메뉴 건너뛰기




Volumn 8, Issue 2, 2018, Pages 150-164

The expanding world of N-MYC-driven tumors

Author keywords

[No Author keywords available]

Indexed keywords

ALISERTIB; CHROMOGRANIN A; GLUCAGON; N MYC PROTO ONCOGENE PROTEIN; NAVITOCLAX; SONIC HEDGEHOG PROTEIN; VENETOCLAX; WNT PROTEIN; BIOLOGICAL MARKER; TUMOR MARKER;

EID: 85041428603     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-17-0273     Document Type: Review
Times cited : (173)

References (172)
  • 1
    • 0018773455 scopus 로고
    • DNA and RNA from uninfected vertebrate cells contain nucleotide sequences related to the putative transforming gene of avian myelocytomatosis virus
    • Sheiness D, Bishop JM. DNA and RNA from uninfected vertebrate cells contain nucleotide sequences related to the putative transforming gene of avian myelocytomatosis virus. J Virol 1979; 31: 514-21.
    • (1979) J Virol , vol.31 , pp. 514-521
    • Sheiness, D.1    Bishop, J.M.2
  • 2
    • 0021047844 scopus 로고
    • Transposition and amplification of oncogene-related sequences in human neuroblastomas
    • Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F, et al. Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell 1983; 35: 359-67.
    • (1983) Cell , vol.35 , pp. 359-367
    • Kohl, N.E.1    Kanda, N.2    Schreck, R.R.3    Bruns, G.4    Latt, S.A.5    Gilbert, F.6
  • 3
    • 0022392771 scopus 로고
    • L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer
    • Nau MM, Brooks BJ, Battey J, Sausville E, Gazdar AF, Kirsch IR, et al. L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature 1985; 318: 69-73.
    • (1985) Nature , vol.318 , pp. 69-73
    • Nau, M.M.1    Brooks, B.J.2    Battey, J.3    Sausville, E.4    Gazdar, A.F.5    Kirsch, I.R.6
  • 4
    • 0021063273 scopus 로고
    • Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
    • Schwab M, Alitalo K, Klempnauer KH, Varmus HE, Bishop JM, Gilbert F, et al. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature 1983; 305: 245-8.
    • (1983) Nature , vol.305 , pp. 245-248
    • Schwab, M.1    Alitalo, K.2    Klempnauer, K.H.3    Varmus, H.E.4    Bishop, J.M.5    Gilbert, F.6
  • 5
    • 0022654681 scopus 로고
    • Human N-myc is closely related in organization and nucleotide sequence to c-myc
    • Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, et al. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature 1986; 319: 73-7.
    • (1986) Nature , vol.319 , pp. 73-77
    • Kohl, N.E.1    Legouy, E.2    DePinho, R.A.3    Nisen, P.D.4    Smith, R.K.5    Gee, C.E.6
  • 7
    • 0023136649 scopus 로고
    • Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity
    • Sarid J, Halazonetis TD, Murphy W, Leder P. Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. Proc Natl Acad Sci U S A 1987; 84: 170-3.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 170-173
    • Sarid, J.1    Halazonetis, T.D.2    Murphy, W.3    Leder, P.4
  • 10
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. MYC on the path to cancer. Cell 2012; 149: 22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 13
    • 0027080193 scopus 로고
    • Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene
    • Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, et al. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev 1992; 6: 2248-57.
    • (1992) Genes Dev , vol.6 , pp. 2248-2257
    • Charron, J.1    Malynn, B.A.2    Fisher, P.3    Stewart, V.4    Jeannotte, L.5    Goff, S.P.6
  • 14
    • 0027315650 scopus 로고
    • A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice
    • Davis AC, Wims M, Spotts GD, Hann SR, Bradley A. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev 1993; 7: 671-82.
    • (1993) Genes Dev , vol.7 , pp. 671-682
    • Davis, A.C.1    Wims, M.2    Spotts, G.D.3    Hann, S.R.4    Bradley, A.5
  • 15
    • 0027312135 scopus 로고
    • Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse
    • Sawai S, Shimono A, Wakamatsu Y, Palmes C, Hanaoka K, Kondoh H. Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. Development 1993; 117: 1445-55.
    • (1993) Development , vol.117 , pp. 1445-1455
    • Sawai, S.1    Shimono, A.2    Wakamatsu, Y.3    Palmes, C.4    Hanaoka, K.5    Kondoh, H.6
  • 16
    • 0027066738 scopus 로고
    • Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    • Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev 1992; 6: 2235-47.
    • (1992) Genes Dev , vol.6 , pp. 2235-2247
    • Stanton, B.R.1    Perkins, A.S.2    Tessarollo, L.3    Sassoon, D.A.4    Parada, L.F.5
  • 17
    • 0027436980 scopus 로고
    • Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus
    • Moens CB, Stanton BR, Parada LF, Rossant J. Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development 1993; 119: 485-99.
    • (1993) Development , vol.119 , pp. 485-499
    • Moens, C.B.1    Stanton, B.R.2    Parada, L.F.3    Rossant, J.4
  • 18
    • 0032554783 scopus 로고    scopus 로고
    • Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
    • Nagy A, Moens C, Ivanyi E, Pawling J, Gertsenstein M, Hadjantonakis AK, et al. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr Biol 1998; 8: 661-4.
    • (1998) Curr Biol , vol.8 , pp. 661-664
    • Nagy, A.1    Moens, C.2    Ivanyi, E.3    Pawling, J.4    Gertsenstein, M.5    Hadjantonakis, A.K.6
  • 19
    • 50249178184 scopus 로고    scopus 로고
    • Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function
    • Dubois NC, Adolphe C, Ehninger A, Wang RA, Robertson EJ, Trumpp A. Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function. Development 2008; 135: 2455-65.
    • (2008) Development , vol.135 , pp. 2455-2465
    • Dubois, N.C.1    Adolphe, C.2    Ehninger, A.3    Wang, R.A.4    Robertson, E.J.5    Trumpp, A.6
  • 20
    • 33751018274 scopus 로고    scopus 로고
    • Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc
    • Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, et al. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol 2006; 26: 8418-26.
