메뉴 건너뛰기




Volumn 59, Issue , 2019, Pages 447-462

Organoids for drug discovery and personalized medicine

Author keywords

Acetylcholine; Drug screening; Lgr5; Organoid; Personalized medicine; Stem cell; Wnt

Indexed keywords

ADULT STEM CELL; CELL DIFFERENTIATION; CHOLINERGIC SYSTEM; CRISPR-CAS9 SYSTEM; DEVELOPMENTAL BIOLOGY; DNA MODIFICATION; DRUG RESEARCH; DRUG SCREENING; ENTEROPATHY; GENE MUTATION; HOMEOSTASIS; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINE TISSUE; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NONHUMAN; ORGANOID; PERSONALIZED MEDICINE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; ANIMAL; CYTOLOGY; DRUG DEVELOPMENT; PROCEDURES;

EID: 85059797550     PISSN: 03621642     EISSN: 15454304     Source Type: Book Series    
DOI: 10.1146/annurev-pharmtox-010818-021108     Document Type: Review
Times cited : (146)

References (138)
  • 1
    • 0000734316 scopus 로고
    • Differentiation in culture of mixed aggregates of dissociated tissue cells
    • Trinkaus JP, Groves PW. 1955. Differentiation in culture of mixed aggregates of dissociated tissue cells. PNAS 41:787-95
    • (1955) PNAS , vol.41 , pp. 787-795
    • Trinkaus, J.P.1    Groves, P.W.2
  • 2
    • 54949102049 scopus 로고    scopus 로고
    • Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals
    • Eiraku M, Watanabe K, Matsuo-Takasaki M, Kawada M, Yonemura S, et al. 2008. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 3:519-32
    • (2008) Cell Stem Cell , vol.3 , pp. 519-532
    • Eiraku, M.1    Watanabe, K.2    Matsuo-Takasaki, M.3    Kawada, M.4    Yonemura, S.5
  • 3
    • 84904396621 scopus 로고    scopus 로고
    • Organogenesis in a dish: Modeling development and disease using organoid technologies
    • Lancaster MA, Knoblich JA. 2014. Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345:1247125
    • (2014) Science , vol.345 , pp. 1247125
    • Lancaster, M.A.1    Knoblich, J.A.2
  • 4
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, et al. 2009. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459:262-65
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3    Van De Wetering, M.4    Barker, N.5
  • 5
    • 84958767810 scopus 로고    scopus 로고
    • Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
    • Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, et al. 2016. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351:1329-33
    • (2016) Science , vol.351 , pp. 1329-1333
    • Howitt, M.R.1    Lavoie, S.2    Michaud, M.3    Blum, A.M.4    Tran, S.V.5
  • 6
    • 84954286513 scopus 로고    scopus 로고
    • Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
    • von Moltke J, Ji M, Liang HE, Locksley RM. 2016. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529:221-25
    • (2016) Nature , vol.529 , pp. 221-225
    • Von Moltke, J.1    Ji, M.2    Liang, H.E.3    Locksley, R.M.4
  • 7
    • 84954561117 scopus 로고    scopus 로고
    • Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
    • Gerbe F, Sidot E, Smyth DJ, Ohmoto M, Matsumoto I, et al. 2016. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529:226-30
    • (2016) Nature , vol.529 , pp. 226-230
    • Gerbe, F.1    Sidot, E.2    Smyth, D.J.3    Ohmoto, M.4    Matsumoto, I.5
  • 8
    • 84872534651 scopus 로고    scopus 로고
    • Cytosystems dynamics in self-organization of tissue architecture
    • Sasai Y. 2013. Cytosystems dynamics in self-organization of tissue architecture. Nature 493:318-26
    • (2013) Nature , vol.493 , pp. 318-326
    • Sasai, Y.1
  • 10
    • 84893169271 scopus 로고    scopus 로고
    • Engineering of three-dimensional microenvi-ronments to promote contractile behavior in primary intestinal organoids
    • DiMarco RL, Su J, Yan KS, Dewi R, Kuo C, et al. 2014. Engineering of three-dimensional microenvi-ronments to promote contractile behavior in primary intestinal organoids. Integr. Biol. 6:127-42
    • (2014) Integr. Biol. , vol.6 , pp. 127-142
    • DiMarco, R.L.1    Su, J.2    Yan, K.S.3    Dewi, R.4    Kuo, C.5
  • 11
    • 84901035061 scopus 로고    scopus 로고
    • Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy
    • Grabinger T, Luks L, Kostadinova F, Zimberlin C, Medema JP, et al. 2014. Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy. Cell Death Dis. 5:e1228
    • (2014) Cell Death Dis. , vol.5 , pp. e1228
    • Grabinger, T.1    Luks, L.2    Kostadinova, F.3    Zimberlin, C.4    Medema, J.P.5
  • 12
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi E, Capecchi MR. 2008. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40:915-20
    • (2008) Nat. Genet. , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 13
    • 80054041585 scopus 로고    scopus 로고
    • A reverse stem cell population in small intestine renders Lgr5-positive cell dispensable
    • Tian H, Biehs B, Warming S, Leong KG, Rangell L, et al. 2011. A reverse stem cell population in small intestine renders Lgr5-positive cell dispensable. Nature 478:255-59
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1    Biehs, B.2    Warming, S.3    Leong, K.G.4    Rangell, L.5
  • 14
    • 84862946094 scopus 로고    scopus 로고
    • The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
    • Yan KS, Chia LA, Li X, Ootani A, Su J, et al. 2012. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. PNAS 109:466-71
    • (2012) PNAS , vol.109 , pp. 466-471
    • Yan, K.S.1    Chia, L.A.2    Li, X.3    Ootani, A.4    Su, J.5
  • 15
    • 84913594397 scopus 로고    scopus 로고
    • Genome editing. the new frontier of genome engineering with CRISPR-Cas9
    • Doudna JA, Charpentier E. 2014. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346:1258096
    • (2014) Science , vol.346 , pp. 1258096
    • Doudna, J.A.1    Charpentier, E.2
  • 16
    • 84990040785 scopus 로고    scopus 로고
    • CRISPR/Cas9-mediated genome editing of mouse small intestinal organoids
    • Schwank G, Clevers H. 2016. CRISPR/Cas9-mediated genome editing of mouse small intestinal organoids. Methods Mol. Biol. 1422:3-11
