메뉴 건너뛰기




Volumn 24, Issue 5, 2018, Pages 541-550

Understanding the tumor immune microenvironment (TIME) for effective therapy

(18)  Binnewies, Mikhail a   Roberts, Edward W a   Kersten, Kelly a   Chan, Vincent b   Fearon, Douglas F c   Merad, Miriam d   Coussens, Lisa M e   Gabrilovich, Dmitry I f   Ostrand Rosenberg, Suzanne g,h   Hedrick, Catherine C i   Vonderheide, Robert H j   Pittet, Mikael J k   Jain, Rakesh K k   Zou, Weiping l   Howcroft, T Kevin m   Woodhouse, Elisa C m   Weinberg, Robert A n   Krummel, Matthew F a,b  


Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HUMORAL ANTIBODY;

EID: 85045833745     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/s41591-018-0014-x     Document Type: Article
Times cited : (3720)

References (111)
  • 1
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • Topalian, S. L., Drake, C. G. & Pardoll, D. M. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 27, 450-461 (2015).
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 2
    • 85007543412 scopus 로고    scopus 로고
    • Patterns of immune infiltration in breast cancer and their clinical implications: A gene-expression-based retrospective study
    • Ali, H. R., Chlon, L., Pharoah, P. D., Markowetz, F. & Caldas, C. Patterns of immune infiltration in breast cancer and their clinical implications: A gene-expression-based retrospective study. PLoS Med. 13, e1002194 (2016).
    • (2016) PLoS Med. , vol.13 , pp. e1002194
    • Ali, H.R.1    Chlon, L.2    Pharoah, P.D.3    Markowetz, F.4    Caldas, C.5
  • 3
    • 84928927858 scopus 로고    scopus 로고
    • Robust enumeration of cell subsets from tissue expression profiles
    • Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods 12, 453-457 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 453-457
    • Newman, A.M.1
  • 4
    • 85034614124 scopus 로고    scopus 로고
    • xCell: Digitally portraying the tissue cellular heterogeneity landscape
    • Aran, D., Hu, Z. & Butte, A. J. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 18, 220 (2017).
    • (2017) Genome Biol. , vol.18 , pp. 220
    • Aran, D.1    Hu, Z.2    Butte, A.J.3
  • 5
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782-795 (2013).
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1
  • 6
    • 84960466507 scopus 로고    scopus 로고
    • Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability
    • Mlecnik, B. et al. Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability. Immunity 44, 698-711 (2016).
    • (2016) Immunity , vol.44 , pp. 698-711
    • Mlecnik, B.1
  • 7
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst, R. S. et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515, 563-567 (2014).
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1
  • 8
    • 0031961278 scopus 로고    scopus 로고
    • + cells by multi-epitope imaging
    • + cells by multi-epitope imaging. Clin. Exp. Immunol. 112, 21-26 (1998).
    • (1998) Clin. Exp. Immunol. , vol.112 , pp. 21-26
    • Ademmer, K.1
  • 9
    • 84931434511 scopus 로고    scopus 로고
    • + extratumoral macrophages
    • + extratumoral macrophages. Gastroenterology 149, 201-210 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 201-210
    • Beatty, G.L.1
  • 10
    • 84988976297 scopus 로고    scopus 로고
    • Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment
    • Spranger, S. Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment. Int. Immunol. 28, 383-391 (2016).
    • (2016) Int. Immunol. , vol.28 , pp. 383-391
    • Spranger, S.1
  • 11
    • 85055601829 scopus 로고    scopus 로고
    • Lack of immunoediting in murine pancreatic cancer reversed with neoantigen
    • Evans, R. A. et al. Lack of immunoediting in murine pancreatic cancer reversed with neoantigen. JCI Insight 1, e88328 (2016).
    • (2016) JCI Insight , vol.1 , pp. e88328
    • Evans, R.A.1
  • 12
    • 84971657383 scopus 로고    scopus 로고
    • Tertiary lymphoid structures: Prognostic significance and relationship with tumour-infiltrating lymphocytes in triple-negative breast cancer
    • Lee, H. J. et al. Tertiary lymphoid structures: prognostic significance and relationship with tumour-infiltrating lymphocytes in triple-negative breast cancer. J. Clin. Pathol. 69, 422-430 (2016).
