Chromatin states define tumour-specific T cell dysfunction and reprogramming

Nature

Volumn 545, Issue 7655, 2017, Pages 452-456

  Philip, Mary ^a   Fairchild, Lauren ^a,b   Sun, Liping ^a   Horste, Ellen L ^a   Camara, Steven ^a   Shakiba, Mojdeh ^a,b   Scott, Andrew C ^a,b   Viale, Agnes ^a   Lauer, Peter ^c   Merghoub, Taha ^a,b   Hellmann, Matthew D ^a,b   Wolchok, Jedd D ^a,b   Leslie, Christina S ^a   Schietinger, Andrea ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Aduro BioTech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD30 LIGAND; CD38 ANTIGEN; CD5 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EARLY GROWTH RESPONSE FACTOR 2; GAMMA INTERFERON; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; INTERLEUKIN 15; PROGRAMMED DEATH 1 RECEPTOR; T CELL FACTOR PROTEIN; T LYMPHOCYTE RECEPTOR; TACROLIMUS; TAMOXIFEN; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR; TUMOR SPECIFIC TRANSPLANTATION ANTIGEN; TWS 119; UNCLASSIFIED DRUG; CHROMATIN; TRANSCRIPTION FACTOR;

BIOMARKER; CANCER; CELLS AND CELL COMPONENTS; RODENT; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER IMMUNOTHERAPY; CARCINOGENESIS; CD8+ T LYMPHOCYTE; CHROMATIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPIGENETICS; GENE LOCUS; IN VITRO STUDY; LIVER CELL; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION; TUMOR ASSOCIATED LEUKOCYTE; ANIMAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MALE; METABOLISM; NEOPLASMS; PATHOLOGY;

MUS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHROMATIN; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICE; NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 85019673982     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature22367     Document Type: Article

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