

Indexed keywords

MICRORNA; VASCULOTROPIN;

ANGIOGENESIS; ARTERY; ARTICLE; BONE DEVELOPMENT; CARCINOGENESIS; HUMAN; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; REPRODUCTION; TUMOR MICROENVIRONMENT; VASCULARIZATION; VEIN; VERTEBRATE; WOUND HEALING;

ANIMALS; BONE AND BONES; CARDIOVASCULAR SYSTEM; HUMANS; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN ISOFORMS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REPRODUCTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

VERTEBRATA;

EID: 80054012347     PISSN: 10810706     EISSN: 15308995     Source Type: Book Series    
DOI: 10.1146/annurev-cellbio-092910-154002     Document Type: Article

References (180)

1. Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, et al. 1994. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Ophthalmol. 118:445-50 (Pubitemid 24307211)
2. Adamis AP, Shima DT, Tolentino MJ, Gragoudas ES, Ferrara N, et al. 1996. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch. Ophthalmol. 114:66-71 (Pubitemid 26026196)
3. Adams RH, Alitalo K. 2007. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8:464-78 (Pubitemid 46823443)
4. Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, et al. 1999. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13:295-306 (Pubitemid 29095801)
5. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, et al. 1994. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331:1480-87 (Pubitemid 24356306)
6. Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, et al. 1995. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA 92:10457-61
7. Alitalo K, Tammela T, Petrova TV. 2005. Lymphangiogenesis in development and human disease. Nature 438:946-53 (Pubitemid 43093960)
8. Almand B, Clark JI, Nikitina E, Van Beynen J, English NR, et al. 2001. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J. Immunol. 166:678-89 (Pubitemid 32038493)
9. Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. 1995. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. 1:1024-28
10. Armulik A, Genove G, Mae M, Nisancioglu MH, Wallgard E, et al. 2010. Pericytes regulate the blood-brain barrier. Nature 468:557-61
11. Artavanis-Tsakonas S, Rand MD, Lake RJ. 1999. Notch signaling: cell fate control and signal integration in development. Science 284:770-76 (Pubitemid 29291335)
12. Astorga J, Carlsson P. 2007. Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134:3753-61 (Pubitemid 350104384)
13. Bais C, Wu X, Yao J, Yang S, Crawford Y, et al. 2010. PlGF blockade does not inhibit angiogenesis during primary tumor growth. Cell 141:166-77
14. Banks RE, Forbes MA, Kinsey SE, Stanley A, Ingham E, et al. 1998. Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology. Br. J. Cancer 77:956-64 (Pubitemid 28101786)
15. Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H. 2009. The role of vascular endothelial growth factor in wound healing. J. Surg. Res. 153:347-58
16. Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D. 1996. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87:3336-43 (Pubitemid 26115364)
17. Bartel DP. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281-97
18. Benedito R, Roca C, Sorensen I, Adams S, Gossler A, et al. 2009. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 137:1124-35
19. Bentley K, Mariggi G, Gerhardt H, Bates PA. 2009. Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis. PLoS Comput. Biol. 5:e1000549
20. Bhowmick NA, Neilson EG, Moses HL. 2004. Stromal fibroblasts in cancer initiation and progression. Nature 432:332-37 (Pubitemid 39551661)
21. Bingle L, Brown NJ, Lewis CE. 2002. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196:254-65 (Pubitemid 34189413)
22. Blum Y, Belting HG, Ellertsdottir E, Herwig L, Luders F, Affolter M. 2008. Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo. Dev. Biol. 316:312-22
23. Bolos V, Grego-Bessa J, de la Pompa JL. 2007. Notch signaling in development and cancer. Endocr. Rev. 28:339-63 (Pubitemid 46984831)
24. Brock TA, Dvorak HF, Senger DR. 1991. Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am. J. Pathol. 138:213-21
25. Brown DM, Campochiaro PA, Singh RP, Li Z, Gray S, et al. 2010. Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 117:1124-33.
