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Volumn 28, Issue 8, 2016, Pages 383-391

Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment

Author keywords

Checkpoint blockade; Immune evasion; Immunotherapy; Oncogenes

Indexed keywords

ADAPTIVE IMMUNITY; CELL INFILTRATION; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; IMMUNOLOGY; IMMUNOTHERAPY; INFLAMMATION; NEOPLASM; PROCEDURES; TUMOR ASSOCIATED LEUKOCYTE; TUMOR ESCAPE;

EID: 84988976297     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxw014     Document Type: Review
Times cited : (221)

References (73)
  • 1
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S., O'Day, S. J., McDermott, D. F. et al. 2010. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363:711.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 2
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian, S. L., Sznol, M., McDermott, D. F. et al. 2014. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J. Clin. Oncol. 32:1020.
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1020
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3
  • 3
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L., Hodi, F. S., Brahmer, J. R. et al. 2012. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366:2443.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 4
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin, J., Chiarion-Sileni, V., Gonzalez, R. et al. 2015. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373:23.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 23
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 5
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh, P. C., Harview, C. L., Yearley, J. H. et al. 2014. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515:568.
    • (2014) Nature , vol.515 , pp. 568
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3
  • 6
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon, J., Costes, A., Sanchez-Cabo, F. et al. 2006. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313:1960.
    • (2006) Science , vol.313 , pp. 1960
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 7
    • 0030787373 scopus 로고    scopus 로고
    • Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer
    • Ropponen, K. M., Eskelinen, M. J., Lipponen, P. K., Alhava, E. and Kosma, V. M. 1997. Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J. Pathol. 182:318.
    • (1997) J. Pathol. , vol.182 , pp. 318
    • Ropponen, K.M.1    Eskelinen, M.J.2    Lipponen, P.K.3    Alhava, E.4    Kosma, V.M.5
  • 8
    • 0032529466 scopus 로고    scopus 로고
    • CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer
    • Naito, Y., Saito, K., Shiiba, K. et al. 1998. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res. 58:3491.
    • (1998) Cancer Res. , vol.58 , pp. 3491
    • Naito, Y.1    Saito, K.2    Shiiba, K.3
  • 9
    • 66149156276 scopus 로고    scopus 로고
    • Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment
    • Harlin, H., Meng, Y., Peterson, A. C. et al. 2009. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res. 69:3077.
    • (2009) Cancer Res. , vol.69 , pp. 3077
    • Harlin, H.1    Meng, Y.2    Peterson, A.C.3
  • 10
    • 84887865311 scopus 로고    scopus 로고
    • T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins
    • Salerno, E. P., Olson, W. C., McSkimming, C., Shea, S. and Slingluff, C. L. Jr 2014. T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins. Int. J. Cancer 134:563.
    • (2014) Int. J. Cancer , vol.134 , pp. 563
    • Salerno, E.P.1    Olson, W.C.2    McSkimming, C.3    Shea, S.4    SlingluffJr., C.L.5
  • 11
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
    • 200ra116
    • Spranger, S., Spaapen, R. M., Zha, Y. et al. 2013. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci. Transl. Med. 5:200ra116.
    • (2013) Sci. Transl. Med. , vol.5
    • Spranger, S.1    Spaapen, R.M.2    Zha, Y.3
  • 12
    • 56449097442 scopus 로고    scopus 로고
    • Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    • Hildner, K., Edelson, B. T., Purtha, W. E. et al. 2008. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 322:1097.
    • (2008) Science , vol.322 , pp. 1097
    • Hildner, K.1    Edelson, B.T.2    Purtha, W.E.3
  • 13
    • 84858613590 scopus 로고    scopus 로고
    • Marginating dendritic cells of the tumor microenvironment crosspresent tumor antigens and stably engage tumor-specific T cells
    • Engelhardt, J. J., Boldajipour, B., Beemiller, P. et al. 2012. Marginating dendritic cells of the tumor microenvironment crosspresent tumor antigens and stably engage tumor-specific T cells. Cancer Cell 21:402.
    • (2012) Cancer Cell , vol.21 , pp. 402
    • Engelhardt, J.J.1    Boldajipour, B.2    Beemiller, P.3
  • 14
    • 80355136945 scopus 로고    scopus 로고
    • Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells
    • Fuertes, M. B., Kacha, A. K., Kline, J. et al. 2011. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells. J. Exp. Med. 208:2005.
