Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Cell Stem Cell

Volumn 22, Issue 3, 2018, Pages 454-467.e6

  Seino, Takashi ^a   Kawasaki, Shintaro ^a   Shimokawa, Mariko ^a   Tamagawa, Hiroki ^a   Toshimitsu, Kohta ^a   Fujii, Masayuki ^a   Ohta, Yuki ^a   Matano, Mami ^a   Nanki, Kosaku ^a   Kawasaki, Kenta ^a   Takahashi, Sirirat ^a   Sugimoto, Shinya ^a   Iwasaki, Eisuke ^a   Takagi, Junichi ^b   Itoi, Takao ^c   Kitago, Minoru ^a   Kitagawa, Yuko ^a   Kanai, Takanori ^a   Sato, Toshiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

CRISPR Cas9; GATA6; organoids; pancreatic cancer; stem cell niche; Wnt

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; K RAS PROTEIN; NOGGIN; NUTLIN 3; PROTEIN P53; SMAD4 PROTEIN; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTOME; WNT PROTEIN; LIGAND;

ANIMAL EXPERIMENT; ARTICLE; CANCER ASSOCIATED FIBROBLAST; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; FINE NEEDLE ASPIRATION BIOPSY; GENE EDITING; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ORGANOID; PANCREAS TUMOR; PRIORITY JOURNAL; STEM CELL NICHE; TUMOR GROWTH; UPREGULATION; WHOLE EXOME SEQUENCING; WNT SIGNALING; CRISPR CAS SYSTEM; EPITHELIUM CELL; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; METABOLISM; PATHOLOGY;

CRISPR-CAS SYSTEMS; DISEASE PROGRESSION; EPITHELIAL CELLS; FIBROBLASTS; GATA6 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ENGINEERING; HUMANS; LIGANDS; ORGANOIDS; PANCREATIC NEOPLASMS; STEM CELL NICHE; WNT SIGNALING PATHWAY;

EID: 85040451325     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.12.009     Document Type: Article

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