    • (2016) J. Clin. Pathol. , vol.69 , pp. 422-430
    • Lee, H.J.1
  • 13
    • 84997108103 scopus 로고    scopus 로고
    • Tertiary lymphoid structures in cancers: Prognostic value, regulation, and manipulation for therapeutic intervention
    • Sautès-Fridman, C. et al. Tertiary lymphoid structures in cancers: prognostic value, regulation, and manipulation for therapeutic intervention. Front. Immunol. 7, 407 (2016).
    • (2016) Front. Immunol. , vol.7 , pp. 407
    • Sautès-Fridman, C.1
  • 14
    • 84947863720 scopus 로고    scopus 로고
    • Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
    • Finkin, S. et al. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat. Immunol. 16, 1235-1244 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 1235-1244
    • Finkin, S.1
  • 16
    • 84964314430 scopus 로고    scopus 로고
    • Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation
    • Lutz, E. R. et al. Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation. Cancer Immunol. Res. 2, 616-631 (2014).
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 616-631
    • Lutz, E.R.1
  • 17
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
    • Sumimoto, H., Imabayashi, F., Iwata, T. & Kawakami, Y. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J. Exp. Med. 203, 1651-1656 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3    Kawakami, Y.4
  • 18
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta, Y., Lee, K. E., Hajdu, C. H., Miller, G. & Bar-Sagi, D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 21, 836-847 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3    Miller, G.4    Bar-Sagi, D.5
  • 19
    • 84862150896 scopus 로고    scopus 로고
    • Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    • Bayne, L. J. et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21, 822-835 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 822-835
    • Bayne, L.J.1
  • 20
    • 84911937777 scopus 로고    scopus 로고
    • Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity
    • Broz, M. L. et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell 26, 638-652 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 638-652
    • Broz, M.L.1
  • 21
    • 85019144614 scopus 로고    scopus 로고
    • Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy
    • Spranger, S., Dai, D., Horton, B. & Gajewski, T. F. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy. Cancer Cell 31, 711-723.e714 (2017).
    • (2017) Cancer Cell , vol.31 , pp. 711-723
    • Spranger, S.1    Dai, D.2    Horton, B.3    Gajewski, T.F.4
  • 22
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
    • Spranger, S., Bao, R. & Gajewski, T. F. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature 523, 231-235 (2015).
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 23
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian, B.-Z. et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475, 222-225 (2011).
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.-Z.1
  • 24
    • 84922689090 scopus 로고    scopus 로고
    • PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer
    • Bonavita, E. et al. PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell 160, 700-714 (2015).
    • (2015) Cell , vol.160 , pp. 700-714
    • Bonavita, E.1
  • 25
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis, J. & Pollard, J. W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124, 263-266 (2006).
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 26
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin, E. Y., Nguyen, A. V., Russell, R. G. & Pollard, J. W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727-740 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 27
    • 0028057251 scopus 로고
    • Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis
    • Scholl, S. M. et al. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J. Natl. Cancer Inst. 86, 120-126 (1994).
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 120-126
    • Scholl, S.M.1
  • 28
    • 67651160649 scopus 로고    scopus 로고
    • + T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • + T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16, 91-102 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • DeNardo, D.G.1
  • 29
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard, J. W. Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 4, 71-78 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 30
    • 84866918738 scopus 로고    scopus 로고
    • Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma
    • Khalili, J. S. et al. Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma. Clin. Cancer Res. 18, 5329-5340 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 5329-5340
    • Khalili, J.S.1
  • 31
    • 84876291823 scopus 로고    scopus 로고
    • Non-cell-autonomous tumor suppression by p53
    • Lujambio, A. et al. Non-cell-autonomous tumor suppression by p53. Cell 153, 449-460 (2013).
    • (2013) Cell , vol.153 , pp. 449-460
    • Lujambio, A.1
  • 32
    • 84946571753 scopus 로고    scopus 로고
    • The consensus molecular subtypes of colorectal cancer
    • Guinney, J. et al. The consensus molecular subtypes of colorectal cancer. Nat. Med. 21, 1350-1356 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1350-1356
    • Guinney, J.1
  • 33
    • 84931426001 scopus 로고    scopus 로고
    • Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
    • Angelova, M. et al. Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy. Genome Biol. 16, 64 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 64
    • Angelova, M.1
  • 34
    • 84982161471 scopus 로고    scopus 로고
    • Immune and stromal classification of colorectal cancer is associated with molecular subtypes and relevant for precision immunotherapy
    • Becht, E. et al. Immune and stromal classification of colorectal cancer is associated with molecular subtypes and relevant for precision immunotherapy. Clin. Cancer Res. 22, 4057-4066 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 4057-4066
    • Becht, E.1
  • 35
    • 84919385463 scopus 로고    scopus 로고
    • Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type
    • Gatalica, Z. et al. Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type. Cancer Epidemiol. Biomarkers Prev. 23, 2965-2970 (2014).