    • (2006) Mol Cell Biol , vol.26 , pp. 8418-8426
    • Muncan, V.1    Sansom, O.J.2    Tertoolen, L.3    Phesse, T.J.4    Begthel, H.5    Sancho, E.6
  • 21
    • 0035320527 scopus 로고    scopus 로고
    • Defining the specific physiological requirements for c-Myc in T cell development
    • Douglas NC, Jacobs H, Bothwell AL, Hayday AC. Defining the specific physiological requirements for c-Myc in T cell development. Nat Immunol 2001; 2: 307-15.
    • (2001) Nat Immunol , vol.2 , pp. 307-315
    • Douglas, N.C.1    Jacobs, H.2    Bothwell, A.L.3    Hayday, A.C.4
  • 22
    • 0035856918 scopus 로고    scopus 로고
    • c-Myc regulates mammalian body size by controlling cell number but not cell size
    • Trumpp A, Refaeli Y, Oskarsson T, Gasser S, Murphy M, Martin GR, et al. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 2001; 414: 768-73.
    • (2001) Nature , vol.414 , pp. 768-773
    • Trumpp, A.1    Refaeli, Y.2    Oskarsson, T.3    Gasser, S.4    Murphy, M.5    Martin, G.R.6
  • 23
    • 0037108268 scopus 로고    scopus 로고
    • N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation
    • Knoepfler PS, Cheng PF, Eisenman RN. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 2002; 16: 2699-712.
    • (2002) Genes Dev , vol.16 , pp. 2699-2712
    • Knoepfler, P.S.1    Cheng, P.F.2    Eisenman, R.N.3
  • 24
    • 0034213414 scopus 로고    scopus 로고
    • N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation
    • Malynn BA, de Alboran IM, O’Hagan RC, Bronson R, Davidson L, DePinho RA, et al. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev 2000; 14: 1390-9.
    • (2000) Genes Dev , vol.14 , pp. 1390-1399
    • Malynn, B.A.1    de Alboran, I.M.2    O’Hagan, R.C.3    Bronson, R.4    Davidson, L.5    DePinho, R.A.6
  • 25
    • 0032945178 scopus 로고    scopus 로고
    • The conditional probability of survival of patients with primary malignant brain tumors: Surveillance, epidemiology, and end results (SEER) data
    • Davis FG, McCarthy BJ, Freels S, Kupelian V, Bondy ML. The conditional probability of survival of patients with primary malignant brain tumors: surveillance, epidemiology, and end results (SEER) data. Cancer 1999; 85: 485-91.
    • (1999) Cancer , vol.85 , pp. 485-491
    • Davis, F.G.1    McCarthy, B.J.2    Freels, S.3    Kupelian, V.4    Bondy, M.L.5
  • 28
    • 0021241701 scopus 로고
    • Expression and amplification of the N-myc gene in primary retinoblastoma
    • Lee WH, Murphree AL, Benedict WF. Expression and amplification of the N-myc gene in primary retinoblastoma. Nature 1984; 309: 458-60.
    • (1984) Nature , vol.309 , pp. 458-460
    • Lee, W.H.1    Murphree, A.L.2    Benedict, W.F.3
  • 29
    • 0021995001 scopus 로고
    • N-myc amplification in malignant astrocytoma
    • Garson JA, McIntyre PG, Kemshead JT. N-myc amplification in malignant astrocytoma. Lancet 1985; 2: 718-9.
    • (1985) Lancet , vol.2 , pp. 718-719
    • Garson, J.A.1    McIntyre, P.G.2    Kemshead, J.T.3
  • 30
    • 84877621282 scopus 로고    scopus 로고
    • Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN
    • Bjerke L, Mackay A, Nandhabalan M, Burford A, Jury A, Popov S, et al. Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN. Cancer Discov 2013; 3: 512-9.
    • (2013) Cancer Discov , vol.3 , pp. 512-519
    • Bjerke, L.1    Mackay, A.2    Nandhabalan, M.3    Burford, A.4    Jury, A.5    Popov, S.6
  • 31
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One 2009; 4: e7752.
    • (2009) PLoS One , vol.4
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3    Ozawa, T.4    Tandon, A.5    Pedraza, A.6
  • 32
    • 0034998193 scopus 로고    scopus 로고
    • Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
    • Hui AB, Lo KW, Yin XL, Poon WS, Ng HK. Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab Invest 2001; 81: 717-23.
    • (2001) Lab Invest , vol.81 , pp. 717-723
    • Hui, A.B.1    Lo, K.W.2    Yin, X.L.3    Poon, W.S.4    Ng, H.K.5
  • 33
    • 57449090950 scopus 로고    scopus 로고
    • Malignant gliomas with primitive neuroectodermal tumor-like components: A clinicopathologic and genetic study of 53 cases
    • Perry A, Miller CR, Gujrati M, Scheithauer BW, Zambrano SC, Jost SC, et al. Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. Brain Pathol 2009; 19: 81-90.
    • (2009) Brain Pathol , vol.19 , pp. 81-90
    • Perry, A.1    Miller, C.R.2    Gujrati, M.3    Scheithauer, B.W.4    Zambrano, S.C.5    Jost, S.C.6
  • 34
    • 84861399134 scopus 로고    scopus 로고
    • Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    • Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, et al. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 2012; 21: 601-13.
    • (2012) Cancer Cell , vol.21 , pp. 601-613
    • Swartling, F.J.1    Savov, V.2    Persson, A.I.3    Chen, J.4    Hackett, C.S.5    Northcott, P.A.6
  • 35
    • 84860168795 scopus 로고    scopus 로고
    • Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets
    • Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, et al. Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov 2011; 1: 487-95.
    • (2011) Cancer Discov , vol.1 , pp. 487-495
    • Beltran, H.1    Rickman, D.S.2    Park, K.3    Chae, S.S.4    Sboner, A.5    MacDonald, T.Y.6
  • 37
    • 0024432837 scopus 로고
    • N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas
    • van Lohuizen M, Breuer M, Berns A. N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas. EMBO J 1989; 8: 133-6.
    • (1989) EMBO J , vol.8 , pp. 133-136
    • van Lohuizen, M.1    Breuer, M.2    Berns, A.3
  • 39
    • 20044391414 scopus 로고    scopus 로고
    • Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtype
    • Williamson D, Lu YJ, Gordon T, Sciot R, Kelsey A, Fisher C, et al. Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtype. J Clin Oncol 2005; 23: 880-8.
