Tertiary lymphoid organs in infection and autoimmunity

Trends in Immunology

Volumn 33, Issue 6, 2012, Pages 297-305

  Neyt, Katrijn ^a,d   Perros, Frédéric ^b   GeurtsvanKessel, Corine H ^c,d   Hammad, Hamida ^a,d   Lambrecht, Bart N ^a,d  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c Universite Paris Sud   (France)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL13 CHEMOKINE; FIBROBLAST GROWTH FACTOR 2; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOTOXIN ALPHA BETA; LYMPHOTOXIN BETA RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; SCATTER FACTOR; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN C; VASCULOTROPIN D;

ANTIGEN PRESENTING CELL; AUTOIMMUNITY; B LYMPHOCYTE; CHRONIC INFLAMMATION; HUMAN; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INFECTION; LUPUS ERYTHEMATOSUS; LYMPH NODE; LYMPHOID ORGAN; NONHUMAN; ORGANOGENESIS; REVIEW; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; TERTIARY LYMPHOID ORGAN; TH17 CELL; TISSUE STRUCTURE;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; HUMANS; INFECTION; LYMPHOID TISSUE; MODELS, IMMUNOLOGICAL;

EID: 84861666266     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2012.04.006     Document Type: Review

References (83)

1. Turley S.J., et al. The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs. Nat. Rev. Immunol. 2010, 10:813-825.
2. van de Pavert S.A., Mebius R.E. New insights into the development of lymphoid tissues. Nat. Rev. Immunol. 2010, 10:664-674.
3. Roozendaal R., Mebius R.E. Stromal cell-immune cell interactions. Annu. Rev. Immunol. 2011, 29:23-43.
4. Eberl G., et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 2004, 5:64-73.
5. Vondenhoff M.F., et al. LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J. Immunol. 2009, 182:5439-5445.
6. Peduto L., et al. Inflammation recapitulates the ontogeny of lymphoid stromal cells. J. Immunol. 2009, 182:5789-5799.
7. van de Pavert S.A., et al. Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat. Immunol. 2009, 10:1193-1199.
8. Veiga-Fernandes H., et al. Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 2007, 446:547-551.
9. Hjelmstrom P., et al. Lymphoid tissue homing chemokines are expressed in chronic inflammation. Am. J. Pathol. 2000, 156:1133-1138.
10. Kratz A., et al. Chronic inflammation caused by lymphotoxin is lymphoid neogenesis. J. Exp. Med. 1996, 183:1461-1472.
11. Luther S.A., et al. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 2000, 12:471-481.
12. Marinkovic T., et al. Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid. J. Clin. Invest. 2006, 116:2622-2632.
13. Goya S., et al. Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung. J. Pathol. 2003, 200:82-87.
14. Chen S.C., et al. Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice. J. Immunol. 2002, 168:1001-1008.
15. Drayton D.L., et al. Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J. Exp. Med. 2003, 197:1153-1163.
16. Fan L., et al. Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis. J. Immunol. 2000, 164:3955-3959.
17. Rangel-Moreno J., et al. Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:10577-10582.
18. Gatumu M.K., et al. Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjogren's syndrome in salivary glands of non-obese diabetic mice. Arthritis Res. Ther. 2009, 11:R24.
19. Grabner R., et al. Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J. Exp. Med. 2009, 206:233-248.
20. Wengner A.M., et al. CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis. Arthritis Rheum. 2007, 56:3271-3283.
21. Furtado G.C., et al. Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:5026-5031.
22. Winter S., et al. The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation. J. Mol. Med. (Berl.) 2010, 88:1169-1180.
23. Moyron-Quiroz J.E., et al. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat. Med. 2004, 10:927-934.
24. McDonald K.G., et al. Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid follicles. J. Immunol. 2005, 174:5720-5728.
25. Timmer T.C., et al. Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. Arthritis Rheum. 2007, 56:2492-2502.
26. Perros F., et al. Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 2012, 185:311-321.
27. Fukuyama S., et al. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity 2002, 17:31-40.
28. Krege J., et al. Antigen-dependent rescue of nose-associated lymphoid tissue (NALT) development independent of LTbetaR and CXCR5 signaling. Eur. J. Immunol. 2009, 39:2765-2778.
29. Nagatake T., et al. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J. Exp. Med. 2009, 206:2351-2364.
30. Rangel-Moreno J., et al. The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nat. Immunol. 2011, 12:639-646.
31. Lochner M., et al. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells. J. Exp. Med. 2011, 208:125-134.
32. Rangel-Moreno J., et al. Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens. Immunity 2009, 30:731-743.
33. Link A., et al. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am. J. Pathol. 2011, 178:1662-1675.
34. Cupedo T., et al. Induction of secondary and tertiary lymphoid structures in the skin. Immunity 2004, 21:655-667.
35. Endres R., et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J. Exp. Med. 1999, 189:159-168.
36. Ansel K.M., et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 2000, 406:309-314.
37. GeurtsvanKessel C.H., et al. Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice. J. Exp. Med. 2009, 206:2339-2349.
