Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

EMBO Journal

Volumn 32, Issue 20, 2013, Pages 2708-2721

  Huch, Meritxell ^a   Bonfanti, Paola ^b   Boj, Sylvia F ^a   Sato, Toshiro ^a,d   Loomans, Cindy J M ^a,c   Van De Wetering, Marc ^a   Sojoodi, Mozhdeh ^b   Li, Vivian S W ^a,e   Schuijers, Jurian ^a   Gracanin, Ana ^a   Ringnalda, Femke ^a,c   Begthel, Harry ^a   Hamer, Karien ^a   Mulder, Joyce ^a   Van Es, Johan H ^a   De Koning, Eelco ^a,c   Vries, Robert G J ^a   Heimberg, Harry ^b   Clevers, Hans ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b DIABETES RESEARCH CENTER   (Belgium)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d KEIO UNIVERSITY   (Japan)

^e NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

beta cell; duct cell; pancreas; stem cell; Wnt

Indexed keywords

PEPTIDES AND PROTEINS; R SPONDIN; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENE; GENE EXPRESSION; IN VITRO STUDY; LGR5 GENE; MOUSE; NONHUMAN; PANCREAS; PANCREAS DUCT; PANCREAS INJURY; PRIORITY JOURNAL; STEM CELL;

ADULT STEM CELLS; ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; MICE; MICE, INBRED C57BL; MICE, NUDE; MICE, SCID; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MULTIPOTENT STEM CELLS; PANCREAS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THROMBOSPONDINS;

EID: 84885846800     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.204     Document Type: Article

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