Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Science

Volumn 352, Issue 6282, 2016, Pages 189-196

  Tirosh, Itay ^a   Izar, Benjamin ^a,b,c   Prakadan, Sanjay M ^a,d,e,f   Wadsworth, Marc H ^a,d,e,f   Treacy, Daniel ^a   Trombetta, John J ^a   Rotem, Asaf ^a,b,c   Rodman, Christopher ^a   Lian, Christine ^g   Murphy, George ^g   Fallahi Sichani, Mohammad ^b   Dutton Regester, Ken ^a,b,h   Lin, Jia Ren ^b   Cohen, Ofir ^a   Shah, Parin ^b   Lu, Diana ^a   Genshaft, Alex S ^a,d,e,f   Hughes, Travis K ^a,b,d,f   Ziegler, Carly G K ^a,b,d,f   Kazer, Samuel W ^a,d,e,f   Gaillard, Aleth ^a,d,e,f   Kolb, Kellie E ^a,d,e,f   Villani, Alexandra Chloé ^a   Johannessen, Cory M ^a   Andreev, Aleksandr Y ^a   Van Allen, Eliezer M ^a,b,c   Bertagnolli, Monica ^b,g   Sorger, Peter K ^b,f   Sullivan, Ryan J ⁱ   Flaherty, Keith T ⁱ   Frederick, Dennie T ⁱ   Jané Valbuena, Judit ^a   Yoon, Charles H ^b,g   Rozenblatt Rosen, Orit ^a   Shalek, Alex K ^a,b,d,e,f,j   Regev, Aviv ^a,e,k   Garraway, Levi A ^a,b,c,f   more..

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f HARVARD UNIVERSITY   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

ⁱ MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

^k HOWARD HUGHES MEDICAL INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; RNA; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTOME;

CANCER; CELLS AND CELL COMPONENTS; DRUG RESISTANCE; ENZYME ACTIVITY; GENETIC ANALYSIS; GENOMICS; GENOTYPE; HETEROGENEITY; IMMUNE SYSTEM; PHENOTYPE; RNA; TUMOR;

ARTICLE; CANCER CELL; CELL CYCLE; CELL INFILTRATION; CELL INTERACTION; CLINICAL ARTICLE; COPY NUMBER VARIATION; GENE EXPRESSION; GENETIC HETEROGENEITY; GENOMICS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; MELANOMA CELL; METASTATIC MELANOMA; PRIORITY JOURNAL; RNA SEQUENCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR MICROENVIRONMENT; CELL COMMUNICATION; DRUG RESISTANCE; ENDOTHELIUM CELL; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MELANOMA; METABOLISM; METASTASIS; NUCLEOTIDE SEQUENCE; PATHOLOGY; SECONDARY; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; SKIN TUMOR; STROMA CELL;

BASE SEQUENCE; CELL COMMUNICATION; CELL CYCLE; DRUG RESISTANCE, NEOPLASM; ENDOTHELIAL CELLS; GENOMICS; HUMANS; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MELANOMA; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; NEOPLASM METASTASIS; RNA; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; SKIN NEOPLASMS; STROMAL CELLS; T-LYMPHOCYTES; TRANSCRIPTOME; TUMOR MICROENVIRONMENT;

EID: 84963614956     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad0501     Document Type: Article

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