26. Byrd N, Becker S, Maye P, Narasimhaiah R, St-Jacques B, et al, 2002, Hedgehog is required for murine yolk sac angiogenesis, Development. 129, 361-72. (Pubitemid 34863803)
27. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, et al. 1996. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-39 (Pubitemid 26102719)
28. Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, et al. 2001. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7:575-83 (Pubitemid 32448325)
29. Carmeliet P, Ng Y-S, Nuyens D, Theilmeier G, Brusselmans K, et al. 1999. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat. Med. 5:495-502 (Pubitemid 29220207)
30. Chappell JC, Taylor SM, Ferrara N, Bautch VL. 2009. Local guidance of emerging vessel sprouts requires soluble Flt-1. Dev. Cell 17:377-86
31. Chung AS, Lee J, Ferrara N. 2010. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat. Rev. Cancer 10:505-14
32. Coultas L, Chawengsaksophak K, Rossant J. 2005. Endothelial cells and VEGF in vascular development. Nature 438:937-45 (Pubitemid 43093959)
33. Coussens LM, Tinkle CL, Hanahan D, Werb Z. 2000. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103:481-90
34. Crawford Y, Kasman I, Yu L, Zhong C, Wu X, et al. 2009. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 15:21-34
35. Damsky CH, Fisher SJ. 1998. Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors. Curr. Opin. Cell Biol. 10:660-66 (Pubitemid 28477026)
36. Dayan F, Mazure NM, Brahimi-Horn MC, Pouyssegur J. 2008. A dialogue between the hypoxia-inducible factor and the tumor microenvironment. Cancer Microenviron. 1:53-68
37. Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ. 2009. Increased circulatingmyeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol. Immunother. 58:49-59
38. Dong J, Grunstein J, Tejada M, Peale F, Frantz G, et al. 2004. VEGF-null cells require PDGFR αsignalingmediated stromal fibroblast recruitment for tumorigenesis. EMBO J. 23:2800-10 (Pubitemid 39013552)
39. Duarte A, Hirashima M, Benedito R, Trindade A, Diniz P, et al. 2004. Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 18:2474-78 (Pubitemid 39362889)
40. Eklund L, Olsen BR. 2006. Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp. Cell Res. 312:630-41 (Pubitemid 43290339)
41. EmaM, Rossant J. 2003. Cell fate decisions in early blood vessel formation. Trends Cardiovasc. Med. 13:254-59 (Pubitemid 36960174)
42. Ferrara N. 2004. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25:581-611 (Pubitemid 39099316)
43. Ferrara N. 2010a. Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action. Mol. Biol. Cell 21:687-90
44. Ferrara N. 2010b. Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis. Curr. Opin. Hematol. 17:219-24
45. Ferrara N. 2010c. Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat. Med. 16:1107-11
46. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, et al. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439-42 (Pubitemid 26102720)
47. Ferrara N, Chen H, Davis-Smyth T, Gerber HP, Nguyen TN, et al. 1998. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat. Med. 4:336-40 (Pubitemid 28144094)
48. Ferrara N, Damico L, Shams N, Lowman H, Kim R. 2006. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 26:859-70 (Pubitemid 44547437)
49. Ferrara N, Gerber HP, LeCouter J. 2003. The biology of VEGF and its receptors. Nat. Med. 9:669-76 (Pubitemid 36749215)
50. Ferrara N, Kerbel RS. 2005. Angiogenesis as a therapeutic target. Nature 438:967-74 (Pubitemid 43093963)
51. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, et al. 2008. miR-126 regulates angiogenic signaling and vascular integrity. Dev. Cell 15:272-84
52. Flanagan JG, Vanderhaeghen P. 1998. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 21:309-45 (Pubitemid 28150666)
53. Fraisl P, Mazzone M, Schmidt T, Carmeliet P. 2009. Regulation of angiogenesis by oxygen and metabolism. Dev. Cell 16:167-79
54. Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, et al. 2009. Polarization of tumor-associated neutrophil phenotype by TGF-β: "N1" versus "N2" TAN. Cancer Cell 16:183-94
55. Gabrilovich DI, Nagaraj S. 2009. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9:162-74
56. Garner A. 1994. Vascular diseases. In Pathobiology of Ocular Disease, ed. A Garner, GK Klintworth, pp. 1625-710. NewYork: Marcel Dekker
57. Gerber HP, Malik AK, Solar GP, Sherman D, Liang XH, et al. 2002. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417:954-58 (Pubitemid 34716872)
58. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. 1999. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5:623-28 (Pubitemid 29289424)