    • (2005) J Clin Oncol , vol.23 , pp. 880-888
    • Williamson, D.1    Lu, Y.J.2    Gordon, T.3    Sciot, R.4    Kelsey, A.5    Fisher, C.6
  • 40
    • 80053644624 scopus 로고    scopus 로고
    • Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor
    • Williams RD, Al-Saadi R, Natrajan R, Mackay A, Chagtai T, Little S, et al. Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor. Genes Chromosomes Cancer 2011; 50: 982-95.
    • (2011) Genes Chromosomes Cancer , vol.50 , pp. 982-995
    • Williams, R.D.1    Al-Saadi, R.2    Natrajan, R.3    Mackay, A.4    Chagtai, T.5    Little, S.6
  • 42
    • 84996848697 scopus 로고    scopus 로고
    • Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
    • Fielitz K, Althoff K, De Preter K, Nonnekens J, Ohli J, Elges S, et al. Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells. Oncotarget 2016; 7: 74415-26.
    • (2016) Oncotarget , vol.7 , pp. 74415-74426
    • Fielitz, K.1    Althoff, K.2    De Preter, K.3    Nonnekens, J.4    Ohli, J.5    Elges, S.6
  • 43
    • 84988695241 scopus 로고    scopus 로고
    • The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells
    • King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, et al. The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells. Nat Immunol 2016; 17: 1312-21.
    • (2016) Nat Immunol , vol.17 , pp. 1312-1321
    • King, B.1    Boccalatte, F.2    Moran-Crusio, K.3    Wolf, E.4    Wang, J.5    Kayembe, C.6
  • 44
    • 36349014998 scopus 로고    scopus 로고
    • Overexpression of N-Myc rapidly causes acute myeloid leukemia in mice
    • Kawagoe H, Kandilci A, Kranenburg TA, Grosveld GC. Overexpression of N-Myc rapidly causes acute myeloid leukemia in mice. Cancer Res 2007; 67: 10677-85.
    • (2007) Cancer Res , vol.67 , pp. 10677-10685
    • Kawagoe, H.1    Kandilci, A.2    Kranenburg, T.A.3    Grosveld, G.C.4
  • 45
    • 0037384465 scopus 로고    scopus 로고
    • Molecular characterization of prostatic small-cell neuroendocrine carcinoma
    • Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, et al. Molecular characterization of prostatic small-cell neuroendocrine carcinoma. Prostate 2003; 55: 55-64.
    • (2003) Prostate , vol.55 , pp. 55-64
    • Clegg, N.1    Ferguson, C.2    True, L.D.3    Arnold, H.4    Moorman, A.5    Quinn, J.E.6
  • 46
    • 84991790827 scopus 로고    scopus 로고
    • N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
    • Dardenne E, Beltran H, Benelli M, Gayvert K, Berger A, Puca L, et al. N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. Cancer Cell 2016; 30: 563-77.
    • (2016) Cancer Cell , vol.30 , pp. 563-577
    • Dardenne, E.1    Beltran, H.2    Benelli, M.3    Gayvert, K.4    Berger, A.5    Puca, L.6
  • 48
    • 84962090106 scopus 로고    scopus 로고
    • N-Myc drives neuroendocrine prostate cancer initiated from human prostate epithelial cells
    • Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, et al. N-Myc drives neuroendocrine prostate cancer initiated from human prostate epithelial cells. Cancer Cell 2016; 29: 536-47.
    • (2016) Cancer Cell , vol.29 , pp. 536-547
    • Lee, J.K.1    Phillips, J.W.2    Smith, B.A.3    Park, J.W.4    Stoyanova, T.5    McCaffrey, E.F.6
  • 49
    • 84957623685 scopus 로고    scopus 로고
    • Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
    • Beltran H, Prandi D, Mosquera JM, Benelli M, Puca L, Cyrta J, et al. Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nat Med 2016; 22: 298-305.
    • (2016) Nat Med , vol.22 , pp. 298-305
    • Beltran, H.1    Prandi, D.2    Mosquera, J.M.3    Benelli, M.4    Puca, L.5    Cyrta, J.6
  • 50
    • 50249133616 scopus 로고    scopus 로고
    • Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
    • Gurel B, Iwata T, Koh CM, Jenkins RB, Lan F, Van Dang C, et al. Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis. Mod Pathol 2008; 21: 1156-67.
    • (2008) Mod Pathol , vol.21 , pp. 1156-1167
    • Gurel, B.1    Iwata, T.2    Koh, C.M.3    Jenkins, R.B.4    Lan, F.5    Van Dang, C.6
  • 51
    • 85020278745 scopus 로고    scopus 로고
    • Biology and evolution of poorly differentiated neuroendocrine tumors
    • Rickman DS, Beltran H, Demichelis F, Rubin MA. Biology and evolution of poorly differentiated neuroendocrine tumors. Nat Med 2017; 23: 1-10.
    • (2017) Nat Med , vol.23 , pp. 1-10
    • Rickman, D.S.1    Beltran, H.2    Demichelis, F.3    Rubin, M.A.4
  • 52
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 2003; 3: 203-16.
    • (2003) Nat Rev Cancer , vol.3 , pp. 203-216
    • Brodeur, G.M.1
  • 54
    • 0022388606 scopus 로고
    • Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
    • Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 1985; 313: 1111-6.
    • (1985) N Engl J Med , vol.313 , pp. 1111-1116
    • Seeger, R.C.1    Brodeur, G.M.2    Sather, H.3    Dalton, A.4    Siegel, S.E.5    Wong, K.Y.6
  • 55
    • 0021261878 scopus 로고
    • Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
    • Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 1984; 224: 1121-4.
    • (1984) Science , vol.224 , pp. 1121-1124
    • Brodeur, G.M.1    Seeger, R.C.2    Schwab, M.3    Varmus, H.E.4    Bishop, J.M.5
  • 56
    • 0021276218 scopus 로고
    • Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc
    • Schwab M, Varmus HE, Bishop JM, Grzeschik KH, Naylor SL, Sakaguchi AY, et al. Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc. Nature 1984; 308: 288-91.
    • (1984) Nature , vol.308 , pp. 288-291
    • Schwab, M.1    Varmus, H.E.2    Bishop, J.M.3    Grzeschik, K.H.4    Naylor, S.L.5    Sakaguchi, A.Y.6
  • 58
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455: 1061-8.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 59
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones DT, Jager N, Kool M, Zichner T, Hutter B, Sultan M, et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 2012; 488: 100-5.