38. Peters A., et al. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 2011, 35:986-996.
39. Fleige H., et al. Induction of BALT in the absence of IL-17. Nat. Immunol. 2011, 13:1.
40. Lee Y., et al. Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure. Immunity 2006, 25:499-509.
41. Ludewig B., et al. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J. Exp. Med. 1998, 188:1493-1501.
42. van Rijt L.S., et al. Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice. Am. J. Respir. Crit. Care Med. 2011, 184:303-311.
43. Muniz L.R., et al. A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures. J. Immunol. 2011, 187:828-834.
44. Van Pottelberge G.R., et al. Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD. Eur. Respir. J. 2010, 36:781-791.
45. Nacionales D.C., et al. Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane). Am. J. Pathol. 2006, 168:1227-1240.
46. Halle S., et al. Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. J. Exp. Med. 2009, 206:2593-2601.
47. Fletcher A.L., et al. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J. Exp. Med. 2010, 207:689-697.
48. Link A., et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat. Immunol. 2007, 8:1255-1265.
49. Lotzer K., et al. Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling. Arterioscler. Thromb. Vasc. Biol. 2010, 30:395-402.
50. Hogg J.C., et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004, 350:2645-2653.
51. Marchal-Somme J., et al. Dendritic cells accumulate in human fibrotic interstitial lung disease. Am. J. Respir. Crit. Care Med. 2007, 176:1007-1014.
52. Rangel-Moreno J., et al. Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J. Clin. Invest. 2006, 116:3183-3194.
53. Bouskra D., et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 2008, 456:507-510.
54. Cabello H., et al. Bacterial colonization of distal airways in healthy subjects and chronic lung disease: a bronchoscopic study. Eur. Respir. J. 1997, 10:1137-1144.
55. Moyron-Quiroz J.E., et al. Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs. Immunity 2006, 25:643-654.
56. Shomer N.H., et al. Helicobacter-induced chronic active lymphoid aggregates have characteristics of tertiary lymphoid tissue. Infect. Immun. 2003, 71:3572-3577.
57. Velaga S., et al. Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J. Immunol. 2009, 182:2610-2619.
58. Demoor T., et al. Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis. Eur. Respir. J. 2009, 34:405-416.
59. Kim T.S., et al. Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J. Exp. Med. 2010, 207:1161-1172.
60. Astorri E., et al. Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets. J. Immunol. 2010, 185:3359-3368.
61. Kendall P.L., et al. Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes. J. Immunol. 2007, 178:5643-5651.
62. Magliozzi R., et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007, 130:1089-1104.
63. Nasr I.W., et al. Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection. Am. J. Transplant. 2007, 7:1071-1079.
64. Thaunat O., et al. Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis. J. Immunol. 2010, 185:717-728.
65. Sato M., et al. Stromal activation and formation of lymphoid-like stroma in chronic lung allograft dysfunction. Transplantation 2011, 91:1398-1405.
66. Armengol M.P., et al. Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am. J. Pathol. 2001, 159:861-873.
67. Chang A., et al. In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. J. Immunol. 2011, 186:1849-1860.
68. Serafini B., et al. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 2004, 14:164-174.
69. Chiavolini D., et al. Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia. PLoS ONE 2010, 5:e11156.
70. Wiley J.A., et al. Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses. PLoS ONE 2009, 4:e7142.
71. Henry R.A., Kendall P.L. CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice. J. Immunol. 2010, 185:1460-1465.
72. Moghaddami M., et al. Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine. Gastroenterology 1998, 115:1414-1425.
73. Yeung M.M., et al. Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression. Gut 2000, 47:215-227.
74. Takemura S., et al. Lymphoid neogenesis in rheumatoid synovitis. J. Immunol. 2001, 167:1072-1080.
75. Sharifi S., et al. Nodular lymphoid lesion of the liver: an immune-mediated disorder mimicking low-grade malignant lymphoma. Am. J. Surg. Pathol. 1999, 23:302-308.
76. Magliozzi R., et al. Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2004, 148:11-23.
77. Hill M.E., et al. The myasthenia gravis thymus: a rare source of human autoantibody-secreting plasma cells for testing potential therapeutics. J. Neuroimmunol. 2008, 201-202:50-56.
78. Katakai T., et al. Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. J. Immunol. 2003, 171:4359-4368.
79. Baddoura F.K., et al. Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection. Am. J. Transplant. 2005, 5:510-516.
80. Hiramatsu K., et al. Inhalation of diesel exhaust for three months affects major cytokine expression and induces bronchus-associated lymphoid tissue formation in murine lungs. Exp. Lung Res. 2003, 29:607-622.
81. Mahendra G., et al. Necrotic and inflammatory changes in metal-on-metal resurfacing hip arthroplasties. Acta Orthop. 2009, 80:653-659.
82. de Chaisemartin L., et al. Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer. Cancer Res. 2011, 71:6391-6399.
83. Ghosh S., et al. In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium. J. Immunol. 2005, 174:2860-2869.