    • (2011) J. Exp. Med. , vol.208 , pp. 2005
    • Fuertes, M.B.1    Kacha, A.K.2    Kline, J.3
  • 15
    • 84911937777 scopus 로고    scopus 로고
    • Dissecting the tumor myeloid compartment reveals rare activating antigenpresenting cells critical for T cell immunity
    • Broz, M. L., Binnewies, M., Boldajipour, B. et al. 2014. Dissecting the tumor myeloid compartment reveals rare activating antigenpresenting cells critical for T cell immunity. Cancer Cell 26:638.
    • (2014) Cancer Cell , vol.26 , pp. 638
    • Broz, M.L.1    Binnewies, M.2    Boldajipour, B.3
  • 16
    • 84912120595 scopus 로고    scopus 로고
    • STINGdependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo, S. R., Fuertes, M. B., Corrales, L. et al. 2014. STINGdependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41:830.
    • (2014) Immunity , vol.41 , pp. 830
    • Woo, S.R.1    Fuertes, M.B.2    Corrales, L.3
  • 17
    • 84929705879 scopus 로고    scopus 로고
    • Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
    • Corrales, L., Glickman, L. H., McWhirter, S. M. et al. 2015. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 11:1018.
    • (2015) Cell Rep. , vol.11 , pp. 1018
    • Corrales, L.1    Glickman, L.H.2    McWhirter, S.M.3
  • 18
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder, A., Makarov, V., Merghoub, T. et al. 2014. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371:2189.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2189
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 19
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N. A., Hellmann, M. D., Snyder, A. et al. 2015. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348:124.
    • (2015) Science , vol.348 , pp. 124
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 20
    • 84988981283 scopus 로고    scopus 로고
    • Density of immunogenic antigens and presence or absence of the T cell-inflamed tumor microenvironment in metastatic melanoma
    • Gajewski, T., Zha, Y., Hernandez, K. et al. 2015. Density of immunogenic antigens and presence or absence of the T cell-inflamed tumor microenvironment in metastatic melanoma. J. Clin. Oncol. 33.
    • (2015) J. Clin. Oncol. , vol.33
    • Gajewski, T.1    Zha, Y.2    Hernandez, K.3
  • 21
    • 84932646690 scopus 로고    scopus 로고
    • Nonredundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints
    • Mikucki, M. E., Fisher, D. T., Matsuzaki, J. et al. 2015. Nonredundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nat. Commun. 6:7458.
    • (2015) Nat. Commun. , vol.6 , pp. 7458
    • Mikucki, M.E.1    Fisher, D.T.2    Matsuzaki, J.3
  • 22
    • 84887017053 scopus 로고    scopus 로고
    • CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2
    • Bedognetti, D., Spivey, T. L., Zhao, Y. et al. 2013. CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2. Br. J. Cancer 109:2412.
    • (2013) Br. J. Cancer , vol.109 , pp. 2412
    • Bedognetti, D.1    Spivey, T.L.2    Zhao, Y.3
  • 23
    • 84936953099 scopus 로고    scopus 로고
    • Melanomaintrinsic beta-catenin signalling prevents anti-tumour immunity
    • Spranger, S., Bao, R. Y. and Gajewski, T. F. 2015. Melanomaintrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 523:231.
    • (2015) Nature , vol.523 , pp. 231
    • Spranger, S.1    Bao, R.Y.2    Gajewski, T.F.3
  • 25
    • 78651451436 scopus 로고    scopus 로고
    • Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression
    • DuPage, M., Cheung, A. F., Mazumdar, C. et al. 2011. Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell 19:72.
    • (2011) Cancer Cell , vol.19 , pp. 72
    • DuPage, M.1    Cheung, A.F.2    Mazumdar, C.3
  • 26
    • 0032555614 scopus 로고    scopus 로고
    • Prevention of allogeneic fetal rejection by tryptophan catabolism
    • Munn, D. H., Zhou, M., Attwood, J. T. et al. 1998. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281:1191.
    • (1998) Science , vol.281 , pp. 1191
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3
  • 27
    • 34848819211 scopus 로고    scopus 로고
    • Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment
    • Gajewski, T. F. 2007. Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment. Clin. Cancer Res. 13(Pt 1):5256.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 5256
    • Gajewski, T.F.1
  • 28
    • 84922980334 scopus 로고    scopus 로고
    • Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma
    • Yeung, O. W., Lo, C. M., Ling, C. C. et al. 2015. Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma. J. Hepatol. 62:607.
    • (2015) J. Hepatol. , vol.62 , pp. 607
    • Yeung, O.W.1    Lo, C.M.2    Ling, C.C.3
  • 29
    • 36248976097 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan, P., Zheng, L., Ishihara, S., Reed, J. and Lenardo, M. J. 2007. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat. Immunol. 8:1353.