    • (2016) Methods Mol. Biol. , vol.1422 , pp. 3-11
    • Schwank, G.1    Clevers, H.2
  • 18
    • 85029574202 scopus 로고    scopus 로고
    • Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
    • Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, et al. 2017. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science 358:234-38
    • (2017) Science , vol.358 , pp. 234-238
    • Drost, J.1    Van Boxtel, R.2    Blokzijl, F.3    Mizutani, T.4    Sasaki, N.5
  • 19
    • 84959369430 scopus 로고    scopus 로고
    • Single-cell analysis tools for drug discovery and development
    • Heath JR, Ribas A, Mischel PS. 2016. Single-cell analysis tools for drug discovery and development. Nat. Rev. Drug Discov. 15:204-16
    • (2016) Nat. Rev. Drug Discov. , vol.15 , pp. 204-216
    • Heath, J.R.1    Ribas, A.2    Mischel, P.S.3
  • 20
  • 21
    • 84959091265 scopus 로고    scopus 로고
    • Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes
    • Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, et al. 2016. Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J. Gastroenterol. 51:206-13
    • (2016) J. Gastroenterol. , vol.51 , pp. 206-213
    • Nozaki, K.1    Mochizuki, W.2    Matsumoto, Y.3    Matsumoto, T.4    Fukuda, M.5
  • 22
    • 84867198093 scopus 로고    scopus 로고
    • Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury
    • Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS. 2012. Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science 338:108-13
    • (2012) Science , vol.338 , pp. 108-113
    • Miyoshi, H.1    Ajima, R.2    Luo, C.T.3    Yamaguchi, T.P.4    Stappenbeck, T.S.5
  • 23
    • 84904066077 scopus 로고    scopus 로고
    • Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
    • Li X, Nadauld L, Ootani A, Corney DC, Pai RK, et al. 2014. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat. Med. 20:769-77
    • (2014) Nat. Med. , vol.20 , pp. 769-777
    • Li, X.1    Nadauld, L.2    Ootani, A.3    Corney, D.C.4    Pai, R.K.5
  • 25
    • 84942319402 scopus 로고    scopus 로고
    • HIC1 tumor suppressor loss potentiates TLR2/NF-κB signaling and promotes tissue damage-associated tumorigenesis
    • Janeckova L, Pospichalova V, Fafilek B, Vojtechova M, Tureckova J, et al. 2015. HIC1 tumor suppressor loss potentiates TLR2/NF-κB signaling and promotes tissue damage-associated tumorigenesis. Mol. Cancer Res. 13:1139-48
    • (2015) Mol. Cancer Res. , vol.13 , pp. 1139-1148
    • Janeckova, L.1    Pospichalova, V.2    Fafilek, B.3    Vojtechova, M.4    Tureckova, J.5
  • 26
    • 84934440078 scopus 로고    scopus 로고
    • Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium
    • Kitamura Y, Murata Y, Park JH, Kotani T, Imada S, et al. 2015. Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium. Genes Cells 20:578-89
    • (2015) Genes Cells , vol.20 , pp. 578-589
    • Kitamura, Y.1    Murata, Y.2    Park, J.H.3    Kotani, T.4    Imada, S.5
  • 27
    • 84923172083 scopus 로고    scopus 로고
    • Suppressing TGFβsignaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer
    • Oshima H, Nakayama M, Han TS, Naoi K, Ju X, et al. 2015. Suppressing TGFβsignaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer. Cancer Res. 75:766-76
    • (2015) Cancer Res. , vol.75 , pp. 766-776
    • Oshima, H.1    Nakayama, M.2    Han, T.S.3    Naoi, K.4    Ju, X.5
  • 28
    • 84930823922 scopus 로고    scopus 로고
    • Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity
    • Riemer P, Sreekumar A, Reinke S, Rad R, Schafer R, et al. 2015. Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity. Oncogene 34:3164-75
    • (2015) Oncogene , vol.34 , pp. 3164-3175
    • Riemer, P.1    Sreekumar, A.2    Reinke, S.3    Rad, R.4    Schafer, R.5
  • 29
    • 84928974420 scopus 로고    scopus 로고
    • Prospective derivation of a living organoid biobank of colorectal cancer patients
    • van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, et al. 2015. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161:933-45
    • (2015) Cell , vol.161 , pp. 933-945
    • Van De Wetering, M.1    Francies, H.E.2    Francis, J.M.3    Bounova, G.4    Iorio, F.5
  • 30
    • 84959357347 scopus 로고    scopus 로고
    • Organoids as an in vitro model of human development and disease
    • Fatehullah A, Tan SH, Barker N. 2016. Organoids as an in vitro model of human development and disease. Nat. Cell Biol. 18:246-54
    • (2016) Nat. Cell Biol. , vol.18 , pp. 246-254
    • Fatehullah, A.1    Tan, S.H.2    Barker, N.3
  • 31
    • 84975275212 scopus 로고    scopus 로고
    • Modeling development and disease with organoids
    • Clevers H. 2016. Modeling development and disease with organoids. Cell 165:1586-97
    • (2016) Cell , vol.165 , pp. 1586-1597
    • Clevers, H.1
  • 32
    • 84942121762 scopus 로고    scopus 로고
    • Modeling mouse and human development using organoid cultures
    • Huch M, Koo B-K. 2015. Modeling mouse and human development using organoid cultures. Development 142:3113-25
    • (2015) Development , vol.142 , pp. 3113-3125
    • Huch, M.1    Koo, B.-K.2
  • 33
    • 84910136913 scopus 로고    scopus 로고
    • Three-dimensional organotypic culture: Experimental modelsofmammalian biology and disease
    • Shamir ER, Ewald AJ. 2014. Three-dimensional organotypic culture: experimental modelsofmammalian biology and disease. Nat. Rev. Mol. Cell Biol. 15:647-64
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 647-664
    • Shamir, E.R.1    Ewald, A.J.2
  • 34
    • 85008716319 scopus 로고    scopus 로고
    • Organoids: A historical perspective of thinking in three dimensions
    • Simian M, Bissell MJ. 2017. Organoids: a historical perspective of thinking in three dimensions. J. Cell Biol. 216:31-40
    • (2017) J. Cell Biol. , vol.216 , pp. 31-40
    • Simian, M.1    Bissell, M.J.2
  • 35
    • 84915746977 scopus 로고    scopus 로고
    • Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice
    • Takahashi T, Ohnishi H, Sugiura Y, Honda K, Suematsu M, et al. 2014. Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice. FEBS J. 281:4672-90