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1    Jager, N.2    Kool, M.3    Zichner, T.4    Hutter, B.5    Sultan, M.6
  • 60
    • 84862907854 scopus 로고    scopus 로고
    • Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    • Wu J, Jiao Y, Dal Molin M, Maitra A, De Wilde RF, Wood LD, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A 2011; 108: 21188-93.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 21188-21193
    • Wu, J.1    Jiao, Y.2    Dal Molin, M.3    Maitra, A.4    De Wilde, R.F.5    Wood, L.D.6
  • 61
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer
    • Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, et al. COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res 2011; 39: D945-50.
    • (2011) Nucleic Acids Res , vol.39 , pp. D945-D950
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3    Cole, C.4    Kok, C.Y.5    Beare, D.6
  • 63
    • 77953523121 scopus 로고    scopus 로고
    • Recent advances in neuroblastoma
    • Maris JM. Recent advances in neuroblastoma. N Engl J Med 2010; 362: 2202-11.
    • (2010) N Engl J Med , vol.362 , pp. 2202-2211
    • Maris, J.M.1
  • 65
    • 84933040610 scopus 로고    scopus 로고
    • A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
    • Althoff K, Beckers A, Bell E, Nortmeyer M, Thor T, Sprussel A, et al. A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene 2015; 34: 3357-68.
    • (2015) Oncogene , vol.34 , pp. 3357-3368
    • Althoff, K.1    Beckers, A.2    Bell, E.3    Nortmeyer, M.4    Thor, T.5    Sprussel, A.6
  • 68
    • 55649123695 scopus 로고    scopus 로고
    • Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
    • Westermann F, Muth D, Benner A, Bauer T, Henrich KO, Oberthuer A, et al. Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol 2008; 9: R150.
    • (2008) Genome Biol , vol.9 , pp. R150
    • Westermann, F.1    Muth, D.2    Benner, A.3    Bauer, T.4    Henrich, K.O.5    Oberthuer, A.6
  • 69
    • 0036293677 scopus 로고    scopus 로고
    • TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins
    • Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, et al. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol 2002; 22: 5054-63.
    • (2002) Mol Cell Biol , vol.22 , pp. 5054-5063
    • Nikiforov, M.A.1    Chandriani, S.2    Park, J.3    Kotenko, I.4    Matheos, D.5    Johnsson, A.6
  • 70
    • 84945918266 scopus 로고    scopus 로고
    • Telomerase activation by genomic rearrangements in high-risk neuroblastoma
    • Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, et al. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature 2015; 526: 700-4.
    • (2015) Nature , vol.526 , pp. 700-704
    • Peifer, M.1    Hertwig, F.2    Roels, F.3    Dreidax, D.4    Gartlgruber, M.5    Menon, R.6
  • 73
    • 40849108663 scopus 로고    scopus 로고
    • Selective blockade of microRNA processing by Lin28
    • Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science 2008; 320: 97-100.
    • (2008) Science , vol.320 , pp. 97-100
    • Viswanathan, S.R.1    Daley, G.Q.2    Gregory, R.I.3
  • 74
    • 31644450515 scopus 로고    scopus 로고
    • Target-dependent specification of the neurotransmitter phenotype: Cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling
    • Stanke M, Duong CV, Pape M, Geissen M, Burbach G, Deller T, et al. Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development 2006; 133: 141-50.
    • (2006) Development , vol.133 , pp. 141-150
    • Stanke, M.1    Duong, C.V.2    Pape, M.3    Geissen, M.4    Burbach, G.5    Deller, T.6
  • 76
    • 84905715895 scopus 로고    scopus 로고
    • Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models
    • Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, et al. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell 2014; 26: 248-61.
    • (2014) Cancer Cell , vol.26 , pp. 248-261
    • Nguyen, L.H.1    Robinton, D.A.2    Seligson, M.T.3    Wu, L.4    Li, L.5    Rakheja, D.6
  • 77
    • 84885896439 scopus 로고    scopus 로고
    • LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
    • Madison BB, Liu Q, Zhong X, Hahn CM, Lin N, Emmett MJ, et al. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev 2013; 27: 2233-45.
    • (2013) Genes Dev , vol.27 , pp. 2233-2245
    • Madison, B.B.1    Liu, Q.2    Zhong, X.3    Hahn, C.M.4    Lin, N.5    Emmett, M.J.6
  • 80
    • 84875810807 scopus 로고    scopus 로고
    • Characterisation of retinoblastomas without RB1 mutations: Genomic, gene expression, and clinical studies
    • Rushlow DE, Mol BM, Kennett JY, Yee S, Pajovic S, Theriault BL, et al. Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. Lancet Oncol 2013; 14: 327-34.
    • (2013) Lancet Oncol , vol.14 , pp. 327-334
    • Rushlow, D.E.1    Mol, B.M.2    Kennett, J.Y.3    Yee, S.4    Pajovic, S.5    Theriault, B.L.6
  • 81
    • 13444249786 scopus 로고    scopus 로고
    • The search for the retinoblastoma cell of origin
    • Dyer MA, Bremner R. The search for the retinoblastoma cell of origin. Nat Rev Cancer 2005; 5: 91-101.
    • (2005) Nat Rev Cancer , vol.5 , pp. 91-101
    • Dyer, M.A.1    Bremner, R.2
  • 82
    • 2942574955 scopus 로고    scopus 로고
    • Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma
    • Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 2004; 5: 539-51.
    • (2004) Cancer Cell , vol.5 , pp. 539-551
    • Chen, D.1    Livne-Bar, I.2    Vanderluit, J.L.3    Slack, R.S.4    Agochiya, M.5    Bremner, R.6
  • 85
    • 84870542355 scopus 로고    scopus 로고
    • Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation
    • Sangwan M, McCurdy SR, Livne-Bar I, Ahmad M, Wrana JL, Chen D, et al. Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation. Oncogene 2012; 31: 5019-28.
    • (2012) Oncogene , vol.31 , pp. 5019-5028
    • Sangwan, M.1    McCurdy, S.R.2    Livne-Bar, I.3    Ahmad, M.4    Wrana, J.L.5    Chen, D.6
  • 86
    • 85015974252 scopus 로고    scopus 로고
    • A mouse model of MYCN-driven retinoblastoma reveals MYCNindependent tumor reemergence
    • Wu N, Jia D, Bates B, Basom R, Eberhart CG, MacPherson D. A mouse model of MYCN-driven retinoblastoma reveals MYCNindependent tumor reemergence. J Clin Invest 2017; 127: 888-98.