    • (2007) Nat. Immunol. , vol.8 , pp. 1353
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 30
    • 33749132564 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
    • Read, S., Greenwald, R., Izcue, A. et al. 2006. Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J. Immunol. 177:4376.
    • (2006) J. Immunol. , vol.177 , pp. 4376
    • Read, S.1    Greenwald, R.2    Izcue, A.3
  • 31
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing, K., Onishi, Y., Prieto-Martin, P. et al. 2008. CTLA-4 control over Foxp3+ regulatory T cell function. Science 322:271.
    • (2008) Science , vol.322 , pp. 271
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 32
    • 33750832563 scopus 로고    scopus 로고
    • T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    • Kobie, J. J., Shah, P. R., Yang, L., Rebhahn, J. A., Fowell, D. J. and Mosmann, T. R. 2006. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J. Immunol. 177:6780.
    • (2006) J. Immunol. , vol.177 , pp. 6780
    • Kobie, J.J.1    Shah, P.R.2    Yang, L.3    Rebhahn, J.A.4    Fowell, D.J.5    Mosmann, T.R.6
  • 33
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio, S., Dwyer, K. M., Gao, W. et al. 2007. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204:1257.
    • (2007) J. Exp. Med. , vol.204 , pp. 1257
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3
  • 34
    • 84902184973 scopus 로고    scopus 로고
    • Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction
    • Bauer, C. A., Kim, E. Y., Marangoni, F. et al. 2014. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J. Clin. Invest. 124:2425.
    • (2014) J. Clin. Invest. , vol.124 , pp. 2425
    • Bauer, C.A.1    Kim, E.Y.2    Marangoni, F.3
  • 35
    • 84874273811 scopus 로고    scopus 로고
    • The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells
    • Marangoni, F., Murooka, T. T., Manzo, T. et al. 2013. The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity 38:237.
    • (2013) Immunity , vol.38 , pp. 237
    • Marangoni, F.1    Murooka, T.T.2    Manzo, T.3
  • 36
    • 33645067654 scopus 로고    scopus 로고
    • Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo
    • Tadokoro, C. E., Shakhar, G., Shen, S. et al. 2006. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J. Exp. Med. 203:505.
    • (2006) J. Exp. Med. , vol.203 , pp. 505
    • Tadokoro, C.E.1    Shakhar, G.2    Shen, S.3
  • 37
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • 127ra37
    • Taube, J. M., Anders, R. A., Young, G. D. et al. 2012. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci. Transl. Med. 4:127ra37.
    • (2012) Sci. Transl. Med. , vol.4
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3
  • 39
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry, E. J. 2011. T cell exhaustion. Nat. Immunol. 12:492.
    • (2011) Nat. Immunol. , vol.12 , pp. 492
    • Wherry, E.J.1
  • 40
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman, G. J., Long, A. J., Iwai, Y. et al. 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027.
    • (2000) J. Exp. Med. , vol.192 , pp. 1027
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 41
    • 79957925314 scopus 로고    scopus 로고
    • Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
    • Baitsch, L., Baumgaertner, P., Devêvre, E. et al. 2011. Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients. J. Clin. Invest. 121:2350.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2350
    • Baitsch, L.1    Baumgaertner, P.2    Devêvre, E.3
  • 42
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski, T. F., Schreiber, H. and Fu, Y. X. 2013. Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14:1014.
    • (2013) Nat. Immunol. , vol.14 , pp. 1014
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 43
    • 84977161108 scopus 로고    scopus 로고
    • Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
    • Spranger, S., Koblish, H. K., Horton, B., Scherle, P. A., Newton, R. and Gajewski, T. F. 2014. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J. Immunother. Cancer 2:3.
    • (2014) J. Immunother. Cancer , vol.2 , pp. 3
    • Spranger, S.1    Koblish, H.K.2    Horton, B.3    Scherle, P.A.4    Newton, R.5    Gajewski, T.F.6
  • 44
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow, M. A., Chesney, J., Pavlick, A. C. et al. 2015. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 372:2006.
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2006
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3
  • 45
    • 79955785050 scopus 로고    scopus 로고
    • Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production
    • Curran, M. A., Kim, M., Montalvo, W., Al-Shamkhani, A. and Allison, J. P. 2011. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS One 6:e19499.
    • (2011) PLoS One , vol.6
    • Curran, M.A.1    Kim, M.2    Montalvo, W.3    Al-Shamkhani, A.4    Allison, J.P.5
  • 46
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. and Anderson, A. C. 2010. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207:2187.