    • (2014) FEBS J. , vol.281 , pp. 4672-4690
    • Takahashi, T.1    Ohnishi, H.2    Sugiura, Y.3    Honda, K.4    Suematsu, M.5
  • 36
    • 84941242479 scopus 로고    scopus 로고
    • Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy
    • Mahe MM, Sundaram N, Watson CL, Shroyer NF, Helmrath MA. 2015. Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy. J. Vis. Exp. 97:52483
    • (2015) J. Vis. Exp. , vol.97 , pp. 52483
    • Mahe, M.M.1    Sundaram, N.2    Watson, C.L.3    Shroyer, N.F.4    Helmrath, M.A.5
  • 37
    • 84953350010 scopus 로고    scopus 로고
    • Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease
    • Okamoto R, Watanabe M. 2015. Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J. Gastroenterol. 51:11-21
    • (2015) J. Gastroenterol. , vol.51 , pp. 11-21
    • Okamoto, R.1    Watanabe, M.2
  • 38
    • 84927690290 scopus 로고    scopus 로고
    • The use of murine-derived fundic organoids in studies of gastric physiology
    • Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, et al. 2015. The use of murine-derived fundic organoids in studies of gastric physiology. J. Physiol. 593:1809-27
    • (2015) J. Physiol. , vol.593 , pp. 1809-1827
    • Schumacher, M.A.1    Aihara, E.2    Feng, R.3    Engevik, A.4    Shroyer, N.F.5
  • 39
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield R. 1978. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4:7-25
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 40
    • 31444444485 scopus 로고    scopus 로고
    • The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    • Ohlstein B, Spradling A. 2006. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 439:470-74
    • (2006) Nature , vol.439 , pp. 470-474
    • Ohlstein, B.1    Spradling, A.2
  • 41
    • 31444452338 scopus 로고    scopus 로고
    • Evidence that stem cells reside in the adult Drosophila midgut epithelium
    • Micchelli CA, Perrimon N. 2006. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439:475-79
    • (2006) Nature , vol.439 , pp. 475-479
    • Micchelli, C.A.1    Perrimon, N.2
  • 42
    • 0016325705 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types
    • Cheng H, Leblond CP. 1974. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anat. 141:537-61
    • (1974) Am. J. Anat. , vol.141 , pp. 537-561
    • Cheng, H.1    Leblond, C.P.2
  • 43
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, et al. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449:1003-7
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    Van Es, J.H.2    Kuipers, J.3    Kujala, P.4    Van Den Born, M.5
  • 44
    • 84907487414 scopus 로고    scopus 로고
    • An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
    • Clevers H, Loh KM, Nusse R. 2014. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 346:1248012
    • (2014) Science , vol.346 , pp. 1248012
    • Clevers, H.1    Loh, K.M.2    Nusse, R.3
  • 45
    • 80054857419 scopus 로고    scopus 로고
    • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    • Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, et al. 2011. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 141:1762-72
    • (2011) Gastroenterology , vol.141 , pp. 1762-1772
    • Sato, T.1    Stange, D.E.2    Ferrante, M.3    Vries, R.G.4    Van Es, J.H.5
  • 46
    • 79551686425 scopus 로고    scopus 로고
    • Direct differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, et al. 2011. Direct differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470:105-9
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1    Mayhew, C.N.2    Rankin, S.A.3    Kuhar, M.F.4    Vallance, J.E.5
  • 47
    • 78751644734 scopus 로고    scopus 로고
    • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    • Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, et al. 2011. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469:415-18
    • (2011) Nature , vol.469 , pp. 415-418
    • Sato, T.1    Van Es, J.H.2    Snippert, H.J.3    Stange, D.E.4    Vries, R.G.5
  • 48
    • 84862994618 scopus 로고    scopus 로고
    • MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
    • Yilmaz OH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, et al. 2012. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 486:490-95
    • (2012) Nature , vol.486 , pp. 490-495
    • Yilmaz, O.H.1    Katajisto, P.2    Lamming, D.W.3    Gültekin, Y.4    Bauer-Rowe, K.E.5
  • 49
    • 0032478536 scopus 로고    scopus 로고
    • Structural diversity of leucine-rich repeat proteins
    • Kajava AV. 1998. Structural diversity of leucine-rich repeat proteins. J. Mol. Biol. 277:519-27
    • (1998) J. Mol. Biol. , vol.277 , pp. 519-527
    • Kajava, A.V.1
  • 50
    • 84858332552 scopus 로고    scopus 로고
    • An evolutionary comparison of leucine-rich repeat containing G protein-coupled receptors reveals a novel LGR subtype
    • Van Hiel MB, Vandersmissen HP, Van Loy T, Vanden Broeck J. 2012. An evolutionary comparison of leucine-rich repeat containing G protein-coupled receptors reveals a novel LGR subtype. Peptides 34:193-200
    • (2012) Peptides , vol.34 , pp. 193-200
    • Van Hiel, M.B.1    Vandersmissen, H.P.2    Van Loy, T.3    Vanden Broeck, J.4
  • 51
    • 0034464024 scopus 로고    scopus 로고
    • The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): Identification of LGR6 and LGR7 and the signaling mechanism for LGR7
    • Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, et al. 2000. The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol. Endocrinol. 14:1257-71
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1257-1271
    • Hsu, S.Y.1    Kudo, M.2    Chen, T.3    Nakabayashi, K.4    Bhalla, A.5
  • 52
    • 0037200034 scopus 로고    scopus 로고
    • INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
    • Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, et al. 2002. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J. Biol. Chem. 277:31283-86
    • (2002) J. Biol. Chem. , vol.277 , pp. 31283-31286
