Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Cell Reports

Volumn 19, Issue 1, 2017, Pages 203-217

  Tsujikawa, Takahiro ^a,b   Kumar, Sushil ^a   Borkar, Rohan N ^d   Azimi, Vahid ^d   Thibault, Guillaume ^c   Chang, Young Hwan ^a,c   Balter, Ariel ^a   Kawashima, Rie ^a   Choe, Gina ^a   Sauer, David ^b   El Rassi, Edward ^b   Clayburgh, Daniel R ^a,b   Kulesz Martin, Molly F ^a,b   Lutz, Eric R ^e,f   Zheng, Lei ^e,f   Jaffee, Elizabeth M ^e,f   Leyshock, Patrick ^a   Margolin, Adam A ^a   Mori, Motomi ^a   Gray, Joe W ^a,c   Flint, Paul W ^a,b   Coussens, Lisa M ^a   more..

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Oregon Health and Science University Department of Biomedical Engineering   (United States)

^d INTEL CORPORATION   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

cancer immunology; digital pathology; head and neck cancer; image cytometry; immunohistochemistry; multiplex; pancreatic cancer; tissue biomarker

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; PROGRAMMED DEATH 1 LIGAND 1; TUMOR MARKER;

ARTICLE; CD8+ T LYMPHOCYTE; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FORMALIN FIXED PARAFFIN EMBEDDED TISSUE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE CYTOMETRY; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; MULTIPLEX IMMUNOHISTOCHEMISTRY; PANCREAS ADENOCARCINOMA; PROGNOSIS; QUANTITATIVE ANALYSIS; T LYMPHOCYTE ACTIVATION; TISSUE MICROARRAY; TISSUE PREPARATION; TREATMENT RESPONSE; VACCINATION; WART VIRUS; AGED; COHORT ANALYSIS; FEMALE; HEAD AND NECK TUMOR; IMMUNOLOGICAL MONITORING; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; NONPARAMETRIC TEST; PROCEDURES; SQUAMOUS CELL CARCINOMA; VALIDATION STUDY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMAGE CYTOMETRY; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MONITORING, IMMUNOLOGIC; PROGNOSIS; STATISTICS, NONPARAMETRIC; TISSUE ARRAY ANALYSIS;

EID: 85016985952     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.03.037     Document Type: Article

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