A Non-Neuronal Cardiac Cholinergic System Plays a Protective Role in Myocardium Salvage during Ischemic Insults

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Kakinuma, Yoshihiko ^a   Akiyama, Tsuyoshi ^b   Okazaki, Kayo ^a   Arikawa, Mikihiko ^a   Noguchi, Tatsuya ^a   Sato, Takayuki ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; BETA CATENIN; CARRIER PROTEIN; CHOLINE ACETYLTRANSFERASE; CHOLINE TRANSPORTER 1; CONNEXIN 43; HEMICHOLINIUM 3; NORADRENALIN; OXYGEN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COMMUNICATION; CELL DEATH; CELL ENERGY; CELL HYPOXIA; CELL PROTECTION; CELL STRAIN HEK293; CELL VIABILITY; CHOLINE ACETYLTRANSFERASE GENE; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENERGY METABOLISM; GENE; GENE DELETION; GENE INACTIVATION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART PROTECTION; IN VIVO STUDY; MALE; MOUSE; NON NEURONAL CARDIAC CHOLINERGIC SYSTEM; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SALVAGE THERAPY; UPREGULATION;

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CELL COMMUNICATION; CELL LINE; CHOLINE O-ACETYLTRANSFERASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL ISCHEMIA; MYOCARDIUM; REACTIVE OXYGEN SPECIES;

EID: 84870523732     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050761     Document Type: Article

References (30)

1. Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, et al. (2005) Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha. FEBS Lett 579: 2111-2118.
2. Ando M, Katare RG, Kakinuma Y, Zhang D, Yamasaki F, et al. (2005) Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein. Circulation 112: 164-170.
3. Zhang Y, Kakinuma Y, Ando M, Katare RG, Yamasaki F, et al. (2006) Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes. J Pharmacol Sci 101: 214-222.
4. Katare RG, Ando M, Kakinuma Y, Arikawa M, Handa T, et al. (2009) Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. J Thorac Cardiovasc Surg 137: 223-231.
5. Handa T, Katare RG, Kakinuma Y, Arikawa M, Ando M, et al. (2009) Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail 15: 805-811.
6. Katare RG, Ando M, Kakinuma Y, Arikawa M, Yamasaki F, et al. (2010) Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury. J Mol Cell Cardiol 49: 234-244.
7. Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, et al. (2010) Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. J Mol Cell Cardiol 48: 680-693.
8. Arikawa M, Katare RG, Kakinuma Y, Handa T, Ando M, et al. (2007) Progression of ventricular dysfunction after myocardial infarction is prevented by anti-Alzheimer's disease drug, donepezil. Circulation 116: II_291.
9. Okazaki Y, Zheng C, Li M, Sugimachi M, (2010) Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure. J Physiol Sci 60: 67-74.
10. Kakinuma Y, Katare RG, Arikawa M, Muramoto K, Yamasaki F, et al. (2008) A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function. FEBS Lett 582: 332-340.
11. Kakinuma Y, Akiyama T, Sato T, (2009) Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium. FEBS J 276: 5111-5125.
12. McNeil PL, Murphy RF, Lanni F, Taylor DL, (1984) A method for incorporating macromolecules into adherent cells. J Cell Biol 98: 1556-1564.
13. Wessler I, Kirkpatrick CJ, (2008) Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol 154: 1558-1571.
14. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, et al. (1998) HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A 95: 2979-2984.
15. Rapoport N, Marin AP, Timoshin AA, (2000) Effect of a polymeric surfactant on electron transport in HL-60 cells. Arch Biochem Biophys 384: 100-108.
16. Kirkpatrick CJ, Bittinger F, Nozadze K, Wessler I, (2003) Expression and function of the non-neuronal cholinergic system in endothelial cells. Life Sci 72: 2111-2116.
17. Kawashima K, Fujii T, (2004) Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. Front Biosci 9: 2063-2085.
18. Lips KS, Volk C, Schmitt BM, Pfeil U, Arndt P, et al. (2005) Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol 33: 79-88.
19. Li M, Zheng C, Sato T, Kawada T, Sugimachi M, et al. (2004) Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 109: 120-124.
20. Schwartz PJ, De Ferrari GM, Sanzo A, Landolina M, Rordorf R, et al. (2008) Long term vagal stimulation in patients with advanced heart failure: first experience in man. Eur J Heart Fail 10: 884-891.
21. De Ferrari GM, Schwartz PJ, (2011) Vagus nerve stimulation: from pre-clinical to clinical application: challenges and future directions. Heart Fail Rev 16: 195-203.
22. Hoover DB, Ganote CE, Ferguson SM, Blakely RD, Parsons RL, (2004) Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovasc Res 62: 112-121.
23. Kawano H, Okada R, Yano K, (2003) Histological study on the distribution of autonomic nerves in the human heart. Heart Vessels 18: 32-39.
24. Kuwabara M, Kakinuma Y, Katare RG, Ando M, Yamasaki F, et al. (2007) Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin. FEBS Lett 581: 4821-4830.
25. Kostin S, Hein S, Bauer EP, Schaper J, (1999) Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Circ Res 85: 154-167.
26. Wu JC, Tsai RY, Chung TH, (2003) Role of catenins in the development of gap junctions in rat cardiomyocytes. J Cell Biochem 88: 823-835.
27. Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, et al. (2007) Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet 370: 575-579.
28. Ali ZA, Callaghan CJ, Lim E, Ali AA, Nouraei SA, et al. (2007) Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: a randomized controlled trial. Circulation 116 (11 Suppl): I98-105.
29. Bøtker HE, Kharbanda R, Schmidt MR, Bøttcher M, Kaltoft AK, et al. (2010) Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375: 727-734.
30. Hausenloy DJ, Yellon DM, (2008) Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res 79: 377-386.