    • Kumagai, J.1    Hsu, S.Y.2    Matsumi, H.3    Roh, J.S.4    Fu, P.5
  • 53
    • 0000437998 scopus 로고    scopus 로고
    • Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
    • Hsu SY, Liang SG, Hsueh AJ. 1998. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol. Endocrinol. 12:1830-45
    • (1998) Mol. Endocrinol. , vol.12 , pp. 1830-1845
    • Hsu, S.Y.1    Liang, S.G.2    Hsueh, A.J.3
  • 54
    • 0032543410 scopus 로고    scopus 로고
    • Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily
    • McDonald T, Wang R, Bailey W, Xie G, Chen F, et al. 1998. Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily. Biochem. Biophys. Res. Commun. 247:266-70
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 266-270
    • McDonald, T.1    Wang, R.2    Bailey, W.3    Xie, G.4    Chen, F.5
  • 55
    • 79960990066 scopus 로고    scopus 로고
    • R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
    • Carmon KS, Gong X, Lin Q, Thomas A, Liu Q. 2011. R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling. PNAS 108:11452-57
    • (2011) PNAS , vol.108 , pp. 11452-11457
    • Carmon, K.S.1    Gong, X.2    Lin, Q.3    Thomas, A.4    Liu, Q.5
  • 56
    • 84864021917 scopus 로고    scopus 로고
    • LGR5 interacts and co-internalizes with Wnt receptors to modulate Wnt/β-catenin signaling
    • Carmon KS, Lin Q, Gong X, Thomas A, Liu Q. 2012. LGR5 interacts and co-internalizes with Wnt receptors to modulate Wnt/β-catenin signaling. Mol. Cell Biol. 32:2054-64
    • (2012) Mol. Cell Biol. , vol.32 , pp. 2054-2064
    • Carmon, K.S.1    Lin, Q.2    Gong, X.3    Thomas, A.4    Liu, Q.5
  • 57
    • 80051926611 scopus 로고    scopus 로고
    • Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling
    • de Lau W, Barker N, Low TY, Koo BK, Li VS, et al. 2011. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signaling. Nature 476:293-97
    • (2011) Nature , vol.476 , pp. 293-297
    • De Lau, W.1    Barker, N.2    Low, T.Y.3    Koo, B.K.4    Li, V.S.5
  • 58
    • 80053560465 scopus 로고    scopus 로고
    • LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signaling
    • Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, et al. 2011. LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signaling. EMBO Rep. 12:1055-61
    • (2011) EMBO Rep. , vol.12 , pp. 1055-1061
    • Glinka, A.1    Dolde, C.2    Kirsch, N.3    Huang, Y.L.4    Kazanskaya, O.5
  • 59
    • 84864012571 scopus 로고    scopus 로고
    • R-spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5
    • Ruffner H, Sprunger J, Charlat O, Leighton-Davies J, Grosshans B, et al. 2012. R-spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLOS ONE 7:e40976
    • (2012) PLOS ONE , vol.7 , pp. e40976
    • Ruffner, H.1    Sprunger, J.2    Charlat, O.3    Leighton-Davies, J.4    Grosshans, B.5
  • 60
    • 84861218349 scopus 로고    scopus 로고
    • LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor
    • Gong X, Carmon KS, Lin Q, Thomas A, Yi J, et al. 2012. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PLOS ONE 7:e37137
    • (2012) PLOS ONE , vol.7 , pp. e37137
    • Gong, X.1    Carmon, K.S.2    Lin, Q.3    Thomas, A.4    Yi, J.5
  • 61
    • 77951833781 scopus 로고    scopus 로고
    • Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells
    • Barker N, Clevers H. 2010. Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology 138:1681-96
    • (2010) Gastroenterology , vol.138 , pp. 1681-1696
    • Barker, N.1    Clevers, H.2
  • 62
    • 84878304558 scopus 로고    scopus 로고
    • Lgr proteins in epithelial stem cell biology
    • Barker N, Tan S, Clevers H. 2013. Lgr proteins in epithelial stem cell biology. Development 140:2484-94
    • (2013) Development , vol.140 , pp. 2484-2494
    • Barker, N.1    Tan, S.2    Clevers, H.3
  • 64
    • 33750448274 scopus 로고    scopus 로고
    • Cholinergic regulation of epithelial ion transport in the mammalian intestine
    • Hirota CL, McKay DM. 2006. Cholinergic regulation of epithelial ion transport in the mammalian intestine. Br. J. Pharmacol. 149:463-79
    • (2006) Br. J. Pharmacol. , vol.149 , pp. 463-479
    • Hirota, C.L.1    McKay, D.M.2
  • 65
    • 79951688517 scopus 로고    scopus 로고
    • Non-neuronal release of ACh plays a key role in secretory response to luminal propionate in rat colon
    • Yajima T, Inoue R, Matsumoto M, Yajima M. 2011. Non-neuronal release of ACh plays a key role in secretory response to luminal propionate in rat colon. J. Physiol. 589:953-62
    • (2011) J. Physiol. , vol.589 , pp. 953-962
    • Yajima, T.1    Inoue, R.2    Matsumoto, M.3    Yajima, M.4
  • 66
    • 0344255794 scopus 로고    scopus 로고
    • The lymphocytic cholinergic system and its contribution to the regulation of immune activity
    • Kawashima K, Fujii T. 2003. The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life Sci. 74:675-96
    • (2003) Life Sci. , vol.74 , pp. 675-696
    • Kawashima, K.1    Fujii, T.2
  • 67
    • 33750009187 scopus 로고    scopus 로고
    • Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis
    • Danielson P, Alfredson H, Forsgren S. 2006. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc. Res. Tech. 69:808-19
    • (2006) Microsc. Res. Tech. , vol.69 , pp. 808-819
    • Danielson, P.1    Alfredson, H.2    Forsgren, S.3
  • 69
    • 33646856174 scopus 로고    scopus 로고
    • Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse
    • Kummer W, Wiegand S, Akinci S, Wessler I, Schinkel AH, et al. 2006. Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir. Res. 7:65
    • (2006) Respir. Res. , vol.7 , pp. 65
    • Kummer, W.1    Wiegand, S.2    Akinci, S.3    Wessler, I.4    Schinkel, A.H.5
  • 70
    • 31444451453 scopus 로고    scopus 로고
    • In vivo release of non-neuronal acetylcholine from the human skin as measured by dermal microdialysis: Effect of botulinum toxin
    • Schlereth T, Birklein F, Haack K, Schiffmann S, Kilbinger H, et al. 2006. In vivo release of non-neuronal acetylcholine from the human skin as measured by dermal microdialysis: effect of botulinum toxin. Br. J. Pharmacol. 147:183-87