    • (2014) Cancer Epidemiol. Biomarkers Prev. , vol.23 , pp. 2965-2970
    • Gatalica, Z.1
  • 36
    • 85019257096 scopus 로고    scopus 로고
    • Immunotherapy for colorectal cancer
    • Boland, P. M. & Ma, W. W. Immunotherapy for colorectal cancer. Cancers (Basel) 9, E50 (2017).
    • (2017) Cancers (Basel) , vol.9 , pp. E50
    • Boland, P.M.1    Ma, W.W.2
  • 37
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: Complex tissues that interface with the entire organism
    • Egeblad, M., Nakasone, E. S. & Werb, Z. Tumors as organs: complex tissues that interface with the entire organism. Dev. Cell 18, 884-901 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 38
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail, D. F. & Joyce, J. A. Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 19, 1423-1437 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 40
    • 24344436369 scopus 로고    scopus 로고
    • Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    • Willimsky, G. & Blankenstein, T. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature 437, 141-146 (2005).
    • (2005) Nature , vol.437 , pp. 141-146
    • Willimsky, G.1    Blankenstein, T.2
  • 41
    • 31544457405 scopus 로고    scopus 로고
    • Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses
    • Garbe, A. I. et al. Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses. Cancer Res. 66, 508-516 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 508-516
    • Garbe, A.I.1
  • 42
    • 78651451436 scopus 로고    scopus 로고
    • Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression
    • DuPage, M. et al. Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell 19, 72-85 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 72-85
    • DuPage, M.1
  • 43
    • 84926528302 scopus 로고    scopus 로고
    • Overcoming T cell exhaustion in infection and cancer
    • Pauken, K. E. & Wherry, E. J. Overcoming T cell exhaustion in infection and cancer. Trends Immunol. 36, 265-276 (2015).
    • (2015) Trends Immunol. , vol.36 , pp. 265-276
    • Pauken, K.E.1    Wherry, E.J.2
  • 44
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry, E. J. T cell exhaustion. Nat. Immunol. 12, 492-499 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 45
    • 85019673982 scopus 로고    scopus 로고
    • Chromatin states define tumour-specific T cell dysfunction and reprogramming
    • Philip, M. et al. Chromatin states define tumour-specific T cell dysfunction and reprogramming. Nature 545, 452-456 (2017).
    • (2017) Nature , vol.545 , pp. 452-456
    • Philip, M.1
  • 46
    • 84994364943 scopus 로고    scopus 로고
    • Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
    • Pauken, K. E. et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science 354, 1160-1165 (2016).
    • (2016) Science , vol.354 , pp. 1160-1165
    • Pauken, K.E.1
  • 47
    • 84994330192 scopus 로고    scopus 로고
    • Tumor-specific T cell dysfunction is a dynamic antigen-driven differentiation program initiated early during tumorigenesis
    • Schietinger, A. et al. Tumor-specific T cell dysfunction is a dynamic antigen-driven differentiation program initiated early during tumorigenesis. Immunity 45, 389-401 (2016).
    • (2016) Immunity , vol.45 , pp. 389-401
    • Schietinger, A.1
  • 48
    • 84912089439 scopus 로고    scopus 로고
    • + T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells
    • + T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Cancer Cell 26, 623-637 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 623-637
    • Ruffell, B.1
  • 49
    • 85033725863 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors
    • Kumar, V. et al. Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors. Cancer Cell 32, 654-668.e5 (2017).