59. Gerety SS, Wang HU, Chen ZF, Anderson DJ. 1999. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol. Cell 4:403-14 (Pubitemid 29499793)
60. Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, et al. 2003. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161:1163-77 (Pubitemid 36870177)
61. Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR. 2004. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351:2805-16 (Pubitemid 40051904)
62. Grego-Bessa J, Luna-Zurita L, del Monte G, Bolos V, Melgar P, et al. 2007. Notch signaling is essential for ventricular chamber development. Dev. Cell 12:415-29
63. Gustafsson E, Fassler R. 2000. Insights into extracellular matrix functions from mutant mouse models. Exp. Cell Res. 261:52-68
64. Haigh JJ, Gerber HP, Ferrara N, Wagner EF. 2000. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development 127:1445-53 (Pubitemid 30232595)
65. Hazzard TM, Xu F, Stouffer RL. 2002. Injection of soluble vascular endothelial growth factor receptor 1 into the preovulatory follicle disrupts ovulation and subsequent luteal function in rhesus monkeys. Biol. Reprod. 67:1305-12
66. Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, et al. 2001. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J. Cell Biol. 153:543-53 (Pubitemid 34280141)
67. Hendrix MJ, Seftor EA, Hess AR, Seftor RE. 2003. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat. Rev. Cancer 3:411-21 (Pubitemid 37328845)
68. Heryanto B, Girling JE, Rogers PA. 2004. Intravascular neutrophils partially mediate the endometrial endothelial cell proliferative response to estrogen in ovariectomised mice. Reproduction 127:613-20 (Pubitemid 38745079)
69. Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. 1998. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 95:9349-54 (Pubitemid 28506234)
70. Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, et al. 2002. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2:289-300 (Pubitemid 41043963)
71. Hlatky L, Tsionou C, Hahnfeldt P, Coleman CN. 1994. Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression. Cancer Res. 54:6083-86
72. Holderfield MT, Hughes CC. 2008. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-βin vascular morphogenesis. Circ. Res. 102:637-52 (Pubitemid 351457853)
73. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. 1991. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. 5:1806-14
74. Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. 1992. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 267:26031-37 (Pubitemid 23014012)
75. Iruela-Arispe ML, Davis GE. 2009. Cellular and molecular mechanisms of vascular lumen formation. Dev. Cell 16:222-31
76. Jager RD, Mieler WF, Miller JW. 2008. Age-related macular degeneration. N. Engl. J. Med. 358:2606-17
77. Jain RK. 1996. Delivery of molecular medicine to solid tumors. Science 271:1079-80 (Pubitemid 26075221)
78. Jain RK. 2003. Molecular regulation of vessel maturation. Nat. Med. 9:685-93 (Pubitemid 36749217)
79. Jain RK. 2005. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:58-62 (Pubitemid 40093472)
80. Kalluri R, Zeisberg M. 2006. Fibroblasts in cancer. Nat. Rev. Cancer 6:392-401
81. Kamei M, Saunders WB, Bayless KJ, Dye L, Davis GE, Weinstein BM. 2006. Endothelial tubes assemble from intracellular vacuoles in vivo. Nature 442:453-56 (Pubitemid 44264794)
82. Karsenty G. 2003. The complexities of skeletal biology. Nature 423:316-18 (Pubitemid 40852704)
83. Kerbel RS. 2008. Tumor angiogenesis. N. Engl. J. Med. 358:2039-49 (Pubitemid 351656458)
84. Keyt BA, Berleau LT, Nguyen HV, Chen H, Heinsohn H, et al. 1996. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271:7788-95 (Pubitemid 26111064)
85. Kim KJ, Li B, Winer J, Armanini M, Gillett N, et al. 1993. Inhibition of vascular endothelial growth factorinduced angiogenesis suppresses tumour growth in vivo. Nature 362:841-44 (Pubitemid 23132159)
86. Kim VN. 2005. MicroRNA biogenesis: coordinated cropping and dicing. Nat. Rev. Mol. Cell Biol. 6:376-85 (Pubitemid 40637855)
87. Kowanetz M, Wu X, Lee J, Tan M, Hagenbeek T, et al. 2010. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc. Natl. Acad. Sci. USA 107:21248-55
88. Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. 2007. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ. Res. 101:59-68 (Pubitemid 47094624)
89. Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, et al. 2008. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 135:3989-93