    • (2006) Br. J. Pharmacol. , vol.147 , pp. 183-187
    • Schlereth, T.1    Birklein, F.2    Haack, K.3    Schiffmann, S.4    Kilbinger, H.5
  • 71
    • 69449097681 scopus 로고    scopus 로고
    • Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium
    • Kakinuma Y, Akiyama T, Sato T. 2009. Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium. FEBS J. 276:5111-25
    • (2009) FEBS J. , vol.276 , pp. 5111-5125
    • Kakinuma, Y.1    Akiyama, T.2    Sato, T.3
  • 72
    • 84870523732 scopus 로고    scopus 로고
    • A non-neuronal cardiac cholinergic system plays a protective role in myocardium salvage during ischemic insulta
    • Kakinuma Y, Akiyama T, Okazaki K, Arikawa M, Noguchi T, et al. 2012. A non-neuronal cardiac cholinergic system plays a protective role in myocardium salvage during ischemic insulta. PLOS ONE 7:e50761
    • (2012) PLOS ONE , vol.7 , pp. e50761
    • Kakinuma, Y.1    Akiyama, T.2    Okazaki, K.3    Arikawa, M.4    Noguchi, T.5
  • 73
    • 84906614796 scopus 로고    scopus 로고
    • A non-neuronal cholinergic system regulates cellular ATP levels to maintain cell viability
    • Oikawa S, Iketani S, Kakinuma Y. 2014. A non-neuronal cholinergic system regulates cellular ATP levels to maintain cell viability. Cell Physiol. Biochem. 34:781-89
    • (2014) Cell Physiol. Biochem. , vol.34 , pp. 781-789
    • Oikawa, S.1    Iketani, S.2    Kakinuma, Y.3
  • 74
    • 0035134690 scopus 로고    scopus 로고
    • An independent non-neuronal cholinergic system in lymphocytes
    • Fujii T, Kawashima K. 2001. An independent non-neuronal cholinergic system in lymphocytes. Jpn. J. Pharmacol. 85:11-15
    • (2001) Jpn. J. Pharmacol. , vol.85 , pp. 11-15
    • Fujii, T.1    Kawashima, K.2
  • 75
    • 84984808387 scopus 로고    scopus 로고
    • i oscillations and c-fos gene expression after muscarinic acetylcholine receptor activation in leukemic T cells
    • i oscillations and c-fos gene expression after muscarinic acetylcholine receptor activation in leukemic T cells. Life Sci. 161:45-50
    • (2016) Life Sci. , vol.161 , pp. 45-50
    • Mashimo, M.1    Yurie, Y.2    Kawashima, K.3    Fujii, T.4
  • 76
    • 34249329852 scopus 로고    scopus 로고
    • Expression and possible functions of the cholinergic system in a murine embryonic stem cell line
    • Paraoanu LE, Steinert G, Koehler A, Wessler I, Layer PG. 2007. Expression and possible functions of the cholinergic system in a murine embryonic stem cell line. Life Sci. 80:2375-79
    • (2007) Life Sci. , vol.80 , pp. 2375-2379
    • Paraoanu, L.E.1    Steinert, G.2    Koehler, A.3    Wessler, I.4    Layer, P.G.5
  • 77
    • 77955510036 scopus 로고    scopus 로고
    • Acetylcholine as a possible signaling molecule in embryonic stem cells: Studies on survival, proliferation and death
    • Landgraf D, Barth M, Layer PG, Sperling LE. 2010. Acetylcholine as a possible signaling molecule in embryonic stem cells: studies on survival, proliferation and death. Chem. Biol. Interact. 187:115-19
    • (2010) Chem. Biol. Interact. , vol.187 , pp. 115-119
    • Landgraf, D.1    Barth, M.2    Layer, P.G.3    Sperling, L.E.4
  • 78
    • 84860495137 scopus 로고    scopus 로고
    • Involvement of nicotinic acetylcholine receptor in the proliferation of mouse induced pluripotent stem cells
    • Ishizuka T, Ozawa A, Goshima H, Watanabe Y. 2012. Involvement of nicotinic acetylcholine receptor in the proliferation of mouse induced pluripotent stem cells. Life Sci. 90:637-48
    • (2012) Life Sci. , vol.90 , pp. 637-648
    • Ishizuka, T.1    Ozawa, A.2    Goshima, H.3    Watanabe, Y.4
  • 79
    • 85017108800 scopus 로고    scopus 로고
    • Stem cell-derived organoids and their application for medical research and patient treatment
    • Bartfeld S, Clevers H. 2017. Stem cell-derived organoids and their application for medical research and patient treatment. J. Mol. Med. 95:729-38
    • (2017) J. Mol. Med. , vol.95 , pp. 729-738
    • Bartfeld, S.1    Clevers, H.2
  • 81
    • 84885672388 scopus 로고    scopus 로고
    • + chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
    • + chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 155:357-68
    • (2013) Cell , vol.155 , pp. 357-368
    • Stange, D.E.1    Koo, B.-K.2    Huch, M.3    Sibbel, G.4    Basak, O.5
  • 82
    • 84922875352 scopus 로고    scopus 로고
    • In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
    • Bartfeld S, Bayram T, van de Wetering M, Huch M, Begthel H, et al. 2015. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148:126-36
    • (2015) Gastroenterology , vol.148 , pp. 126-136
    • Bartfeld, S.1    Bayram, T.2    Van De Wetering, M.3    Huch, M.4    Begthel, H.5
  • 83
    • 84885846800 scopus 로고    scopus 로고
    • Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    • Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, et al. 2013. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J. 32:2708-21
    • (2013) EMBO J. , vol.32 , pp. 2708-2721
    • Huch, M.1    Bonfanti, P.2    Boj, S.F.3    Sato, T.4    Loomans, C.J.5
  • 84
    • 84920983131 scopus 로고    scopus 로고
    • Organoid models of human and mouse ductal pancreatic cancer
    • Boj SF, Hwang C-I, Baker LA, Chio IIC, Engle DD, et al. 2015. Organoid models of human and mouse ductal pancreatic cancer. Cell 160:324-38
    • (2015) Cell , vol.160 , pp. 324-338
    • Boj, S.F.1    Hwang, C.-I.2    Baker, L.A.3    Chio, I.I.C.4    Engle, D.D.5
  • 85
    • 84885617460 scopus 로고    scopus 로고
    • Artificial three-dimensional niches deconstruct pancreas development in vitro
    • Greggio C, Franceschi FD, Figueirdo-Larsen M, Gobaa S, Ranga A, et al. 2013. Artificial three-dimensional niches deconstruct pancreas development in vitro. Development 140:4452-62
    • (2013) Development , vol.140 , pp. 4452-4462
    • Greggio, C.1    Franceschi, F.D.2    Figueirdo-Larsen, M.3    Gobaa, S.4    Ranga, A.5
  • 86