    • (2017) J Clin Invest , vol.127 , pp. 888-898
    • Wu, N.1    Jia, D.2    Bates, B.3    Basom, R.4    Eberhart, C.G.5    MacPherson, D.6
  • 90
    • 33749024194 scopus 로고    scopus 로고
    • N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth
    • Hatton BA, Knoepfler PS, Kenney AM, Rowitch DH, de Alboran IM, Olson JM, et al. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res 2006; 66: 8655-61.
    • (2006) Cancer Res , vol.66 , pp. 8655-8661
    • Hatton, B.A.1    Knoepfler, P.S.2    Kenney, A.M.3    Rowitch, D.H.4    de Alboran, I.M.5    Olson, J.M.6
  • 93
    • 84857013044 scopus 로고    scopus 로고
    • A mouse model of the most aggressive subgroup of human medulloblastoma
    • Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, et al. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 2012; 21: 168-80.
    • (2012) Cancer Cell , vol.21 , pp. 168-180
    • Kawauchi, D.1    Robinson, G.2    Uziel, T.3    Gibson, P.4    Rehg, J.5    Gao, C.6
  • 95
    • 34047263220 scopus 로고    scopus 로고
    • Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors
    • Zindy F, Uziel T, Ayrault O, Calabrese C, Valentine M, Rehg JE, et al. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 2007; 67: 2676-84.
    • (2007) Cancer Res , vol.67 , pp. 2676-2684
    • Zindy, F.1    Uziel, T.2    Ayrault, O.3    Calabrese, C.4    Valentine, M.5    Rehg, J.E.6
  • 96
    • 84865863019 scopus 로고    scopus 로고
    • K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    • Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E, et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol 2012; 124: 439-47.
    • (2012) Acta Neuropathol , vol.124 , pp. 439-447
    • Khuong-Quang, D.A.1    Buczkowicz, P.2    Rakopoulos, P.3    Liu, X.Y.4    Fontebasso, A.M.5    Bouffet, E.6
  • 97
    • 28844442337 scopus 로고    scopus 로고
    • Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9
    • Kawagoe H, Grosveld GC. Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9. Blood 2005; 106: 4269-77.
    • (2005) Blood , vol.106 , pp. 4269-4277
    • Kawagoe, H.1    Grosveld, G.C.2
  • 99
    • 8644219660 scopus 로고    scopus 로고
    • c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
    • Wilson A, Murphy MJ, Oskarsson T, Kaloulis K, Bettess MD, Oser GM, et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 2004; 18: 2747-63.
    • (2004) Genes Dev , vol.18 , pp. 2747-2763
    • Wilson, A.1    Murphy, M.J.2    Oskarsson, T.3    Kaloulis, K.4    Bettess, M.D.5    Oser, G.M.6
  • 100
    • 84893809132 scopus 로고    scopus 로고
    • Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells
    • Huijbers IJ, Bin Ali R, Pritchard C, Cozijnsen M, Kwon MC, Proost N, et al. Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med 2014; 6: 212-25.
    • (2014) EMBO Mol Med , vol.6 , pp. 212-225
    • Huijbers, I.J.1    Bin Ali, R.2    Pritchard, C.3    Cozijnsen, M.4    Kwon, M.C.5    Proost, N.6
  • 101
    • 84974605091 scopus 로고    scopus 로고
    • Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer
    • Kim DW, Wu N, Kim YC, Cheng PF, Basom R, Kim D, et al. Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev 2016; 30: 1289-99.
    • (2016) Genes Dev , vol.30 , pp. 1289-1299
    • Kim, D.W.1    Wu, N.2    Kim, Y.C.3    Cheng, P.F.4    Basom, R.5    Kim, D.6
  • 102
    • 85009505564 scopus 로고    scopus 로고
    • MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition
    • Mollaoglu G, Guthrie MR, Bohm S, Bragelmann J, Can I, Ballieu PM, et al. MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition. Cancer Cell 2017; 31: 270-85.
    • (2017) Cancer Cell , vol.31 , pp. 270-285
    • Mollaoglu, G.1    Guthrie, M.R.2    Bohm, S.3    Bragelmann, J.4    Can, I.5    Ballieu, P.M.6
  • 103
    • 84866851740 scopus 로고    scopus 로고
    • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
    • Peifer M, Fernandez-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 2012; 44: 1104-10.
    • (2012) Nat Genet , vol.44 , pp. 1104-1110
    • Peifer, M.1    Fernandez-Cuesta, L.2    Sos, M.L.3    George, J.4    Seidel, D.5    Kasper, L.H.6
  • 104
    • 84895808107 scopus 로고    scopus 로고
    • MYC, MAX, and small cell lung cancer
    • Rudin CM, Poirier JT. MYC, MAX, and small cell lung cancer. Cancer Discov 2014; 4: 273-4.
    • (2014) Cancer Discov , vol.4 , pp. 273-274
    • Rudin, C.M.1    Poirier, J.T.2
  • 105
    • 84867627577 scopus 로고    scopus 로고
    • A framework for identification of actionable cancer genome dependencies in small cell lung cancer
    • Sos ML, Dietlein F, Peifer M, Schottle J, Balke-Want H, Muller C, et al. A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc Natl Acad Sci U S A 2012; 109: 17034-9.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17034-17039
    • Sos, M.L.1    Dietlein, F.2    Peifer, M.3    Schottle, J.4    Balke-Want, H.5    Muller, C.6
  • 108
    • 79956207689 scopus 로고    scopus 로고
    • Pancreatic ductal adenocarcinoma and transcription factors: Role of c-Myc
    • Skoudy A, Hernandez-Munoz I, Navarro P. Pancreatic ductal adenocarcinoma and transcription factors: role of c-Myc. J Gastrointest Cancer 2011; 42: 76-84.
    • (2011) J Gastrointest Cancer , vol.42 , pp. 76-84
    • Skoudy, A.1    Hernandez-Munoz, I.2    Navarro, P.3
  • 111
    • 84873048485 scopus 로고    scopus 로고
    • Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer
    • Mosquera JM, Beltran H, Park K, MacDonald TY, Robinson BD, Tagawa ST, et al. Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia 2013; 15: 1-10.
    • (2013) Neoplasia , vol.15 , pp. 1-10
    • Mosquera, J.M.1    Beltran, H.2    Park, K.3    MacDonald, T.Y.4    Robinson, B.D.5    Tagawa, S.T.6
  • 112
    • 0015370976 scopus 로고
    • Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. CA: Cancer J Clin 1972; 22: 232-40.