    • (2010) J. Exp. Med. , vol.207 , pp. 2187
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3    Blazar, B.R.4    Kuchroo, V.K.5    Anderson, A.C.6
  • 47
    • 84862776855 scopus 로고    scopus 로고
    • Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
    • Matsushita, H., Vesely, M. D., Koboldt, D. C. et al. 2012. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature 482:400.
    • (2012) Nature , vol.482 , pp. 400
    • Matsushita, H.1    Vesely, M.D.2    Koboldt, D.C.3
  • 48
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • Schreiber, R. D., Old, L. J. and Smyth, M. J. 2011. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331:1565.
    • (2011) Science , vol.331 , pp. 1565
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 49
    • 84920921528 scopus 로고    scopus 로고
    • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
    • Gubin, M. M., Zhang, X., Schuster, H. et al. 2014. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515:577.
    • (2014) Nature , vol.515 , pp. 577
    • Gubin, M.M.1    Zhang, X.2    Schuster, H.3
  • 50
    • 33745015018 scopus 로고    scopus 로고
    • Characterization of melanocyte-specific inducible Cre recombinase transgenic mice
    • Bosenberg, M., Muthusamy, V., Curley, D. P. et al. 2006. Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis 44:262.
    • (2006) Genesis , vol.44 , pp. 262
    • Bosenberg, M.1    Muthusamy, V.2    Curley, D.P.3
  • 51
    • 83455171909 scopus 로고    scopus 로고
    • β-catenin signaling controls metastasis in Braf-activated Ptendeficient melanomas
    • Damsky, W. E., Curley, D. P., Santhanakrishnan, M. et al. 2011. β-catenin signaling controls metastasis in Braf-activated Ptendeficient melanomas. Cancer Cell 20:741.
    • (2011) Cancer Cell , vol.20 , pp. 741
    • Damsky, W.E.1    Curley, D.P.2    Santhanakrishnan, M.3
  • 52
    • 65649147543 scopus 로고    scopus 로고
    • Braf(V600E) cooperates with Pten loss to induce metastatic melanoma
    • Dankort, D., Curley, D. P., Cartlidge, R. A. et al. 2009. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat. Genet. 41:544.
    • (2009) Nat. Genet. , vol.41 , pp. 544
    • Dankort, D.1    Curley, D.P.2    Cartlidge, R.A.3
  • 53
    • 56449083451 scopus 로고    scopus 로고
    • Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer
    • Cheung, A. F., Dupage, M. J., Dong, H. K., Chen, J. and Jacks, T. 2008. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Res. 68:9459.
    • (2008) Cancer Res. , vol.68 , pp. 9459
    • Cheung, A.F.1    Dupage, M.J.2    Dong, H.K.3    Chen, J.4    Jacks, T.5
  • 54
    • 84946912433 scopus 로고    scopus 로고
    • Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
    • Peng, D., Kryczek, I., Nagarsheth, N. et al. 2015. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature 527:249.
    • (2015) Nature , vol.527 , pp. 249
    • Peng, D.1    Kryczek, I.2    Nagarsheth, N.3
  • 55
    • 79958696667 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression
    • Schmid, M. C., Avraamides, C. J., Dippold, H. C. et al. 2011. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 19:715.
    • (2011) Cancer Cell. , vol.19 , pp. 715
    • Schmid, M.C.1    Avraamides, C.J.2    Dippold, H.C.3
  • 56
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: a magic bullet?
    • Coussens, L. M., Zitvogel, L. and Palucka, A. K. 2013. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science 339:286.
    • (2013) Science , vol.339 , pp. 286
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 57
    • 84923175260 scopus 로고    scopus 로고
    • Understanding local macrophage phenotypes in disease: modulating macrophage function to treat cancer
    • Bronte, V. and Murray, P. J. 2015. Understanding local macrophage phenotypes in disease: modulating macrophage function to treat cancer. Nat. Med. 21:117.
    • (2015) Nat. Med. , vol.21 , pp. 117
    • Bronte, V.1    Murray, P.J.2
  • 58
    • 84957093642 scopus 로고    scopus 로고
    • Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
    • Peng, W., Chen, J. Q., Liu, C. et al. 2016. Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. Cancer Discov. 6:202.
    • (2016) Cancer Discov. , vol.6 , pp. 202
    • Peng, W.1    Chen, J.Q.2    Liu, C.3
  • 59
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue, W., Zender, L., Miething, C. et al. 2007. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445:656.