    • 84920989984 scopus 로고    scopus 로고
    • Long-term culture of genome-stable bipotent stem cells from adult human liver
    • Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, et al. 2015. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 160:299-312
    • (2015) Cell , vol.160 , pp. 299-312
    • Huch, M.1    Gehart, H.2    Van Boxtel, R.3    Hamer, K.4    Blokzijl, F.5
  • 87
    • 84907552531 scopus 로고    scopus 로고
    • Identification of multipotent luminal progenitor cells in human prostate organoid cultures
    • Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, et al. 2014. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 159:163-75
    • (2014) Cell , vol.159 , pp. 163-175
    • Karthaus, W.R.1    Iaquinta, P.J.2    Drost, J.3    Gracanin, A.4    Van Boxtel, R.5
  • 88
    • 84922067781 scopus 로고    scopus 로고
    • Single luminal epithelial progenitors can generate prostate organoids in culture
    • Chua CW, Shibata M, Lei M, Toivanen R, Barlow LJ, et al. 2014. Single luminal epithelial progenitors can generate prostate organoids in culture. Nat. Cell Biol. 16:951-61
    • (2014) Nat. Cell Biol. , vol.16 , pp. 951-961
    • Chua, C.W.1    Shibata, M.2    Lei, M.3    Toivanen, R.4    Barlow, L.J.5
  • 89
    • 84919623629 scopus 로고    scopus 로고
    • Cellular heterogeneity in the esophagus implicates the presence of a nonquiescent epithelial stem cell population
    • DeWard AD, Cramer J, Lagasse E. 2014. Cellular heterogeneity in the esophagus implicates the presence of a nonquiescent epithelial stem cell population. Cell Rep. 9:701-11
    • (2014) Cell Rep. , vol.9 , pp. 701-711
    • DeWard, A.D.1    Cramer, J.2    Lagasse, E.3
  • 90
    • 84930016564 scopus 로고    scopus 로고
    • Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma
    • Scanu T, Spaapen RM, Bakker JM, Pratap CB, Wu L, et al. 2015. Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma. Cell Host Microbe 17:763-74
    • (2015) Cell Host Microbe , vol.17 , pp. 763-774
    • Scanu, T.1    Spaapen, R.M.2    Bakker, J.M.3    Pratap, C.B.4    Wu, L.5
  • 91
    • 84961263047 scopus 로고    scopus 로고
    • R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders
    • Lugli N, Kamileri I, Keogh A, Malinka T, Sarris ME, et al. 2016. R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders. EMBO Rep. 17:769-79
    • (2016) EMBO Rep. , vol.17 , pp. 769-779
    • Lugli, N.1    Kamileri, I.2    Keogh, A.3    Malinka, T.4    Sarris, M.E.5
  • 92
    • 84917734391 scopus 로고    scopus 로고
    • Single Lgr5-or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo
    • Ren W, Lewandowski BC, Watson J, Aihara E, Iwatsuki K, et al. 2014. Single Lgr5-or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo. PNAS 111:16401-6
    • (2014) PNAS , vol.111 , pp. 16401-16406
    • Ren, W.1    Lewandowski, B.C.2    Watson, J.3    Aihara, E.4    Iwatsuki, K.5
  • 93
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, et al. 2011. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470:105-9
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1    Mayhew, C.N.2    Rankin, S.A.3    Kuhar, M.F.4    Vallance, J.E.5
  • 94
    • 84866067664 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein
    • Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, et al. 2012. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat. Biotechnol. 30:876-82
    • (2012) Nat. Biotechnol. , vol.30 , pp. 876-882
    • Wong, A.P.1    Bear, C.E.2    Chin, S.3    Pasceri, P.4    Thompson, T.O.5
  • 95
    • 84925459906 scopus 로고    scopus 로고
    • In vitro generation of human pluripotent stem cell derived lung organoids
    • Dye BR, Hill DR, Ferguson MA, Tsai Y-H, Nagy MS, et al. 2015. In vitro generation of human pluripotent stem cell derived lung organoids. eLife 4:e05098
    • (2015) ELife , vol.4 , pp. e05098
    • Dye, B.R.1    Hill, D.R.2    Ferguson, M.A.3    Tsai, Y.-H.4    Nagy, M.S.5
  • 96
    • 84892149549 scopus 로고    scopus 로고
    • Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
    • Huang SX, Islam MN, O'Neill J, Hu Z, Yang Y-G, et al. 2014. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat. Biotechnol. 32:84-91
    • (2014) Nat. Biotechnol. , vol.32 , pp. 84-91
    • Huang, S.X.1    Islam, M.N.2    O'Neill, J.3    Hu, Z.4    Yang, Y.-G.5
  • 97
    • 84881184980 scopus 로고    scopus 로고
    • Vascularized and functional human liver from an iPSC-derived organ bud transplant
    • Takebe T, Sekine K, Enomura M, Koike H, Kimura M, et al. 2013. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499:481-84
    • (2013) Nature , vol.499 , pp. 481-484
    • Takebe, T.1    Sekine, K.2    Enomura, M.3    Koike, H.4    Kimura, M.5
  • 98
    • 84947706099 scopus 로고    scopus 로고
    • Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells
    • Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, et al. 2015. Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells. Cell Stem Cell 17:527-42
    • (2015) Cell Stem Cell , vol.17 , pp. 527-542
    • Kurmann, A.A.1    Serra, M.2    Hawkins, F.3    Rankin, S.A.4    Mori, M.5
  • 99
    • 84859551885 scopus 로고    scopus 로고
    • Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells
    • Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, et al. 2012. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell 10:398-411
    • (2012) Cell Stem Cell , vol.10 , pp. 398-411
    • Longmire, T.A.1    Ikonomou, L.2    Hawkins, F.3    Christodoulou, C.4    Cao, Y.5
  • 100
    • 84918561297 scopus 로고    scopus 로고
    • Modeling human development and disease in pluripotent stem-cell-derived gastric organoids
    • McCracken KW, Catá EM, Crawford CM, Sinagoga KL, Schumacher M, et al. 2014. Modeling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516:400-4
    • (2014) Nature , vol.516 , pp. 400-404
    • McCracken, K.W.1    Catá, E.M.2    Crawford, C.M.3    Sinagoga, K.L.4    Schumacher, M.5
  • 102
    • 84946215806 scopus 로고    scopus 로고
    • Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-and patient-derived tumor organoids
    • Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, et al. 2015. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-and patient-derived tumor organoids. Nat. Med. 21:1364-71
    • (2015) Nat. Med. , vol.21 , pp. 1364-1371
    • Huang, L.1    Holtzinger, A.2    Jagan, I.3    BeGora, M.4    Lohse, I.5
  • 103
    • 84938874118 scopus 로고    scopus 로고
    • Directed differentiation of cholangiocytes from human pluripotent stem cells
    • Ogawa M, Ogawa S, Bear CE, Ahmadi S, Chin S, et al. 2015. Directed differentiation of cholangiocytes from human pluripotent stem cells. Nat. Biotechnol. 33:853-61
    • (2015) Nat. Biotechnol. , vol.33 , pp. 853-861
    • Ogawa, M.1    Ogawa, S.2    Bear, C.E.3    Ahmadi, S.4    Chin, S.5
  • 104
    • 84891281146 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells
    • Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, et al. 2013. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat. Cell Biol. 15:1507-15
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1507-1515
    • Xia, Y.1    Nivet, E.2    Sancho-Martinez, I.3    Gallegos, T.4    Suzuki, K.5
  • 105
    • 84891737192 scopus 로고    scopus 로고
    • Redefining the in vivo organ of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells
    • Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, et al. 2014. Redefining the in vivo organ of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14:53-67
    • (2014) Cell Stem Cell , vol.14 , pp. 53-67
    • Taguchi, A.1    Kaku, Y.2    Ohmori, T.3    Sharmin, S.4    Ogawa, M.5
  • 106
    • 84891298711 scopus 로고    scopus 로고
    • Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
    • Takasato M, Er PX, Becroft M, Vanslambrouck JM, Stanley EG, et al. 2014. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat. Cell Biol. 16:118-26
    • (2014) Nat. Cell Biol. , vol.16 , pp. 118-126
    • Takasato, M.1    Er, P.X.2    Becroft, M.3    Vanslambrouck, J.M.4    Stanley, E.G.5
  • 107
    • 84945283561 scopus 로고    scopus 로고
    • Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
    • Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, et al. 2015. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526:564-68
    • (2015) Nature , vol.526 , pp. 564-568
    • Takasato, M.1    Er, P.X.2    Chiu, H.S.3    Maier, B.4    Baillie, G.J.5
  • 108
    • 85033381363 scopus 로고    scopus 로고
    • Higher-order kidney organogenesis from pluripotent stem cells
    • Taguchi A, Nishinakamura R. 2017. Higher-order kidney organogenesis from pluripotent stem cells. Cell Stem Cell 21:730-46
    • (2017) Cell Stem Cell , vol.21 , pp. 730-746
    • Taguchi, A.1    Nishinakamura, R.2
  • 109
    • 84949504069 scopus 로고    scopus 로고
    • The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
    • Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, et al. 2015. The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat. Commun. 6:8989
    • (2015) Nat. Commun. , vol.6 , pp. 8989
    • Kessler, M.1    Hoffmann, K.2    Brinkmann, V.3    Thieck, O.4    Jackisch, S.5
  • 110
    • 79953749322 scopus 로고    scopus 로고
    • Self-organizing optic-cup morphogenesis in three-dimensional culture
    • Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, et al. 2011. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472:51-56
    • (2011) Nature , vol.472 , pp. 51-56
    • Eiraku, M.1    Takata, N.2    Ishibashi, H.3    Kawada, M.4    Sakakura, E.5
  • 111
    • 84862526635 scopus 로고    scopus 로고
    • Self-formation of optic cups and storable stratified neural retina from human ESCs
    • Nakano T, Ando S, Takata N, Kawada M, Muguruma K, et al. 2012. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 10:771-85
    • (2012) Cell Stem Cell , vol.10 , pp. 771-785
    • Nakano, T.1    Ando, S.2    Takata, N.3    Kawada, M.4    Muguruma, K.5
  • 112
    • 84922791023 scopus 로고    scopus 로고
    • Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells
    • Muguruma K, Nishiyama A, Kawakami H, Hashimoto K, Sasai Y. 2015. Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell Rep. 10:537-50
    • (2015) Cell Rep. , vol.10 , pp. 537-550
    • Muguruma, K.1    Nishiyama, A.2    Kawakami, H.3    Hashimoto, K.4    Sasai, Y.5
  • 113
    • 84947292300 scopus 로고    scopus 로고
    • Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
    • Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, et al. 2015. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nat. Commun. 6:8896
    • (2015) Nat. Commun. , vol.6 , pp. 8896
    • Sakaguchi, H.1    Kadoshima, T.2    Soen, M.3    Narii, N.4    Ishida, Y.5
  • 114
    • 82555187011 scopus 로고    scopus 로고
    • Self-formation of functional adenohypophysis in three-dimensional culture
    • Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, et al. 2011. Self-formation of functional adenohypophysis in three-dimensional culture. Nature 480:57-62
    • (2011) Nature , vol.480 , pp. 57-62
    • Suga, H.1    Kadoshima, T.2    Minaguchi, M.3    Ohgushi, M.4    Soen, M.5
  • 115
    • 49449094458 scopus 로고    scopus 로고
    • Acetylcholine beyond neurons: The non-neuronal cholinergic system in humans
    • Wessler I, Kirkpatrick CJ. 2008. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br. J. Pharmacol. 154:1558-71
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 1558-1571
    • Wessler, I.1    Kirkpatrick, C.J.2
  • 116
    • 84965181368 scopus 로고    scopus 로고
    • Drug discovery goes three-dimensional: Goodbye to flat high-throughput screening?
    • Eglen RM, Randle DH. 2015. Drug discovery goes three-dimensional: goodbye to flat high-throughput screening? Assay Drug Dev. Technol. 13:262-65
    • (2015) Assay Drug Dev. Technol. , vol.13 , pp. 262-265
    • Eglen, R.M.1    Randle, D.H.2
  • 117
    • 84987921460 scopus 로고    scopus 로고
    • Pluripotent stem cells for disease modeling and drug screening: New perspectives for treatment of cystic fibrosis?