    • (1972) CA: Cancer J Clin , vol.22 , pp. 232-240
    • Huggins, C.1    Hodges, C.V.2
  • 113
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 2012; 338: 1465-9.
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1    Wu, Z.J.2    Groner, A.C.3    He, H.H.4    Cai, C.5    Lis, R.T.6
  • 114
    • 33846579213 scopus 로고    scopus 로고
    • Small cell carcinomas of the gastrointestinal tract: Clinicopathological features and treatment approach
    • Brenner B, Tang LH, Shia J, Klimstra DS, Kelsen DP. Small cell carcinomas of the gastrointestinal tract: clinicopathological features and treatment approach. Semin Oncol 2007; 34: 43-50.
    • (2007) Semin Oncol , vol.34 , pp. 43-50
    • Brenner, B.1    Tang, L.H.2    Shia, J.3    Klimstra, D.S.4    Kelsen, D.P.5
  • 115
    • 42649089083 scopus 로고    scopus 로고
    • Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
    • Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, et al. Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?. Am J Surg Pathol 2008; 32: 719-31.
    • (2008) Am J Surg Pathol , vol.32 , pp. 719-731
    • Shia, J.1    Tang, L.H.2    Weiser, M.R.3    Brenner, B.4    Adsay, N.V.5    Stelow, E.B.6
  • 116
    • 84934292801 scopus 로고    scopus 로고
    • Transformation from non-small-cell lung cancer to small-cell lung cancer: Molecular drivers and cells of origin
    • Oser MG, Niederst MJ, Sequist LV, Engelman JA. Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. Lancet Oncol 2015; 16: e165-72.
    • (2015) Lancet Oncol , vol.16 , pp. e165-e172
    • Oser, M.G.1    Niederst, M.J.2    Sequist, L.V.3    Engelman, J.A.4
  • 118
    • 65549118291 scopus 로고    scopus 로고
    • Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate
    • Hansel DE, Nakayama M, Luo J, Abukhdeir AM, Park BH, Bieberich CJ, et al. Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate. Prostate 2009; 69: 603-9.
    • (2009) Prostate , vol.69 , pp. 603-609
    • Hansel, D.E.1    Nakayama, M.2    Luo, J.3    Abukhdeir, A.M.4    Park, B.H.5    Bieberich, C.J.6
  • 119
    • 79961031503 scopus 로고    scopus 로고
    • ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: Evidence supporting monoclonal origin
    • Williamson SR, Zhang S, Yao JL, Huang J, Lopez-Beltran A, Shen S, et al. ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin. Mod Pathol 2011; 24: 1120-7.
    • (2011) Mod Pathol , vol.24 , pp. 1120-1127
    • Williamson, S.R.1    Zhang, S.2    Yao, J.L.3    Huang, J.4    Lopez-Beltran, A.5    Shen, S.6
  • 120
    • 85009286726 scopus 로고    scopus 로고
    • Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
    • Ku SY, Rosario S, Wang Y, Mu P, Seshadri M, Goodrich ZW, et al. Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance. Science 2017; 355: 78-83.
    • (2017) Science , vol.355 , pp. 78-83
    • Ku, S.Y.1    Rosario, S.2    Wang, Y.3    Mu, P.4    Seshadri, M.5    Goodrich, Z.W.6
  • 121
    • 85009250505 scopus 로고    scopus 로고
    • SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer
    • Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, et al. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science 2017; 355: 84-8.
    • (2017) Science , vol.355 , pp. 84-88
    • Mu, P.1    Zhang, Z.2    Benelli, M.3    Karthaus, W.R.4    Hoover, E.5    Chen, C.C.6
  • 122
    • 85020302825 scopus 로고    scopus 로고
    • Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer
    • Zou M, Toivanen R, Mitrofanova A, Floc’h N, Hayati S, Sun Y, et al. Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer. Cancer Discov 2017; 7: 736-49.
    • (2017) Cancer Discov , vol.7 , pp. 736-749
    • Zou, M.1    Toivanen, R.2    Mitrofanova, A.3    Floc’h, N.4    Hayati, S.5    Sun, Y.6
  • 123
    • 84892369037 scopus 로고    scopus 로고
    • Targets in small cell lung cancer
    • Teicher BA. Targets in small cell lung cancer. Biochem Pharmacol 2014; 87: 211-9.
    • (2014) Biochem Pharmacol , vol.87 , pp. 211-219
    • Teicher, B.A.1
  • 124
    • 0034910622 scopus 로고    scopus 로고
    • Molecular genetics of small cell lung carcinoma
    • Wistuba II, Gazdar AF, Minna JD. Molecular genetics of small cell lung carcinoma. Semin Oncol 2001; 28: 3-13.
    • (2001) Semin Oncol , vol.28 , pp. 3-13
    • Wistuba, I.I.1    Gazdar, A.F.2    Minna, J.D.3
  • 125
    • 85009505564 scopus 로고    scopus 로고
    • MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition
    • Mollaoglu G, Guthrie MR, Bohm S, Bragelmann J, Can I, Ballieu PM, et al. MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition. Cancer Cell 2017; 31: 270-85.
    • (2017) Cancer Cell , vol.31 , pp. 270-285
    • Mollaoglu, G.1    Guthrie, M.R.2    Bohm, S.3    Bragelmann, J.4    Can, I.5    Ballieu, P.M.6
  • 126
    • 0025990074 scopus 로고
    • The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max (p20/22) in human neuroblastoma cells
    • Wenzel A, Cziepluch C, Hamann U, Schurmann J, Schwab M. The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max (p20/22) in human neuroblastoma cells. EMBO J 1991; 10: 3703-12.
    • (1991) EMBO J , vol.10 , pp. 3703-3712
    • Wenzel, A.1    Cziepluch, C.2    Hamann, U.3    Schurmann, J.4    Schwab, M.5
  • 127
    • 84942370919 scopus 로고    scopus 로고
    • MYC: Connecting selective transcriptional control to global RNA production
    • Kress TR, Sabo A, Amati B. MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer 2015; 15: 593-607.
    • (2015) Nat Rev Cancer , vol.15 , pp. 593-607
    • Kress, T.R.1    Sabo, A.2    Amati, B.3
  • 129
    • 84982732197 scopus 로고    scopus 로고
    • Different promoter affinities account for specificity in MYCdependent gene regulation
    • pii: e15161
    • Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, et al. Different promoter affinities account for specificity in MYCdependent gene regulation. Elife 2016; 5: pii: e15161.
