Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Nature Communications

Volumn 7, Issue , 2016, Pages

  Ruhland, Megan K ^a   Loza, Andrew J ^a   Capietto, Aude Helene ^a   Luo, Xianmin ^a   Knolhoff, Brett L ^a   Flanagan, Kevin C ^a   Belt, Brian A ^a   Alspach, Elise ^a   Leahy, Kathleen ^a   Luo, Jingqin ^a   Schaffer, Andras ^a   Edwards, John R ^a   Longmore, Gregory ^a,b   Faccio, Roberta ^a,b   Denardo, David G ^a,b   Stewart, Sheila A ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; CD11B ANTIGEN; COLONY STIMULATING FACTOR 1; CXCL1 CHEMOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; LY ANTIGEN; LY6G ANTIGEN, MOUSE;

CANCER; CELLS AND CELL COMPONENTS; IMMUNE RESPONSE; PHENOTYPE; RISK FACTOR; RODENT; SENESCENCE; SKIN; STOMATA; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CARCINOGENESIS; CD8+ T LYMPHOCYTE; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE TEST; IMMUNOSURVEILLANCE; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; STROMA CELL; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; ADULT; ANIMAL; CELL LINE; FIBROBLAST; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; METABOLISM; MIDDLE AGED; MYELOID-DERIVED SUPPRESSOR CELL; PATHOLOGY; REGULATORY T LYMPHOCYTE;

ADULT; ANIMALS; ANTIGENS, LY; CARCINOGENESIS; CD11B ANTIGEN; CELL LINE; CELL PROLIFERATION; CELLULAR SENESCENCE; FIBROBLASTS; HUMANS; IMMUNOLOGIC SURVEILLANCE; IMMUNOSUPPRESSION; INFLAMMATION; INTERLEUKIN-6; MICE; MIDDLE AGED; MYELOID-DERIVED SUPPRESSOR CELLS; SKIN; STROMAL CELLS; T-LYMPHOCYTES, REGULATORY; TUMOR MICROENVIRONMENT;

EID: 84976439950     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11762     Document Type: Article

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