메뉴 건너뛰기




Volumn 210, Issue 11, 2013, Pages 2435-2466

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DIPHTHERIA TOXIN; GAMMA INTERFERON; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 84886805255     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20130762     Document Type: Article
Times cited : (231)

References (51)
  • 1
    • 84874830056 scopus 로고    scopus 로고
    • Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types
    • Ascierto, P.A., M. Kalos, D.A. Schaer, M.K. Callahan, and J.D. Wolchok. 2013. Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor types. Clin. Cancer Res. 19:1009-1020. http://dx.doi.org/10.1158/1078-0432.CCR-12-2982
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1009-1020
    • Ascierto, P.A.1    Kalos, M.2    Schaer, D.A.3    Callahan, M.K.4    Wolchok, J.D.5
  • 5
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen, L., and D.B. Flies. 2013. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat. Rev. Immunol. 13:227-242. http://dx.doi.org/10.1038/nri3405
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 6
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumorpromoting chronic inflammation: a magic bullet?
    • Coussens, L.M., L. Zitvogel, and A.K. Palucka. 2013. Neutralizing tumorpromoting chronic inflammation: a magic bullet? Science. 339:286-291. http://dx.doi.org/10.1126/science.1232227
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 7
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran, M.A., W. Montalvo, H. Yagita, and J.P. Allison. 2010. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl. Acad. Sci. USA. 107:4275-4280. http://dx.doi.org/10.1073/pnas.0915174107
    • (2010) Proc. Natl. Acad. Sci. USA. , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 8
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • Demaria, S., N. Kawashima, A.M. Yang, M.L. Devitt, J.S. Babb, J.P. Allison, and S.C. Formenti. 2005. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin. Cancer Res. 11:728-734.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3    Devitt, M.L.4    Babb, J.S.5    Allison, J.P.6    Formenti, S.C.7
  • 9
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo, D.G., J.B. Barreto, P. Andreu, L. Vasquez, D. Tawfik, N. Kolhatkar, and L.M. Coussens. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 16:91-102. http://dx.doi.org/10.1016/j.ccr.2009.06.018
    • (2009) Cancer Cell. , vol.16 , pp. 91-102
    • DeNardo, D.G.1    Barreto, J.B.2    Andreu, P.3    Vasquez, L.4    Tawfik, D.5    Kolhatkar, N.6    Coussens, L.M.7
  • 10
    • 84865553173 scopus 로고    scopus 로고
    • Combination immunotherapy approaches
    • Drake, C.G. 2012. Combination immunotherapy approaches. Ann. Oncol. 23:viii41-6. http://dx.doi.org/10.1093/annonc/mds262
    • (2012) Ann. Oncol. , vol.23 , pp. 841-846
    • Drake, C.G.1
  • 11
    • 84860507700 scopus 로고    scopus 로고
    • T-regulatory cells: key players in tumor immune escape and angiogenesis
    • Facciabene, A., G.T. Motz, and G. Coukos. 2012. T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res. 72:2162-2171. http://dx.doi.org/10.1158/0008-5472.CAN-11-3687
    • (2012) Cancer Res. , vol.72 , pp. 2162-2171
    • Facciabene, A.1    Motz, G.T.2    Coukos, G.3
  • 12
    • 67649359533 scopus 로고    scopus 로고
    • Systemic effects of local radiotherapy
    • Formenti, S.C., and S. Demaria. 2009. Systemic effects of local radiotherapy. Lancet Oncol. 10:718-726. http://dx.doi.org/10.1016/S1470-2045(09)70082-8
    • (2009) Lancet Oncol. , vol.10 , pp. 718-726
    • Formenti, S.C.1    Demaria, S.2
  • 13
    • 84886427186 scopus 로고    scopus 로고
    • Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell-Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects
    • In press
    • Fransen, M.F., T.C. van der Sluis, F. Ossendorp, R. Arens, and C.J. Melief. 2013. Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell-Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects. Clin. Cancer Res. In press.
    • (2013) Clin. Cancer Res.