    • (2016) Elife , vol.5
    • Lorenzin, F.1    Benary, U.2    Baluapuri, A.3    Walz, S.4    Jung, L.A.5    von Eyss, B.6
  • 130
    • 84928928863 scopus 로고    scopus 로고
    • Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC
    • Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, et al. Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. Mol Cell 2015; 58: 440-52.
    • (2015) Mol Cell , vol.58 , pp. 440-452
    • Thomas, L.R.1    Wang, Q.2    Grieb, B.C.3    Phan, J.4    Foshage, A.M.5    Sun, Q.6
  • 133
    • 84904823447 scopus 로고    scopus 로고
    • Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
    • Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature 2014; 511: 483-7.
    • (2014) Nature , vol.511 , pp. 483-487
    • Walz, S.1    Lorenzin, F.2    Morton, J.3    Wiese, K.E.4    von Eyss, B.5    Herold, S.6
  • 134
    • 0032493894 scopus 로고    scopus 로고
    • The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
    • McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 1998; 94: 363-74.
    • (1998) Cell , vol.94 , pp. 363-374
    • McMahon, S.B.1    Van Buskirk, H.A.2    Dugan, K.A.3    Copeland, T.D.4    Cole, M.D.5
  • 135
    • 84953637969 scopus 로고    scopus 로고
    • Ubiquitin-dependent turnover of MYC antagonizes MYC/ PAF1C complex accumulation to drive transcriptional elongation
    • Jaenicke LA, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg AK, et al. Ubiquitin-dependent turnover of MYC antagonizes MYC/ PAF1C complex accumulation to drive transcriptional elongation. Mol Cell 2016; 61: 54-67.
    • (2016) Mol Cell , vol.61 , pp. 54-67
    • Jaenicke, L.A.1    von Eyss, B.2    Carstensen, A.3    Wolf, E.4    Xu, W.5    Greifenberg, A.K.6
  • 136
    • 84903268527 scopus 로고    scopus 로고
    • Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling
    • Rossetto D, Cramet M, Wang AY, Steunou AL, Lacoste N, Schulze JM, et al. Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling. EMBO J 2014; 33: 1397-415.
    • (2014) EMBO J , vol.33 , pp. 1397-1415
    • Rossetto, D.1    Cramet, M.2    Wang, A.Y.3    Steunou, A.L.4    Lacoste, N.5    Schulze, J.M.6
  • 139
    • 18644371442 scopus 로고    scopus 로고
    • Negative regulation of the mammalian UV response by Myc through association with Miz-1
    • Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, et al. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 2002; 10: 509-21.
    • (2002) Mol Cell , vol.10 , pp. 509-521
    • Herold, S.1    Wanzel, M.2    Beuger, V.3    Frohme, C.4    Beul, D.5    Hillukkala, T.6
  • 140
    • 2942650133 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
    • Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004; 101: 9085-90.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9085-9090
    • Welcker, M.1    Orian, A.2    Jin, J.3    Grim, J.E.4    Harper, J.W.5    Eisenman, R.N.6
  • 142
    • 24144441250 scopus 로고    scopus 로고
    • The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors
    • Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM. The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell 2005; 9: 327-38.
    • (2005) Dev Cell , vol.9 , pp. 327-338
    • Sjostrom, S.K.1    Finn, G.2    Hahn, W.C.3    Rowitch, D.H.4    Kenney, A.M.5
  • 143
    • 0029819179 scopus 로고    scopus 로고
    • A predictive scale for evaluating cyclin- dependent kinase substrates. A comparison of p34cdc2 and p33cdk2
    • Holmes JK, Solomon MJ. A predictive scale for evaluating cyclin- dependent kinase substrates. A comparison of p34cdc2 and p33cdk2. J Biol Chem 1996; 271: 25240-6.
    • (1996) J Biol Chem , vol.271 , pp. 25240-25246
    • Holmes, J.K.1    Solomon, M.J.2
  • 145
    • 84987673668 scopus 로고    scopus 로고
    • HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
    • Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, et al. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med 2016; 22: 1180-6.
    • (2016) Nat Med , vol.22 , pp. 1180-1186
    • Tavana, O.1    Li, D.2    Dai, C.3    Lopez, G.4    Banerjee, D.5    Kon, N.6
  • 147
    • 84995527874 scopus 로고    scopus 로고
    • Polo-like Kinase-1 regulates Myc stabilization and activates a feedforward circuit promoting tumor cell survival
    • Xiao D, Yue M, Su H, Ren P, Jiang J, Li F, et al. Polo-like Kinase-1 regulates Myc stabilization and activates a feedforward circuit promoting tumor cell survival. Mol Cell 2016; 64: 493-506.
    • (2016) Mol Cell , vol.64 , pp. 493-506
    • Xiao, D.1    Yue, M.2    Su, H.3    Ren, P.4    Jiang, J.5    Li, F.6
  • 149
    • 84976614642 scopus 로고    scopus 로고
    • PROTAC-induced BET protein degradation as a therapy for castration- resistant prostate cancer
    • Raina K, Lu J, Qian Y, Altieri M, Gordon D, Rossi AM, et al. PROTAC-induced BET protein degradation as a therapy for castration- resistant prostate cancer. Proc Natl Acad Sci U S A 2016; 113: 7124-9.
    • (2016) Proc Natl Acad Sci U S A , vol.113 , pp. 7124-7129
    • Raina, K.1    Lu, J.2    Qian, Y.3    Altieri, M.4    Gordon, D.5    Rossi, A.M.6
  • 150
    • 84932634729 scopus 로고    scopus 로고
    • Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation
    • Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, et al. Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 2015; 348: 1376-81.
    • (2015) Science , vol.348 , pp. 1376-1381
    • Winter, G.E.1    Buckley, D.L.2    Paulk, J.3    Roberts, J.M.4    Souza, A.5    Dhe-Paganon, S.6
  • 151
  • 153
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011; 146: 904-17.
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3    Rahl, P.B.4    Shi, J.5    Jacobs, H.M.6
  • 156
    • 84906968200 scopus 로고    scopus 로고
    • BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
    • Henssen A, Thor T, Odersky A, Heukamp L, El-Hindy N, Beckers A, et al. BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Oncotarget 2013; 4: 2080-95.