    • (2017) Cancer Cell , vol.32 , pp. 654-668
    • Kumar, V.1
  • 50
    • 84886805255 scopus 로고    scopus 로고
    • Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
    • Bos, P. D., Plitas, G., Rudra, D., Lee, S. Y. & Rudensky, A. Y. Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J. Exp. Med. 210, 2435-2466 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 2435-2466
    • Bos, P.D.1    Plitas, G.2    Rudra, D.3    Lee, S.Y.4    Rudensky, A.Y.5
  • 51
    • 85027340338 scopus 로고    scopus 로고
    • Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression
    • Zhu, Y. et al. Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression. Immunity 47, 323-338.e6 (2017).
    • (2017) Immunity , vol.47 , pp. 323-338
    • Zhu, Y.1
  • 52
    • 84901215262 scopus 로고    scopus 로고
    • The cellular and molecular origin of tumor-associated macrophages
    • Franklin, R. A. et al. The cellular and molecular origin of tumor-associated macrophages. Science 344, 921-925 (2014).
    • (2014) Science , vol.344 , pp. 921-925
    • Franklin, R.A.1
  • 53
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: Nomenclature and experimental guidelines
    • Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014).
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 54
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani, A. et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25, 677-686 (2004).
    • (2004) Trends Immunol. , vol.25 , pp. 677-686
    • Mantovani, A.1
  • 56
    • 84960124795 scopus 로고    scopus 로고
    • Bruton tyrosine kinase-dependent immune cell cross-talk drives pancreas cancer
    • Gunderson, A. J. et al. Bruton tyrosine kinase-dependent immune cell cross-talk drives pancreas cancer. Cancer Discov 6, 270-285 (2016).
    • (2016) Cancer Discov , vol.6 , pp. 270-285
    • Gunderson, A.J.1
  • 57
    • 84996523368 scopus 로고    scopus 로고
    • PI3Kγ is a molecular switch that controls immune suppression
    • Kaneda, M. M. et al. PI3Kγ is a molecular switch that controls immune suppression. Nature 539, 437-442 (2016).
    • (2016) Nature , vol.539 , pp. 437-442
    • Kaneda, M.M.1
  • 58
    • 85017279150 scopus 로고    scopus 로고
    • Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance
    • Daley, D. et al. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat. Med. 23, 556-567 (2017).
    • (2017) Nat. Med. , vol.23 , pp. 556-567
    • Daley, D.1
  • 59
    • 84978872467 scopus 로고    scopus 로고
    • + dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma
    • + dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma. Cancer Cell 30, 324-336 (2016).
    • (2016) Cancer Cell , vol.30 , pp. 324-336
    • Roberts, E.W.1
  • 60
    • 84964344569 scopus 로고    scopus 로고
    • + dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition
    • + dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition. Immunity 44, 924-938 (2016).
    • (2016) Immunity , vol.44 , pp. 924-938
    • Salmon, H.1
  • 61
    • 56449097442 scopus 로고    scopus 로고
    • + dendritic cells in cytotoxic T cell immunity
    • + dendritic cells in cytotoxic T cell immunity. Science 322, 1097-1100 (2008).
    • (2008) Science , vol.322 , pp. 1097-1100
    • Hildner, K.1
  • 62
    • 84954053287 scopus 로고    scopus 로고
    • Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells
    • Sánchez-Paulete, A. R. et al. Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells. Cancer Discov 6, 71-79 (2016).
    • (2016) Cancer Discov , vol.6 , pp. 71-79
    • Sánchez-Paulete, A.R.1
  • 63
    • 84961145493 scopus 로고    scopus 로고
    • FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis
    • Qian, B.-Z. et al. FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J. Exp. Med. 212, 1433-1448 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 1433-1448
    • Qian, B.-Z.1
  • 64
    • 84934307169 scopus 로고    scopus 로고
    • CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages
    • Kitamura, T. et al. CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J. Exp. Med. 212, 1043-1059 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 1043-1059
    • Kitamura, T.1
  • 65
    • 84961656295 scopus 로고    scopus 로고
    • Visualization of immediate immune responses to pioneer metastatic cells in the lung
    • Headley, M. B. et al. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature 531, 513-517 (2016).
    • (2016) Nature , vol.531 , pp. 513-517
    • Headley, M.B.1
  • 66
    • 84947754755 scopus 로고    scopus 로고
    • Patrolling monocytes control tumor metastasis to the lung
    • Hanna, R. N. et al. Patrolling monocytes control tumor metastasis to the lung. Science 350, 985-990 (2015).