    • Fransen, M.F.1    van der Sluis, T.C.2    Ossendorp, F.3    Arens, R.4    Melief, C.J.5
  • 14
    • 84880669245 scopus 로고    scopus 로고
    • IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
    • Gasteiger, G., S. Hemmers, M.A. Firth, A. Le Floc'h, M. Huse, J.C. Sun, and A.Y. Rudensky. 2013. IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J. Exp. Med. 210:1167-1178. http://dx.doi.org/10.1084/jem.20122462
    • (2013) J. Exp. Med. , vol.210 , pp. 1167-1178
    • Gasteiger, G.1    Hemmers, S.2    Firth, M.A.3    Le Floc'h, A.4    Huse, M.5    Sun, J.C.6    Rudensky, A.Y.7
  • 15
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
    • Guy, C.T., R.D. Cardiff, and W.J. Muller. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12:954-961. Heimann, R., and S. Hellman. 2000. Clinical progression of breast cancer malignant behavior: what to expect and when to expect it. J. Clin. Oncol. 18:591-599.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 16
    • 0033965087 scopus 로고    scopus 로고
    • Clinical progression of breast cancer malignant behavior: what to expect and when to expect it
    • Heimann, R., and S. Hellman. 2000. Clinical progression of breast cancer malignant behavior: what to expect and when to expect it. J. Clin. Oncol. 18:591-599.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 591-599
    • Heimann, R.1    Hellman, S.2
  • 20
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, J.M., J.P. Rasmussen, and A.Y. Rudensky. 2007. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8:191-197. http://dx.doi.org/10.1038/ni1428
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 21
    • 76249088097 scopus 로고    scopus 로고
    • Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
    • Kim, J., K. Lahl, S. Hori, C. Loddenkemper, A. Chaudhry, P. deRoos, A. Rudensky, and T. Sparwasser. 2009. Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J. Immunol. 183:7631-7634. http://dx.doi.org/10.4049/jimmunol.0804308
    • (2009) J. Immunol. , vol.183 , pp. 7631-7634
    • Kim, J.1    Lahl, K.2    Hori, S.3    Loddenkemper, C.4    Chaudhry, A.5    deRoos, P.6    Rudensky, A.7    Sparwasser, T.8
  • 22
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    • Klages, K., C.T. Mayer, K. Lahl, C. Loddenkemper, M.W. Teng, S.F. Ngiow, M.J. Smyth, A. Hamann, J. Huehn, and T. Sparwasser. 2010. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res. 70:7788-7799. http://dx.doi.org/10.1158/0008-5472.CAN-10-1736
    • (2010) Cancer Res. , vol.70 , pp. 7788-7799
    • Klages, K.1    Mayer, C.T.2    Lahl, K.3    Loddenkemper, C.4    Teng, M.W.5    Ngiow, S.F.6    Smyth, M.J.7    Hamann, A.8    Huehn, J.9    Sparwasser, T.10
  • 23
    • 34547423966 scopus 로고    scopus 로고
    • Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras
    • Komatsu, N., and S. Hori. 2007. Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras. Proc. Natl. Acad. Sci. USA. 104:8959-8964. http://dx.doi.org/10.1073/pnas.0702004104
    • (2007) Proc. Natl. Acad. Sci. USA. , vol.104 , pp. 8959-8964
    • Komatsu, N.1    Hori, S.2
  • 24
    • 78649557780 scopus 로고    scopus 로고
    • Efficient Treg depletion induces T-cell infiltration and rejection of large tumors
    • Li, X., E. Kostareli, J. Suffner, N. Garbi, and G.J. Hämmerling. 2010. Efficient Treg depletion induces T-cell infiltration and rejection of large tumors. Eur. J. Immunol. 40:3325-3335. http://dx.doi.org/10.1002/eji.201041093
    • (2010) Eur. J. Immunol. , vol.40 , pp. 3325-3335
    • Li, X.1    Kostareli, E.2    Suffner, J.3    Garbi, N.4    Hämmerling, G.J.5
  • 25
    • 0142244181 scopus 로고    scopus 로고
    • Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    • Lin, E.Y., J.G. Jones, P. Li, L. Zhu, K.D. Whitney, W.J. Muller, and J.W. Pollard. 2003. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am. J. Pathol. 163:2113-2126. http://dx.doi.org/10.1016/S0002-9440(10)63568-7
    • (2003) Am. J. Pathol. , vol.163 , pp. 2113-2126
    • Lin, E.Y.1    Jones, J.G.2    Li, P.3    Zhu, L.4    Whitney, K.D.5    Muller, W.J.6    Pollard, J.W.7
  • 26
    • 53149113444 scopus 로고    scopus 로고
    • Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice
    • Lucas, J.A., J. Menke, W.A. Rabacal, F.J. Schoen, A.H. Sharpe, and V.R. Kelley. 2008. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J. Immunol. 181:2513-2521.