    • (2013) Oncotarget , vol.4 , pp. 2080-2095
    • Henssen, A.1    Thor, T.2    Odersky, A.3    Heukamp, L.4    El-Hindy, N.5    Beckers, A.6
  • 157
    • 84904036266 scopus 로고    scopus 로고
    • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
    • Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med 2014; 20: 732-40.
    • (2014) Nat Med , vol.20 , pp. 732-740
    • Tang, Y.1    Gholamin, S.2    Schubert, S.3    Willardson, M.I.4    Lee, A.5    Bandopadhayay, P.6
  • 159
    • 84938249789 scopus 로고    scopus 로고
    • BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells
    • Coude MM, Braun T, Berrou J, Dupont M, Bertrand S, Masse A, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget 2015; 6: 17698-712.
    • (2015) Oncotarget , vol.6 , pp. 17698-17712
    • Coude, M.M.1    Braun, T.2    Berrou, J.3    Dupont, M.4    Bertrand, S.5    Masse, A.6
  • 160
    • 84959145415 scopus 로고    scopus 로고
    • Phase I population pharmacokinetic assessment of the oral bromodomain inhibitor OTX015 in patients with haematologic malignancies
    • Odore E, Lokiec F, Cvitkovic E, Bekradda M, Herait P, Bourdel F, et al. Phase I population pharmacokinetic assessment of the oral bromodomain inhibitor OTX015 in patients with haematologic malignancies. Clin Pharmacokinet 2016; 55: 397-405.
    • (2016) Clin Pharmacokinet , vol.55 , pp. 397-405
    • Odore, E.1    Lokiec, F.2    Cvitkovic, E.3    Bekradda, M.4    Herait, P.5    Bourdel, F.6
  • 161
    • 57849107571 scopus 로고    scopus 로고
    • Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
    • Otto T, Horn S, Brockmann M, Eilers U, Schuttrumpf L, Popov N, et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell 2009; 15: 67-78.
    • (2009) Cancer Cell , vol.15 , pp. 67-78
    • Otto, T.1    Horn, S.2    Brockmann, M.3    Eilers, U.4    Schuttrumpf, L.5    Popov, N.6
  • 162
    • 84880042989 scopus 로고    scopus 로고
    • Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma
    • Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L, et al. Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell 2013; 24: 75-89.
    • (2013) Cancer Cell , vol.24 , pp. 75-89
    • Brockmann, M.1    Poon, E.2    Berry, T.3    Carstensen, A.4    Deubzer, H.E.5    Rycak, L.6
  • 163
    • 77950878509 scopus 로고    scopus 로고
    • Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: Insights into selectivity and drug design
    • Dodson CA, Kosmopoulou M, Richards MW, Atrash B, Bavetsias V, Blagg J, et al. Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design. Biochem J 2010; 427: 19-28.
    • (2010) Biochem J , vol.427 , pp. 19-28
    • Dodson, C.A.1    Kosmopoulou, M.2    Richards, M.W.3    Atrash, B.4    Bavetsias, V.5    Blagg, J.6
  • 165
    • 84859399268 scopus 로고    scopus 로고
    • An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735
    • Hook KE, Garza SJ, Lira ME, Ching KA, Lee NV, Cao J, et al. An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. Mol Cancer Ther 2012; 11: 710-9.
    • (2012) Mol Cancer Ther , vol.11 , pp. 710-719
    • Hook, K.E.1    Garza, S.J.2    Lira, M.E.3    Ching, K.A.4    Lee, N.V.5    Cao, J.6
  • 166
    • 84977272887 scopus 로고    scopus 로고
    • Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity
    • Chen Z, Wang Z, Pang JC, Yu Y, Bieerkehazhi S, Lu J, et al. Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep 2016; 6: 29090.
    • (2016) Sci Rep , vol.6 , pp. 29090
    • Chen, Z.1    Wang, Z.2    Pang, J.C.3    Yu, Y.4    Bieerkehazhi, S.5    Lu, J.6
  • 167
    • 84911942289 scopus 로고    scopus 로고
    • CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer
    • Chipumuro E, Marco E, Christensen CL, Kwiatkowski N, Zhang T, Hatheway CM, et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell 2014; 159: 1126-39.
    • (2014) Cell , vol.159 , pp. 1126-1139
    • Chipumuro, E.1    Marco, E.2    Christensen, C.L.3    Kwiatkowski, N.4    Zhang, T.5    Hatheway, C.M.6
  • 168
    • 0037474220 scopus 로고    scopus 로고
    • E2F proteins regulate MYCN expression in neuroblastomas
    • Strieder V, Lutz W. E2F proteins regulate MYCN expression in neuroblastomas. J Biol Chem 2003; 278: 2983-9.
    • (2003) J Biol Chem , vol.278 , pp. 2983-2989
    • Strieder, V.1    Lutz, W.2
  • 169
    • 84958592490 scopus 로고    scopus 로고
    • Exploitation of the apoptosis-primed state of MYCN-amplified neuroblastoma to develop a potent and specific targeted therapy combination
    • Ham J, Costa C, Sano R, Lochmann TL, Sennott EM, Patel NU, et al. Exploitation of the apoptosis-primed state of MYCN-amplified neuroblastoma to develop a potent and specific targeted therapy combination. Cancer Cell 2016; 29: 159-72.
    • (2016) Cancer Cell , vol.29 , pp. 159-172
    • Ham, J.1    Costa, C.2    Sano, R.3    Lochmann, T.L.4    Sennott, E.M.5    Patel, N.U.6
  • 170
    • 79952775174 scopus 로고    scopus 로고
    • RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
    • Cole KA, Huggins J, Laquaglia M, Hulderman CE, Russell MR, Bosse K, et al. RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A 2011; 108: 3336-41.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3336-3341
    • Cole, K.A.1    Huggins, J.2    Laquaglia, M.3    Hulderman, C.E.4    Russell, M.R.5    Bosse, K.6
  • 172
    • 84960842480 scopus 로고    scopus 로고
    • MYC regulates the antitumor immune response through CD47 and PD-L1
    • Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, et al. MYC regulates the antitumor immune response through CD47 and PD-L1. Science 2016; 352: 227-31.
    • (2016) Science , vol.352 , pp. 227-231
    • Casey, S.C.1    Tong, L.2    Li, Y.3    Do, R.4    Walz, S.5    Fitzgerald, K.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.