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Volumn 20, Issue 7, 2014, Pages 769-777

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; ASPARTIC ACID; GLYCINE; K RAS PROTEIN; MICRORNA; MICRORNA 483; PROTEIN P53; SMAD4 PROTEIN; SOMATOMEDIN B; UNCLASSIFIED DRUG;

EID: 84904066077     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3585     Document Type: Article
Times cited : (348)

References (43)
  • 1
    • 84874875145 scopus 로고    scopus 로고
    • Concise review: The relevance of human stem cell-derived organoid models for epithelial translational medicine
    • Hynds, R.E. & Giangreco, A. Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine. Stem Cells 31, 417-422 (2013).
    • (2013) Stem Cells , vol.31 , pp. 417-422
    • Hynds, R.E.1    Giangreco, A.2
  • 2
    • 84878760040 scopus 로고    scopus 로고
    • Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications
    • Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190-1194 (2013).
    • (2013) Science , vol.340 , pp. 1190-1194
    • Sato, T.1    Clevers, H.2
  • 4
    • 73049116186 scopus 로고    scopus 로고
    • Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    • Barker, N. et al. Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6, 25-36 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 25-36
    • Barker, N.1
  • 5
    • 84879582311 scopus 로고    scopus 로고
    • Microdissection and culture of murine pancreatic ductal epithelial cells
    • Pylayeva-Gupta, Y., Lee, K.E. & Bar-Sagi, D. Microdissection and culture of murine pancreatic ductal epithelial cells. Methods Mol. Biol. 980, 267-279 (2013).
    • (2013) Methods Mol. Biol , vol.980 , pp. 267-279
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Bar-Sagi, D.3
  • 6
    • 84874613949 scopus 로고    scopus 로고
    • Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel
    • Jin, L. et al. Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc. Natl. Acad. Sci. USA 110, 3907-3912 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 3907-3912
    • Jin, L.1
  • 7
    • 79952119288 scopus 로고    scopus 로고
    • The adult mouse and human pancreas contain rare multipotent stem cells that express insulin
    • Smukler, S.R. et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 8, 281-293 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 281-293
    • Smukler, S.R.1
  • 8
    • 84885846800 scopus 로고    scopus 로고
    • Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    • Huch, M. et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J. 32, 2708-2721 (2013).
    • (2013) EMBO J , vol.32 , pp. 2708-2721
    • Huch, M.1
  • 9
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    • Ootani, A. et al. Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat. Med. 15, 701-706 (2009).
    • (2009) Nat. Med , vol.15 , pp. 701-706
    • Ootani, A.1
  • 10
    • 84875554273 scopus 로고    scopus 로고
    • Establishment of a long-term three-dimensional primary culture of mouse glandular stomach epithelial cells within the stem cell niche
    • Katano, T. et al. Establishment of a long-term three-dimensional primary culture of mouse glandular stomach epithelial cells within the stem cell niche. Biochem. Biophys. Res. Commun. 432, 558-563 (2013).
    • (2013) Biochem. Biophys. Res. Commun , vol.432 , pp. 558-563
    • Katano, T.1
  • 11
    • 77954518306 scopus 로고    scopus 로고
    • Tumor engineering: The other face of tissue engineering
    • Ghajar, C.M. & Bissell, M.J. Tumor engineering: the other face of tissue engineering. Tissue Eng. Part A 16, 2153-2156 (2010).
    • (2010) Tissue Eng. Part A , vol.16 , pp. 2153-2156
    • Ghajar, C.M.1    Bissell, M.J.2
  • 12
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
  • 13
    • 73949159687 scopus 로고    scopus 로고
    • Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor
    • Wescott, M.P. et al. Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor. Mol. Biol. Cell 20, 4838-4844 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 4838-4844
    • Wescott, M.P.1
  • 14
    • 76249094159 scopus 로고    scopus 로고
    • Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
    • Rovira, M. et al. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc. Natl. Acad. Sci. USA 107, 75-80 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 75-80
    • Rovira, M.1
  • 15
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and Kras G12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani, S.R. et al. Trp53R172H and Kras G12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469-483 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1
  • 16
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 17
    • 42649125571 scopus 로고    scopus 로고
    • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
    • Haigis, K.M. et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat. Genet. 40, 600-608 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 600-608
    • Haigis, K.M.1
  • 18
    • 33748988989 scopus 로고    scopus 로고
    • Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
    • Sansom, O.J. et al. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc. Natl. Acad. Sci. USA 103, 14122-14127 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 14122-14127
    • Sansom, O.J.1
  • 19
    • 4043059169 scopus 로고    scopus 로고
    • Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    • el Marjou, F. et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186-193 (2004).
    • (2004) Genesis , vol.39 , pp. 186-193
    • El Marjou, F.1
  • 20
    • 0030843461 scopus 로고    scopus 로고
    • Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
    • Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120-123 (1997).
    • (1997) Science , vol.278 , pp. 120-123
    • Shibata, H.1
  • 21
    • 76549117990 scopus 로고    scopus 로고
    • Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
    • Hung, K.E. et al. Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc. Natl. Acad. Sci. USA 107, 1565-1570 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 1565-1570
    • Hung, K.E.1
  • 22
    • 60449086469 scopus 로고    scopus 로고
    • Mouse models of colon cancer