90. Kut C, Mac Gabhann F, Popel AS. 2007. Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer. Br. J. Cancer 97:978-85 (Pubitemid 47519292)
91. Kvanta A, Algvere PV, Berglin L, Seregard S. 1996. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Investig. Ophthalmol. Vis. Sci. 37:1929-34 (Pubitemid 26324159)
92. Lavine KJ, Kovacs A, Ornitz DM. 2008. Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J. Clin. Investig. 118:2404-14 (Pubitemid 351952997)
93. Lawson ND, Scheer N, Pham VN, Kim CH, Chitnis AB, et al. 2001. Notch signaling is required for arterialvenous differentiation during embryonic vascular development. Development 128:3675-83 (Pubitemid 32998917)
94. Lawson ND, Vogel AM, Weinstein BM. 2002. sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev. Cell 3:127-36 (Pubitemid 34778401)
95. LeCouter J, Lin R, Tejada M, Frantz G, Peale F, et al. 2003a. The endocrine-gland-derivedVEGFhomologue Bv8 promotes angiogenesis in the testis: localization of Bv8 receptors to endothelial cells. Proc. Natl. Acad. Sci. USA 100:2685-90 (Pubitemid 36297559)
96. LeCouter J, Moritz DR, Li B, Phillips GL, Liang XH, et al. 2003b. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299:890-93 (Pubitemid 36182447)
97. LeCouter J, Zlot C, Tejada M, Peale F, Ferrara N. 2004. Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc. Natl. Acad. Sci. USA 101:16813-18 (Pubitemid 39601321)
98. Lee CY, Vogeli KM, Kim SH, Chong SW, Jiang YJ, et al. 2009. Notch signaling functions as a cell-fate switch between the endothelial and hematopoietic lineages. Curr. Biol. 19:1616-22
99. Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, et al. 2007a. Autocrine VEGF signaling is required for vascular homeostasis. Cell 130:691-703 (Pubitemid 47268059)
100. Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J. Cell Biol. 169:681-91 (Pubitemid 41002860)
101. Lee TH, Seng S, Sekine M, Hinton C, Fu Y, et al. 2007b. Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1. PLoS Med. 4:e186
102. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306-9 (Pubitemid 20066716)
103. Lewis BP, Burge CB, Bartel DP. 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20 (Pubitemid 40094598)
104. Liao D, Johnson RS. 2007. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 26:281-90 (Pubitemid 47101669)
105. Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M. 2010. Autocrine VEGF signaling synergizes with EGFRin tumor cells to promote epithelial cancer development. Cell 140:268-79
106. Lindblom P, Gerhardt H, Liebner S, Abramsson A, Enge M, et al. 2003. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev. 17:1835-40 (Pubitemid 36944561)
107. Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, et al. 2007. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc. Natl. Acad. Sci. USA 104:3219-24 (Pubitemid 46364140)
108. Lopez PF, Sippy BD, Lambert HM, Thach AB, Hinton DR. 1996. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Investig. Ophthalmol. Vis. Sci. 37:855-68
109. Maes C, Stockmans I, Moermans K, Van Looveren R, Smets N, et al. 2004. Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J. Clin. Investig. 113:188-99 (Pubitemid 38544204)
110. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. 2002. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549-55 (Pubitemid 35223554)
111. Martin P, Leibovich SJ. 2005. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 15:599-607 (Pubitemid 41619424)
112. Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ. 1996. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res. 56:3436-40 (Pubitemid 26251633)
113. McCourt M, Wang JH, Sookhai S, Redmond HP. 1999. Proinflammatory mediators stimulate neutrophildirected angiogenesis. Arch. Surg. 134:1325-31
114. Mercurio AM, Bachelder RE, Bates RC, Chung J. 2004. Autocrine signaling in carcinoma: VEGF and the α6β4 integrin. Semin. Cancer Biol. 14:115-22 (Pubitemid 38234753)
115. Metcalf D. 1989. The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 339:27-30 (Pubitemid 19115887)
116. Michaelson IC. 1948. The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders. Trans. Ophthalmol. Soc. U. K. 68:137-80
117. Miller JW, Adamis AP, Shima DT, D'Amore PA, Moulton RS, et al. 1994. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am. J. Pathol. 145:574-84 (Pubitemid 24285965)
118. Mohle R, Green D, Moore MA, Nachman RL, Rafii S. 1997. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc. Natl. Acad. Sci. USA 94:663-68 (Pubitemid 27053690)
119. Mueller MD, Lebovic DI, Garrett E, Taylor RN. 2000. Neutrophils infiltrating the endometrium express vascular endothelial growth factor: potential role in endometrial angiogenesis. Fertil. Steril. 74:107-12 (Pubitemid 30427282)
