Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 50, 2013, Pages 20176-20181

  Kokolus, Kathleen M ^a   Capitano, Maegan L ^a   Lee, Chen Ting ^a   Eng, Jason W L ^a   Waight, Jeremy D ^a   Hylander, Bonnie L ^a   Sexton, Sandra ^a   Hong, Chi Chen ^a   Gordon, Christopher J ^b   Abrams, Scott I ^a   Repasky, Elizabeth A ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Metabolism; Murine tumor models

Indexed keywords

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE MEASUREMENT; CARCINOGENESIS; CD8+ T LYMPHOCYTE; COLD STRESS; CONTROLLED STUDY; CYTOTOXICITY; ENVIRONMENTAL TEMPERATURE; LYMPHOCYTE; METASTASIS; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TEMPERATURE STRESS; THERMOGENESIS; TUMOR GROWTH; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT;

EID: 84890278138     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304291110     Document Type: Article

References (39)

1. Voskoglou-Nomikos T, Pater JL, Seymour L (2003) Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. Clin Cancer Res 9(11):4227-4239.
2. Seok J, et al. (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 110(9):3507-3512.
3. Terrien J, Perret M, Aujard F (2011) Behavioral thermoregulation in mammals: A review. Front Biosci (Landmark Ed) 16:1428-1444.
4. Gordon CJ (2012) Thermal physiology of laboratory mice: Defining thermoneutrality. J Therm Biol 37:654-685.
5. Lodhi IJ, Semenkovich CF (2009) Why we should put clothes on mice. Cell Metab 9(2):111-112.
6. Gaskill BN, et al. (2012) Heat or insulation: Behavioral titration of mouse preference for warmth or access to a nest. PLoS ONE 7(3):e32799.
7. Karp CL (2012) Unstressing intemperate models: How cold stress undermines mouse modeling. J Exp Med 209(6):1069-1074.
8. Cannon B, Nedergaard J (2004) Brown adipose tissue: Function and physiological significance. Physiol Rev 84(1):277-359.
9. National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals (2011) Guide for the Care and Use of Laboratory Animals (National Academies, Washington, DC), 8th Ed.
10. Rudaya AY, Steiner AA, Robbins JR, Dragic AS, Romanovsky AA (2005) Thermoregulatory responses to lipopolysaccharide in the mouse: Dependence on the dose and ambient temperature. Am J Physiol Regul Integr Comp Physiol 289(5):R1244-R1252.
11. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9(2):203-209.
12. Nguyen KD, et al. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480(7375):104-108.
13. Pulaski BA, Ostrand-Rosenberg S (2001) Mouse 4T1 breast tumor model. Curr Protoc Immunol May;Chapter 20:Unit 20.2.
14. Danna EA, et al. (2004) Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease. Cancer Res 64(6):2205-2211.
15. Swann JB, et al. (2008) Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci USA 105(2):652-656.
16. Shankaran V, et al. (2001) IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410(6832):1107-1111.
17. Teng MW, et al. (2010) IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proc Natl Acad Sci USA 107(18):8328-8333.
18. Huang AY, et al. (1996) The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proc Natl Acad Sci USA 93(18):9730-9735.
19. Ostrand-Rosenberg S (2008) Immune surveillance: A balance between protumor and antitumor immunity. Curr Opin Genet Dev 18(1):11-18.
20. Cortez-Retamozo V, et al. (2012) Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci USA 109(7):2491-2496.
21. Corzo CA, et al. (2010) HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 207(11):2439-2453.
22. Overton JM (2010) Phenotyping small animals as models for the human metabolic syndrome: Thermoneutrality matters. Int J Obes (Lond) 34(Suppl 2):S53-S58.
23. Shimizu I, et al. (2005) Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain 116(1-2):96-108.
24. Fox CJ, Hammerman PS, Thompson CB (2005) Fuel feeds function: Energy metabolism and the T-cell response. Nat Rev Immunol 5(11):844-852.
25. Pearce EL, Pearce EJ (2013) Metabolic pathways in immune cell activation and quiescence. Immunity 38(4):633-643.
26. Lochmiller RL, Deerenberg C (2000) Trade-offs in evolutionary immunology: just what is the cost of immunity? Oikos 88:87-98.
27. Martin LB, Weil ZM, Nelson RJ (2008) Seasonal changes in vertebrate immune activity: Mediation by physiological trade-offs. Philos Trans R Soc Lond B Biol Sci 363(1490):321-339.
28. Rauw WM (2012) Immune response from a resource allocation perspective. Front Genet 3:267-280.
29. Padgett DA, Glaser R (2003) How stress influences the immune response. Trends Immunol 24(8):444-448.
30. Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331(6024):1565-1570.
31. Zitvogel L, et al. (2008) The anticancer immune response: Indispensable for therapeutic success? J Clin Invest 118(6):1991-2001.
32. Repasky EA, Evans SS, Dewhirst MW (2013) Temperature matters! And why it should matter to tumor immunologists. Cancer Immunol Res 1(4):1-7.
33. Fisher DT, et al. (2011) IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J Clin Invest 121(10):3846-3859.
34. Hursting SD, Berger NA (2010) Energy balance, host-related factors, and cancer progression. J Clin Oncol 28(26):4058-4065.
35. Cannon B, Nedergaard J (2012) Yes, even human brown fat is on fire! J Clin Invest 122(2):486-489.
36. Ouellet V, et al. (2012) Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 122(2):545-552.
37. Kokolus KM, Hong CC, Repasky EA (2010) Feeling too hot or cold after breast cancer: Is it just a nuisance or a potentially important prognostic factor? Int J Hyperthermia 26(7):662-680.
38. Fyfe G, et al. (1995) Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 13(3):688-696.
39. Lotze MT, et al. (1985) In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2. J Immunol 135(4):2865-2875.