메뉴 건너뛰기




Volumn 34, Issue 26, 2015, Pages 3357-3368

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; ALISERTIB; CRE RECOMBINASE; DOPAMINE BETA MONOOXYGENASE; NERVE CELL ADHESION MOLECULE; TYROSINE 3 MONOOXYGENASE; INTEGRASE; MYCN PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN;

EID: 84933040610     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.269     Document Type: Article
Times cited : (101)

References (44)
  • 1
    • 80655124594 scopus 로고    scopus 로고
    • Progress in treatment and risk stratification of neuroblastoma: Impact on future clinical and basic research
    • Ora I, Eggert A. Progress in treatment and risk stratification of neuroblastoma: impact on future clinical and basic research. Semin Cancer Biol 2011; 21: 217-228.
    • (2011) Semin Cancer Biol , vol.21 , pp. 217-228
    • Ora, I.1    Eggert, A.2
  • 3
    • 79551480067 scopus 로고    scopus 로고
    • The connections between neural crest development and neuroblastoma
    • Jiang M, Stanke J, Lahti JM. The connections between neural crest development and neuroblastoma. Curr Top Dev Biol 2011; 94: 77-127.
    • (2011) Curr Top Dev Biol , vol.94 , pp. 77-127
    • Jiang, M.1    Stanke, J.2    Lahti, J.M.3
  • 4
    • 77953523121 scopus 로고    scopus 로고
    • Recent advances in neuroblastoma
    • Maris JM. Recent advances in neuroblastoma. N Engl J Med 2010; 362: 2202-2211.
    • (2010) N Engl J Med , vol.362 , pp. 2202-2211
    • Maris, J.M.1
  • 5
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 2003; 3: 203-216.
    • (2003) Nat Rev Cancer , vol.3 , pp. 203-216
    • Brodeur, G.M.1
  • 6
  • 8
    • 20244370742 scopus 로고    scopus 로고
    • Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma
    • Vandesompele J, Baudis M, De Preter K, Van Roy N, Ambros P, Bown N et al. Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma. J Clin Oncol 2005; 23: 2280-2299.
    • (2005) J Clin Oncol , vol.23 , pp. 2280-2299
    • Vandesompele, J.1    Baudis, M.2    De Preter, K.3    Van Roy, N.4    Ambros, P.5    Bown, N.6
  • 11
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545-15550.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3    Mukherjee, S.4    Ebert, B.L.5    Gillette, M.A.6
  • 12
    • 33846404136 scopus 로고    scopus 로고
    • Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis
    • Whiteford CC, Bilke S, Greer BT, Chen Q, Braunschweig TA, Cenacchi N et al. Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis. Cancer Res 2007; 67: 32-40.
    • (2007) Cancer Res , vol.67 , pp. 32-40
    • Whiteford, C.C.1    Bilke, S.2    Greer, B.T.3    Chen, Q.4    Braunschweig, T.A.5    Cenacchi, N.6
  • 13
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012; 483: 603-607.
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1    Caponigro, G.2    Stransky, N.3    Venkatesan, K.4    Margolin, A.A.5    Kim, S.6
  • 14
    • 55649123695 scopus 로고    scopus 로고
    • Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
    • Westermann F, Muth D, Benner A, Bauer T, Henrich KO, Oberthuer A et al. Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol 2008; 9: R150.
    • (2008) Genome Biol , vol.9 , pp. R150
    • Westermann, F.1    Muth, D.2    Benner, A.3    Bauer, T.4    Henrich, K.O.5    Oberthuer, A.6
  • 17
    • 84880042989 scopus 로고    scopus 로고
    • Small molecule inhibitors of aurora-A induce proteasomal degradation of N-myc in childhood neuroblastoma
    • Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L et al. Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell 2013; 24: 75-89.
    • (2013) Cancer Cell , vol.24 , pp. 75-89
    • Brockmann, M.1    Poon, E.2    Berry, T.3    Carstensen, A.4    Deubzer, H.E.5    Rycak, L.6
  • 18
    • 79551628428 scopus 로고    scopus 로고
    • Treatment and outcomes of patients with relapsed, high-risk neuroblastoma: Results of German trials
    • Simon T, Berthold F, Borkhardt A, Kremens B, De Carolis B, Hero B. Treatment and outcomes of patients with relapsed, high-risk neuroblastoma: results of German trials. Pediatric Blood Cancer 2011; 56: 578-583.