    • (2015) Science , vol.350 , pp. 985-990
    • Hanna, R.N.1
  • 67
    • 84950299450 scopus 로고    scopus 로고
    • Neutrophils support lung colonization of metastasis-initiating breast cancer cells
    • Wculek, S. K. & Malanchi, I. Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature 528, 413-417 (2015).
    • (2015) Nature , vol.528 , pp. 413-417
    • Wculek, S.K.1    Malanchi, I.2
  • 68
    • 84962367349 scopus 로고    scopus 로고
    • Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: A single-centre, open-label, dose-finding, non-randomised, phase 1b trial
    • Nywening, T. M. et al. Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: A single-centre, open-label, dose-finding, non-randomised, phase 1b trial. Lancet Oncol. 17, 651-662 (2016).
    • (2016) Lancet Oncol. , vol.17 , pp. 651-662
    • Nywening, T.M.1
  • 69
    • 84926473508 scopus 로고    scopus 로고
    • IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
    • Coffelt, S. B. et al. IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature 522, 345-348 (2015).
    • (2015) Nature , vol.522 , pp. 345-348
    • Coffelt, S.B.1
  • 70
    • 84922660501 scopus 로고    scopus 로고
    • Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils
    • Casbon, A.-J. et al. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc. Natl. Acad. Sci. USA 112, E566-E575 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. E566-E575
    • Casbon, A.-J.1
  • 71
    • 80052566377 scopus 로고    scopus 로고
    • Tumor entrained neutrophils inhibit seeding in the premetastatic lung
    • Granot, Z. et al. Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20, 300-314 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 300-314
    • Granot, Z.1
  • 72
    • 84934973340 scopus 로고    scopus 로고
    • MET is required for the recruitment of anti-tumoural neutrophils
    • Finisguerra, V. et al. MET is required for the recruitment of anti-tumoural neutrophils. Nature 522, 349-353 (2015).
    • (2015) Nature , vol.522 , pp. 349-353
    • Finisguerra, V.1
  • 73
    • 84976515614 scopus 로고    scopus 로고
    • CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma
    • Steele, C. W. et al. CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell 29, 832-845 (2016).
    • (2016) Cancer Cell , vol.29 , pp. 832-845
    • Steele, C.W.1
  • 75
    • 84865974140 scopus 로고    scopus 로고
    • Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
    • Jamieson, T. et al. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J. Clin. Invest. 122, 3127-3144 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3127-3144
    • Jamieson, T.1
  • 76
    • 84895871023 scopus 로고    scopus 로고
    • Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
    • Bald, T. et al. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 507, 109-113 (2014).
    • (2014) Nature , vol.507 , pp. 109-113
    • Bald, T.1
  • 79
    • 84928536340 scopus 로고    scopus 로고
    • The impact of diet on asthma and allergic diseases
    • Julia, V., Macia, L. & Dombrowicz, D. The impact of diet on asthma and allergic diseases. Nat. Rev. Immunol. 15, 308-322 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 308-322
    • Julia, V.1    Macia, L.2    Dombrowicz, D.3
  • 80
    • 84923046255 scopus 로고    scopus 로고
    • Cholesterol, inflammation and innate immunity
    • Tall, A. R. & Yvan-Charvet, L. Cholesterol, inflammation and innate immunity. Nat. Rev. Immunol. 15, 104-116 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 104-116
    • Tall, A.R.1    Yvan-Charvet, L.2
  • 81
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper, L. V., Littman, D. R. & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268-1273 (2012).
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 82
    • 79960943019 scopus 로고    scopus 로고
    • Elevated 17β-estradiol protects females from influenza A virus pathogenesis by suppressing inflammatory responses
    • Robinson, D. P., Lorenzo, M. E., Jian, W. & Klein, S. L. Elevated 17β-estradiol protects females from influenza A virus pathogenesis by suppressing inflammatory responses. PLoS Pathog. 7, e1002149 (2011).
    • (2011) PLoS Pathog. , vol.7
    • Robinson, D.P.1    Lorenzo, M.E.2    Jian, W.3    Klein, S.L.4
  • 83
    • 85028364235 scopus 로고    scopus 로고
    • Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: Exploratory results from a randomised, double-blind, placebo-controlled trial
    • Ridker, P. M. et al. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet 390, 1833-1842 (2017).
