Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles

Current Biology

Volumn 8, Issue 11, 1998, Pages 661-666

  Nagy, A ^a,b   Moens, C ^a,d   Ivanyi, E ^a,c   Pawling, J ^a   Gertsenstein, M ^a   Hadjantonakis, A K ^a   Pirity, M ^a   Rossant, J ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^d UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MAMMALIA; MUS MUSCULUS; RODENTIA;

EID: 0032554783     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(98)70254-4     Document Type: Article

References (6)

1. Sauer B: Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae. Mol Cell Biol 1987, 7:2087-2096.
2. Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC: Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 1991, 65:1153-1163.
3. DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW: Structure and expression of the murine N-myc gene. Proc Natl Acad Sci USA 1986, 83:1827-1831.
4. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder J: Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 1993, 90:8424-8428.
5. Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL: Essential role of Mash-2 in extraembryonic development. Nature 1994, 371:333-336.
6. Sauer B, Henderson N: Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase. New Biologist 1990, 2:441-449.