120. Murdoch C, Muthana M, Coffelt SB, Lewis CE. 2008. The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8:618-31
121. Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen D, et al. 1998. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 97:99-107 (Pubitemid 28036160)
122. Nagy JA, Chang SH, Dvorak AM, Dvorak HF. 2009. Why are tumour blood vessels abnormal and why is it important to know? Br. J. Cancer 100:865-69
123. Nagy JA, Dvorak AM, DvorakHF. 2007. VEGF-A and the induction of pathological angiogenesis. Annu. Rev. Pathol. 2:251-75 (Pubitemid 46448066)
124. Neufeld G, Kessler O. 2008. The semaphorins: versatile regulators of tumour progression and tumour angiogenesis. Nat. Rev. Cancer 8:632-45
125. Nikolic I, Plate KH, Schmidt MH. 2010. EGFL7 meets miRNA-126: an angiogenesis alliance. J. Angiogenes. Res. 2:9
126. Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, et al. 2005. Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation byDelta1/Jagged1-activated Notch1 signaling. J. Biol. Chem. 280:15842-48 (Pubitemid 40616705)
127. Ohtani K, Dimmeler S. 2011. Control of cardiovascular differentiation by microRNAs. Basic Res. Cardiol. 106:5-11
128. Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, et al. 1998. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc. Natl. Acad. Sci. USA 95:11709-14 (Pubitemid 28460479)
129. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, et al. 2005. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-48 (Pubitemid 40692295)
130. Otsuka M, Zheng M, Hayashi M, Lee JD, Yoshino O, et al. 2008. Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J. Clin. Investig. 118:1944-54 (Pubitemid 351632396)
131. Ozaki H, Seo MS, Ozaki K, Yamada H, Yamada E, et al. 2000. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am. J. Pathol. 156:697-707 (Pubitemid 30643824)
132. Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, et al. 2008. Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 10:329-40
133. Park JE, Chen HH, Winer J, Houck KA, Ferrara N. 1994. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 269:25646-54
134. Park JE, Keller G-A, Ferrara N. 1993. The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4:1317-26 (Pubitemid 24045761)
135. Phillips HS, Hains J, Leung DW, Ferrara N. 1990. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology 127:965-67 (Pubitemid 20248145)
136. PietrasK, Pahler J, Bergers G, HanahanD. 2008. Functions of paracrine PDGFsignaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med. 5:e19
137. Pola R, Ling LE, Silver M, Corbley MJ, Kearney M, et al. 2001. Themorphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat. Med. 7:706-11 (Pubitemid 32588027)
138. Psaila B, Lyden D. 2009. The metastatic niche: adapting the foreign soil. Nat. Rev. Cancer 9:285-93
139. Pugh CW, Ratcliffe PJ. 2003. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Semin. Cancer Biol. 13:83-89 (Pubitemid 36269184)
140. Queen MM, Ryan RE, Holzer RG, Keller-Peck CR, Jorcyk CL. 2005. Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression. Cancer Res. 65:8896-904 (Pubitemid 41377379)
141. Ricci-Vitiani L, Pallini R, Biffoni M, Todaro M, Invernici G, et al. 2010. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468:824-28
142. Ruhrberg C, Gerhardt H, Golding M, Watson R, Ioannidou S, et al. 2002. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16:2684-98
143. Sawamiphak S, Seidel S, Essmann CL, Wilkinson GA, Pitulescu ME, et al. 2010. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 465:487-91
144. Schipani E, Maes C, Carmeliet G, Semenza GL. 2009. Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J. Bone Miner. Res. 24:1347-53
145. SchmidtM, Paes K, DeMaziere A, Smyczek T, Yang S, et al. 2007. EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development 134:2913-23 (Pubitemid 47386904)
146. Schultz GS, Wysocki A. 2009. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen. 17:153-62
147. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, et al. 1995. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376:62-66
148. Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI. 2006. TheMyc-dependent angiogenic switch in tumors is mediated by interleukin 1β. Genes Dev. 20:2527-38 (Pubitemid 44396838)
149. Shibuya M. 2006. Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. Angiogenesis 9:225-30
150. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, et al. 1996. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J. Clin. Endocrinol. Metab. 81:3112-18 (Pubitemid 26323917)