    • (2017) Lancet , vol.390 , pp. 1833-1842
    • Ridker, P.M.1
  • 84
    • 21444450527 scopus 로고    scopus 로고
    • Low-dose aspirin in the primary prevention of cancer: The Women's Health Study: A randomized controlled trial
    • Cook, N. R. et al. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: A randomized controlled trial. J. Am. Med. Assoc. 294, 47-55 (2005).
    • (2005) J. Am. Med. Assoc. , vol.294 , pp. 47-55
    • Cook, N.R.1
  • 85
    • 83955161674 scopus 로고    scopus 로고
    • Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial
    • Burn, J. et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial. Lancet 378, 2081-2087 (2011).
    • (2011) Lancet , vol.378 , pp. 2081-2087
    • Burn, J.1
  • 86
    • 84941419767 scopus 로고    scopus 로고
    • Cyclooxygenase-dependent tumor growth through evasion of immunity
    • Zelenay, S. et al. Cyclooxygenase-dependent tumor growth through evasion of immunity. Cell 162, 1257-1270 (2015).
    • (2015) Cell , vol.162 , pp. 1257-1270
    • Zelenay, S.1
  • 87
    • 77953914366 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression depend on the C/EBPβ transcription factor
    • Marigo, I. et al. Tumor-induced tolerance and immune suppression depend on the C/EBPβ transcription factor. Immunity 32, 790-802 (2010).
    • (2010) Immunity , vol.32 , pp. 790-802
    • Marigo, I.1
  • 88
    • 81155131681 scopus 로고    scopus 로고
    • Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism
    • Waight, J. D., Hu, Q., Miller, A., Liu, S. & Abrams, S. I. Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism. PLoS One 6, e27690 (2011).
    • (2011) PLoS One , vol.6
    • Waight, J.D.1    Hu, Q.2    Miller, A.3    Liu, S.4    Abrams, S.I.5
  • 89
    • 85036536357 scopus 로고    scopus 로고
    • high neutrophils
    • high neutrophils. Science 358, eaal5081 (2017).
    • (2017) Science , vol.358
    • Engblom, C.1
  • 90
    • 84874227016 scopus 로고    scopus 로고
    • Angiotensin II drives the production of tumor-promoting macrophages
    • Cortez-Retamozo, V. et al. Angiotensin II drives the production of tumor-promoting macrophages. Immunity 38, 296-308 (2013).
    • (2013) Immunity , vol.38 , pp. 296-308
    • Cortez-Retamozo, V.1
  • 91
    • 84994387582 scopus 로고    scopus 로고
    • PF4 promotes platelet production and lung cancer growth
    • Pucci, F. et al. PF4 promotes platelet production and lung cancer growth. Cell Rep. 17, 1764-1772 (2016).
    • (2016) Cell Rep. , vol.17 , pp. 1764-1772
    • Pucci, F.1
  • 92
    • 84875658458 scopus 로고    scopus 로고
    • - myeloid-derived suppressor cells are increased with age and a history of cancer
    • - myeloid-derived suppressor cells are increased with age and a history of cancer. J. Leukoc. Biol. 93, 633-637 (2013).
    • (2013) J. Leukoc. Biol. , vol.93 , pp. 633-637
    • Verschoor, C.P.1
  • 93
    • 84976439950 scopus 로고    scopus 로고
    • Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
    • Ruhland, M. K. et al. Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nat. Commun. 7, 11762 (2016).
    • (2016) Nat. Commun. , vol.7
    • Ruhland, M.K.1
  • 94
    • 84929497622 scopus 로고    scopus 로고
    • Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2
    • Hale, M. et al. Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2. PLoS One 10, e0118784 (2015).
    • (2015) PLoS One , vol.10 , pp. e0118784
    • Hale, M.1
  • 95
    • 85009430958 scopus 로고    scopus 로고
    • Tumor cell-independent estrogen signaling drives disease progression through mobilization of myeloid-derived suppressor cells
    • Svoronos, N. et al. Tumor cell-independent estrogen signaling drives disease progression through mobilization of myeloid-derived suppressor cells. Cancer Discov 7, 72-85 (2017).
    • (2017) Cancer Discov , vol.7 , pp. 72-85
    • Svoronos, N.1
  • 96
    • 85013485353 scopus 로고    scopus 로고
    • FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice
    • Thompson, M. G., Peiffer, D. S., Larson, M., Navarro, F. & Watkins, S. K. FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice. Cancer Immunol. Immunother. 66, 615-625 (2017).
