Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells

Cell Stem Cell

Volumn 17, Issue 5, 2015, Pages 527-542

  Kurmann, Anita A ^a,b   Serra, Maria ^b,c   Hawkins, Finn ^b,c   Rankin, Scott A ^d   Mori, Munemasa ^b,c   Astapova, Inna ^a   Ullas, Soumya ^e   Lin, Sui ^d   Bilodeau, Melanie ^f   Rossant, Janet ^f,g   Jean, Jyh C ^b,c   Ikonomou, Laertis ^b,c   Deterding, Robin R ^h   Shannon, John M ^d   Zorn, Aaron M ^d   Hollenberg, Anthony N ^a   Kotton, Darrell N ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON MEDICAL CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

^h CHILDREN S HOSPITAL COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; THYROID HORMONE; TRANSCRIPTION FACTOR PAX8;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; ENDODERM; EPITHELIUM CELL; FOREGUT; GERM CELL; HAPLOINSUFFICIENCY; HYPOTHYROIDISM; IN VIVO STUDY; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION; THYROID CELL; THYROID EPITHELIUM CELL; THYROID FOLLICLE CELL; THYROID FUNCTION; XENOPUS; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; HUMAN; PHYSIOLOGY; REGENERATION; THYROID GLAND; TRANSGENIC MOUSE; TRANSPLANTATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; HUMANS; MICE; MICE, TRANSGENIC; PLURIPOTENT STEM CELLS; REGENERATION; THYROID GLAND; XENOPUS;

EID: 84947706099     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.09.004     Document Type: Article

References (39)