151. Shojaei F, Wu X, Malik AK, Zhong C, Baldwin ME, et al. 2007a. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat. Biotechnol. 25:911-20 (Pubitemid 47236916)
152. Shojaei F, Wu X, Qu X, Kowanetz M, Yu L, et al. 2009. G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc. Natl. Acad. Sci. USA 106:6742-47
153. Shojaei F, Wu X, Zhong C, Yu L, Liang XH, et al. 2007b. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450:825-31 (Pubitemid 350231321)
154. Smith SK. 2001. Regulation of angiogenesis in the endometrium. Trends Endocrinol. Metab. 12:147-51 (Pubitemid 33713554)
155. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. 1998. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92:735-45 (Pubitemid 28155313)
156. Strilic B, Kucera T, Eglinger J, Hughes MR, McNagny KM, et al. 2009. The molecular basis of vascular lumen formation in the developing mouse aorta. Dev. Cell 17:505-15
157. Suarez Y, Fernandez-Hernando C, Yu J, Gerber SA, Harrison KD, et al. 2008. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc. Natl. Acad. Sci. USA 105:14082-87
158. Suchting S, Freitas C, leNoble F, Benedito R, Breant C, et al. 2007. TheNotch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl. Acad. Sci. USA 104:3225-30 (Pubitemid 46364141)
159. Tazzyman S, Lewis CE, Murdoch C. 2009. Neutrophils: key mediators of tumour angiogenesis. Int. J. Exp. Pathol. 90:222-31
160. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, et al. 1991. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266:11947-54
161. Tlsty TD, Coussens LM. 2006. Tumor stroma and regulation of cancer development. Annu. Rev. Pathol. 1:119-50
162. Torry DS, Torry RJ. 1997. Angiogenesis and the expression of vascular endothelial growth factor in endometrium and placenta. Am. J. Reprod. Immunol. 37:21-29 (Pubitemid 27075965)
163. Urbich C, Kuehbacher A, Dimmeler S. 2008. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc. Res. 79:581-88
164. Van Rooij E, Marshall WS, Olson EN. 2008. Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ. Res. 103:919-28
165. Vogeli KM, Jin SW, Martin GR, Stainier DY. 2006. A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature 443:337-39 (Pubitemid 44435152)
166. Wang HU, Chen ZF, Anderson DJ. 1998. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93:741-53 (Pubitemid 28257581)
167. Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, et al. 2010a. Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468:829-33
168. Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, et al. 2008. The endothelial-specificmicroRNA miR-126 governs vascular integrity and angiogenesis. Dev. Cell 15:261-71
169. Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, et al. 2010b. Ephrin-B2 controls VEGFinduced angiogenesis and lymphangiogenesis. Nature 465:483-86
170. White AC, Lavine KJ, Ornitz DM. 2007. FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development 134:3743-52 (Pubitemid 350104383)
171. Wu Y, Zhong Z, Huber J, Bassi R, Finnerty B, et al. 2006. Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer. Clin. Cancer Res. 12:6573-84 (Pubitemid 44799733)
172. Xian X, Hakansson J, Stahlberg A, Lindblom P, Betsholtz C, et al. 2006. Pericytes limit tumor cell metastasis. J. Clin. Investig. 116:642-51 (Pubitemid 43326873)
173. Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, et al. 2010. Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res. 70:6139-49
174. Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, et al. 2004. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6:409-21 (Pubitemid 39361441)
175. Yang L, Huang J, Ren X, Gorska AE, Chytil A, et al. 2008. Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13:23-35 (Pubitemid 350309741)
176. Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G. 2005. Dicer is required for embryonic angiogenesis during mouse development. J. Biol. Chem. 280:9330-35 (Pubitemid 40409626)
177. Yao J, Wu X, Zhuang G, Kasman IM, Vogt T, et al. 2011. Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-P1GF antibodies efficacy. Proc. Natl. Acad. Sci. USA 28:11590-95
178. Zelzer E, Glotzer DJ, Hartmann C, Thomas D, Fukai N, et al. 2001. Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech. Dev. 106:97-106 (Pubitemid 32701077)
179. Zhong C, Qu X, Tan M, Meng YG, Ferrara N. 2009. Characterization and regulation of Bv8 in human blood cells. Clin. Cancer Res. 15:2675-84
180. Zhong TP, Childs S, Leu JP, Fishman MC. 2001. Gridlock signalling pathway fashions the first embryonic artery. Nature 414:216-20 (Pubitemid 33051237)