    • (2017) Cancer Immunol. Immunother. , vol.66 , pp. 615-625
    • Thompson, M.G.1    Peiffer, D.S.2    Larson, M.3    Navarro, F.4    Watkins, S.K.5
  • 97
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
    • Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350, 1084-1089 (2015).
    • (2015) Science , vol.350 , pp. 1084-1089
    • Sivan, A.1
  • 98
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
    • Vétizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
    • (2015) Science , vol.350 , pp. 1079-1084
    • Vétizou, M.1
  • 99
    • 84890278138 scopus 로고    scopus 로고
    • Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature
    • Kokolus, K. M. et al. Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature. Proc. Natl. Acad. Sci. USA 110, 20176-20181 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 20176-20181
    • Kokolus, K.M.1
  • 100
    • 84895541678 scopus 로고    scopus 로고
    • Stressful presentations: Mild cold stress in laboratory mice influences phenotype of dendritic cells in naïve and tumor-bearing mice
    • Kokolus, K. M. et al. Stressful presentations: mild cold stress in laboratory mice influences phenotype of dendritic cells in naïve and tumor-bearing mice. Front. Immunol. 5, 23 (2014).
    • (2014) Front. Immunol. , vol.5 , pp. 23
    • Kokolus, K.M.1
  • 101
    • 84994577858 scopus 로고    scopus 로고
    • Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity
    • Flint, T. R. et al. Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metab. 24, 672-684 (2016).
    • (2016) Cell Metab. , vol.24 , pp. 672-684
    • Flint, T.R.1
  • 102
    • 84979780741 scopus 로고    scopus 로고
    • Caloric restriction mimetics enhance anticancer immunosurveillance
    • Pietrocola, F. et al. Caloric restriction mimetics enhance anticancer immunosurveillance. Cancer Cell 30, 147-160 (2016).
    • (2016) Cancer Cell , vol.30 , pp. 147-160
    • Pietrocola, F.1
  • 103
    • 84979761874 scopus 로고    scopus 로고
    • Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity
    • Di Biase, S. et al. Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity. Cancer Cell 30, 136-146 (2016).
    • (2016) Cancer Cell , vol.30 , pp. 136-146
    • Di Biase, S.1
  • 104
    • 84986253848 scopus 로고    scopus 로고
    • Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation
    • Wang, A. et al. Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation. Cell 166, 1512-1525 (2016). e1512.
    • (2016) Cell , vol.166 , pp. 1512-1525
    • Wang, A.1
  • 105
    • 84959133719 scopus 로고    scopus 로고
    • Combination cancer immunotherapies tailored to the tumour microenvironment
    • Smyth, M. J., Ngiow, S. F., Ribas, A. & Teng, M. W. Combination cancer immunotherapies tailored to the tumour microenvironment. Nat. Rev. Clin. Oncol. 13, 143-158 (2016).
    • (2016) Nat. Rev. Clin. Oncol. , vol.13 , pp. 143-158
    • Smyth, M.J.1    Ngiow, S.F.2    Ribas, A.3    Teng, M.W.4
  • 106
    • 85016985952 scopus 로고    scopus 로고
    • Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis
    • Tsujikawa, T. et al. Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis. Cell Rep. 19, 203-217 (2017).
    • (2017) Cell Rep. , vol.19 , pp. 203-217
    • Tsujikawa, T.1
  • 107
    • 85009756462 scopus 로고    scopus 로고
    • Systemic immunity is required for effective cancer immunotherapy
    • Spitzer, M. H. et al. Systemic immunity is required for effective cancer immunotherapy. Cell 168, 487-502.e15 (2017).
    • (2017) Cell , vol.168 , pp. 487-502
    • Spitzer, M.H.1
  • 108
    • 85018766073 scopus 로고    scopus 로고
    • Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses
    • Lavin, Y. et al. Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses. Cell 169, 750-765.e17 (2017).
    • (2017) Cell , vol.169 , pp. 750-765
    • Lavin, Y.1
  • 109
    • 84963614956 scopus 로고    scopus 로고
    • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
    • Tirosh, I. et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189-196 (2016).
    • (2016) Science , vol.352 , pp. 189-196
    • Tirosh, I.1
  • 110
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1
  • 111
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang, H. et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153, 910-918 (2013).
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.