Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

Nature Biotechnology

Volumn 35, Issue 6, 2017, Pages 577-582

  O'Rourke, Kevin P ^a,b   Loizou, Evangelia ^b,c   Livshits, Geulah ^b   Schatoff, Emma M ^a,d   Baslan, Timour ^b   Manchado, Eusebio ^b   Simon, Janelle ^b   Romesser, Paul B ^b   Leach, Benjamin ^d   Han, Teng ^c,d   Pauli, Chantal ^d   Beltran, Himisha ^d   Rubin, Mark A ^d   Dow, Lukas E ^d   Lowe, Scott W ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ENGINEERING; MAMMALS; PATHOLOGY; TUMORS;

COLORECTAL CANCER; COLORECTAL CANCERS (CRC); GENETIC STUDIES; MOUSE MODELS; PRE-CLINICAL; RAPID GENERATIONS; TIME DEPENDENT; WNT SIGNALING;

DISEASES;

APC PROTEIN; CYTOKERATIN 20; MUCIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CANCER TRANSPLANTATION; CARCINOGENESIS; CELL DIFFERENTIATION; COLON EPITHELIUM; COLORECTAL CANCER; CONTROLLED STUDY; DISSEMINATED CANCER; FOLLOW UP; GENETICALLY ENGINEERED MOUSE STRAIN; GENOTYPE; HISTOPATHOLOGY; HUMAN; IMMUNOCOMPETENT CELL; LONG TERM CARE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR ENGRAFTMENT; TUMOR GROWTH; WNT SIGNALING PATHWAY; ANIMAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COLORECTAL TUMOR; DISEASE MODEL; FEMALE; GENE EDITING; GENETICS; LIVER TUMOR; MALE; METASTASIS; ORGAN TRANSPLANTATION; PROCEDURES; SECONDARY; TRANSGENIC MOUSE; TUMOR CELL LINE; TUMOR GENE;

ANIMALS; CARCINOGENESIS; CELL LINE, TUMOR; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; GENE EDITING; GENES, NEOPLASM; LIVER NEOPLASMS; MALE; MICE; MICE, TRANSGENIC; NEOPLASM METASTASIS; ORGAN TRANSPLANTATION;

EID: 85020422654     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3837     Document Type: Article

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