1. F. Antonica, D.F. Kasprzyk, R. Opitz, M. Iacovino, X.H. Liao, A.M. Dumitrescu, S. Refetoff, K. Peremans, M. Manto, M. Kyba, and S. Costagliola Generation of functional thyroid from embryonic stem cells Nature 491 2012 66 71
2. M.C. Arufe, M. Lu, A. Kubo, G. Keller, T.F. Davies, and R.Y. Lin Directed differentiation of mouse embryonic stem cells into thyroid follicular cells Endocrinology 147 2006 3007 3015
3. M.C. Arufe, M. Lu, and R.Y. Lin Differentiation of murine embryonic stem cells to thyrocytes requires insulin and insulin-like growth factor-1 Biochem. Biophys. Res. Commun. 381 2009 264 270
4. D. Bachiller, J. Klingensmith, N. Shneyder, U. Tran, R. Anderson, J. Rossant, and E.M. De Robertis The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome Development 130 2003 3567 3578
5. M. Bilodeau, S. Shojaie, C. Ackerley, M. Post, and J. Rossant Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential Stem Cell Rep. 3 2014 634 649
6. M. Bouchard, A. Souabni, and M. Busslinger Tissue-specific expression of cre recombinase from the Pax8 locus Genesis 38 2004 105 109
7. G. Celli, W.J. LaRochelle, S. Mackem, R. Sharp, and G. Merlino Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning EMBO J. 17 1998 1642 1655
8. A.M. Crane, P. Kramer, J.H. Bui, W.J. Chung, X.S. Li, M.L. Gonzalez-Garay, F. Hawkins, W. Liao, D. Mora, S. Choi, and et al. Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells Stem Cell Rep. 4 2015 569 577
9. H. Fagman, and M. Nilsson Morphogenesis of the thyroid gland Mol. Cell. Endocrinol. 323 2010 35 54
10. H. Fagman, J. Liao, J. Westerlund, L. Andersson, B.E. Morrow, and M. Nilsson The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning Hum. Mol. Genet. 16 2007 276 285
11. A.M. Goss, Y. Tian, T. Tsukiyama, E.D. Cohen, D. Zhou, M.M. Lu, T.P. Yamaguchi, and E.E. Morrisey Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut Dev. Cell 17 2009 290 298
12. M.D. Green, A. Chen, M.C. Nostro, S.L. d'Souza, C. Schaniel, I.R. Lemischka, V. Gouon-Evans, G. Keller, and H.W. Snoeck Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells Nat. Biotechnol. 29 2011 267 272
13. A. Hamvas, R.R. Deterding, S.E. Wert, F.V. White, M.K. Dishop, D.N. Alfano, A.C. Halbower, B. Planer, M.J. Stephan, D.A. Uchida, and et al. Heterogeneous pulmonary phenotypes associated with mutations in the thyroid transcription factor gene NKX2-1 Chest 144 2013 794 804
14. S.R. Hilfer, L.B. Iszard, and E.K. Hilfer Follicle formation in the embryonic chick thyroid. II. Reorganization after dissociation Z. Zellforsch. Mikrosk. Anat. 92 1968 256 269
15. S.X. Huang, M.N. Islam, J. O'Neill, Z. Hu, Y.G. Yang, Y.W. Chen, M. Mumau, M.D. Green, G. Vunjak-Novakovic, J. Bhattacharya, and H.W. Snoeck Efficient generation of lung and airway epithelial cells from human pluripotent stem cells Nat. Biotechnol. 32 2014 84 91
16. N. Jiang, Y. Hu, X. Liu, Y. Wu, H. Zhang, G. Chen, J. Liang, X. Lu, and S. Liu Differentiation of E14 mouse embryonic stem cells into thyrocytes in vitro Thyroid 20 2010 77 84
17. Y. Kameda, M. Ito, T. Nishimaki, and N. Gotoh FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus Dev. Dyn. 238 2009 503 513
18. H. Krude, B. Schütz, H. Biebermann, A. von Moers, D. Schnabel, H. Neitzel, H. Tönnies, D. Weise, A. Lafferty, S. Schwarz, and et al. Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency J. Clin. Invest. 109 2002 475 480
19. M.A. Lancaster, and J.A. Knoblich Organogenesis in a dish: modeling development and disease using organoid technologies Science 345 2014 1247125
20. G. Lania, Z. Zhang, T. Huynh, C. Caprio, A.M. Moon, F. Vitelli, and A. Baldini Early thyroid development requires a Tbx1-Fgf8 pathway Dev. Biol. 328 2009 109 117
21. T.A. Longmire, L. Ikonomou, F. Hawkins, C. Christodoulou, Y. Cao, J.C. Jean, L.W. Kwok, H. Mou, J. Rajagopal, S.S. Shen, and et al. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells Cell Stem Cell 10 2012 398 411
22. R. Ma, R. Latif, and T.F. Davies Thyrotropin-independent induction of thyroid endoderm from embryonic stem cells by activin A Endocrinology 150 2009 1970 1975
23. R. Ma, R. Latif, and T.F. Davies Thyroid follicle formation and thyroglobulin expression in multipotent endodermal stem cells Thyroid 23 2013 385 391
24. R. Ma, R. Latif, and T.F. Davies Human embryonic stem cells form functional thyroid follicles Thyroid 25 2015 455 461
25. J.M. Mallette, and A. Anthony Growth in culture of trypsin dissociated thyroid cells from adult rats Exp. Cell Res. 41 1966 642 651
26. A. Martin, M. Valentine, P. Unger, C. Lichtenstein, A.E. Schwartz, E.W. Friedman, L.D. Shultz, and T.F. Davies Preservation of functioning human thyroid organoids in the scid mouse: 1. System characterization J. Clin. Endocrinol. Metab. 77 1993 305 310
27. K.W. McCracken, E.M. Catá, C.M. Crawford, K.L. Sinagoga, M. Schumacher, B.E. Rockich, Y.H. Tsai, C.N. Mayhew, J.R. Spence, Y. Zavros, and J.M. Wells Modelling human development and disease in pluripotent stem-cell-derived gastric organoids Nature 516 2014 400 404
28. C.E. Murry, and G. Keller Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development Cell 132 2008 661 680
29. F.W. Pagliuca, J.R. Millman, M. Gürtler, M. Segel, A. Van Dervort, J.H. Ryu, Q.P. Peterson, D. Greiner, and D.A. Melton Generation of functional human pancreatic β cells in vitro Cell 159 2014 428 439
30. R. Parlato, A. Rosica, A. Rodriguez-Mallon, A. Affuso, M.P. Postiglione, C. Arra, A. Mansouri, S. Kimura, R. Di Lauro, and M. De Felice An integrated regulatory network controlling survival and migration in thyroid organogenesis Dev. Biol. 276 2004 464 475
31. A. Petryk, R.M. Anderson, M.P. Jarcho, I. Leaf, C.S. Carlson, J. Klingensmith, W. Shawlot, and M.B. O'Connor The mammalian twisted gastrulation gene functions in foregut and craniofacial development Dev. Biol. 267 2004 374 386
32. M.P. Postiglione, R. Parlato, A. Rodriguez-Mallon, A. Rosica, P. Mithbaokar, M. Maresca, R.C. Marians, T.F. Davies, M.S. Zannini, M. De Felice, and R. Di Lauro Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland Proc. Natl. Acad. Sci. U S A 99 2002 15462 15467
33. A.E. Serls, S. Doherty, P. Parvatiyar, J.M. Wells, and G.H. Deutsch Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung Development 132 2005 35 47
34. E.T. Shifley, A.P. Kenny, S.A. Rankin, and A.M. Zorn Prolonged FGF signaling is necessary for lung and liver induction in Xenopus BMC Dev. Biol. 12 2012 27
35. A. Somers, J.C. Jean, C.A. Sommer, A. Omari, C.C. Ford, J.A. Mills, L. Ying, A.G. Sommer, J.M. Jean, B.W. Smith, and et al. Generation of Transgene-Free Lung Disease-Specific Human iPS Cells Using a Single Excisable Lentiviral Stem Cell Cassette Stem Cells 28 2010 1728 1740
36. S.S. Trueba, J. Augé, G. Mattei, H. Etchevers, J. Martinovic, P. Czernichow, M. Vekemans, M. Polak, and T. Attié-Bitach PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations J. Clin. Endocrinol. Metab. 90 2005 455 462
37. F. Vitelli, I. Taddei, M. Morishima, E.N. Meyers, E.A. Lindsay, and A. Baldini A genetic link between Tbx1 and fibroblast growth factor signaling Development 129 2002 4605 4611
38. T. Wendl, D. Adzic, J.J. Schoenebeck, S. Scholpp, M. Brand, D. Yelon, and K.B. Rohr Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals Development 134 2007 2871 2879
39. L.S. Zuckier, O. Dohan, Y. Li, C.J. Chang, N. Carrasco, and E. Dadachova Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo J. Nucl. Med. 45 2004 500 507