    • Taketo, M.M. & Edelmann, W. Mouse models of colon cancer. Gastroenterology 136, 780-798 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 780-798
    • Taketo, M.M.1    Edelmann, W.2
  • 23
    • 20444476625 scopus 로고    scopus 로고
    • SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
    • Tanaka, T., Soriano, M.A. & Grusby, M.J. SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity 22, 729-736 (2005).
    • (2005) Immunity , vol.22 , pp. 729-736
    • Tanaka, T.1    Soriano, M.A.2    Grusby, M.J.3
  • 24
    • 34248171703 scopus 로고    scopus 로고
    • Control of beta-cell differentiation by the pancreatic mesenchyme
    • Attali, M. et al. Control of beta-cell differentiation by the pancreatic mesenchyme. Diabetes 56, 1248-1258 (2007).
    • (2007) Diabetes , vol.56 , pp. 1248-1258
    • Attali, M.1
  • 25
    • 38449083536 scopus 로고    scopus 로고
    • In vivo and in vitro techniques to study pancreas development and islet cell function
    • Duvillié, B., Heinis, M. & Stetsyuk, V. In vivo and in vitro techniques to study pancreas development and islet cell function. Endocr. Dev. 12, 46-54 (2007).
    • (2007) Endocr. Dev , vol.12 , pp. 46-54
    • Duvillié, B.1    Heinis, M.2    Stetsyuk, V.3
  • 26
    • 78249289929 scopus 로고    scopus 로고
    • Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
    • Lee, K.E. & Bar-Sagi, D. Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell 18, 448-458 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 448-458
    • Lee, K.E.1    Bar-Sagi, D.2
  • 27
    • 84879726891 scopus 로고    scopus 로고
    • Genetic reconstitution of tumorigenesis in primary intestinal cells
    • Onuma, K. et al. Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc. Natl. Acad. Sci. USA 110, 11127-11132 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 11127-11132
    • Onuma, K.1
  • 28
    • 84857120037 scopus 로고    scopus 로고
    • Outgrowth of single oncogene-expressing cells from suppressive epithelial environments
    • Leung, C.T. & Brugge, J.S. Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature 482, 410-413 (2012).
    • (2012) Nature , vol.482 , pp. 410-413
    • Leung, C.T.1    Brugge, J.S.2
  • 29
    • 84879798872 scopus 로고    scopus 로고
    • An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
    • Kim, J. et al. An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Reports 3, 2088-2099 (2013).
    • (2013) Cell Reports , vol.3 , pp. 2088-2099
    • Kim, J.1
  • 30
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013).
    • (2013) Science , vol.339 , pp. 1546-1558
    • Vogelstein, B.1
  • 31
    • 82255179056 scopus 로고    scopus 로고
    • Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
    • March, H.N. et al. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat. Genet. 43, 1202-1209 (2011).
    • (2011) Nat. Genet , vol.43 , pp. 1202-1209
    • March, H.N.1
  • 32
    • 63049105067 scopus 로고    scopus 로고
    • A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
    • Starr, T.K. et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 323, 1747-1750 (2009).
    • (2009) Science , vol.323 , pp. 1747-1750
    • Starr, T.K.1
  • 33
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607 (2012).
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1
  • 34
    • 52949111487 scopus 로고    scopus 로고
    • CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
    • Firestein, R. et al. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity. Nature 455, 547-551 (2008).
    • (2008) Nature , vol.455 , pp. 547-551
    • Firestein, R.1
  • 35
    • 77951048682 scopus 로고    scopus 로고
    • Oncogenic role of miR-483-3p at the IGF2/483 locus
    • Veronese, A. et al. Oncogenic role of miR-483-3p at the IGF2/483 locus. Cancer Res. 70, 3140-3149 (2010).
    • (2010) Cancer Res , vol.70 , pp. 3140-3149
    • Veronese, A.1
  • 36
    • 33644506750 scopus 로고    scopus 로고
    • Soluble IGF2 receptor rescues Apc Min/+ intestinal adenoma progression induced by Igf2 loss of imprinting
    • Harper, J. et al. Soluble IGF2 receptor rescues Apc Min/+ intestinal adenoma progression induced by Igf2 loss of imprinting. Cancer Res. 66, 1940-1948 (2006).
    • (2006) Cancer Res , vol.66 , pp. 1940-1948
    • Harper, J.1
  • 37
    • 59449098943 scopus 로고    scopus 로고
    • A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction
    • Timp, W., Levchenko, A. & Feinberg, A.P. A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction. Cell Cycle 8, 383-390 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 383-390
    • Timp, W.1    Levchenko, A.2    Feinberg, A.P.3
  • 38
    • 0034652480 scopus 로고    scopus 로고
    • Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc Min/+ mice
    • Hassan, A.B. & Howell, J.A. Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc Min/+ mice. Cancer Res. 60, 1070-1076 (2000).
    • (2000) Cancer Res , vol.60 , pp. 1070-1076
    • Hassan, A.B.1    Howell, J.A.2
  • 39
    • 77950193822 scopus 로고    scopus 로고
    • DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    • Qu, Z. et al. DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 70, 1766-1772 (2010).
    • (2010) Cancer Res , vol.70 , pp. 1766-1772
    • Qu, Z.1
  • 40
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence, J.R. et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470, 105-109 (2011).
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1
  • 41
    • 79953308650 scopus 로고    scopus 로고
    • Oncogene-mediated human lung epithelial cell transformation produces adenocarcinoma phenotypes in vivo
    • Sasai, K. et al. Oncogene-mediated human lung epithelial cell transformation produces adenocarcinoma phenotypes in vivo. Cancer Res. 71, 2541-2549 (2011).
    • (2011) Cancer Res , vol.71 , pp. 2541-2549
    • Sasai, K.1
  • 42
    • 27644582893 scopus 로고    scopus 로고
    • Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
    • Dickins, R.A. et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat. Genet. 37, 1289-1295 (2005).
    • (2005) Nat. Genet , vol.37 , pp. 1289-1295
    • Dickins, R.A.1


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