    • (2011) Pediatric Blood Cancer , vol.56 , pp. 578-583
    • Simon, T.1    Berthold, F.2    Borkhardt, A.3    Kremens, B.4    De Carolis, B.5    Hero, B.6
  • 19
    • 31644450515 scopus 로고    scopus 로고
    • Targetdependent specification of the neurotransmitter phenotype: Cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling
    • Stanke M, Duong CV, Pape M, Geissen M, Burbach G, Deller T et al. Targetdependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. Development 2006; 133: 141-150.
    • (2006) Development , vol.133 , pp. 141-150
    • Stanke, M.1    Duong, C.V.2    Pape, M.3    Geissen, M.4    Burbach, G.5    Deller, T.6
  • 20
    • 0034194577 scopus 로고    scopus 로고
    • Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma
    • Weiss WA, Godfrey T, Francisco C, Bishop JM. Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma. Cancer Res 2000; 60: 2483-2487.
    • (2000) Cancer Res , vol.60 , pp. 2483-2487
    • Weiss, W.A.1    Godfrey, T.2    Francisco, C.3    Bishop, J.M.4
  • 21
    • 0141816855 scopus 로고    scopus 로고
    • Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors
    • Hackett CS, Hodgson JG, Law ME, Fridlyand J, Osoegawa K, de Jong PJ et al. Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors. Cancer Res 2003; 63: 5266-5273.
    • (2003) Cancer Res , vol.63 , pp. 5266-5273
    • Hackett, C.S.1    Hodgson, J.G.2    Law, M.E.3    Fridlyand, J.4    Osoegawa, K.5    De Jong, P.J.6
  • 23
    • 79952110151 scopus 로고    scopus 로고
    • Mouse models for miRNA expression: The ROSA26 locus
    • Casola S. Mouse models for miRNA expression: the ROSA26 locus. Methods Mol Biol 2010; 667: 145-163.
    • (2010) Methods Mol Biol , vol.667 , pp. 145-163
    • Casola, S.1
  • 24
    • 84855855098 scopus 로고    scopus 로고
    • A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters
    • Tchorz JS, Suply T, Ksiazek I, Giachino C, Cloetta D, Danzer CP et al. A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PLoS One 2012; 7: e30011.
    • (2012) PLoS One , vol.7 , pp. e30011
    • Tchorz, J.S.1    Suply, T.2    Ksiazek, I.3    Giachino, C.4    Cloetta, D.5    Danzer, C.P.6
  • 25
    • 84871305046 scopus 로고    scopus 로고
    • Tumor development, growth characteristics and spectrum of genetic aberrations in the TH-MYCN mouse model of neuroblastoma
    • Rasmuson A, Segerstrom L, Nethander M, Finnman J, Elfman LH, Javanmardi N et al. Tumor development, growth characteristics and spectrum of genetic aberrations in the TH-MYCN mouse model of neuroblastoma. PLoS ONE 2012; 7: e51297.
    • (2012) PLoS ONE , vol.7 , pp. e51297
    • Rasmuson, A.1    Segerstrom, L.2    Nethander, M.3    Finnman, J.4    Elfman, L.H.5    Javanmardi, N.6
  • 26
    • 34548232360 scopus 로고    scopus 로고
    • P-TEFb is a crucial co-factor for Myc transactivation
    • Gargano B, Amente S, Majello B, Lania L. P-TEFb is a crucial co-factor for Myc transactivation. Cell Cycle 2007; 6: 2031-2037.
    • (2007) Cell Cycle , vol.6 , pp. 2031-2037
    • Gargano, B.1    Amente, S.2    Majello, B.3    Lania, L.4
  • 27
    • 0037131186 scopus 로고    scopus 로고
    • Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter
    • Eberhardy SR, Farnham PJ. Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem 2002; 277: 40156-40162.
    • (2002) J Biol Chem , vol.277 , pp. 40156-40162
    • Eberhardy, S.R.1    Farnham, P.J.2
  • 28
    • 38549113034 scopus 로고    scopus 로고
    • Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression
    • Yang Z, He N, Zhou Q. Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression. Mol Cell Biol 2008; 28: 967-976.
    • (2008) Mol Cell Biol , vol.28 , pp. 967-976
    • Yang, Z.1    He, N.2    Zhou, Q.3
  • 29
    • 33947398087 scopus 로고    scopus 로고
    • Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome
    • Schramm A, Vandesompele J, Schulte JH, Dreesmann S, Kaderali L, Brors B et al. Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome. Clin Cancer Res 2007; 13: 1459-1465.
