Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

Cancer Cell

Volumn 30, Issue 2, 2016, Pages 324-336

  Roberts, Edward W ^a   Broz, Miranda L ^a,d   Binnewies, Mikhail ^a   Headley, Mark B ^a   Nelson, Amanda E ^a   Wolf, Denise M ^a   Kaisho, Tsuneyasu ^b   Bogunovic, Dusan ^c   Bhardwaj, Nina ^c   Krummel, Matthew F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d Precision Immune Inc   (United States)

Author keywords

2 photon imaging; anti tumor T cell priming; antigen presentation; antigen trafficking; dendritic cells; draining lymph node; melanoma; tumor; tumor immune response

Indexed keywords

CD103 ANTIGEN; CD11B ANTIGEN; CD141 ANTIGEN; CD8ALPHA ANTIGEN; CHEMOKINE RECEPTOR CCR7; GLYCOPROTEIN GP 100; SIALOADHESIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG; ALPHA E INTEGRINS; ALPHA INTEGRIN; BLOOD DENDRITIC CELL ANTIGEN 3, HUMAN; CCR7 PROTEIN, HUMAN; CCR7 PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; MEMBRANE ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CELL MIGRATION; CELLULAR IMMUNITY; CLINICAL OUTCOME; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; LYMPH VESSEL ENDOTHELIUM; MACROPHAGE; MELANOMA; MOUSE; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; ANTIGEN PRESENTATION; C57BL MOUSE; CELL MOTION; EXPERIMENTAL MELANOMA; IMMUNOLOGY; LYMPH NODE; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DENDRITIC CELLS; HUMANS; INTEGRIN ALPHA CHAINS; LYMPH NODES; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, CCR7;

EID: 84978872467     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2016.06.003     Document Type: Article

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