Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer

Cancer Research

Volumn 75, Issue 4, 2015, Pages 766-776

  Oshima, Hiroko ^a   Nakayama, Mizuho ^a,b   Han, Tae Su ^a,b   Naoi, Kuniko ^a   Ju, Xiaoli ^a   Maeda, Yusuke ^a   Robine, Sylvie ^c   Tsuchiya, Kiichiro ^d   Sato, Toshiro ^e   Sato, Hiroshi ^a   Taketo, Makoto Mark ^f   Oshima, Masanobu ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c INSTITUT CURIE   (France)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; GELATINASE A; MATRIX METALLOPROTEINASE 14; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; APC PROTEIN; MMP2 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL EXPANSION; CELL INFILTRATION; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; INFLAMMATION; INTESTINE CANCER; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; INTESTINE MUCOSA; MACROPHAGE; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE REGENERATION; TUMOR INVASION; TUMOR MICROENVIRONMENT; ULCERATIVE COLITIS; X IRRADIATION; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; COLON TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTESTINE TUMOR; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; MATRIX METALLOPROTEINASE 2; MICE; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR MICROENVIRONMENT;

EID: 84923172083     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-2036     Document Type: Article

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