    • (2008) J. Immunol. , vol.181 , pp. 2513-2521
    • Lucas, J.A.1    Menke, J.2    Rabacal, W.A.3    Schoen, F.J.4    Sharpe, A.H.5    Kelley, V.R.6
  • 28
    • 0032404099 scopus 로고    scopus 로고
    • Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice
    • Mokyr, M.B., T. Kalinichenko, L. Gorelik, and J.A. Bluestone. 1998. Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res. 58:5301-5304.
    • (1998) Cancer Res. , vol.58 , pp. 5301-5304
    • Mokyr, M.B.1    Kalinichenko, T.2    Gorelik, L.3    Bluestone, J.A.4
  • 30
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D.M. 2012. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer. 12:252-264. http://dx.doi.org/10.1038/nrc3239
    • (2012) Nat. Rev. Cancer. , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 31
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs, K.S., S.A. Quezada, C.A. Chambers, A.J. Korman, and J.P. Allison. 2009. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J. Exp. Med. 206:1717-1725. http://dx.doi.org/10.1084/jem.20082492
    • (2009) J. Exp. Med. , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 32
    • 42449105650 scopus 로고    scopus 로고
    • Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
    • Podsypanina, K., K. Politi, L.J. Beverly, and H.E. Varmus. 2008. Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras. Proc. Natl. Acad. Sci. USA. 105:5242-5247. http://dx.doi.org/10.1073/pnas.0801197105
    • (2008) Proc. Natl. Acad. Sci. USA. , vol.105 , pp. 5242-5247
    • Podsypanina, K.1    Politi, K.2    Beverly, L.J.3    Varmus, H.E.4
  • 33
    • 84859457094 scopus 로고    scopus 로고
    • Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma
    • Postow, M.A., J. Harding, and J.D. Wolchok. 2012. Targeting immune checkpoints: releasing the restraints on anti-tumor immunity for patients with melanoma. Cancer J. 18:153-159. http://dx.doi.org/10.1097/PPO.0b013e318250c001
    • (2012) Cancer J. , vol.18 , pp. 153-159
    • Postow, M.A.1    Harding, J.2    Wolchok, J.D.3
  • 34
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • Quezada, S.A., K.S. Peggs, M.A. Curran, and J.P. Allison. 2006. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J. Clin. Invest. 116:1935-1945. http://dx.doi.org/10.1172/JCI27745
    • (2006) J. Clin. Invest. , vol.116 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 36
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumorinfiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato, E., S.H. Olson, J. Ahn, B. Bundy, H. Nishikawa, F. Qian, A.A. Jungbluth, D. Frosina, S. Gnjatic, C. Ambrosone, et al. 2005. Intraepithelial CD8+ tumorinfiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc. Natl. Acad. Sci. USA. 102:18538-18543. http://dx.doi.org/10.1073/pnas.0509182102
    • (2005) Proc. Natl. Acad. Sci. USA. , vol.102 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3    Bundy, B.4    Nishikawa, H.5    Qian, F.6    Jungbluth, A.A.7    Frosina, D.8    Gnjatic, S.9    Ambrosone, C.10
  • 37
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber, R.D., L.J. Old, and M.J. Smyth. 2011. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science. 331:1565-1570. http://dx.doi.org/10.1126/science.1203486
    • (2011) Science. , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 38
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells
    • Selby, M.J., J.J. Engelhardt, M. Quigley, K.A. Henning, T. Chen, M. Srinivasan, and A.J. Korman. 2013. Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells. Cancer Immunology Research. 1:32-42. http://dx.doi.org/10.1158/2326-6066.CIR-13-0013
