Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice

FEBS Journal

Volumn 281, Issue 20, 2014, Pages 4672-4690

  Takahashi, Toshio ^a   Ohnishi, Hiroe ^b,g   Sugiura, Yuki ^c,d   Honda, Kurara ^c,d   Suematsu, Makoto ^c,d   Kawasaki, Takashi ^b   Deguchi, Tomonori ^b   Fujii, Takeshi ^e   Orihashi, Kaoru ^f   Hippo, Yoshitaka ^f   Watanabe, Takehiro ^a   Yamagaki, Tohru ^a   Yuba, Shunsuke ^b  

^a SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^f NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^g KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cholinergic system; Gut; Lgr5; Non neuronal acetylcholine; Organoid

Indexed keywords

ACETYLCHOLINE; BETA TUBULIN; CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE; HEPATOCYTE NUCLEAR FACTOR 1; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; MUCIN 2; MUSCARINIC RECEPTOR; NEUROGENIN 3; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR SOX9; UVOMORULIN; WNT11 PROTEIN; WNT3 PROTEIN; CHOLINERGIC RECEPTOR STIMULATING AGENT; CRE RECOMBINASE; ENHANCED GREEN FLUORESCENT PROTEIN; G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; INTEGRASE; LGR5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHOLINERGIC SYSTEM; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; CRYPT CELL; ENZYME LOCALIZATION; GENE EXPRESSION; INTESTINE EPITHELIUM; INTESTINE VILLUS; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; STEM CELL; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; CYTOPLASM; DRUG EFFECTS; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; GENETICS; INTESTINE MUCOSA; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ACETYLCHOLINE; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC AGONISTS; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; IMMUNOENZYME TECHNIQUES; INTEGRASES; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; ORGANOIDS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STEM CELLS;

EID: 84915746977     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12974     Document Type: Article

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