    • (2007) Nature , vol.445 , pp. 656
    • Xue, W.1    Zender, L.2    Miething, C.3
  • 60
    • 84885458655 scopus 로고    scopus 로고
    • p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
    • Iannello, A., Thompson, T. W., Ardolino, M., Lowe, S. W. and Raulet, D. H. 2013. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J. Exp. Med. 210:2057.
    • (2013) J. Exp. Med. , vol.210 , pp. 2057
    • Iannello, A.1    Thompson, T.W.2    Ardolino, M.3    Lowe, S.W.4    Raulet, D.H.5
  • 61
    • 84928040878 scopus 로고    scopus 로고
    • Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
    • Quigley, D., Silwal-Pandit, L., Dannenfelser, R. et al. 2015. Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53. Mol. Cancer Res. 13:493.
    • (2015) Mol. Cancer Res. , vol.13 , pp. 493
    • Quigley, D.1    Silwal-Pandit, L.2    Dannenfelser, R.3
  • 62
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
    • Bassères, D. S. and Baldwin, A. S. 2006. Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene 25:6817.
    • (2006) Oncogene , vol.25 , pp. 6817
    • Bassères, D.S.1    Baldwin, A.S.2
  • 63
    • 84858726313 scopus 로고    scopus 로고
    • Regulation of cell death and autophagy by IKK and NF-kappaB: critical mechanisms in immune function and cancer
    • Baldwin, A. S. 2012. Regulation of cell death and autophagy by IKK and NF-kappaB: critical mechanisms in immune function and cancer. Immunol. Rev. 246:327.
    • (2012) Immunol. Rev. , vol.246 , pp. 327
    • Baldwin, A.S.1
  • 64
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    • Pikarsky, E., Porat, R. M., Stein, I. et al. 2004. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431:461.
    • (2004) Nature , vol.431 , pp. 461
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3
  • 65
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F. R., Eckmann, L., Greten, T. F. et al. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285.
    • (2004) Cell , vol.118 , pp. 285
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3
  • 66
    • 84864834764 scopus 로고    scopus 로고
    • NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells
    • Muthuswamy, R., Berk, E., Junecko, B. F. et al. 2012. NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells. Cancer Res. 72:3735.
    • (2012) Cancer Res. , vol.72 , pp. 3735
    • Muthuswamy, R.1    Berk, E.2    Junecko, B.F.3
  • 67
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • Wang, T., Niu, G., Kortylewski, M. et al. 2004. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat. Med. 10:48.
    • (2004) Nat. Med. , vol.10 , pp. 48
    • Wang, T.1    Niu, G.2    Kortylewski, M.3
  • 68
    • 20144376844 scopus 로고    scopus 로고
    • Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
    • Burdelya, L., Kujawski, M., Niu, G. et al. 2005. Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J. Immunol. 174:3925.
    • (2005) J. Immunol. , vol.174 , pp. 3925
    • Burdelya, L.1    Kujawski, M.2    Niu, G.3
  • 69
    • 84907998102 scopus 로고    scopus 로고
    • Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity
    • Toso, A., Revandkar, A., Di Mitri, D. et al. 2014. Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity. Cell Rep. 9:75.
    • (2014) Cell Rep. , vol.9 , pp. 75
    • Toso, A.1    Revandkar, A.2    Di Mitri, D.3
  • 70
    • 84862570245 scopus 로고    scopus 로고
    • Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis
    • Ihara, S., Kida, H., Arase, H. et al. 2012. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res. 72:2990.
    • (2012) Cancer Res. , vol.72 , pp. 2990
    • Ihara, S.1    Kida, H.2    Arase, H.3
  • 71
    • 84958124766 scopus 로고    scopus 로고
    • Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
    • Pfirschke, C., Engblom, C., Rickelt, S. et al. 2016. Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity 44:343.
    • (2016) Immunity , vol.44 , pp. 343
    • Pfirschke, C.1    Engblom, C.2    Rickelt, S.3
  • 72
    • 84872514398 scopus 로고    scopus 로고
    • BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice
    • Liu, C., Peng, W., Xu, C. et al. 2013. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin. Cancer Res. 19:393.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 393
    • Liu, C.1    Peng, W.2    Xu, C.3
  • 73
    • 84926525215 scopus 로고    scopus 로고
    • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
    • Twyman-Saint Victor, C., Rech, A. J., Maity, A. et al. 2015. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520:373.
    • (2015) Nature , vol.520 , pp. 373
    • Twyman-Saint Victor, C.1    Rech, A.J.2    Maity, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.