    • (2013) Cancer Immunology Research. , vol.1 , pp. 32-42
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3    Henning, K.A.4    Chen, T.5    Srinivasan, M.6    Korman, A.J.7
  • 39
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran, V., H. Ikeda, A.T. Bruce, J.M. White, P.E. Swanson, L.J. Old, and R.D. Schreiber. 2001. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature. 410:1107-1111. http://dx.doi.org/10.1038/35074122
    • (2001) Nature. , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6    Schreiber, R.D.7
  • 40
  • 42
    • 79952193038 scopus 로고    scopus 로고
    • Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • Tan, W., W. Zhang, A. Strasner, S. Grivennikov, J.Q. Cheng, R.M. Hoffman, and M. Karin. 2011. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 470:548-553. http://dx.doi.org/10.1038/nature09707
    • (2011) Nature. , vol.470 , pp. 548-553
    • Tan, W.1    Zhang, W.2    Strasner, A.3    Grivennikov, S.4    Cheng, J.Q.5    Hoffman, R.M.6    Karin, M.7
  • 43
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng, M.W., S.F. Ngiow, B. von Scheidt, N. McLaughlin, T. Sparwasser, and M.J. Smyth. 2010. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res. 70:7800-7809. http://dx.doi.org/10.1158/0008-5472.CAN-10-1681
    • (2010) Cancer Res. , vol.70 , pp. 7800-7809
    • Teng, M.W.1    Ngiow, S.F.2    von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5    Smyth, M.J.6
  • 44
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian, S.L., C.G. Drake, and D.M. Pardoll. 2012a. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr. Opin. Immunol. 24:207-212. http://dx.doi.org/10.1016/j.coi.2011.12.009
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 46
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas, A., A.A. Hurwitz, and J.P. Allison. 1999. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J. Exp. Med. 190:355-366. http://dx.doi.org/10.1084/jem.190.3.355
    • (1999) J. Exp. Med. , vol.190 , pp. 355-366
    • van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 47
    • 17944364189 scopus 로고    scopus 로고
    • Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy
    • van Elsas, A., R.P. Sutmuller, A.A. Hurwitz, J. Ziskin, J. Villasenor, J.P. Medema, W.W. Overwijk, N.P. Restifo, C.J. Melief, R. Offringa, and J.P. Allison. 2001. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J. Exp. Med. 194:481-489. http://dx.doi.org/10.1084/jem.194.4.481
    • (2001) J. Exp. Med. , vol.194 , pp. 481-489
    • van Elsas, A.1    Sutmuller, R.P.2    Hurwitz, A.A.3    Ziskin, J.4    Villasenor, J.5    Medema, J.P.6    Overwijk, W.W.7    Restifo, N.P.8    Melief, C.J.9    Offringa, R.10    Allison, J.P.11
  • 48
    • 84855873376 scopus 로고    scopus 로고
    • Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy
    • Waitz, R., S.B. Solomon, E.N. Petre, A.E. Trumble, M. Fassò, L. Norton, and J.P. Allison. 2012. Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy. Cancer Res. 72:430-439. http://dx.doi.org/10.1158/0008-5472.CAN-11-1782
    • (2012) Cancer Res. , vol.72 , pp. 430-439
    • Waitz, R.1    Solomon, S.B.2    Petre, E.N.3    Trumble, A.E.4    Fassò, M.5    Norton, L.6    Allison, J.P.7
  • 50
    • 24344436369 scopus 로고    scopus 로고
    • Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    • Willimsky, G., and T. Blankenstein. 2005. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature. 437:141-146. http://dx.doi.org/10.1038/nature03954
    • (2005) Nature. , vol.437 , pp. 141-146
    • Willimsky, G.1    Blankenstein, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.