    • (2007) Clin Cancer Res , vol.13 , pp. 1459-1465
    • Schramm, A.1    Vandesompele, J.2    Schulte, J.H.3    Dreesmann, S.4    Kaderali, L.5    Brors, B.6
  • 30
    • 79961002472 scopus 로고    scopus 로고
    • High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma
    • Schulte JH, Bachmann HS, Brockmeyer B, Depreter K, Oberthur A, Ackermann S et al. High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma. Clin Cancer Res 2011; 17: 5082-5092.
    • (2011) Clin Cancer Res , vol.17 , pp. 5082-5092
    • Schulte, J.H.1    Bachmann, H.S.2    Brockmeyer, B.3    Depreter, K.4    Oberthur, A.5    Ackermann, S.6
  • 31
    • 62449197931 scopus 로고    scopus 로고
    • Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy
    • Schulte JH, Lim S, Schramm A, Friedrichs N, Koster J, Versteeg R et al. Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer research 2009; 69: 2065-2071.
    • (2009) Cancer Research , vol.69 , pp. 2065-2071
    • Schulte, J.H.1    Lim, S.2    Schramm, A.3    Friedrichs, N.4    Koster, J.5    Versteeg, R.6
  • 32
    • 84874760668 scopus 로고    scopus 로고
    • MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells
    • Schulte JH, Lindner S, Bohrer A, Maurer J, De Preter K, Lefever S et al. MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells. Oncogene 2012; 32: 1059-1065.
    • (2012) Oncogene , vol.32 , pp. 1059-1065
    • Schulte, J.H.1    Lindner, S.2    Bohrer, A.3    Maurer, J.4    De Preter, K.5    Lefever, S.6
  • 34
    • 3543105225 scopus 로고    scopus 로고
    • Circular binary segmentation for the analysis of array-based DNA copy number data
    • Olshen AB, Venkatraman ES, Lucito R, Wigler M. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics 2004; 5: 557-572.
    • (2004) Biostatistics , vol.5 , pp. 557-572
    • Olshen, A.B.1    Venkatraman, E.S.2    Lucito, R.3    Wigler, M.4
  • 37
    • 84055212052 scopus 로고    scopus 로고
    • MiRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples
    • De Preter K, Mestdagh P, Vermeulen J, Zeka F, Naranjo A, Bray I et al. miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples. Clin Cancer Res 2011; 17: 7684-7692.
    • (2011) Clin Cancer Res , vol.17 , pp. 7684-7692
    • De Preter, K.1    Mestdagh, P.2    Vermeulen, J.3    Zeka, F.4    Naranjo, A.5    Bray, I.6
  • 38
    • 10744224439 scopus 로고    scopus 로고
    • Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
    • Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E et al. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 2003; 115: 629-640.
    • (2003) Cell , vol.115 , pp. 629-640
    • Mootha, V.K.1    Bunkenborg, J.2    Olsen, J.V.3    Hjerrild, M.4    Wisniewski, J.R.5    Stahl, E.6
  • 40
    • 52949154642 scopus 로고    scopus 로고
    • High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma
    • Fredlund E, Ringner M, Maris JM, Pahlman S. High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. Proc Natl Acad Sci USA 2008; 105: 14094-14099.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14094-14099
    • Fredlund, E.1    Ringner, M.2    Maris, J.M.3    Pahlman, S.4
  • 41
    • 77949267058 scopus 로고    scopus 로고
    • MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
    • Mestdagh P, Fredlund E, Pattyn F, Schulte JH, Muth D, Vermeulen J et al. MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors. Oncogene 2010; 29: 1394-1404.
    • (2010) Oncogene , vol.29 , pp. 1394-1404
    • Mestdagh, P.1    Fredlund, E.2    Pattyn, F.3    Schulte, J.H.4    Muth, D.5    Vermeulen, J.6
  • 42
    • 66149106730 scopus 로고    scopus 로고
    • Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness
    • Cimmino F, Schulte JH, Zollo M, Koster J, Versteeg R, Iolascon A et al. Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness. Oncogene 2009; 28: 2015-2023.
    • (2009) Oncogene , vol.28 , pp. 2015-2023
    • Cimmino, F.1    Schulte, J.H.2    Zollo, M.3    Koster, J.4    Versteeg, R.5    Iolascon, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.