    • Martin U. 2015. Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis? Mol. Cell Pediatr. 2:15
    • (2015) Mol. Cell Pediatr. , vol.2 , pp. 15
    • Martin, U.1
  • 118
    • 84938883598 scopus 로고    scopus 로고
    • Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
    • Sampaziotis F, Cardoso De Brito M, Madrigal P, Bertero A, Saeb-Parsy K, et al. 2015. Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nat. Biotechnol. 33:845-52
    • (2015) Nat. Biotechnol. , vol.33 , pp. 845-852
    • Sampaziotis, F.1    Cardoso De Brito, M.2    Madrigal, P.3    Bertero, A.4    Saeb-Parsy, K.5
  • 120
    • 84874875145 scopus 로고    scopus 로고
    • Concise review: The relevance of human stem cell-derived organoids models for epithelial translational medicine
    • Hynds RE, Giangreco A. 2013. Concise review: the relevance of human stem cell-derived organoids models for epithelial translational medicine. Stem Cells 31:417-22
    • (2013) Stem Cells , vol.31 , pp. 417-422
    • Hynds, R.E.1    Giangreco, A.2
  • 122
    • 84928974420 scopus 로고    scopus 로고
    • Prospective derivation of a living organoid biobank of colorectal cancer patients
    • van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, et al. 2015. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161:933-45
    • (2015) Cell , vol.161 , pp. 933-945
    • Van De Wetering, M.1    Francies, H.E.2    Francis, J.M.3    Bounova, G.4    Iorio, F.5
  • 123
    • 84971516758 scopus 로고    scopus 로고
    • A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis
    • Fujii M, Shimokawa M, Date S, Takano A, Matano M, et al. 2016. A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis. Cell Stem Cell 18:827-38
    • (2016) Cell Stem Cell , vol.18 , pp. 827-838
    • Fujii, M.1    Shimokawa, M.2    Date, S.3    Takano, A.4    Matano, M.5
  • 124
    • 84975464759 scopus 로고    scopus 로고
    • Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
    • Dekkers JF, Berkers G, Kruisselbrink E, Vonk A, de Jonge HR, et al. 2016. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Sci. Transl. Med. 8:344ra84
    • (2016) Sci. Transl. Med. , vol.8 , pp. 344ra84
    • Dekkers, J.F.1    Berkers, G.2    Kruisselbrink, E.3    Vonk, A.4    De Jonge, H.R.5
  • 125
    • 84893947796 scopus 로고    scopus 로고
    • The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength
    • de Law W, Peng WC, Gros P, Clevers H. 2014. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev. 28:305-16
    • (2014) Genes Dev. , vol.28 , pp. 305-316
    • De Law, W.1    Peng, W.C.2    Gros, P.3    Clevers, H.4
  • 127
    • 84902144564 scopus 로고    scopus 로고
    • Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells
    • Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, et al. 2014. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Rep. 2:838-52
    • (2014) Stem Cell Rep. , vol.2 , pp. 838-852
    • Forster, R.1    Chiba, K.2    Schaeffer, L.3    Regalado, S.G.4    Lai, C.S.5
  • 129
    • 84946215806 scopus 로고    scopus 로고
    • Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-and patient-derived tumor organoids
    • Huang L, Holtzinger A, Jagan I, Begora M, Lohse I, et al. 2015. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-and patient-derived tumor organoids. Mat. Med. 21:1364-71
    • (2015) Mat. Med. , vol.21 , pp. 1364-1371
    • Huang, L.1    Holtzinger, A.2    Jagan, I.3    Begora, M.4    Lohse, I.5
  • 130
    • 84959900657 scopus 로고    scopus 로고
    • Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells
    • Nielsen MF, Mortensen MB, Detlefsen S. 2016. Key players in pancreatic cancer-stroma interaction: cancer-associated fibroblasts, endothelial and inflammatory cells. World J. Gastroenterol. 22:2678-700
    • (2016) World J. Gastroenterol. , vol.22 , pp. 2678-2700
    • Nielsen, M.F.1    Mortensen, M.B.2    Detlefsen, S.3
  • 131
    • 85040451325 scopus 로고    scopus 로고
    • Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression
    • Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, et al. 2018. Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression. Cell Stem Cell 22:454-67. e6
    • (2018) Cell Stem Cell , vol.22 , pp. 454-454e6
    • Seino, T.1    Kawasaki, S.2    Shimokawa, M.3    Tamagawa, H.4    Toshimitsu, K.5
  • 132
    • 77952329787 scopus 로고    scopus 로고
    • Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors
    • Vaira V, Fedele G, Pyne S, Fasoli E, Zadra G, et al. 2010. Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors. PNAS 107:8352-56
    • (2010) PNAS , vol.107 , pp. 8352-8356
    • Vaira, V.1    Fedele, G.2    Pyne, S.3    Fasoli, E.4    Zadra, G.5
  • 133
    • 84940450362 scopus 로고    scopus 로고
    • Development and application of human adult stem or progenitor cell organoids
    • Rookmaaker MB, Schutgens F, Verhaar MC, Clevers H. 2015. Development and application of human adult stem or progenitor cell organoids. Nat. Rev. Nephrol. 11:546-54
    • (2015) Nat. Rev. Nephrol. , vol.11 , pp. 546-554
    • Rookmaaker, M.B.1    Schutgens, F.2    Verhaar, M.C.3    Clevers, H.4
  • 134
    • 84890033064 scopus 로고    scopus 로고
    • Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
    • Schwank G, Koo B-K, Sasselli V, Dekkers JF, Heo I, et al. 2013. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 13:653-58
    • (2013) Cell Stem Cell , vol.13 , pp. 653-658
    • Schwank, G.1    Koo, B.-K.2    Sasselli, V.3    Dekkers, J.F.4    Heo, I.5
  • 137
    • 85020422654 scopus 로고    scopus 로고
    • Transplantation of engineering organoids enables rapid generation of metastatic mouse models of colorectal cancer
    • O'Rourke KP, Loizou E, Livshits G, Schattoff EM, Baslan T, et al. 2017. Transplantation of engineering organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nat. Biotechnol. 35:577-82
    • (2017) Nat. Biotechnol. , vol.35 , pp. 577-582
    • O'Rourke, K.P.1    Loizou, E.2    Livshits, G.3    Schattoff, E.M.4    Baslan, T.5
  • 138
    • 85020457568 scopus 로고    scopus 로고
    • In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
    • Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, et al. 2017. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat. Biotechnol. 35:569-76
    • (2017) Nat. Biotechnol. , vol.35 , pp. 569-576
    • Roper, J.1    Tammela, T.2    Cetinbas, N.M.3    Akkad, A.4    Roghanian, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.